JP2015051970A - 化学療法を受けているがん患者向けのアジュバントを製造するための組成物 - Google Patents
化学療法を受けているがん患者向けのアジュバントを製造するための組成物 Download PDFInfo
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3254686A1 (en) * | 2016-06-06 | 2017-12-13 | Charsire Biotechnology Corp. | Soybean seed extract, method for producing the same and uses thereof |
| US20170360866A1 (en) * | 2016-06-15 | 2017-12-21 | Dai-Ming Kuo | Pharmaceutical composition for decreasing the side effects of cancer drug, and manufacturing method and uses thereof |
| JP2017226641A (ja) * | 2016-06-23 | 2017-12-28 | 台灣利得生物科技股▲ふん▼有限公司 | 牛樟芝活性組成物 |
| JP2019510041A (ja) * | 2016-03-30 | 2019-04-11 | マイクロバイオ カンパニー， リミテッド | 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法 |
| US10543243B2 (en) | 2016-06-06 | 2020-01-28 | Charsire Biotechnology Corp. | Soybeam seed extract, method for producing the same and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11179425B2 (en) | 2018-01-09 | 2021-11-23 | Microbio Co., Ltd. | Method of activating tumor-infiltrating lymphocytes (TILs) |
| TWI658831B (zh) * | 2018-02-02 | 2019-05-11 | 神農真菌生技有限公司 | 牛樟芝萃取物的用途 |
| CN109954053A (zh) * | 2019-04-23 | 2019-07-02 | 辽宁抗风竤生物医药科技有限责任公司 | 一种具有治疗乳腺癌食疗组合物及其制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006022038A (ja) * | 2004-07-08 | 2006-01-26 | Microbio Co Ltd | 大豆の発酵抽出物の製造方法 |
| US20070082073A1 (en) * | 2005-05-18 | 2007-04-12 | University Of South Florida | Catechin Adjuvants |
| US20080260695A1 (en) * | 2007-04-20 | 2008-10-23 | Microbio Company Ltd. | Composition for prevention and/or treatment of cancer |
| WO2011036904A1 (ja) * | 2009-09-28 | 2011-03-31 | 国立大学法人鳥取大学 | 制癌剤副作用抑制剤 |
| JP2013529899A (ja) * | 2010-05-14 | 2013-07-25 | 株式会社ジーシーエイチアンドピー | ジンセノサイド成分を増加させた新規な加工人参または加工人参抽出物の製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI252759B (en) * | 2002-07-05 | 2006-04-11 | Microbio Co Ltd | Method of using fermented glycine max (L.) extract for enhancing natural killer cell activity |
| JP2005232032A (ja) * | 2004-02-17 | 2005-09-02 | Kikkoman Corp | 敗血症の予防・治療剤 |
| CN102145159B (zh) * | 2011-03-31 | 2012-08-29 | 青岛大学 | 生姜与土木香组合物、其制备方法及其在制备癌症放、化疗中减毒增效药物中的用途 |
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2014
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006022038A (ja) * | 2004-07-08 | 2006-01-26 | Microbio Co Ltd | 大豆の発酵抽出物の製造方法 |
| US20070082073A1 (en) * | 2005-05-18 | 2007-04-12 | University Of South Florida | Catechin Adjuvants |
| US20080260695A1 (en) * | 2007-04-20 | 2008-10-23 | Microbio Company Ltd. | Composition for prevention and/or treatment of cancer |
| WO2011036904A1 (ja) * | 2009-09-28 | 2011-03-31 | 国立大学法人鳥取大学 | 制癌剤副作用抑制剤 |
| JP2013529899A (ja) * | 2010-05-14 | 2013-07-25 | 株式会社ジーシーエイチアンドピー | ジンセノサイド成分を増加させた新規な加工人参または加工人参抽出物の製造方法 |
Non-Patent Citations (1)
| Title |
|---|
| SUGANUMA, M. ET AL.: "New cancer treatment strategy using combination of green tea catechins and anticancer drugs", CANCER SCI., vol. 102巻, JPN6018020087, 2011, pages pp. 317-323. * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019510041A (ja) * | 2016-03-30 | 2019-04-11 | マイクロバイオ カンパニー， リミテッド | 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法 |
| JP2022058740A (ja) * | 2016-03-30 | 2022-04-12 | マイクロバイオ カンパニー， リミテッド | 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法 |
| JP7442555B2 (ja) | 2016-03-30 | 2024-03-04 | マイクロバイオ カンパニー， リミテッド | 免疫チェックポイントモジュレーターおよび共生微生物叢による発酵産物の併用がん療法 |
| EP3254686A1 (en) * | 2016-06-06 | 2017-12-13 | Charsire Biotechnology Corp. | Soybean seed extract, method for producing the same and uses thereof |
| US10543243B2 (en) | 2016-06-06 | 2020-01-28 | Charsire Biotechnology Corp. | Soybeam seed extract, method for producing the same and uses thereof |
| US20170360866A1 (en) * | 2016-06-15 | 2017-12-21 | Dai-Ming Kuo | Pharmaceutical composition for decreasing the side effects of cancer drug, and manufacturing method and uses thereof |
| CN107510813A (zh) * | 2016-06-15 | 2017-12-26 | 郭道明 | 用于降低癌症治疗药物副作用的医药组合物、制备方法及其用途 |
| US11065293B2 (en) * | 2016-06-15 | 2021-07-20 | Dai-Ming Kuo | Pharmaceutical composition for decreasing the side effects of cancer drug, and manufacturing method and uses thereof |
| JP2017226641A (ja) * | 2016-06-23 | 2017-12-28 | 台灣利得生物科技股▲ふん▼有限公司 | 牛樟芝活性組成物 |
| JP2019147849A (ja) * | 2016-06-23 | 2019-09-05 | 台灣利得生物科技股▲ふん▼有限公司 | 牛樟芝活性組成物の製造方法 |
Also Published As
| Publication number | Publication date |
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| KR20150028754A (ko) | 2015-03-16 |
| CN104415298A (zh) | 2015-03-18 |
| TWI673060B (zh) | 2019-10-01 |
| HK1207820A1 (zh) | 2016-02-12 |
| TW201605461A (zh) | 2016-02-16 |
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