JP2015038512A5 - - Google Patents
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- JP2015038512A5 JP2015038512A5 JP2014235001A JP2014235001A JP2015038512A5 JP 2015038512 A5 JP2015038512 A5 JP 2015038512A5 JP 2014235001 A JP2014235001 A JP 2014235001A JP 2014235001 A JP2014235001 A JP 2014235001A JP 2015038512 A5 JP2015038512 A5 JP 2015038512A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- abundance
- glycerol
- preeclampsia
- risk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000090 biomarker Substances 0.000 claims 22
- 201000011461 pre-eclampsia Diseases 0.000 claims 21
- 238000003556 assay Methods 0.000 claims 20
- 239000002207 metabolite Substances 0.000 claims 10
- XJMMNTGIMDZPMU-UHFFFAOYSA-N 3-methylglutaric acid Chemical compound OC(=O)CC(C)CC(O)=O XJMMNTGIMDZPMU-UHFFFAOYSA-N 0.000 claims 8
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims 8
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 8
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 8
- 230000035935 pregnancy Effects 0.000 claims 8
- XHFVUOPOWJSGSY-UHFFFAOYSA-N C(C=CC=CCCCCCCCCCCCCC)(=O)C(O)[C@@H](O)C(O)C(C=CC=CCCCCCCCCCCCCC)=O Chemical compound C(C=CC=CCCCCCCCCCCCCC)(=O)C(O)[C@@H](O)C(O)C(C=CC=CCCCCCCCCCCCCC)=O XHFVUOPOWJSGSY-UHFFFAOYSA-N 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 7
- MUPIMXWODDPFGR-BGERDNNASA-N C(C=CC=CCCCCCCCCCCCCC)(=O)C(O)[C@@H](O)CO Chemical compound C(C=CC=CCCCCCCCCCCCCC)(=O)C(O)[C@@H](O)CO MUPIMXWODDPFGR-BGERDNNASA-N 0.000 claims 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 4
- KDVFRMMRZOCFLS-UHFFFAOYSA-N 2-oxopentanoic acid Chemical compound CCCC(=O)C(O)=O KDVFRMMRZOCFLS-UHFFFAOYSA-N 0.000 claims 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 4
- WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 4
- LZOSYCMHQXPBFU-UHFFFAOYSA-N O-decanoylcarnitine Chemical compound CCCCCCCCCC(=O)OC(CC([O-])=O)C[N+](C)(C)C LZOSYCMHQXPBFU-UHFFFAOYSA-N 0.000 claims 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 4
- 239000005642 Oleic acid Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 235000011037 adipic acid Nutrition 0.000 claims 4
- 239000001361 adipic acid Substances 0.000 claims 4
- 238000004590 computer program Methods 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 claims 4
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 4
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000002772 monosaccharides Chemical class 0.000 claims 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 4
- 235000021313 oleic acid Nutrition 0.000 claims 4
- JLPJFSCQKHRSQR-UHFFFAOYSA-N oxolan-3-one Chemical compound O=C1CCOC1 JLPJFSCQKHRSQR-UHFFFAOYSA-N 0.000 claims 4
- YHEDRJPUIRMZMP-ZWKOTPCHSA-N sphinganine 1-phosphate Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O YHEDRJPUIRMZMP-ZWKOTPCHSA-N 0.000 claims 4
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 claims 4
- 150000003704 vitamin D3 derivatives Chemical class 0.000 claims 4
- -1 ( decadienoyl) -sn-glycerol metabolite Chemical class 0.000 claims 3
- TVDKGFVJJJTMSW-SQTCDLSVSA-N 17-[(1s)-1,2-dihydroxyethyl]-17-hydroxyheptatriaconta-14,19,21,23,25-pentaene-16,18-dione Chemical compound CCCCCCCCCCCCCC=CC(=O)C(O)([C@@H](O)CO)C(=O)C=CC=CC=CC=CCCCCCCCCCCC TVDKGFVJJJTMSW-SQTCDLSVSA-N 0.000 claims 3
- FKJHLNDJJGVDEE-UHFFFAOYSA-N 2-formylbutanoic acid Chemical compound CCC(C=O)C(O)=O FKJHLNDJJGVDEE-UHFFFAOYSA-N 0.000 claims 3
- 230000036772 blood pressure Effects 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 206010070538 Gestational hypertension Diseases 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 125000004050 enoyl group Chemical group 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 230000035987 intoxication Effects 0.000 claims 1
- 231100000566 intoxication Toxicity 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 230000008774 maternal effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 201000011460 mild pre-eclampsia Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001644 umbilical artery Anatomy 0.000 claims 1
- 210000000685 uterine artery Anatomy 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000036266 weeks of gestation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28846509P | 2009-12-21 | 2009-12-21 | |
| US61/288,465 | 2009-12-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545311A Division JP5756125B2 (ja) | 2009-12-21 | 2010-12-21 | 妊娠高血圧腎症の危険性の検出 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015187177A Division JP6185532B2 (ja) | 2009-12-21 | 2015-09-24 | 妊娠高血圧腎症の危険性の検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015038512A JP2015038512A (ja) | 2015-02-26 |
| JP2015038512A5 true JP2015038512A5 (https=) | 2015-09-10 |
| JP5815830B2 JP5815830B2 (ja) | 2015-11-17 |
Family
ID=43587630
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545311A Expired - Fee Related JP5756125B2 (ja) | 2009-12-21 | 2010-12-21 | 妊娠高血圧腎症の危険性の検出 |
| JP2014235001A Active JP5815830B2 (ja) | 2009-12-21 | 2014-11-19 | 妊娠高血圧腎症の危険性の検出 |
| JP2015187177A Expired - Fee Related JP6185532B2 (ja) | 2009-12-21 | 2015-09-24 | 妊娠高血圧腎症の危険性の検出 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545311A Expired - Fee Related JP5756125B2 (ja) | 2009-12-21 | 2010-12-21 | 妊娠高血圧腎症の危険性の検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015187177A Expired - Fee Related JP6185532B2 (ja) | 2009-12-21 | 2015-09-24 | 妊娠高血圧腎症の危険性の検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9262582B2 (https=) |
| EP (3) | EP3422006B1 (https=) |
| JP (3) | JP5756125B2 (https=) |
| CN (1) | CN102893156A (https=) |
| BR (1) | BR112012016918A2 (https=) |
| ES (1) | ES2970328T3 (https=) |
| RU (1) | RU2012131290A (https=) |
| WO (2) | WO2011080170A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102893156A (zh) * | 2009-12-21 | 2013-01-23 | 爱尔兰国立科克大学 | 子痫前期风险的检测 |
| CN103957813B (zh) * | 2011-11-30 | 2016-08-17 | 皇家飞利浦有限公司 | 用于识别高危妊娠的系统和方法 |
| EP2836832A4 (en) * | 2012-04-13 | 2015-10-14 | Univ Wayne State | EARLY TRIMESTER SCREENING FOR EARLY AND LATE MANIFESTED PREAMBLE LAMPSY |
| WO2014001244A1 (en) * | 2012-06-27 | 2014-01-03 | Roche Diagnostics Gmbh | MEANS AND METHODS APPLYING sFlt-1/PlGF OR ENDOGLIN/PlGF RATIO TO RULE-OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD |
| CN103513042A (zh) * | 2013-09-23 | 2014-01-15 | 中国科学院动物研究所 | 用于预测或早期诊断妊娠高血压疾病的试剂盒 |
| US20170205420A1 (en) * | 2014-06-23 | 2017-07-20 | Wallac Oy | Biochemical markers for use in determining risk of diabetes |
| RU2558465C1 (ru) * | 2014-07-15 | 2015-08-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования Читинская государственная медицинская академия Министерства здравоохранения РФ | Способ доклинической диагностики преэклампсии |
| JP2017535750A (ja) * | 2014-09-24 | 2017-11-30 | マップ アイピー ホールディング リミテッド | 妊娠の予後を提供する方法 |
| WO2016149759A1 (en) * | 2015-03-23 | 2016-09-29 | Adelaide Research & Innovation Pty Ltd | Methods and systems for determining risk of a pregnancy complication occurring |
| WO2017075027A1 (en) * | 2015-10-26 | 2017-05-04 | Brigham Young University | Serum lipid biomarkers of preeclampsia |
| GB201600882D0 (en) | 2016-01-18 | 2016-03-02 | Power Box Ag | Improvements to router apparatus |
| WO2017180876A1 (en) * | 2016-04-13 | 2017-10-19 | Abbott Laboratories | Cardiac troponin i detection during pregnancy for cardiovascular disease identification and risk assessment |
| US10978202B2 (en) * | 2016-04-21 | 2021-04-13 | Perigen Inc. | Method and system for concurrently monitoring multiple obstetrics patients |
| US11682495B2 (en) * | 2016-10-13 | 2023-06-20 | Carnegie Mellon University | Structured medical data classification system for monitoring and remediating treatment risks |
| RU2638785C1 (ru) * | 2016-12-12 | 2017-12-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ прогнозирования риска развития преэклампсии тяжелого течения |
| CN106755492B (zh) * | 2017-01-24 | 2020-04-21 | 深圳金蕊科技有限公司 | 用于预测子痫前期的成套snp及其应用 |
| WO2018174876A1 (en) * | 2017-03-22 | 2018-09-27 | Mprobe Inc. | Methods and compositions for providing a preeclampsia assessment with metabolites |
| JP2018175850A (ja) * | 2017-04-14 | 2018-11-15 | 株式会社Ｎｔｔドコモ | データ収集装置及びデータ収集方法 |
| JP2019041754A (ja) * | 2017-08-31 | 2019-03-22 | 株式会社Ｎｔｔドコモ | 予測装置及び予測方法 |
| US11341138B2 (en) * | 2017-12-06 | 2022-05-24 | International Business Machines Corporation | Method and system for query performance prediction |
| ES3056147T3 (en) * | 2018-02-09 | 2026-02-18 | Metabolomic Diagnostics Ltd | A system and method of generating a model to detect, or predict the risk of, an outcome |
| US20210033619A1 (en) * | 2018-02-09 | 2021-02-04 | Metabolomic Diagnostics Limited | Methods of predicting pre term birth from preeclampsia using metabolic and protein biomarkers |
| GB201802123D0 (en) * | 2018-02-09 | 2018-03-28 | Metabolomic Diagnostics Ltd | A method of processomg a biological sample |
| US20210275486A1 (en) * | 2018-06-21 | 2021-09-09 | Maruha Nichiro Corporation | Renal function maintenance and protection agent, and method for evaluating effect thereof |
| JP7013416B2 (ja) * | 2018-06-21 | 2022-01-31 | マルハニチロ株式会社 | 腎機能維持及び保護剤、並びに、その効果評価方法 |
| CN112673259B (zh) * | 2018-07-20 | 2024-11-22 | 豪夫迈·罗氏有限公司 | 基于igfbp-7的先兆子痫预测 |
| CA3127522A1 (en) * | 2019-01-29 | 2020-08-06 | Metabolomic Diagnostics Limited | Detection of risk of pre-eclampsia in obese pregnant women |
| KR102308865B1 (ko) * | 2019-02-08 | 2021-10-05 | 서울대학교산학협력단 | 전신 홍반 루푸스 산모의 임신 위험도를 평가하는 방법 |
| EP3999846A4 (en) | 2019-07-25 | 2023-08-09 | Overture Life, Inc | IDENTIFICATION OF VIABLE HUMAN EMBRYO |
| CN110534184B (zh) * | 2019-08-29 | 2022-07-15 | 中国人民解放军陆军军医大学第一附属医院 | 一种产科手术资源配置预测系统 |
| CN110806456B (zh) * | 2019-11-12 | 2022-03-15 | 浙江工业大学 | 一种UPLC-HRMS Profile模式非靶向代谢轮廓数据自动解析的方法 |
| US20230132131A1 (en) * | 2020-02-28 | 2023-04-27 | Metabolomic Diagnostics Limited | Prediction of risk of pre-eclampsia |
| CN112820406A (zh) * | 2020-12-30 | 2021-05-18 | 复旦大学附属妇产科医院 | 一种妊娠早期对子痫前期发病风险的预测方法 |
| CN113092777B (zh) * | 2021-03-26 | 2023-11-14 | 泰达国际心血管病医院 | 孕早期进行重症子痫前期患者筛查的方法 |
| KR102366856B1 (ko) * | 2021-04-23 | 2022-02-23 | 이화여자대학교 산학협력단 | 레티노이드 대사체를 이용한 조산의 조기 예측 방법 |
| CN117233367B (zh) * | 2023-11-16 | 2024-02-09 | 哈尔滨脉图精准技术有限公司 | 妊娠期高血压风险评估的代谢标志物 |
| CN118518860B (zh) * | 2024-04-16 | 2025-06-10 | 山东第一医科大学(山东省医学科学院) | 用于诊断或预警急性冠脉综合征的生物标志物及其筛选方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030068653A1 (en) * | 2000-06-01 | 2003-04-10 | Parrott Jeff A. | Determining existence of complications in pregnancies by measuring levels of bioactive lipids |
| DE10043124A1 (de) * | 2000-08-31 | 2002-03-14 | Max Delbrueck Centrum | Verfahren zur Diagnostik von neuronalen Erkrankungen sowie zur Behandlung der defizienten primären Hämostase |
| WO2006086731A2 (en) * | 2005-02-09 | 2006-08-17 | The Gov't.T Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services | Method for identifying the risk of preterm delivery |
| US20080255764A1 (en) * | 2005-09-12 | 2008-10-16 | Phenomenome Discoveries Inc. | Methods for the Diagnosis of Colorectal Cancer and Ovarian Cancer by the Measurement of Vitamin E-Related Metabolites |
| EP1996923B1 (en) * | 2006-03-02 | 2012-06-27 | PerkinElmer Health Sciences, Inc. | Methods for distinguishing isomers using mass spectrometry |
| GB0612669D0 (en) * | 2006-06-27 | 2006-08-09 | Univ Leeds | Biomarkers for preeclampsia |
| GB0613165D0 (en) * | 2006-06-28 | 2006-08-09 | Univ Warwick | Real-time infrared measurement and imaging system |
| US20080071151A1 (en) * | 2006-06-30 | 2008-03-20 | Sogin David C | Method and Apparatus for Diagnosing Pre-eclampsia |
| CN101122600A (zh) * | 2007-08-16 | 2008-02-13 | 复旦大学附属中山医院 | 一种血清小分子代谢产物的检测方法 |
| CN102893156A (zh) * | 2009-12-21 | 2013-01-23 | 爱尔兰国立科克大学 | 子痫前期风险的检测 |
-
2010
- 2010-12-21 CN CN2010800637749A patent/CN102893156A/zh active Pending
- 2010-12-21 ES ES18157264T patent/ES2970328T3/es active Active
- 2010-12-21 JP JP2012545311A patent/JP5756125B2/ja not_active Expired - Fee Related
- 2010-12-21 EP EP18157264.5A patent/EP3422006B1/en active Active
- 2010-12-21 RU RU2012131290/15A patent/RU2012131290A/ru not_active Application Discontinuation
- 2010-12-21 EP EP10803084A patent/EP2517019A1/en not_active Withdrawn
- 2010-12-21 EP EP16205574.3A patent/EP3206033A1/en not_active Withdrawn
- 2010-12-21 BR BR112012016918A patent/BR112012016918A2/pt not_active Application Discontinuation
- 2010-12-21 WO PCT/EP2010/070446 patent/WO2011080170A1/en not_active Ceased
- 2010-12-21 US US13/515,323 patent/US9262582B2/en active Active
- 2010-12-21 WO PCT/CA2010/002046 patent/WO2011075842A1/en not_active Ceased
-
2014
- 2014-11-19 JP JP2014235001A patent/JP5815830B2/ja active Active
-
2015
- 2015-09-24 JP JP2015187177A patent/JP6185532B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-07 US US14/990,231 patent/US20160223517A1/en not_active Abandoned
-
2018
- 2018-05-16 US US15/981,798 patent/US10564146B2/en active Active
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