JP2014534258A5 - - Google Patents
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- Publication number
- JP2014534258A5 JP2014534258A5 JP2014542952A JP2014542952A JP2014534258A5 JP 2014534258 A5 JP2014534258 A5 JP 2014534258A5 JP 2014542952 A JP2014542952 A JP 2014542952A JP 2014542952 A JP2014542952 A JP 2014542952A JP 2014534258 A5 JP2014534258 A5 JP 2014534258A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant protein
- growth factor
- full length
- neutralizing
- vegf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 28
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 28
- 239000003102 growth factor Substances 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 230000003472 neutralizing effect Effects 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 230000002163 immunogen Effects 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 108020003175 receptors Proteins 0.000 claims 8
- 102000005962 receptors Human genes 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102100026827 Protein associated with UVRAG as autophagy enhancer Human genes 0.000 claims 4
- 101710102978 Protein associated with UVRAG as autophagy enhancer Proteins 0.000 claims 4
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 4
- 102000009016 Cholera Toxin Human genes 0.000 claims 3
- 108010049048 Cholera Toxin Proteins 0.000 claims 3
- 238000006386 neutralization reaction Methods 0.000 claims 3
- 102000004152 Bone morphogenetic protein 1 Human genes 0.000 claims 2
- 108090000654 Bone morphogenetic protein 1 Proteins 0.000 claims 2
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims 2
- 102400001368 Epidermal growth factor Human genes 0.000 claims 2
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 2
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 2
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 2
- 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 claims 2
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 2
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 2
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 2
- 102400001320 Transforming growth factor alpha Human genes 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 claims 2
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims 2
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 claims 2
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims 2
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 claims 2
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims 2
- 102100038234 Vascular endothelial growth factor D Human genes 0.000 claims 2
- 229940116977 epidermal growth factor Drugs 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101001010819 Homo sapiens Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 1
- -1 PDGF Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161563128P | 2011-11-23 | 2011-11-23 | |
| US61/563,128 | 2011-11-23 | ||
| US201261654401P | 2012-06-01 | 2012-06-01 | |
| US61/654,401 | 2012-06-01 | ||
| PCT/IB2012/002876 WO2013076580A2 (en) | 2011-11-23 | 2012-11-21 | Recombinant proteins and their therapeutic uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017064763A Division JP6570081B2 (ja) | 2011-11-23 | 2017-03-29 | 組換えタンパク質及びそれらの治療的用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534258A JP2014534258A (ja) | 2014-12-18 |
| JP2014534258A5 true JP2014534258A5 (enExample) | 2016-01-21 |
| JP6121436B2 JP6121436B2 (ja) | 2017-04-26 |
Family
ID=47716105
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542952A Active JP6121436B2 (ja) | 2011-11-23 | 2012-11-21 | 組換えタンパク質及びそれらの治療的用途 |
| JP2017064763A Expired - Fee Related JP6570081B2 (ja) | 2011-11-23 | 2017-03-29 | 組換えタンパク質及びそれらの治療的用途 |
| JP2019072235A Active JP6953467B2 (ja) | 2011-11-23 | 2019-04-04 | 組換えタンパク質及びそれらの治療的用途 |
| JP2021159307A Active JP7470669B2 (ja) | 2011-11-23 | 2021-09-29 | 組換えタンパク質及びそれらの治療的用途 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017064763A Expired - Fee Related JP6570081B2 (ja) | 2011-11-23 | 2017-03-29 | 組換えタンパク質及びそれらの治療的用途 |
| JP2019072235A Active JP6953467B2 (ja) | 2011-11-23 | 2019-04-04 | 組換えタンパク質及びそれらの治療的用途 |
| JP2021159307A Active JP7470669B2 (ja) | 2011-11-23 | 2021-09-29 | 組換えタンパク質及びそれらの治療的用途 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US9902760B2 (enExample) |
| EP (2) | EP2782598B1 (enExample) |
| JP (4) | JP6121436B2 (enExample) |
| KR (2) | KR102274211B1 (enExample) |
| CN (3) | CN108864261A (enExample) |
| AU (3) | AU2012342117B2 (enExample) |
| BR (1) | BR112014012460B1 (enExample) |
| CA (1) | CA2856255C (enExample) |
| DK (1) | DK2782598T3 (enExample) |
| ES (1) | ES2812564T3 (enExample) |
| HR (1) | HRP20201282T1 (enExample) |
| HU (1) | HUE050438T2 (enExample) |
| IL (2) | IL232645B (enExample) |
| LT (1) | LT2782598T (enExample) |
| MX (2) | MX354902B (enExample) |
| MY (2) | MY188083A (enExample) |
| PL (1) | PL2782598T3 (enExample) |
| PT (1) | PT2782598T (enExample) |
| RS (1) | RS60782B1 (enExample) |
| RU (2) | RU2650574C2 (enExample) |
| SI (1) | SI2782598T1 (enExample) |
| WO (1) | WO2013076580A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2782598T (lt) * | 2011-11-23 | 2020-07-27 | In3Bio Ltd. | Rekombinantiniai baltymai ir jų terapinis panaudojimas |
| US20160333087A1 (en) * | 2015-05-12 | 2016-11-17 | Bioven 3 Limited | Methods and compositions for inhibition of egf/egfr pathway in combination with tyrosine kinase inhibitors |
| US20190358320A1 (en) * | 2015-05-12 | 2019-11-28 | In3Bio Ltd. | Methods and compositions for inhibition of egf/egfr pathway in combination with tyrosine kinase inhibitors |
| IL300235A (en) * | 2017-07-18 | 2023-03-01 | In3Bio Ltd | Synthetic proteins and their therapeutic uses |
| CN107880133A (zh) * | 2017-11-04 | 2018-04-06 | 海南大学 | 促皮质素与胰岛素样生长因子1融合蛋白及其制备方法 |
| WO2019179361A1 (zh) * | 2018-03-21 | 2019-09-26 | 傅惠芳 | 改善括约肌闭锁不全的组合物及其医药组成物与用途 |
| US20210393768A1 (en) * | 2018-08-27 | 2021-12-23 | University Of Virginia Patent Foundation | Compositions and methods for preventing and treating virus infection |
| CN114269792B (zh) * | 2019-06-25 | 2025-08-08 | 因斯瑞拜奥有限公司 | 稳定的嵌合合成蛋白及其治疗用途 |
| EP4054619A1 (en) | 2019-11-07 | 2022-09-14 | In3Bio Ltd. | Methods and compositions for use of growth factor antibodies in combination with non-tyrosine targeting kinase inhibitors |
| CN116003601A (zh) * | 2019-12-05 | 2023-04-25 | 启愈生物技术(上海)有限公司 | 一种抗pd-l1纳米抗体及其用途 |
| WO2021195327A1 (en) * | 2020-03-25 | 2021-09-30 | The Regents Of The University Of Colorado, A Body Corporate | Bivalent egf fusion toxins |
| CN113735980A (zh) * | 2021-08-23 | 2021-12-03 | 中国医学科学院北京协和医院 | 一种自融合串联蛋白修饰方法及其应用 |
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| LT2782598T (lt) * | 2011-11-23 | 2020-07-27 | In3Bio Ltd. | Rekombinantiniai baltymai ir jų terapinis panaudojimas |
-
2012
- 2012-11-21 LT LTEP12824705.3T patent/LT2782598T/lt unknown
- 2012-11-21 AU AU2012342117A patent/AU2012342117B2/en active Active
- 2012-11-21 CN CN201810569310.3A patent/CN108864261A/zh active Pending
- 2012-11-21 MX MX2014006232A patent/MX354902B/es active IP Right Grant
- 2012-11-21 JP JP2014542952A patent/JP6121436B2/ja active Active
- 2012-11-21 DK DK12824705.3T patent/DK2782598T3/da active
- 2012-11-21 HR HRP20201282TT patent/HRP20201282T1/hr unknown
- 2012-11-21 US US13/813,844 patent/US9902760B2/en active Active
- 2012-11-21 PL PL12824705T patent/PL2782598T3/pl unknown
- 2012-11-21 CA CA2856255A patent/CA2856255C/en active Active
- 2012-11-21 BR BR112014012460-4A patent/BR112014012460B1/pt active IP Right Grant
- 2012-11-21 PT PT128247053T patent/PT2782598T/pt unknown
- 2012-11-21 RU RU2014124923A patent/RU2650574C2/ru active
- 2012-11-21 KR KR1020197027075A patent/KR102274211B1/ko active Active
- 2012-11-21 KR KR1020147016995A patent/KR102024066B1/ko active Active
- 2012-11-21 CN CN201280067891.1A patent/CN104066447A/zh active Pending
- 2012-11-21 MX MX2018003596A patent/MX381185B/es unknown
- 2012-11-21 ES ES12824705T patent/ES2812564T3/es active Active
- 2012-11-21 RS RS20200986A patent/RS60782B1/sr unknown
- 2012-11-21 HU HUE12824705A patent/HUE050438T2/hu unknown
- 2012-11-21 MY MYPI2018000286A patent/MY188083A/en unknown
- 2012-11-21 EP EP12824705.3A patent/EP2782598B1/en active Active
- 2012-11-21 WO PCT/IB2012/002876 patent/WO2013076580A2/en not_active Ceased
- 2012-11-21 MY MYPI2014701320A patent/MY184576A/en unknown
- 2012-11-21 EP EP20170470.7A patent/EP3744343A1/en not_active Withdrawn
- 2012-11-21 SI SI201231830T patent/SI2782598T1/sl unknown
- 2012-11-21 CN CN201810569766.XA patent/CN108864291A/zh active Pending
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2014
- 2014-05-15 IL IL232645A patent/IL232645B/en active IP Right Grant
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2016
- 2016-01-15 US US14/996,553 patent/US20160207972A1/en not_active Abandoned
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2017
- 2017-03-29 JP JP2017064763A patent/JP6570081B2/ja not_active Expired - Fee Related
- 2017-11-16 US US15/814,723 patent/US11198716B2/en active Active
- 2017-11-30 AU AU2017268634A patent/AU2017268634B2/en not_active Ceased
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2018
- 2018-03-09 RU RU2018108421A patent/RU2766595C2/ru active
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2019
- 2019-04-04 JP JP2019072235A patent/JP6953467B2/ja active Active
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2020
- 2020-02-21 AU AU2020201297A patent/AU2020201297B2/en not_active Ceased
- 2020-12-22 IL IL279676A patent/IL279676A/en unknown
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2021
- 2021-09-29 JP JP2021159307A patent/JP7470669B2/ja active Active
- 2021-11-08 US US17/521,121 patent/US12030920B2/en active Active
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2024
- 2024-07-02 US US18/761,743 patent/US12570708B2/en active Active
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