JP2014533693A - ポリマー系着色剤組成物及び使用方法 - Google Patents
ポリマー系着色剤組成物及び使用方法 Download PDFInfo
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- JP2014533693A JP2014533693A JP2014542475A JP2014542475A JP2014533693A JP 2014533693 A JP2014533693 A JP 2014533693A JP 2014542475 A JP2014542475 A JP 2014542475A JP 2014542475 A JP2014542475 A JP 2014542475A JP 2014533693 A JP2014533693 A JP 2014533693A
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- A—HUMAN NECESSITIES
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| PCT/US2012/065404 WO2013074860A1 (en) | 2011-11-16 | 2012-11-16 | Polymeric colorant compositions and methods of use |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019534360A (ja) * | 2016-11-01 | 2019-11-28 | ミリケン・アンド・カンパニーＭｉｌｌｉｋｅｎ ＆ Ｃｏｍｐａｎｙ | 洗濯ケア組成物における青味剤としてのロイコポリマー |
| JP2019534358A (ja) * | 2016-11-01 | 2019-11-28 | ミリケン・アンド・カンパニーＭｉｌｌｉｋｅｎ ＆ Ｃｏｍｐａｎｙ | 洗濯ケア組成物における青味剤としてのロイコポリマー |
| JP2019535856A (ja) * | 2016-11-01 | 2019-12-12 | ミリケン・アンド・カンパニーＭｉｌｌｉｋｅｎ ＆ Ｃｏｍｐａｎｙ | 洗濯ケア組成物における青味剤としてのロイコポリマー |
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| US20140276354A1 (en) * | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| WO2015158467A1 (en) * | 2014-04-14 | 2015-10-22 | Unilever N.V. | Skin care composition |
| EP3131526B1 (en) * | 2014-04-14 | 2017-11-01 | Unilever N.V. | Skin care composition |
| DE102014107412A1 (de) * | 2014-05-26 | 2015-12-17 | Schülke & Mayr GmbH | Gefärbte desinfizierende Zubereitung auf Basis von Bispyridiniumalkan |
| US10091991B2 (en) | 2014-12-01 | 2018-10-09 | Greenway Pest Products, Llc | Antimicrobial films |
| JP6810360B2 (ja) * | 2016-03-09 | 2021-01-06 | Jsr株式会社 | インク、捺染方法及びテキスタイル用インク剤 |
| EP3703824A1 (en) | 2017-10-31 | 2020-09-09 | Rohm and Haas Company | Multistage colored polymer particle and skin care formulations comprising same |
| US12390487B2 (en) | 2019-04-05 | 2025-08-19 | Solventum Intellectual Properties Company | Antiseptic skin prep composition |
| DE102019219708A1 (de) * | 2019-12-16 | 2021-06-17 | Henkel Ag & Co. Kgaa | Verfahren zum Färben von keratinischem Material, umfassend die Anwendung von einer siliciumorganischen Verbindung, eines Hydroxycarbonsäureesters, eines Diols und einer farbgebenden Verbindung |
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| US4051138A (en) * | 1975-12-08 | 1977-09-27 | Dynapol | Water-soluble amine-linked polymeric colorants |
| US4542012A (en) | 1982-07-02 | 1985-09-17 | Minnesota Mining And Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods |
| US4584192A (en) | 1984-06-04 | 1986-04-22 | Minnesota Mining & Manufacturing Company | Film-forming composition containing an antimicrobial agent and methods of use |
| SE454842B (sv) * | 1984-11-01 | 1988-06-06 | Pharmacia Ab | Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne |
| US5367370A (en) | 1992-06-11 | 1994-11-22 | Mita Industrial Co., Ltd. | Mounting apparatus for a document-placing table on an image forming machine document feeder |
| US5288159A (en) | 1992-12-04 | 1994-02-22 | Minnesota Mining And Manufacturing Company | Liquid applicator with frangible ampoule and support |
| PL174222B1 (pl) * | 1993-01-27 | 1998-06-30 | Inst Farmaceutyczny | Środek farmaceutyczny działający na ośrodkowy układ nerwowy |
| US5547662A (en) | 1993-08-27 | 1996-08-20 | Becton, Dickinson And Company | Preparation of a skin surface for a surgical procedure |
| CN1178712C (zh) | 1998-01-30 | 2004-12-08 | 美国3M公司 | 手术准备液涂药器和方法 |
| US6420455B1 (en) | 1999-06-18 | 2002-07-16 | 3M Innovative Properties Company | Antimicrobial composition containing photosensitizers articles, and methods of use |
| EP1081025B1 (en) | 1999-09-02 | 2004-12-29 | Nissan Motor Company, Limited | Body structure in floor section of vehicle |
| GB9920774D0 (en) | 1999-09-03 | 1999-11-03 | Avecia Ltd | Polymer |
| US6422778B2 (en) | 2000-04-03 | 2002-07-23 | 3M Innovative Properties Company | Surgical prep solution applicator system and methods |
| US6432396B1 (en) | 2000-07-06 | 2002-08-13 | 3M Innovative Properties Company | Limiting the presence of microorganisms using polymer-bound metal-containing compositions |
| US7459167B1 (en) | 2000-07-27 | 2008-12-02 | 3M Innovative Properties Company | Biocidal polyurethane compositions and methods of use |
| US6605666B1 (en) | 2000-07-27 | 2003-08-12 | 3M Innovative Properties Company | Polyurethane film-forming dispersions in alcohol-water system |
| JP2002361908A (ja) | 2000-11-15 | 2002-12-18 | Seiko Epson Corp | 液体噴射装置、及び、噴射ヘッドのクリーニング方法 |
| BR0210979A (pt) * | 2001-06-08 | 2004-06-08 | David S Soane | Composições de protetor solar colorido |
| US7030203B2 (en) | 2001-09-28 | 2006-04-18 | 3M Innovative Properties Company | Water-in-oil emulsions with ethylene oxide groups, compositions, and methods |
| FR2830776A1 (fr) * | 2001-10-16 | 2003-04-18 | Oreal | Nanocapsules a base de polyesters sulfoniques hydrodispersibles colores |
| US7147873B2 (en) | 2002-01-16 | 2006-12-12 | 3M Innovative Properties Company | Antiseptic compositions and methods |
| US6838078B2 (en) | 2002-01-16 | 2005-01-04 | 3M Innovative Properties Company | Film-forming compositions and methods |
| US6930184B2 (en) | 2002-07-26 | 2005-08-16 | 3M Innovative Properties Company | Functional fluorescent dyes |
| US7261701B2 (en) | 2002-10-03 | 2007-08-28 | 3M Innovative Properties Co. | Skin antiseptic composition dispenser and methods of use |
| US6729786B1 (en) | 2003-03-14 | 2004-05-04 | Mediflex Hospital Products, Inc. | Liquid applicator for coloring a liquid |
| US7273896B2 (en) * | 2003-04-10 | 2007-09-25 | Angiotech Pharmaceuticals (Us), Inc. | Compositions and methods of using a transient colorant |
| EP1489144A1 (en) | 2003-06-18 | 2004-12-22 | DSM IP Assets B.V. | Water-soluble polymeric dye |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| US20060051384A1 (en) | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
| US9028852B2 (en) | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
| CA2581883A1 (en) * | 2004-09-27 | 2006-04-06 | Technion Research & Development Foundation Ltd. | Novel antimicrobial agents |
| US20080175811A1 (en) | 2005-05-16 | 2008-07-24 | Novapharm Research (Australia) Pty Ltd. | Method and Composition For Use In Preparation of a Patient For Surgery |
| CN101489379B (zh) | 2006-10-27 | 2014-06-04 | 3M创新有限公司 | 抗微生物组合物 |
| BRPI0819567A2 (pt) | 2007-12-31 | 2015-05-05 | 3M Innovative Properties Co | "composições antimicrobianas, método para aprimorar a adesão molhada do artigo adesivo médico e método para evitar ou tratar uma condição da pele de um mamífero |
| AU2009204189B2 (en) * | 2008-01-08 | 2014-01-16 | Quick-Med Technologies, Inc. | Disinfectant alcohol-soluble quaternary ammonium polymers |
| MX2011006181A (es) | 2008-12-15 | 2011-06-20 | Basf Se | Polimeros para el cabello. |
-
2012
- 2012-11-16 WO PCT/US2012/065404 patent/WO2013074860A1/en not_active Ceased
- 2012-11-16 BR BR112014011868A patent/BR112014011868A2/pt active Search and Examination
- 2012-11-16 CN CN201280056595.1A patent/CN104039310A/zh active Pending
- 2012-11-16 IN IN3706CHN2014 patent/IN2014CN03706A/en unknown
- 2012-11-16 JP JP2014542475A patent/JP2014533693A/ja active Pending
- 2012-11-16 EP EP12791064.4A patent/EP2779998A1/en not_active Withdrawn
- 2012-11-16 US US14/358,817 patent/US9717798B2/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019534360A (ja) * | 2016-11-01 | 2019-11-28 | ミリケン・アンド・カンパニーＭｉｌｌｉｋｅｎ ＆ Ｃｏｍｐａｎｙ | 洗濯ケア組成物における青味剤としてのロイコポリマー |
| JP2019534358A (ja) * | 2016-11-01 | 2019-11-28 | ミリケン・アンド・カンパニーＭｉｌｌｉｋｅｎ ＆ Ｃｏｍｐａｎｙ | 洗濯ケア組成物における青味剤としてのロイコポリマー |
| JP2019535856A (ja) * | 2016-11-01 | 2019-12-12 | ミリケン・アンド・カンパニーＭｉｌｌｉｋｅｎ ＆ Ｃｏｍｐａｎｙ | 洗濯ケア組成物における青味剤としてのロイコポリマー |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013074860A1 (en) | 2013-05-23 |
| BR112014011868A2 (pt) | 2017-05-16 |
| EP2779998A1 (en) | 2014-09-24 |
| US20140323578A1 (en) | 2014-10-30 |
| US9717798B2 (en) | 2017-08-01 |
| CN104039310A (zh) | 2014-09-10 |
| IN2014CN03706A (enExample) | 2015-10-09 |
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