JP2014532628A5 - - Google Patents
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- JP2014532628A5 JP2014532628A5 JP2014537369A JP2014537369A JP2014532628A5 JP 2014532628 A5 JP2014532628 A5 JP 2014532628A5 JP 2014537369 A JP2014537369 A JP 2014537369A JP 2014537369 A JP2014537369 A JP 2014537369A JP 2014532628 A5 JP2014532628 A5 JP 2014532628A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- change
- composition
- nanoparticle
- functionalized biocompatible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 210000004027 cell Anatomy 0.000 claims description 52
- 239000002105 nanoparticle Substances 0.000 claims description 29
- 210000004962 mammalian cell Anatomy 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 230000000975 bioactive effect Effects 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 108091023040 Transcription factor Proteins 0.000 claims description 4
- 102000040945 Transcription factor Human genes 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 230000003915 cell function Effects 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 230000000877 morphologic effect Effects 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000002062 proliferating effect Effects 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 230000035899 viability Effects 0.000 claims description 3
- 101100239628 Danio rerio myca gene Proteins 0.000 claims description 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims description 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims description 2
- 238000009830 intercalation Methods 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 101150111214 lin-28 gene Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 description 8
- 230000001413 cellular effect Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550213P | 2011-10-21 | 2011-10-21 | |
| US61/550,213 | 2011-10-21 | ||
| PCT/US2012/061391 WO2013059831A1 (en) | 2011-10-21 | 2012-10-22 | Functionalized nanoparticles for intracellular delivery of biologically active molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017128822A Division JP6560302B2 (ja) | 2011-10-21 | 2017-06-30 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532628A JP2014532628A (ja) | 2014-12-08 |
| JP2014532628A5 true JP2014532628A5 (enExample) | 2015-12-10 |
Family
ID=48141479
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537369A Withdrawn JP2014532628A (ja) | 2011-10-21 | 2012-10-22 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
| JP2017128822A Expired - Fee Related JP6560302B2 (ja) | 2011-10-21 | 2017-06-30 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
| JP2018164676A Pending JP2018184485A (ja) | 2011-10-21 | 2018-09-03 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017128822A Expired - Fee Related JP6560302B2 (ja) | 2011-10-21 | 2017-06-30 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
| JP2018164676A Pending JP2018184485A (ja) | 2011-10-21 | 2018-09-03 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9675708B2 (enExample) |
| EP (2) | EP2769217A4 (enExample) |
| JP (3) | JP2014532628A (enExample) |
| KR (3) | KR20200040924A (enExample) |
| CN (2) | CN104094119A (enExample) |
| AU (3) | AU2012325723A1 (enExample) |
| BR (1) | BR112014009753B1 (enExample) |
| CA (2) | CA2938661A1 (enExample) |
| HK (1) | HK1201089A1 (enExample) |
| IN (1) | IN2014DN03224A (enExample) |
| MX (3) | MX2014004778A (enExample) |
| RU (2) | RU2014120465A (enExample) |
| SG (2) | SG11201401658SA (enExample) |
| WO (1) | WO2013059831A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201401658SA (en) * | 2011-10-21 | 2014-07-30 | Stemgenics Inc | Functionalized nanoparticles for intracellular delivery of biologically active molecules |
| JP6518197B2 (ja) * | 2013-03-01 | 2019-05-22 | ステルス バイオセラピューティックス コープ | バース症候群の予防または治療のための方法及び組成物 |
| CN116474071A (zh) | 2013-03-01 | 2023-07-25 | 康德生物医疗有限公司 | 治疗线粒体疾病的方法 |
| US10047395B2 (en) | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| US11306326B2 (en) | 2013-08-23 | 2022-04-19 | Rutgers, The State University Of New Jersey | Biologically active synthetic nanoparticle constructs and methods of use thereof |
| EP3035917A4 (en) * | 2013-08-23 | 2017-03-01 | Rutgers, the State University of New Jersey | Biologically active synthetic nanoparticle constructs and methods of use therof |
| WO2015120421A1 (en) * | 2014-02-10 | 2015-08-13 | Nvigen, Inc. | Cell modulation nanocomposition, and methods of use |
| CN105440112A (zh) * | 2015-12-07 | 2016-03-30 | 国家纳米科学中心 | 多肽-白蛋白偶联药物、其制备方法及应用 |
| KR20190028665A (ko) * | 2016-06-03 | 2019-03-19 | 스템제닉스 인코포레이티드 | 기능화된 나노입자(functionalized nanoparticles)를 사용하여 선택된(예정된) 분화된 세포에 대한 사람 체세포의 직접적인 재프로그래밍 |
| EP3463316A4 (en) * | 2016-06-03 | 2020-05-27 | Stemgenics, Inc. | FUNCTIONALIZED NANOPARTICLES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES AND METHODS OF MAKING AND USING THE SAME |
| CA3039924A1 (en) * | 2016-10-11 | 2018-04-19 | Stemgenics, Inc. | Nanoparticles functionalized with gene editing tools and related methods |
| US11491114B2 (en) | 2016-10-12 | 2022-11-08 | Curioralrx, Llc | Formulations for enteric delivery of therapeutic agents |
| IL299915A (en) * | 2017-01-04 | 2023-03-01 | Nanotics Llc | Methods for assembling cleaning particles |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| WO2018226529A1 (en) * | 2017-06-05 | 2018-12-13 | The Regents Of The University Of Michigan | Complexes for delivery of antigenic peptides |
| WO2019099685A1 (en) | 2017-11-15 | 2019-05-23 | Rutgers, The State University Of New Jersey | Biodegradable hybrid inorganic nanoscaffolding materials and methods of use and manufacture thereof |
| CN108287235B (zh) * | 2018-02-07 | 2021-03-09 | 常州天地人和生物科技有限公司 | 一种高效、稳定的磁性免疫微球的制备和应用 |
| US20200326325A1 (en) | 2019-04-12 | 2020-10-15 | Lisa Diamond | Nanosensor chip with compound nanopores |
| CN112111042B (zh) * | 2019-06-21 | 2024-04-05 | 康码（上海）生物科技有限公司 | 一种生物磁性微球及其制备方法和使用方法 |
| CN110642876A (zh) * | 2019-10-10 | 2020-01-03 | 南京市口腔医院 | 半胱氨酸修饰金纳米颗粒和制备方法、应用及促进骨组织再生产品 |
| CN112472685B (zh) * | 2020-12-10 | 2023-03-24 | 哈尔滨工业大学 | 一种杂化中性粒细胞机器人的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001019405A2 (de) * | 1999-09-14 | 2001-03-22 | Biomedical Apherese Systeme Gmbh | Magnetische nanoteilchen mit biochemischer wirksamkeit und verfahren zu ihrer herstellung sowie ihre verwendung |
| US7329638B2 (en) * | 2003-04-30 | 2008-02-12 | The Regents Of The University Of Michigan | Drug delivery compositions |
| JP4901471B2 (ja) * | 2004-02-19 | 2012-03-21 | 国立大学法人京都大学 | 体細胞核初期化物質のスクリーニング方法 |
| CA2600370A1 (en) * | 2005-03-14 | 2006-09-14 | Board Of Regents Of The University Of Texas System | Bioactive fus1 peptides and nanoparticle-polypeptide complexes |
| CN101389314A (zh) | 2005-03-14 | 2009-03-18 | 得克萨斯大学体系董事会 | 生物活性fus1肽和纳米颗粒-多肽复合物 |
| JP5570721B2 (ja) * | 2005-06-17 | 2014-08-13 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | ナノ粒子の製造方法、システム、及び材料 |
| US20090093551A1 (en) * | 2006-12-08 | 2009-04-09 | Bhatia Sangeeta N | Remotely triggered release from heatable surfaces |
| CA2672998C (en) | 2007-01-02 | 2013-08-06 | University Of Central Florida Research Foundation, Inc. | Methods and materials for stimulating proliferation of stem cells |
| KR100925689B1 (ko) | 2007-07-25 | 2009-11-10 | 한국생명공학연구원 | 항체와 나노입자를 세포 내로 동시에 전달할 수 있는다기능성 단백질 |
| WO2009035541A1 (en) | 2007-09-10 | 2009-03-19 | Merck & Co., Inc. | Method of treating inherited severe neutropenia |
| KR100951719B1 (ko) * | 2007-10-02 | 2010-04-07 | 재단법인서울대학교산학협력재단 | 세포투과성 펩타이드와 형광표지 자성나노입자의 복합체 및그 용도 |
| US20110190729A1 (en) | 2007-11-30 | 2011-08-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving sox2 protein |
| EP2250278B1 (en) | 2008-02-21 | 2023-04-05 | Burnham Institute for Medical Research | Methods and compositions related to peptides and proteins with c-terminal elements |
| CN102272142A (zh) * | 2008-12-23 | 2011-12-07 | 帷幄生物技术公司 | 非遗传修饰性重编程细胞的组合物和方法 |
| BRPI1015952B8 (pt) * | 2009-04-07 | 2022-06-28 | Dow Agrosciences Llc | Método de introdução de uma nuclease sequência-específica (ssn) em uma célula vegetal |
| SG11201401658SA (en) * | 2011-10-21 | 2014-07-30 | Stemgenics Inc | Functionalized nanoparticles for intracellular delivery of biologically active molecules |
-
2012
- 2012-10-22 SG SG11201401658SA patent/SG11201401658SA/en unknown
- 2012-10-22 JP JP2014537369A patent/JP2014532628A/ja not_active Withdrawn
- 2012-10-22 SG SG10201601746TA patent/SG10201601746TA/en unknown
- 2012-10-22 WO PCT/US2012/061391 patent/WO2013059831A1/en not_active Ceased
- 2012-10-22 BR BR112014009753-4A patent/BR112014009753B1/pt not_active IP Right Cessation
- 2012-10-22 MX MX2014004778A patent/MX2014004778A/es unknown
- 2012-10-22 IN IN3224DEN2014 patent/IN2014DN03224A/en unknown
- 2012-10-22 EP EP12842115.3A patent/EP2769217A4/en not_active Withdrawn
- 2012-10-22 AU AU2012325723A patent/AU2012325723A1/en not_active Abandoned
- 2012-10-22 KR KR1020207010401A patent/KR20200040924A/ko not_active Ceased
- 2012-10-22 KR KR1020197018256A patent/KR20190077124A/ko not_active Ceased
- 2012-10-22 KR KR20147010620A patent/KR20150001711A/ko not_active Ceased
- 2012-10-22 HK HK15101563.8A patent/HK1201089A1/xx unknown
- 2012-10-22 MX MX2018002306A patent/MX367656B/es unknown
- 2012-10-22 US US14/353,280 patent/US9675708B2/en active Active - Reinstated
- 2012-10-22 RU RU2014120465/15A patent/RU2014120465A/ru unknown
- 2012-10-22 CN CN201280063870.2A patent/CN104094119A/zh active Pending
- 2012-10-22 CN CN201610644097.9A patent/CN106822868A/zh active Pending
- 2012-10-22 RU RU2018135567A patent/RU2018135567A/ru not_active Application Discontinuation
- 2012-10-22 EP EP18160010.7A patent/EP3400956A1/en not_active Withdrawn
- 2012-10-22 CA CA2938661A patent/CA2938661A1/en not_active Abandoned
- 2012-10-22 CA CA2853128A patent/CA2853128C/en active Active
-
2014
- 2014-04-21 MX MX2018010696A patent/MX2018010696A/es unknown
-
2017
- 2017-06-30 JP JP2017128822A patent/JP6560302B2/ja not_active Expired - Fee Related
-
2018
- 2018-05-31 AU AU2018203848A patent/AU2018203848A1/en not_active Abandoned
- 2018-09-03 JP JP2018164676A patent/JP2018184485A/ja active Pending
-
2020
- 2020-08-27 AU AU2020223737A patent/AU2020223737A1/en not_active Abandoned
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