JP2014513983A5 - - Google Patents
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- Publication number
- JP2014513983A5 JP2014513983A5 JP2014510518A JP2014510518A JP2014513983A5 JP 2014513983 A5 JP2014513983 A5 JP 2014513983A5 JP 2014510518 A JP2014510518 A JP 2014510518A JP 2014510518 A JP2014510518 A JP 2014510518A JP 2014513983 A5 JP2014513983 A5 JP 2014513983A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- zscan4
- seq
- reprogramming
- contacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 230000008672 reprogramming Effects 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000001082 somatic cell Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 230000001419 dependent effect Effects 0.000 claims 7
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 4
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 3
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 2
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 2
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 2
- 101150111214 lin-28 gene Proteins 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 1
- -1 Nanog Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000002510 keratinocyte Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 210000004976 peripheral blood cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486004P | 2011-05-13 | 2011-05-13 | |
| US61/486,004 | 2011-05-13 | ||
| US201161529055P | 2011-08-30 | 2011-08-30 | |
| US61/529,055 | 2011-08-30 | ||
| PCT/US2012/037643 WO2012158561A1 (en) | 2011-05-13 | 2012-05-11 | Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017108578A Division JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513983A JP2014513983A (ja) | 2014-06-19 |
| JP2014513983A5 true JP2014513983A5 (enExample) | 2015-07-16 |
| JP6189829B2 JP6189829B2 (ja) | 2017-08-30 |
Family
ID=47177285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510518A Active JP6189829B2 (ja) | 2011-05-13 | 2012-05-11 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
| JP2017108578A Pending JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017108578A Pending JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9932560B2 (enExample) |
| EP (1) | EP2707479B1 (enExample) |
| JP (2) | JP6189829B2 (enExample) |
| AU (1) | AU2012256014B2 (enExample) |
| CA (1) | CA2835825C (enExample) |
| WO (1) | WO2012158561A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6189829B2 (ja) | 2011-05-13 | 2017-08-30 | ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンティド・バイ・ザ・セクレタリー・フォー・ザ・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシズ | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
| CA3176825A1 (en) | 2013-03-15 | 2014-09-18 | Elixirgen Therapeutics, Inc. | Methods of using zscan4 for treating a disease or condition associated with a karyotype abnormality |
| WO2016099602A1 (en) * | 2014-12-18 | 2016-06-23 | University Of Utah Research Foundation | Induced pluripotent stem cell and method for producing the same |
| CN105219729B (zh) * | 2015-09-28 | 2018-09-25 | 首都医科大学宣武医院 | 一种利用非整合质粒载体诱导神经干细胞的方法及其用途 |
| CN106800590B (zh) * | 2015-11-25 | 2021-04-09 | 杭州智鹤丹谷生物医药有限公司 | 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用 |
| CN110268072B (zh) * | 2016-12-15 | 2023-11-07 | Illumina公司 | 确定旁系同源基因的方法和系统 |
| CN107475378B (zh) * | 2017-08-03 | 2021-03-30 | 复旦大学 | 用于检测女性原发不孕的patl2基因及检测该基因突变的试剂盒 |
| WO2019060450A1 (en) * | 2017-09-19 | 2019-03-28 | The Broad Institute, Inc. | METHODS AND SYSTEMS FOR RECONSTRUCTION OF DEVELOPMENT LANDSCAPES BY OPTIMAL TRANSPORT ANALYSIS |
| CN107988147B (zh) * | 2017-12-19 | 2021-11-09 | 江汉大学 | 基于器官芯片与诱导多能干细胞的定向分化用于3d拟表皮构建的方法 |
| US20220306730A1 (en) * | 2019-05-22 | 2022-09-29 | University Of Maryland, Baltimore | Methods of treating cancer by targeting zscan4 activity in cancer stem cells |
| CN110616232B (zh) * | 2019-09-23 | 2023-04-11 | 中国人民解放军陆军军医大学 | Sox30敲除和可恢复型小鼠动物模型构建方法及应用 |
| CN121045395A (zh) * | 2019-11-22 | 2025-12-02 | 阿尔卡梅纳干细胞治疗有限公司 | 用于去抑制re1沉默转录因子靶基因的组合物和方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| US5888762A (en) | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
| KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
| US7198784B2 (en) | 1996-10-17 | 2007-04-03 | Oxford Biomedica (Uk) Limited | Retroviral vectors |
| FR2762615B1 (fr) | 1997-04-28 | 1999-07-16 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes et vecteur le contenant |
| CA2375880A1 (en) | 1999-06-22 | 2000-12-28 | Dnavec Research Inc. | A vector for the expression of two foreign genes |
| US20110171185A1 (en) * | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| DE19933492B4 (de) | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| JP2003514564A (ja) | 1999-11-24 | 2003-04-22 | エムシーエス マイクロ キャリア システムズ ゲーエムベーハー | 核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法 |
| US7211247B2 (en) | 2001-04-09 | 2007-05-01 | University Of Southern California | Lentivirus vectors for gene transfer to alveolar epithelial cells |
| US7081489B2 (en) | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
| US20040014209A1 (en) | 2002-01-23 | 2004-01-22 | Lassar Andrew B. | Compositions and methods for modulating cell differentiation |
| US7354763B2 (en) | 2002-04-16 | 2008-04-08 | Technion Research & Development Foundation Ltd. | Generating vascular smooth muscle cells in vitro from ES cells |
| CA2495478A1 (en) | 2002-08-05 | 2004-02-12 | University Of Rochester | Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof |
| KR100591936B1 (ko) | 2002-11-12 | 2006-06-22 | 포휴먼텍(주) | 세포내 ｄｎａ／ｒｎａ 전달 방법, 및 이것의 기초 및임상학적 응용 |
| CA2516116A1 (en) | 2003-01-16 | 2004-08-05 | St. John's University | Nanoparticle based stabilization of ir fluorescent dyes |
| US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| SG188122A1 (en) | 2004-01-23 | 2013-03-28 | Advanced Cell Tech Inc | Improved modalities for the treatment of degenerative diseases of the retina |
| WO2006052285A2 (en) | 2004-05-13 | 2006-05-18 | The Trustees Of Columbia University In The City Of New York | Polymeric nanoparticles and nanogels for extraction and release of compounds |
| US20060024331A1 (en) | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| DE602006000381T2 (de) | 2005-04-28 | 2008-12-18 | Nipro Corp., Osaka | Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer |
| CA2605551A1 (en) | 2005-05-10 | 2006-11-16 | Naomi Balaban | Compositions for administering rnaiii-inhibiting peptides |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| EP2129771B1 (en) | 2007-03-26 | 2018-09-12 | The Government of the U.S.A. as represented by the Secretary of the Department of Health & Human Services | Methods for modulating embryonic stem cell differentiation |
| ES2722198T3 (es) | 2008-05-02 | 2019-08-08 | Univ Kyoto | Método de reprogramación nuclear |
| EP2473598B1 (en) * | 2009-09-04 | 2017-03-22 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Methods for enhancing genome stability and telomere elongation in embryonic stem cells |
| WO2012129342A1 (en) | 2011-03-23 | 2012-09-27 | Ko Minoru S H | Compositions and methods for enhancing the pluripotency of stem cells |
| JP6189829B2 (ja) | 2011-05-13 | 2017-08-30 | ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンティド・バイ・ザ・セクレタリー・フォー・ザ・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシズ | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
-
2012
- 2012-05-11 JP JP2014510518A patent/JP6189829B2/ja active Active
- 2012-05-11 EP EP12785169.9A patent/EP2707479B1/en active Active
- 2012-05-11 AU AU2012256014A patent/AU2012256014B2/en active Active
- 2012-05-11 US US14/117,589 patent/US9932560B2/en active Active
- 2012-05-11 CA CA2835825A patent/CA2835825C/en active Active
- 2012-05-11 WO PCT/US2012/037643 patent/WO2012158561A1/en not_active Ceased
-
2017
- 2017-05-31 JP JP2017108578A patent/JP2017212985A/ja active Pending
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