JP2014531910A - 再構成後の精製第ｖｉｉｉ因子の安定性を改善するための方法 - Google Patents
再構成後の精製第ｖｉｉｉ因子の安定性を改善するための方法 Download PDFInfo
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Peptides Or Proteins (AREA)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019527541A (ja) * | 2016-06-24 | 2019-10-03 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP2021530437A (ja) * | 2018-05-18 | 2021-11-11 | 鄭州晟斯生物科技有限公司Zhengzhou Gensciences Inc | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20140084208A (ko) | 2011-10-18 | 2014-07-04 | 시에스엘 리미티드 | 정제된 인자 ｖｉｉｉ의 재구성 후의 안정성을 향상시키는 방법 |
| EP4122487A1 (en) * | 2013-03-15 | 2023-01-25 | Bioverativ Therapeutics Inc. | Factor viii polypeptide formulations |
| US9855319B2 (en) * | 2014-04-01 | 2018-01-02 | Advantech Bioscience Farmacêutica Ltda | Stabilization of factor VIII without calcium as an excipient |
| JP2017509659A (ja) * | 2014-04-01 | 2017-04-06 | アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ | 低糖−低グリシンの安定な第ｖｉｉｉ因子製剤 |
| EP3193911B1 (en) * | 2014-07-25 | 2023-09-06 | CSL Behring GmbH | Improved factor viii preparations for use in treating hemophilia a |
| CN106687126B (zh) * | 2014-08-04 | 2020-07-28 | 杰特有限公司 | 因子viii制剂 |
| WO2017222337A1 (ko) * | 2016-06-24 | 2017-12-28 | 재단법인 목암생명과학연구소 | Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도 |
| MX2019006444A (es) | 2016-12-02 | 2019-10-30 | Bioverativ Therapeutics Inc | Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos. |
| EP3687580A1 (en) | 2017-09-27 | 2020-08-05 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising active cells |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | 凍結乾燥方法 |
| US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
| BR112020020084A2 (pt) | 2018-04-04 | 2021-01-05 | Sigilon Therapeutics, Inc. | Partícula, preparação de uma pluralidade de partículas, método de preparação de uma partícula, e, composição de partículas. |
| PL3793588T3 (pl) | 2018-05-18 | 2025-09-01 | Bioverativ Therapeutics Inc. | Sposoby leczenia hemofilii a |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| CN113597532B (zh) | 2019-03-14 | 2023-02-17 | 泰尔茂比司特生物技术有限公司 | 冻干容器填充固定装置、系统及使用方法 |
| EP3736286A1 (en) | 2019-05-09 | 2020-11-11 | Biotest AG | Single chain factor viii molecule |
| WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
| JP2025534667A (ja) | 2022-10-11 | 2025-10-17 | シギロン セラピューティクス， インコーポレイテッド | 疾患治療のための改変細胞及び移植可能エレメント |
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| US20040147436A1 (en) * | 2003-01-28 | 2004-07-29 | Hun-Taek Kim | Factor VIII polypeptide |
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| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| ES8801674A1 (es) | 1985-04-12 | 1988-02-16 | Genetics Inst | Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante. |
| KR910006424B1 (ko) | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
| US5422260A (en) * | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
| IL84168A0 (en) | 1986-10-15 | 1988-03-31 | Rorer Int Overseas | Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same |
| JP2872255B2 (ja) | 1987-01-30 | 1999-03-17 | バイオジエン，インコーポレイティド | ファクター▲ｖｉｉｉ▼の高収量生産法 |
| EP0294910B1 (en) | 1987-06-12 | 1996-09-11 | Immuno Ag | Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them |
| IL86693A (en) | 1987-06-12 | 1994-06-24 | Stichting Centraal Lab | Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them |
| DE3720246A1 (de) | 1987-06-19 | 1988-12-29 | Behringwerke Ag | Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet |
| FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| US5605884A (en) | 1987-10-29 | 1997-02-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Factor VIII formulations in high ionic strength media |
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| DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| WO1997040145A1 (en) | 1996-04-24 | 1997-10-30 | The Regents Of The University Of Michigan | Inactivation resistant factor viii |
| WO2000024759A1 (en) | 1998-10-23 | 2000-05-04 | The Trustees Of The University Of Pennsylvania | Systemic delivery of gene products via skin |
| DE60024268T2 (de) | 1999-07-13 | 2006-08-03 | Biovitrum Ab | Zusammensetzungen mit stabilem faktor viii |
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- 2012-10-18 CA CA2850579A patent/CA2850579A1/en not_active Abandoned
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- 2012-10-18 JP JP2014536237A patent/JP2014531910A/ja not_active Withdrawn
- 2012-10-18 WO PCT/EP2012/070701 patent/WO2013057219A1/en not_active Ceased
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| JPS63503357A (ja) * | 1986-05-29 | 1988-12-08 | ジェネティックス・インスチチュート・インコーポレーテッド | 新規な凝固活性タンパク質 |
| US20040147436A1 (en) * | 2003-01-28 | 2004-07-29 | Hun-Taek Kim | Factor VIII polypeptide |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019527541A (ja) * | 2016-06-24 | 2019-10-03 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP2021118696A (ja) * | 2016-06-24 | 2021-08-12 | モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP7235511B2 (ja) | 2016-06-24 | 2023-03-08 | モガム・インスティテュート・フォー・バイオメディカル・リサーチ | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP2021530437A (ja) * | 2018-05-18 | 2021-11-11 | 鄭州晟斯生物科技有限公司Zhengzhou Gensciences Inc | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
| JP2023093634A (ja) * | 2018-05-18 | 2023-07-04 | 鄭州晟斯生物科技有限公司 | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
| JP7492780B2 (ja) | 2018-05-18 | 2024-05-30 | 鄭州晟斯生物科技有限公司 | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
| US12440572B2 (en) | 2018-05-18 | 2025-10-14 | Zhengzhou Gensciences Inc. | FVIII fusion protein and use thereof |
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| US10537616B2 (en) | 2020-01-21 |
| WO2013057219A1 (en) | 2013-04-25 |
| US20160367641A1 (en) | 2016-12-22 |
| US9394353B2 (en) | 2016-07-19 |
| US20190038722A1 (en) | 2019-02-07 |
| JP2017114889A (ja) | 2017-06-29 |
| US20210308229A1 (en) | 2021-10-07 |
| CN103917554B (zh) | 2017-03-08 |
| AU2012318292A1 (en) | 2013-05-02 |
| AU2012318292B2 (en) | 2015-08-20 |
| EP2768853A1 (en) | 2014-08-27 |
| CA2850579A1 (en) | 2013-04-25 |
| KR20140084208A (ko) | 2014-07-04 |
| US9956269B2 (en) | 2018-05-01 |
| US20140249086A1 (en) | 2014-09-04 |
| CN103917554A (zh) | 2014-07-09 |
| HK1198541A1 (en) | 2015-05-15 |
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