JP2014530066A5 - - Google Patents
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- Publication number
- JP2014530066A5 JP2014530066A5 JP2014535045A JP2014535045A JP2014530066A5 JP 2014530066 A5 JP2014530066 A5 JP 2014530066A5 JP 2014535045 A JP2014535045 A JP 2014535045A JP 2014535045 A JP2014535045 A JP 2014535045A JP 2014530066 A5 JP2014530066 A5 JP 2014530066A5
- Authority
- JP
- Japan
- Prior art keywords
- hemostatic composition
- composition according
- polymer
- bleeding
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 40
- 230000002439 hemostatic effect Effects 0.000 claims description 34
- 229920000249 biocompatible polymer Polymers 0.000 claims description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 16
- 230000000740 bleeding effect Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
- 230000023597 hemostasis Effects 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 7
- 108010035532 Collagen Proteins 0.000 claims description 7
- 229920001436 collagen Polymers 0.000 claims description 7
- 230000006378 damage Effects 0.000 claims description 7
- 206010052428 Wound Diseases 0.000 claims description 6
- 235000018102 proteins Nutrition 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 5
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- -1 succinimidyl ester Chemical class 0.000 claims description 3
- 102000011632 Caseins Human genes 0.000 claims description 2
- 108010076119 Caseins Proteins 0.000 claims description 2
- 102000009123 Fibrin Human genes 0.000 claims description 2
- 108010073385 Fibrin Proteins 0.000 claims description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 102000016359 Fibronectins Human genes 0.000 claims description 2
- 108010067306 Fibronectins Proteins 0.000 claims description 2
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 108010076876 Keratins Proteins 0.000 claims description 2
- 102000011782 Keratins Human genes 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 229950003499 fibrin Drugs 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 239000012948 isocyanate Substances 0.000 claims description 2
- 150000002513 isocyanates Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000009257 reactivity Effects 0.000 claims description 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 102000007547 Laminin Human genes 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 239000003929 acidic solution Substances 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 229920001002 functional polymer Polymers 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 208000034158 bleeding Diseases 0.000 description 3
- 241000252505 Characidae Species 0.000 description 1
- 241000720950 Gluta Species 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229940096118 ella Drugs 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545939P | 2011-10-11 | 2011-10-11 | |
| US61/545,939 | 2011-10-11 | ||
| PCT/EP2012/070054 WO2013053753A2 (en) | 2011-10-11 | 2012-10-10 | Hemostatic composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017087065A Division JP2017153975A (ja) | 2011-10-11 | 2017-04-26 | 止血組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530066A JP2014530066A (ja) | 2014-11-17 |
| JP2014530066A5 true JP2014530066A5 (cg-RX-API-DMAC7.html) | 2015-11-05 |
| JP6195567B2 JP6195567B2 (ja) | 2017-09-13 |
Family
ID=47022655
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535045A Active JP6195567B2 (ja) | 2011-10-11 | 2012-10-10 | 止血組成物 |
| JP2017087065A Pending JP2017153975A (ja) | 2011-10-11 | 2017-04-26 | 止血組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017087065A Pending JP2017153975A (ja) | 2011-10-11 | 2017-04-26 | 止血組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130096062A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2766060B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6195567B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102143252B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103998068B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012318256B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2851332C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2938541T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL231962A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX355924B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013053753A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2545810C2 (ru) | 2008-02-29 | 2015-04-10 | Ферросан Медикал Дивайсиз А/С | Устройство для ускорения остановки кровотечения и/или заживления ран |
| JP6195568B2 (ja) * | 2011-10-11 | 2017-09-13 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 止血組成物 |
| MX356185B (es) | 2011-10-11 | 2018-05-17 | Baxter Int | Composiciones hemostaticas. |
| EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
| EP2977066A3 (en) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| EP3010419B1 (en) | 2013-06-21 | 2020-05-20 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
| JP6489485B2 (ja) | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ／エス | 押し出し増強因子を含んでいる乾燥組成物 |
| RU2546006C1 (ru) | 2014-03-07 | 2015-04-10 | Римма Ильинична Ашкинази | Противовирусное средство |
| KR102132261B1 (ko) | 2014-03-31 | 2020-08-06 | 삼성전자주식회사 | 비교 연산이 필요없이 최종 모듈러 감소를 하는 몽고메리 곱셈 방법 및 곱셈기 |
| CN106999621B (zh) | 2014-10-13 | 2020-07-03 | 弗罗桑医疗设备公司 | 用于止血和伤口愈合的干组合物 |
| BR112017013565B1 (pt) | 2014-12-24 | 2021-12-28 | Ferrosan Medical Devices A/S | Seringa para retenção e mistura de primeira e segunda substâncias |
| WO2016118043A1 (ru) * | 2015-01-20 | 2016-07-28 | Виктор Вениаминович ТЕЦ | Гемостатическое средство |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| RU2602305C1 (ru) * | 2015-09-30 | 2016-11-20 | Общество с ограниченной ответственностью "Санте Фарм" | Гемостатическое средство |
| US11285170B2 (en) | 2017-05-24 | 2022-03-29 | Viktor Veniaminovich Tets | Fractionated antimicrobial compositions and use thereof |
| KR101989054B1 (ko) * | 2017-11-28 | 2019-06-13 | (주)다림티센 | 지혈용 조성물 및 이를 포함하는 용기 |
| WO2019107887A2 (ko) * | 2017-11-28 | 2019-06-06 | (주)다림티센 | 지혈용 조성물 및 이를 포함하는 용기 |
| KR20200093600A (ko) * | 2017-11-28 | 2020-08-05 | 백스터 인터내셔널 인코포레이티드 | 상처-치료용 흡수제 |
| EP3737432B1 (en) | 2018-01-12 | 2022-12-28 | Boston Scientific Scimed Inc. | Powder for achieving hemostasis |
| AU2019266529B2 (en) | 2018-05-09 | 2024-05-23 | Ethicon Inc. | Method for preparing a haemostatic composition |
| KR102438006B1 (ko) | 2020-02-25 | 2022-08-30 | 주식회사 테라시온 바이오메디칼 | 다용도 지혈제 조성물 및 그 제조방법 |
| JPWO2021261080A1 (cg-RX-API-DMAC7.html) * | 2020-06-26 | 2021-12-30 | ||
| WO2022038155A1 (en) * | 2020-08-18 | 2022-02-24 | Universität Basel | Hemostatic elastin-like polypeptides |
| JP2022126909A (ja) * | 2021-02-19 | 2022-08-31 | 国立研究開発法人物質・材料研究機構 | 穿孔部閉鎖材、及び、穿孔部閉鎖材の製造方法 |
| CN113289052B (zh) * | 2021-05-14 | 2023-05-26 | 南方科技大学 | 一种可控交联、降解的材料及其应用 |
| CN113599568A (zh) * | 2021-08-05 | 2021-11-05 | 南方科技大学 | 合成材料类粉剂及其在止血体系的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH264752A (de) * | 1947-06-03 | 1949-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Trägern für Arzneimittel. |
| US4412947A (en) * | 1979-09-12 | 1983-11-01 | Seton Company | Collagen sponge |
| US5614587A (en) * | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| US7320962B2 (en) * | 1996-08-27 | 2008-01-22 | Baxter International Inc. | Hemoactive compositions and methods for their manufacture and use |
| US6458147B1 (en) * | 1998-11-06 | 2002-10-01 | Neomend, Inc. | Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue |
| US7279001B2 (en) * | 1998-11-06 | 2007-10-09 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
| US6312725B1 (en) * | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| AU7084300A (en) * | 1999-08-27 | 2001-03-26 | Cohesion Technologies, Inc. | Compositions that form interpenetrating polymer networks for use as high strength medical sealants |
| WO2003042250A1 (en) * | 2001-11-15 | 2003-05-22 | Biosyntech Canada Inc. | Composition and method to homogeneously modify or cross-link chitosan under neutral conditions |
| US20040106344A1 (en) * | 2002-06-28 | 2004-06-03 | Looney Dwayne Lee | Hemostatic wound dressings containing proteinaceous polymers |
| AU2003279730A1 (en) * | 2002-09-30 | 2004-04-19 | Fibrogen, Inc. | Dry tissue sealant compositions |
| WO2005044142A2 (en) * | 2003-11-10 | 2005-05-19 | Angiotech International Ag | Intravascular devices and fibrosis-inducing agents |
| TWI436793B (zh) * | 2006-08-02 | 2014-05-11 | Baxter Int | 快速作用之乾密封膠及其使用和製造方法 |
| DE102008005469A1 (de) * | 2008-01-21 | 2009-07-23 | Kettenbach Gmbh & Co. Kg | Pastöses Einsetzmaterial zur Erweiterung des Zahnfleischsulcus und dessen Verwendung |
| BRPI1015979A8 (pt) * | 2009-06-16 | 2018-06-19 | Baxter Healthcare Sa | esponja porosa hemostática, e, método para fabricar uma esponja porosa hemostática |
| MX356185B (es) * | 2011-10-11 | 2018-05-17 | Baxter Int | Composiciones hemostaticas. |
| JP6195568B2 (ja) * | 2011-10-11 | 2017-09-13 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 止血組成物 |
-
2012
- 2012-10-10 CN CN201280057486.1A patent/CN103998068B/zh active Active
- 2012-10-10 KR KR1020147012291A patent/KR102143252B1/ko active Active
- 2012-10-10 JP JP2014535045A patent/JP6195567B2/ja active Active
- 2012-10-10 EP EP12772918.4A patent/EP2766060B1/en active Active
- 2012-10-10 WO PCT/EP2012/070054 patent/WO2013053753A2/en not_active Ceased
- 2012-10-10 EP EP22200796.5A patent/EP4137166A1/en not_active Withdrawn
- 2012-10-10 MX MX2014004476A patent/MX355924B/es active IP Right Grant
- 2012-10-10 AU AU2012318256A patent/AU2012318256B2/en active Active
- 2012-10-10 CA CA2851332A patent/CA2851332C/en active Active
- 2012-10-10 ES ES12772918T patent/ES2938541T3/es active Active
- 2012-10-10 US US13/648,789 patent/US20130096062A1/en not_active Abandoned
-
2014
- 2014-04-06 IL IL231962A patent/IL231962A0/en unknown
-
2017
- 2017-04-26 JP JP2017087065A patent/JP2017153975A/ja active Pending
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