JP2014529612A5 - - Google Patents
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- Publication number
- JP2014529612A5 JP2014529612A5 JP2014527345A JP2014527345A JP2014529612A5 JP 2014529612 A5 JP2014529612 A5 JP 2014529612A5 JP 2014527345 A JP2014527345 A JP 2014527345A JP 2014527345 A JP2014527345 A JP 2014527345A JP 2014529612 A5 JP2014529612 A5 JP 2014529612A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- phenyl
- sulfonamide
- propane
- quinoxaline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528033P | 2011-08-26 | 2011-08-26 | |
| US61/528,033 | 2011-08-26 | ||
| US201161528151P | 2011-08-27 | 2011-08-27 | |
| US61/528,151 | 2011-08-27 | ||
| PCT/US2012/052390 WO2013032951A1 (en) | 2011-08-26 | 2012-08-24 | Certain chemical entities, compositions, and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016171707A Division JP6250116B2 (ja) | 2011-08-26 | 2016-09-02 | 特定の化学的実体、組成物、および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529612A JP2014529612A (ja) | 2014-11-13 |
| JP2014529612A5 true JP2014529612A5 (https=) | 2015-10-15 |
| JP6002223B2 JP6002223B2 (ja) | 2016-10-05 |
Family
ID=47744575
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527345A Active JP6002223B2 (ja) | 2011-08-26 | 2012-08-24 | 特定の化学的実体、組成物、および方法 |
| JP2016171707A Active JP6250116B2 (ja) | 2011-08-26 | 2016-09-02 | 特定の化学的実体、組成物、および方法 |
| JP2017223745A Pending JP2018027981A (ja) | 2011-08-26 | 2017-11-21 | 特定の化学的実体、組成物、および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016171707A Active JP6250116B2 (ja) | 2011-08-26 | 2016-09-02 | 特定の化学的実体、組成物、および方法 |
| JP2017223745A Pending JP2018027981A (ja) | 2011-08-26 | 2017-11-21 | 特定の化学的実体、組成物、および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9295671B2 (https=) |
| EP (1) | EP2747767B8 (https=) |
| JP (3) | JP6002223B2 (https=) |
| CN (2) | CN104053442B (https=) |
| AU (1) | AU2012300317B2 (https=) |
| CA (1) | CA2846574C (https=) |
| ES (1) | ES2725790T3 (https=) |
| IL (1) | IL231168B (https=) |
| WO (1) | WO2013032951A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| ES2725790T3 (es) * | 2011-08-26 | 2019-09-27 | Neupharma Inc | Algunas entidades químicas, composiciones, y métodos |
| CN115403531A (zh) | 2011-09-14 | 2022-11-29 | 润新生物公司 | 作为激酶抑制剂的化学实体、组合物及方法 |
| US9249110B2 (en) | 2011-09-21 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
| US9249111B2 (en) | 2011-09-30 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-RAF kinase inhibitors |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| EP2806874B1 (en) | 2012-01-25 | 2017-11-15 | Neupharma, Inc. | Quinoxaline-oxy-phenyl derivatives as kinase inhibitors |
| MX371331B (es) | 2012-04-24 | 2020-01-27 | Vertex Pharma | Inhibidores de la proteina cinasa dependiente de acido desoxirribonucleico(adn-pk). |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| US9688635B2 (en) | 2012-09-24 | 2017-06-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2014075077A1 (en) * | 2012-11-12 | 2014-05-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| ME03336B (me) | 2013-03-12 | 2019-10-20 | Vertex Pharma | Inhibitori dnk-pk |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| BR112016005199B1 (pt) | 2013-08-23 | 2022-02-22 | Neupharma, Inc | Certos compostos químicos, composições, e métodos |
| TWI665195B (zh) * | 2013-09-13 | 2019-07-11 | 半導體能源研究所股份有限公司 | 二苯并［ｆ，ｈ］喹啉衍生物、二苯并［ｆ，ｈ］喹啉衍生物的合成方法、發光元件、發光裝置、電子裝置以及照明設備 |
| JP6408569B2 (ja) | 2013-10-17 | 2018-10-17 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｄｎａ−ｐｋ阻害剤としての（ｓ）−ｎ−メチル−８−（１−（（２’−メチル−［４，５’−ビピリミジン］−６−イル）アミノ）プロパン−２−イル）キノリン−４−カルボキサミドおよびその重水素化誘導体の共結晶 |
| HRP20210319T1 (hr) | 2014-03-26 | 2021-04-30 | Astex Therapeutics Ltd. | Kombinacije inhibitora fgfr i inhibitora igf1r |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| RU2715236C2 (ru) | 2014-03-26 | 2020-02-26 | Астекс Терапьютикс Лтд | Комбинации |
| CA2954879C (en) * | 2014-07-16 | 2022-09-06 | Development Center For Biotechnology | Quinoxaline compounds, method for preparing the same and use thereof |
| TWI719960B (zh) | 2015-02-10 | 2021-03-01 | 英商阿斯迪克治療公司 | 新穎組成物 |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| EP3353164B1 (en) | 2015-09-23 | 2021-11-03 | Janssen Pharmaceutica, N.V. | Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
| US11155555B2 (en) | 2015-09-23 | 2021-10-26 | Janssen Pharmaceutica Nv | Compounds |
| WO2018035061A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP3518931A4 (en) | 2016-09-27 | 2020-05-13 | Vertex Pharmaceuticals Incorporated | METHOD FOR TREATING CANCER WITH A COMBINATION OF DNA-DAMAGING SUBSTANCES AND DNA-PK INHIBITORS |
| WO2019014668A1 (en) * | 2017-07-14 | 2019-01-17 | Asana Biosciences, Llc | FORMULATIONS, METHODS, KIT AND DOSAGE FORMS FOR ENHANCED STABILITY OF ACTIVE PHARMACEUTICAL INGREDIENT |
| NZ766594A (en) | 2018-01-31 | 2025-12-19 | Heparegenix Gmbh | Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| AU2019218893B2 (en) * | 2018-02-08 | 2024-12-05 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP3810139A1 (en) | 2018-06-21 | 2021-04-28 | HepaRegeniX GmbH | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL279641B2 (en) | 2018-07-16 | 2024-04-01 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US10986841B2 (en) | 2018-11-06 | 2021-04-27 | The Clorox Company | Bleach compositions |
| CA3164361A1 (en) | 2020-01-15 | 2021-07-22 | Heparegenix Gmbh | 3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as mkk4 inhibitors for treating liver diseases |
| US11845916B2 (en) | 2020-06-24 | 2023-12-19 | The Clorox Company | Burstable sporicidal cleaning wipe system containing stabilized hypochlorite |
| NZ801119A (en) * | 2020-12-02 | 2026-02-27 | Neupharma Inc | Certain chemical entities, compositions, and methods |
| US11728962B2 (en) | 2021-12-13 | 2023-08-15 | Xilinx, Inc. | Multi-phase clock signal generation circuitry |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464533A (en) | 1982-11-08 | 1984-08-07 | Ppg Industries, Inc. | Herbicidally active quinoline or quinoxaline benzoate derivatives |
| DE3482180D1 (de) | 1983-10-05 | 1990-06-13 | Basf Ag | Cyclohexenol-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses. |
| GB2189238A (en) | 1986-04-15 | 1987-10-21 | Shell Int Research | Heterocyclic phenyl ether compounds |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
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| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
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| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| PT1154774E (pt) | 1999-02-10 | 2005-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de angiogenese |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| WO2002036734A2 (en) | 2000-10-12 | 2002-05-10 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors |
| IL139380A0 (en) | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
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| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
| UA80171C2 (en) | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
| CN101044121A (zh) * | 2003-02-10 | 2007-09-26 | 霍夫曼-拉罗奇有限公司 | 4－氨基嘧啶－5－酮 |
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| ES2395952T3 (es) * | 2005-03-16 | 2013-02-18 | Toyama Chemical Co., Ltd. | Nuevo derivado del ácido antranílico o una sal del mismo |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
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| US20100130471A1 (en) * | 2007-04-05 | 2010-05-27 | Baldwin John J | Renin Inhibitors |
| WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2181987B9 (en) | 2007-08-23 | 2014-09-03 | Takeda Pharmaceutical Company Limited | 2-Carbonylaminobenzothiazoles and their use for the prophylaxis and treatment of cancer |
| EP2065381A1 (de) | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
| NZ586418A (en) | 2007-12-19 | 2012-09-28 | Cancer Rec Tech Ltd | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| EP3147281A1 (en) | 2008-03-17 | 2017-03-29 | Ambit Biosciences Corporation | Quinazoline derivatives as raf kinase modulators and methods of use thereof |
| US20100197688A1 (en) | 2008-05-29 | 2010-08-05 | Nantermet Philippe G | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
| US8110576B2 (en) | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
| WO2010111527A1 (en) | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
| TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| US20130018033A1 (en) | 2009-08-28 | 2013-01-17 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| CN101693723B (zh) * | 2009-10-22 | 2012-09-05 | 浙江大学 | 间三烷氧基苯基二烷基膦四氟硼酸盐及其合成和应用 |
| WO2011068187A1 (ja) | 2009-12-04 | 2011-06-09 | 第一三共株式会社 | キナゾリン誘導体 |
| US8669256B2 (en) | 2010-05-28 | 2014-03-11 | Merck Sharp & Dohme B.V. | Substituted thieno[2,3-b]pyrazine compounds as modulators of B-Raf kinase activity |
| DE102010027215B4 (de) | 2010-07-15 | 2013-09-05 | Continental Automotive Gmbh | Verfahren und Steuergerät zum Steuern einer Brennkraftmaschine |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| CN103619865B (zh) | 2011-02-02 | 2016-10-12 | 苏州润新生物科技有限公司 | 某些化学个体、组合物及方法 |
| WO2012118492A1 (en) * | 2011-03-01 | 2012-09-07 | Array Biopharma Inc. | Heterocyclic sulfonamides as raf inhibitors |
| ES2725790T3 (es) | 2011-08-26 | 2019-09-27 | Neupharma Inc | Algunas entidades químicas, composiciones, y métodos |
| CN115403531A (zh) | 2011-09-14 | 2022-11-29 | 润新生物公司 | 作为激酶抑制剂的化学实体、组合物及方法 |
| US9249110B2 (en) | 2011-09-21 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
| US9249111B2 (en) | 2011-09-30 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-RAF kinase inhibitors |
| EP2806874B1 (en) | 2012-01-25 | 2017-11-15 | Neupharma, Inc. | Quinoxaline-oxy-phenyl derivatives as kinase inhibitors |
| US9688635B2 (en) | 2012-09-24 | 2017-06-27 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2014075077A1 (en) | 2012-11-12 | 2014-05-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
-
2012
- 2012-08-24 ES ES12828679T patent/ES2725790T3/es active Active
- 2012-08-24 WO PCT/US2012/052390 patent/WO2013032951A1/en not_active Ceased
- 2012-08-24 CN CN201280052615.8A patent/CN104053442B/zh active Active
- 2012-08-24 CN CN201710422196.7A patent/CN107245056A/zh active Pending
- 2012-08-24 US US13/594,634 patent/US9295671B2/en active Active
- 2012-08-24 EP EP12828679.6A patent/EP2747767B8/en active Active
- 2012-08-24 JP JP2014527345A patent/JP6002223B2/ja active Active
- 2012-08-24 AU AU2012300317A patent/AU2012300317B2/en active Active
- 2012-08-24 CA CA2846574A patent/CA2846574C/en active Active
-
2014
- 2014-02-26 IL IL231168A patent/IL231168B/en active IP Right Grant
-
2015
- 2015-12-17 US US14/973,492 patent/US9572808B2/en active Active
-
2016
- 2016-09-02 JP JP2016171707A patent/JP6250116B2/ja active Active
-
2017
- 2017-01-06 US US15/400,720 patent/US10137125B2/en active Active
- 2017-11-21 JP JP2017223745A patent/JP2018027981A/ja active Pending
-
2019
- 2019-04-04 US US16/375,466 patent/US10561652B2/en active Active
-
2020
- 2020-08-26 US US17/003,918 patent/US20200390763A1/en not_active Abandoned
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