JP2014529403A5 - - Google Patents

Info

Publication number

JP2014529403A5

JP2014529403A5 JP2014526493A JP2014526493A JP2014529403A5 JP 2014529403 A5 JP2014529403 A5 JP 2014529403A5 JP 2014526493 A JP2014526493 A JP 2014526493A JP 2014526493 A JP2014526493 A JP 2014526493A JP 2014529403 A5 JP2014529403 A5 JP 2014529403A5

Authority

JP

Japan

Prior art keywords

core

microorganism

positive

antigen expression

lysate

Prior art date

2012-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 244000005700 microbiome Species 0.000 claims description 76
• 239000000427 antigen Substances 0.000 claims description 46
• 108091007433 antigens Proteins 0.000 claims description 46
• 102000036639 antigens Human genes 0.000 claims description 46
• 239000006166 lysate Substances 0.000 claims description 29
• 239000000203 mixture Substances 0.000 claims description 27
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
• 238000004113 cell culture Methods 0.000 claims description 16
• 241000115153 Bacteroides xylanisolvens Species 0.000 claims description 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 210000000612 antigen-presenting cell Anatomy 0.000 claims description 5
• 241000606125 Bacteroides Species 0.000 claims description 4
• 238000012286 ELISA Assay Methods 0.000 claims description 4
• 206010028980 Neoplasm Diseases 0.000 claims description 4
• 238000002835 absorbance Methods 0.000 claims description 4
• 125000000837 carbohydrate group Chemical group 0.000 claims description 4
• 210000004443 dendritic cell Anatomy 0.000 claims description 4
• 230000028993 immune response Effects 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 3
• 108020004465 16S ribosomal RNA Proteins 0.000 claims description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 208000018522 Gastrointestinal disease Diseases 0.000 claims description 2
• 230000004913 activation Effects 0.000 claims description 2
• 238000003556 assay Methods 0.000 claims description 2
• 201000011510 cancer Diseases 0.000 claims description 2
• 150000001720 carbohydrates Chemical class 0.000 claims description 2
• 210000004027 cell Anatomy 0.000 claims description 2
• 201000010099 disease Diseases 0.000 claims description 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims description 2
• 230000002708 enhancing effect Effects 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• 238000009396 hybridization Methods 0.000 claims description 2
• 238000000338 in vitro Methods 0.000 claims description 2
• 238000001727 in vivo Methods 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 108090000623 proteins and genes Proteins 0.000 claims description 2
• 230000001850 reproductive effect Effects 0.000 claims description 2
• 235000021391 short chain fatty acids Nutrition 0.000 claims description 2
• 150000004666 short chain fatty acids Chemical class 0.000 claims description 2
• 241000894007 species Species 0.000 claims description 2
• 230000009089 cytolysis Effects 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1