ES2686313T3 - Microorganismos que portan un antígeno tumoral - Google Patents

Microorganismos que portan un antígeno tumoral Download PDF

Info

Publication number
ES2686313T3
ES2686313T3 ES12753463.4T ES12753463T ES2686313T3 ES 2686313 T3 ES2686313 T3 ES 2686313T3 ES 12753463 T ES12753463 T ES 12753463T ES 2686313 T3 ES2686313 T3 ES 2686313T3
Authority
ES
Spain
Prior art keywords
core
positive
microorganism
antigen
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12753463.4T
Other languages
English (en)
Spanish (es)
Inventor
Steffen Goletz
Philippe Ulsemer
Kawe TOUTOUNIAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycotope GmbH
Original Assignee
Glycotope GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycotope GmbH filed Critical Glycotope GmbH
Application granted granted Critical
Publication of ES2686313T3 publication Critical patent/ES2686313T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1257—Gram-negative bacteria from Bacteridaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
ES12753463.4T 2011-08-22 2012-08-22 Microorganismos que portan un antígeno tumoral Active ES2686313T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161526054P 2011-08-22 2011-08-22
US201161526054P 2011-08-22
EP11178322 2011-08-22
EP11178322 2011-08-22
PCT/EP2012/066360 WO2013026887A1 (en) 2011-08-22 2012-08-22 Microorganisms carrying a tumor antigen

Publications (1)

Publication Number Publication Date
ES2686313T3 true ES2686313T3 (es) 2018-10-17

Family

ID=47745974

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12753463.4T Active ES2686313T3 (es) 2011-08-22 2012-08-22 Microorganismos que portan un antígeno tumoral

Country Status (11)

Country Link
US (1) US9700610B2 (https=)
EP (1) EP2748302B1 (https=)
JP (1) JP6148671B2 (https=)
CN (1) CN103814123A (https=)
AU (1) AU2012298496A1 (https=)
BR (1) BR112014004065A2 (https=)
CA (1) CA2844543A1 (https=)
ES (1) ES2686313T3 (https=)
IL (1) IL231065A0 (https=)
RU (1) RU2014110953A (https=)
WO (1) WO2013026887A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1920781B1 (en) * 2006-11-10 2015-03-04 Glycotope GmbH Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors
ES2686313T3 (es) 2011-08-22 2018-10-17 Glycotope Gmbh Microorganismos que portan un antígeno tumoral
EP3090749B1 (en) * 2013-12-20 2023-08-30 Daicel Corporation Nutrient composition having lipid metabolism-improving action
CN116410324A (zh) * 2023-05-24 2023-07-11 西安交通大学医学院第一附属医院 一种肠道微生物脆弱拟杆菌毒素中和纳米抗体及其应用

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4931275A (en) 1985-12-02 1990-06-05 Yeda Research & Development Co., Ltd. Anti-tumor vaccines and their preparation
US5683674A (en) 1987-01-07 1997-11-04 Imperial Cancer Research Technology Ltd. Antibody against human mucin core protein and method of preparing and using same
ATE241011T1 (de) 1991-02-27 2003-06-15 Micromet Ag Serin-reiche peptidlinker
EP0636029B1 (en) 1992-04-13 2000-11-08 Dana-Farber Cancer Institute, Inc. Antibodies specific for carcinoma-associated antigens
US5804187A (en) 1992-11-16 1998-09-08 Cancer Research Fund Of Contra Costa Modified antibodies with human milk fat globule specificity
CA2164088C (en) 1993-06-07 2005-06-14 Gary J. Nabel Plasmids suitable for gene therapy
DE4329004A1 (de) 1993-08-28 1995-03-09 Max Delbrueck Centrum Monoklonale Antikörper gegen das Thomsen-Friedenreich-Antigen, ihre Herstellung und ihre Verwendung zum Tumornachweis
US7137011B1 (en) 1993-09-01 2006-11-14 Sandisk Corporation Removable mother/daughter peripheral card
US5997873A (en) 1994-01-13 1999-12-07 Mount Sinai School Of Medicine Of The City University Of New York Method of preparation of heat shock protein 70-peptide complexes
US5961979A (en) 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
CA2225460A1 (en) 1995-06-23 1997-01-09 Winston Campbell Patterson Transcriptional regulation of genes encoding vascular endothelial growth factor receptors
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
WO1997040182A1 (de) 1996-04-19 1997-10-30 Gabriele Pecher Gentransfizierte humane dendritische zellen, ihre herstellung und ihre verwendung, bevorzugt als vakzine
DE69815707T2 (de) 1997-11-20 2004-07-01 Vical, Inc., San Diego Behandlung von krebs durch verwendung von zytokin-exprimierender polynukleotiden und zusammensetzungen dafür
US5948646A (en) 1997-12-11 1999-09-07 Fordham University Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes
AUPP816899A0 (en) 1999-01-14 1999-02-11 Food Technology Innovations Pty Limited Improved microbial products
WO2000052135A2 (en) 1999-03-02 2000-09-08 Human Genome Sciences, Inc. Engineering intracellular sialylation pathways
DK1167537T3 (da) 1999-03-30 2008-11-10 Japan Tobacco Inc Fremgangsmåde til fremstilling af et monoklonalt antistof
US7147850B2 (en) 1999-08-18 2006-12-12 Altarex Medical Corp. Therapeutic binding agents against MUC-1 antigen and methods for their use
ATE290879T1 (de) 1999-08-18 2005-04-15 Altarex Medical Corp Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung
WO2001023421A2 (en) 1999-09-30 2001-04-05 Corixa Corporation Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
FR2809312B1 (fr) 2000-05-25 2002-07-12 Gervais Danone Sa Utilisation de l. casei dans des compositions immunostimulantes
GB0029360D0 (en) 2000-12-01 2001-01-17 Univ Nottingham Humanised antibodies and uses thereof
US7510735B2 (en) 2001-02-01 2009-03-31 Kabushiki Kaisha Yakult Honsha Method of evaluating the extent of reaching the intestine of bifidobacterium in fermented milk food or drink
DE10139428A1 (de) 2001-08-17 2003-03-27 Nemod Immuntherapie Ag Herstellung und Verwendung von humanen CD124 und CD116 positiven Tumorzelllinien zur Herstellung von allogenen oder semi-allogenen Immuntherapeutika
US20050042714A1 (en) 2001-08-17 2005-02-24 Michael Pawlita Glycoconjugates of sialic acid derivates, methods for their production and use thereof
US20040115177A1 (en) 2001-10-12 2004-06-17 Harris Delbert L. Probiotic compositions and methods against bacterial infection in livestock animals
GB0125473D0 (en) 2001-10-24 2001-12-12 Syngenta Ltd Chemical process
WO2003044051A1 (en) 2001-11-20 2003-05-30 Atgen Co., Ltd. Novel peptides conferring environmental stress resistance and fusion proteins including said peptides
AU2003266236A1 (en) 2002-07-22 2004-02-09 Nemod Immuntherapie Ag Method for the production of an immunostimulating mucin (muc1)
SI1530628T1 (sl) 2002-08-16 2011-02-28 Glycotope Gmbh Postopek za proizvodnjo s temperaturo induciranih lizatov tumorskih celic za uporabo kot imunogenske spojine
DE10256900A1 (de) 2002-11-29 2004-06-24 Nemod Immuntherapie Ag Tumorspezifische Erkennungsmoleküle
US8887358B2 (en) * 2003-02-14 2014-11-18 Christie Marie Cox Burial vault carapace and method for customizing a burial vault carapace
GB0315991D0 (en) 2003-07-08 2003-08-13 Dakocytomation Denmark As Standard
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
ES2425475T3 (es) 2003-08-18 2013-10-15 Glycotope Gmbh Líneas de células tumorales NM-F9 (DSM ACC2606) y NM-D4 (DSM ACC2605), usos de las mismas
FR2861080B1 (fr) 2003-10-20 2006-02-17 Lab Francais Du Fractionnement Anticorps presentant un taux de fucose et de galactose optimise
EP1725673A1 (en) 2004-02-13 2006-11-29 Glycotope Gmbh Sialytated glycoproteins-process conditions and an efficient method for their production
WO2005108423A1 (en) 2004-05-11 2005-11-17 Atgen Co., Ltd. Novel peptides conferring environmental stress resistance and fusion proteins including said peptides
EP1789027B1 (en) 2004-07-26 2013-09-04 The Research Foundation Of State University Of New York Therapeutic use of anti-tf-antigen antibody
US7598134B2 (en) 2004-07-28 2009-10-06 Micron Technology, Inc. Memory device forming methods
WO2007041495A2 (en) * 2005-09-29 2007-04-12 University Of California, San Diego Dampening humoral and innate immunity by inhibition of ppgalnact-1
EP2013357A4 (en) * 2006-04-19 2012-02-22 Biogenerix Ag EXPRESSION OF O-GLYCOSYLATED THERAPEUTIC PROTEINS IN PROKARYOTIC MICROORGANISMS
WO2007124992A1 (en) 2006-04-28 2007-11-08 Unilever N.V. Method of manufacturing a cultured edible product comprising omega-3 polyunsaturated fatty acids
SI2073842T1 (sl) 2006-09-10 2015-05-29 Glycotope Gmbh Uporaba človeških celic izvirajočih iz mieloične levkemije za izražanje protiteles
EP1920781B1 (en) 2006-11-10 2015-03-04 Glycotope GmbH Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors
AR063868A1 (es) * 2007-11-20 2009-02-25 Tecn Conicet Consejo Nac De In Inmunogeno modificado del disacarido de thomsen- friedenreich (tfd) procedimiento de elaboracion, composiciones que lo contine, usos y metodos de tratamiento
US20090324617A1 (en) * 2008-01-24 2009-12-31 Glykos Finland Ltd. Cancer specific glycans and use thereof
AR071787A1 (es) * 2008-05-13 2010-07-14 Glycotope Gmbh Procedimiento de fermentacion, alimento fermentado producido por dicho procedimiento y auxiliar de procesamiento
US8784293B2 (en) 2008-10-07 2014-07-22 Advanced Brain Monitoring, Inc. Systems and methods for optimization of sleep and post-sleep performance
CN101560488A (zh) 2009-05-27 2009-10-21 中国农业大学 分解木质纤维素的酶与菌剂
EP2281844A1 (en) 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies
US20110076356A1 (en) * 2009-09-29 2011-03-31 Ziemer Cherie J Novel Fibro-Biotic Bacterium Isolate
GB2475226A (en) * 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
WO2012112716A1 (en) * 2011-02-16 2012-08-23 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic use of mucin glycans
US8951762B2 (en) * 2011-07-27 2015-02-10 Iowa State University Research Foundation, Inc. Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
ES2686313T3 (es) 2011-08-22 2018-10-17 Glycotope Gmbh Microorganismos que portan un antígeno tumoral
US9234204B2 (en) * 2012-08-07 2016-01-12 TopGeniX, Inc. Topical composition comprising transformed bacteria expressing a compound of interest
US8906668B2 (en) * 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
US9518872B2 (en) 2014-10-14 2016-12-13 Kidde Technologies, Inc. Thermal sensor

Also Published As

Publication number Publication date
CN103814123A (zh) 2014-05-21
JP2014529403A (ja) 2014-11-13
EP2748302B1 (en) 2018-08-15
CA2844543A1 (en) 2013-02-28
US20140302093A1 (en) 2014-10-09
IL231065A0 (en) 2014-03-31
US9700610B2 (en) 2017-07-11
WO2013026887A1 (en) 2013-02-28
JP6148671B2 (ja) 2017-06-14
AU2012298496A1 (en) 2014-02-27
RU2014110953A (ru) 2015-09-27
EP2748302A1 (en) 2014-07-02
BR112014004065A2 (pt) 2017-03-14

Similar Documents

Publication Publication Date Title
ES2715045T3 (es) Microorganismos o fracciones de los mismos capaces de activar inmunidad celular contra carbohidratos
US9226957B2 (en) Compositions and methods of enhancing immune responses
ES2878551T3 (es) Composiciones y procedimientos relativos a una toxina mutante de Clostridium difficile
JPH07503255A (ja) ヘリコバクター感染に対するウレアーゼを基礎とするワクチン
RS57138B1 (sr) Kompozicije koje sadrže bakterijske sojeve
US20240016861A1 (en) Combination therapy for treating or preventing cancer
US20230277602A1 (en) Combination therapy for treating or preventing cancer
ES2686313T3 (es) Microorganismos que portan un antígeno tumoral
TW201332568A (zh) 對抗表現碳青黴烯酶（ｃａｒｂａｐｅｎｅｍａｓｅ）之細菌之免疫組合物及方法
ES2389066A1 (es) Método diva de diferenciación de animales vacunados frente a la brucelosis.
ES2358804T3 (es) Polipéptidos de campylobacter jejuni ubicados en superficie.
JP2021534089A (ja) 細菌株を含む組成物
US20210060094A1 (en) Combination therapy for treating or preventing cancer
BR112020014595A2 (pt) Terapia de combinação para tratamento ou prevenção de câncer
DK1920781T3 (en) Compositions comprising a Core-1 positive microorganism and its use in the treatment or prophylaxis of tumors
Yu et al. Identification of a novel linear epitope on EspA from enterohemorrhagic E. coli using a neutralizing and protective monoclonal antibody
Xun et al. Protective effects of sucralfate on anti–H. pylori VacA IgY in vivo and in vitro
WO2024121125A1 (en) Single-domain antibodies to reduce the risk of cholera infection
WO2004050119A1 (en) Vaccine against enteropathogenic and enterohaemorragic escherichia coli
AU2005286694A1 (en) Methods and compositions relating to mannuronic acid specific binding peptides
HK1136219B (en) Microorganisms or fractions thereof capable of activating cellular immunity against carbohydrates
Jowiya The Response of Campylobacter jejuni to Pancreatic Enzymes
Ahmed Characterization of the immune response to vibrio cholerae O1 antigens and its impact on vaccine development strategies