JP2014528700A5 - - Google Patents
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- JP2014528700A5 JP2014528700A5 JP2014521695A JP2014521695A JP2014528700A5 JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5 JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- composition
- composition according
- seq
- stranded rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508867P | 2011-07-18 | 2011-07-18 | |
| US61/508,867 | 2011-07-18 | ||
| US201161543038P | 2011-10-04 | 2011-10-04 | |
| US61/543,038 | 2011-10-04 | ||
| PCT/US2012/046928 WO2013012806A2 (en) | 2011-07-18 | 2012-07-16 | Protection of cells from alu-rna-induced degenereation and inhibitors for protecting cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528700A JP2014528700A (ja) | 2014-10-30 |
| JP2014528700A5 true JP2014528700A5 (enExample) | 2015-08-20 |
| JP6313203B2 JP6313203B2 (ja) | 2018-04-18 |
Family
ID=47558691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521695A Active JP6313203B2 (ja) | 2011-07-18 | 2012-07-16 | Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9453226B2 (enExample) |
| EP (2) | EP2734240B1 (enExample) |
| JP (1) | JP6313203B2 (enExample) |
| CN (1) | CN103889461B (enExample) |
| AU (1) | AU2012284223B2 (enExample) |
| CA (2) | CA2842034C (enExample) |
| ES (1) | ES2907620T3 (enExample) |
| PT (1) | PT3366302T (enExample) |
| WO (1) | WO2013012806A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010138555A2 (en) | 2009-05-26 | 2010-12-02 | University Of Florida Research Foundation, Inc. | Small peptide expression system in mammalian cells |
| WO2012053741A2 (ko) | 2010-10-22 | 2012-04-26 | 성균관대학교산학협력단 | Rna 간섭을 유도하는 핵산 분자 및 그 용도 |
| US9707235B1 (en) * | 2012-01-13 | 2017-07-18 | University Of Kentucky Research Foundation | Protection of cells from degeneration and treatment of geographic atrophy |
| US20130297023A1 (en) * | 2012-05-07 | 2013-11-07 | Hee-Jeong Im Sampen | Methods and Devices For Treating Intervertebral Disc Disease |
| KR101567576B1 (ko) | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도 |
| WO2014039696A2 (en) | 2012-09-05 | 2014-03-13 | Cold Spring Harbor Laboratory | Transposable elements, tdp-43, and neurodegenerative disorders |
| WO2014164703A1 (en) | 2013-03-11 | 2014-10-09 | University Of Florida Research Foundation, Inc. | Delivery of card protein as therapy for occular inflammation |
| US9326983B2 (en) | 2013-08-01 | 2016-05-03 | University Of Kentucky Research Foundation | Compositions and methods for treating retinal degradation |
| WO2015095609A1 (en) * | 2013-12-19 | 2015-06-25 | The J. David Gladstone Institute | Inhibition of interferon-gamma-inducible protein 16 (ifi16) |
| WO2015127094A1 (en) | 2014-02-19 | 2015-08-27 | University Of Florida Research Foundation, Inc. | Delivery of nrf2 as therapy for protection against reactive oxygen species |
| WO2015138628A1 (en) * | 2014-03-11 | 2015-09-17 | University Of Florida Research Foundation, Inc. | Use of aav-expressed m013 protein as an anti-inflammatory therapeutic |
| WO2016022914A1 (en) * | 2014-08-08 | 2016-02-11 | Moderna Therapeutics, Inc. | Compositions and methods for the treatment of ophthalmic diseases and conditions |
| US11219623B2 (en) | 2015-02-26 | 2022-01-11 | University Of Kentucky Research Foundation | Inflammasome inhibition for the treatment of Parkinson's disease, Alzheimer's disease and multiple sclerosis |
| ES3010307T3 (en) | 2015-02-26 | 2025-04-02 | Univ Kentucky Res Found | Compositions and methods for treating retinal degradation |
| JP7085712B2 (ja) * | 2015-09-03 | 2022-06-17 | ビー．ジー． ネゲヴ テクノロジーズ アンド アプリケーションズ リミテッド、アット ベン－グリオン ユニヴァーシティ | Ｖｄａｃ１由来ペプチドの類似体 |
| US11174484B2 (en) | 2015-11-10 | 2021-11-16 | B. G. Negev Technologies And Applications Ltd., At Ben- Gurion University | Means and methods for reducing tumorigenicity of cancer stem cells |
| JP7027311B2 (ja) * | 2015-11-16 | 2022-03-01 | オリックス ファーマシューティカルズ，インコーポレーテッド | ＭｙＤ８８又はＴＬＲ３を標的とするＲＮＡ複合体を使用した加齢黄斑変性の治療 |
| KR102825946B1 (ko) | 2016-02-02 | 2025-06-27 | 올릭스 주식회사 | IL4Rα, TRPA1, 또는 F2RL1을 표적화하는 RNA 복합체를 사용한 아토피 피부염 및 천식의 치료 |
| CN109415413A (zh) * | 2016-06-07 | 2019-03-01 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 髓样分化因子88(myd88)的主链环化抑制肽 |
| US11130951B2 (en) * | 2016-06-09 | 2021-09-28 | The General Hospital Corporation | Modulating the cellular stress response |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US20190185820A1 (en) * | 2016-08-26 | 2019-06-20 | The Regents Of The University Of California | Compositions and Methods for Inhibiting Stem Cell Aging |
| PL3558335T3 (pl) | 2016-12-23 | 2023-08-21 | Casp-Aid Inc. | Inhibicja kaspazy-1 i jej zastosowanie w zapobieganiu i leczeniu schorzeń neurologicznych |
| JP7424728B2 (ja) | 2017-02-10 | 2024-01-30 | オリック パルマセゥティカルズ インコーポレイテッド | Ｒｎａ干渉のための長鎖の二本鎖ｒｎａ |
| GB2561540A (en) | 2017-03-13 | 2018-10-24 | Nodthera Ltd | Chemical compounds |
| JP2020515625A (ja) * | 2017-04-03 | 2020-05-28 | デューク ユニバーシティ | 細胞死およびインターフェロン発現の差次的誘導のための組成物および方法 |
| US20200345756A1 (en) * | 2017-10-10 | 2020-11-05 | University Of Virginia Patent Foundation | Compositions and methods for treating age-related macular degeneration and geographic atrophy |
| WO2020006229A1 (en) * | 2018-06-27 | 2020-01-02 | Children's Medical Center Corporation | Compounds for inhibition of inflammation |
| KR102138256B1 (ko) * | 2018-09-13 | 2020-08-13 | 한국과학기술연구원 | 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물 |
| EP3863714A4 (en) * | 2018-10-09 | 2022-07-20 | University of Virginia Patent Foundation | ENDOGENOUS CYTOPLASMATIC ALU-COMPLEMENTARY DNA IN AGE-RELATED MACULAR DEGENERATION |
| CN110305957B (zh) * | 2019-08-22 | 2022-07-29 | 中国水产科学研究院淡水渔业研究中心 | 一种鉴定黄颡鱼脂肪肝程度的试剂盒及其鉴定方法 |
| WO2021041317A1 (en) * | 2019-08-23 | 2021-03-04 | University Of Virginia Patent Foundation | Ddx17 and nlrc4 targeting for inflammatory diseases |
| US20230070129A1 (en) * | 2020-01-06 | 2023-03-09 | Seasun Therapeutics | Composition for preventing or treating macular degeneration, containing cell permeable nucleic acid complex as active ingredient |
| WO2021163327A1 (en) * | 2020-02-11 | 2021-08-19 | University Of Virginia Patent Foundation | Compositions and methods for treating and/or preventing ocular disorders |
| CN111358950A (zh) * | 2020-03-20 | 2020-07-03 | 厦门大学 | Caspase-1及ASC/Caspase-8作为靶点的应用 |
| EP4192952A1 (en) * | 2020-08-10 | 2023-06-14 | Novartis AG | Treatments for retinal degenerative diseases |
| MX2023005699A (es) | 2020-11-18 | 2023-05-29 | Novartis Ag | Anticuerpos biespecificos para el uso en el tratamiento de inflamasomopatia nlrc4-gof. |
| CN115969844B (zh) * | 2021-12-28 | 2024-04-02 | 首都医科大学附属北京同仁医院 | Nox2特异性抑制剂在制备视网膜变性药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| AU2988200A (en) * | 1999-02-11 | 2000-08-29 | Trustees Of The University Of Pennsylvania, The | Regulation of photoreceptor degeneration |
| GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US20030186903A1 (en) * | 2001-11-23 | 2003-10-02 | Isis Pharmaceuticals Inc. | Antisense modulation of MyD88 expression |
| WO2003057728A1 (en) * | 2002-01-10 | 2003-07-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A novel splice variant of myd88 and uses thereof |
| EP2314691A3 (en) * | 2002-11-14 | 2012-01-18 | Dharmacon, Inc. | Fuctional and hyperfunctional siRNA |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| US9549895B2 (en) * | 2004-04-23 | 2017-01-24 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving the viability of photoreceptor cells |
| WO2006067091A1 (en) | 2004-12-20 | 2006-06-29 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Myd88 homodimerization inhibitors |
| US7879992B2 (en) * | 2005-01-31 | 2011-02-01 | Isis Pharmaceuticals, Inc. | Modification of MyD88 splicing using modified oligonucleotides |
| EP1746167A1 (en) * | 2005-07-20 | 2007-01-24 | Apoxis SA | Method for the identification of compounds susceptible to inhibit inflammation |
| WO2007077042A1 (en) * | 2006-01-06 | 2007-07-12 | Topotarget Switzerland Sa | New method for the treatment of gout or pseudogout |
| WO2008070579A2 (en) | 2006-12-01 | 2008-06-12 | Loma Linda University Medical Center | Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration |
| AU2008260572A1 (en) * | 2007-05-29 | 2008-12-11 | Yale University | IL- 18 and protein kinase R inhibition for the treatment of COPD |
| US20090227487A1 (en) * | 2008-03-05 | 2009-09-10 | Jeremy Pearl | Methods for the control of macrophage-associated inflammation |
| WO2010017436A2 (en) * | 2008-08-08 | 2010-02-11 | Idera Pharmaceuticals, Inc. | Modulation of myeloid differentation primary response gene 88 (myd88) expression by antisense oligonucleotides |
| EP2560629B1 (en) * | 2010-04-23 | 2020-06-03 | Massachusetts Eye & Ear Infirmary | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
| WO2011153234A2 (en) | 2010-06-01 | 2011-12-08 | University Of Kentucky Research Foundation | Methods of inhibiting alu rna and therapeutic uses thereof |
| US20120177632A1 (en) * | 2011-01-10 | 2012-07-12 | Shinohara Mari L | Methods of optimizing disease treatment |
-
2012
- 2012-07-16 EP EP12814249.4A patent/EP2734240B1/en active Active
- 2012-07-16 CA CA2842034A patent/CA2842034C/en active Active
- 2012-07-16 EP EP18156266.1A patent/EP3366302B1/en active Active
- 2012-07-16 PT PT181562661T patent/PT3366302T/pt unknown
- 2012-07-16 WO PCT/US2012/046928 patent/WO2013012806A2/en not_active Ceased
- 2012-07-16 AU AU2012284223A patent/AU2012284223B2/en active Active
- 2012-07-16 CA CA3205596A patent/CA3205596A1/en active Pending
- 2012-07-16 CN CN201280045438.0A patent/CN103889461B/zh active Active
- 2012-07-16 JP JP2014521695A patent/JP6313203B2/ja active Active
- 2012-07-16 ES ES18156266T patent/ES2907620T3/es active Active
-
2014
- 2014-01-17 US US14/158,357 patent/US9453226B2/en active Active
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