JP2014528700A5 - - Google Patents
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- JP2014528700A5 JP2014528700A5 JP2014521695A JP2014521695A JP2014528700A5 JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5 JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- composition
- composition according
- seq
- stranded rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508867P | 2011-07-18 | 2011-07-18 | |
| US61/508,867 | 2011-07-18 | ||
| US201161543038P | 2011-10-04 | 2011-10-04 | |
| US61/543,038 | 2011-10-04 | ||
| PCT/US2012/046928 WO2013012806A2 (en) | 2011-07-18 | 2012-07-16 | Protection of cells from alu-rna-induced degenereation and inhibitors for protecting cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528700A JP2014528700A (ja) | 2014-10-30 |
| JP2014528700A5 true JP2014528700A5 (enExample) | 2015-08-20 |
| JP6313203B2 JP6313203B2 (ja) | 2018-04-18 |
Family
ID=47558691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521695A Active JP6313203B2 (ja) | 2011-07-18 | 2012-07-16 | Alu−rna誘導変性からの細胞の保護及び細胞保護用阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9453226B2 (enExample) |
| EP (2) | EP3366302B1 (enExample) |
| JP (1) | JP6313203B2 (enExample) |
| CN (1) | CN103889461B (enExample) |
| AU (1) | AU2012284223B2 (enExample) |
| CA (2) | CA2842034C (enExample) |
| ES (1) | ES2907620T3 (enExample) |
| PT (1) | PT3366302T (enExample) |
| WO (1) | WO2013012806A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11512326B2 (en) | 2009-05-26 | 2022-11-29 | University Of Florida Research Foundation, Incorporated | Small angiotensin peptide expression system in mammalian cells |
| CN103328633B (zh) | 2010-10-22 | 2018-07-10 | 成均馆大学校产学协力团 | 诱导rna干扰的核酸分子及其用途 |
| US9707235B1 (en) | 2012-01-13 | 2017-07-18 | University Of Kentucky Research Foundation | Protection of cells from degeneration and treatment of geographic atrophy |
| EP2847215A1 (en) * | 2012-05-07 | 2015-03-18 | Synthes GmbH | Methods and devices for treating intervertebral disc disease |
| CN108148838B (zh) | 2012-05-22 | 2026-07-31 | 奥利克斯医药有限公司 | 具有细胞内穿透能力的诱导rna干扰的核酸分子及用途 |
| US9441223B2 (en) | 2012-09-05 | 2016-09-13 | Cold Spring Harbor Laboratory, LLC | Transposable elements, TDP-43, and neurodegenerative disorders |
| US10981961B2 (en) | 2013-03-11 | 2021-04-20 | University Of Florida Research Foundation, Incorporated | Delivery of card protein as therapy for occular inflammation |
| US9326983B2 (en) | 2013-08-01 | 2016-05-03 | University Of Kentucky Research Foundation | Compositions and methods for treating retinal degradation |
| WO2015095609A1 (en) * | 2013-12-19 | 2015-06-25 | The J. David Gladstone Institute | Inhibition of interferon-gamma-inducible protein 16 (ifi16) |
| US11053291B2 (en) | 2014-02-19 | 2021-07-06 | University Of Florida Research Foundation, Incorporated | Delivery of Nrf2 as therapy for protection against reactive oxygen species |
| EP4050020A1 (en) * | 2014-03-11 | 2022-08-31 | University of Florida Research Foundation, Inc. | Aav-expressed m013 protein as an anti-inflammatroy therapeutic for use in a method of treating inflammatory ocular disease |
| EP3177732A4 (en) * | 2014-08-08 | 2018-04-25 | ModernaTX, Inc. | Compositions and methods for the treatment of ophthalmic diseases and conditions |
| US11219623B2 (en) | 2015-02-26 | 2022-01-11 | University Of Kentucky Research Foundation | Inflammasome inhibition for the treatment of Parkinson's disease, Alzheimer's disease and multiple sclerosis |
| ES2879678T3 (es) | 2015-02-26 | 2021-11-22 | Univ Kentucky Res Found | Composiciones y procedimientos para el tratamiento de la degradación retiniana |
| JP7085712B2 (ja) * | 2015-09-03 | 2022-06-17 | ビー.ジー. ネゲヴ テクノロジーズ アンド アプリケーションズ リミテッド、アット ベン-グリオン ユニヴァーシティ | Vdac1由来ペプチドの類似体 |
| WO2017081686A1 (en) | 2015-11-10 | 2017-05-18 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Means and methods for reducing tumorigenicity of cancer stem cells |
| JP7027311B2 (ja) * | 2015-11-16 | 2022-03-01 | オリックス ファーマシューティカルズ,インコーポレーテッド | MyD88又はTLR3を標的とするRNA複合体を使用した加齢黄斑変性の治療 |
| WO2017134525A1 (en) | 2016-02-02 | 2017-08-10 | Olix Pharmaceuticals, Inc. | TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET lL4Rα, TRPA1, OR F2RL1 |
| CN109415413A (zh) * | 2016-06-07 | 2019-03-01 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 髓样分化因子88(myd88)的主链环化抑制肽 |
| US11130951B2 (en) * | 2016-06-09 | 2021-09-28 | The General Hospital Corporation | Modulating the cellular stress response |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US20190185820A1 (en) * | 2016-08-26 | 2019-06-20 | The Regents Of The University Of California | Compositions and Methods for Inhibiting Stem Cell Aging |
| FI3558335T3 (fi) | 2016-12-23 | 2023-07-19 | Casp Aid Inc | Kaspaasi-1-inhibitio ja sen käyttötarkoituksia neurologisten tilojen ehkäisyyn ja hoitoon |
| WO2018146557A2 (en) | 2017-02-10 | 2018-08-16 | Dong Ki Lee | Long double-stranded rna for rna interference |
| GB2561540A (en) | 2017-03-13 | 2018-10-24 | Nodthera Ltd | Chemical compounds |
| US11613756B2 (en) * | 2017-04-03 | 2023-03-28 | Duke University | Compositions and methods for differential induction of cell death and interferon expression |
| EP3672579A4 (en) * | 2017-10-10 | 2021-06-23 | University of Virginia Patent Foundation | COMPOSITIONS AND METHODS OF TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND GEOGRAPHICAL ATROPHY |
| EP3813805A4 (en) * | 2018-06-27 | 2021-08-25 | Children's Medical Center Corporation | INFLAMMATION INHIBITION COMPOUNDS |
| KR102138256B1 (ko) * | 2018-09-13 | 2020-08-13 | 한국과학기술연구원 | 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물 |
| US20210348164A1 (en) * | 2018-10-09 | 2021-11-11 | University Of Virginia Patent Foundation | Endogenous cytoplasmic alu complementary dna in age-related macular degeneration |
| WO2020089906A1 (en) | 2018-11-01 | 2020-05-07 | National Institute For Biotechnology In The Negev Ltd. | Vdac1 silencing molecules and use thereof |
| CN110305957B (zh) * | 2019-08-22 | 2022-07-29 | 中国水产科学研究院淡水渔业研究中心 | 一种鉴定黄颡鱼脂肪肝程度的试剂盒及其鉴定方法 |
| AU2020340298A1 (en) * | 2019-08-23 | 2022-03-24 | University Of Virginia Patent Foundation | DDX17 and NLRC4 targeting for inflammatory diseases |
| EP4088742A4 (en) * | 2020-01-06 | 2024-07-10 | Seasun Therapeutics | COMPOSITION FOR PREVENTING OR TREATING MACULAR DEGENERATION CONTAINING A CELL-PERMEABLE NUCLEIC ACID COMPLEX AS ACTIVE SUBSTANCE |
| US20230355553A1 (en) * | 2020-02-11 | 2023-11-09 | University Of Virginia Patent Foundation | Compositions and methods for treating and/or preventing ocular disorders |
| CN111358950A (zh) * | 2020-03-20 | 2020-07-03 | 厦门大学 | Caspase-1及ASC/Caspase-8作为靶点的应用 |
| EP4192952A1 (en) * | 2020-08-10 | 2023-06-14 | Novartis AG | Treatments for retinal degenerative diseases |
| CA3201637A1 (en) | 2020-11-18 | 2022-05-27 | Novartis Ag | Bispecific antibodies for use in treatment of nlrc4-gof inflammasomapathy |
| CN114099683B (zh) * | 2021-12-28 | 2022-12-16 | 首都医科大学附属北京同仁医院 | Nox2特异性抑制剂在制备视网膜变性药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| WO2000047218A1 (en) * | 1999-02-11 | 2000-08-17 | The Trustees Of The University Of Pennsylvania | Regulation of photoreceptor degeneration |
| GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US20030186903A1 (en) * | 2001-11-23 | 2003-10-02 | Isis Pharmaceuticals Inc. | Antisense modulation of MyD88 expression |
| CA2472927A1 (en) * | 2002-01-10 | 2003-07-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A novel splice variant of myd88 and uses thereof |
| EP2305813A3 (en) * | 2002-11-14 | 2012-03-28 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| WO2005105133A2 (en) * | 2004-04-23 | 2005-11-10 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving the viability of photoreceptor cells |
| CA2590750A1 (en) * | 2004-12-20 | 2006-06-29 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Myd88 homodimerization inhibitors |
| US7879992B2 (en) * | 2005-01-31 | 2011-02-01 | Isis Pharmaceuticals, Inc. | Modification of MyD88 splicing using modified oligonucleotides |
| EP1746167A1 (en) * | 2005-07-20 | 2007-01-24 | Apoxis SA | Method for the identification of compounds susceptible to inhibit inflammation |
| WO2007077042A1 (en) * | 2006-01-06 | 2007-07-12 | Topotarget Switzerland Sa | New method for the treatment of gout or pseudogout |
| CA2671524A1 (en) | 2006-12-01 | 2008-06-12 | Loma Linda University Medical Center | Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration |
| WO2008150431A1 (en) * | 2007-05-29 | 2008-12-11 | Yale University | Il- 18 and protein kinase r inhibition for the treatment of copd |
| US20090227487A1 (en) * | 2008-03-05 | 2009-09-10 | Jeremy Pearl | Methods for the control of macrophage-associated inflammation |
| US20100092486A1 (en) * | 2008-08-08 | 2010-04-15 | Idera Pharmaceuticals, Inc. | Modulation of myeloid differentation primary response gene 88 (myd88) expression by antisense oligonucleotides |
| US20130137642A1 (en) * | 2010-04-23 | 2013-05-30 | Demetrios Vavvas | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
| US8809517B2 (en) | 2010-06-01 | 2014-08-19 | University Of Kentucky Research Foundation | Method of inhibiting Alu RNA and therapeutic uses thereof |
| US20120177632A1 (en) * | 2011-01-10 | 2012-07-12 | Shinohara Mari L | Methods of optimizing disease treatment |
-
2012
- 2012-07-16 JP JP2014521695A patent/JP6313203B2/ja active Active
- 2012-07-16 AU AU2012284223A patent/AU2012284223B2/en active Active
- 2012-07-16 EP EP18156266.1A patent/EP3366302B1/en active Active
- 2012-07-16 ES ES18156266T patent/ES2907620T3/es active Active
- 2012-07-16 WO PCT/US2012/046928 patent/WO2013012806A2/en not_active Ceased
- 2012-07-16 CN CN201280045438.0A patent/CN103889461B/zh active Active
- 2012-07-16 PT PT181562661T patent/PT3366302T/pt unknown
- 2012-07-16 CA CA2842034A patent/CA2842034C/en active Active
- 2012-07-16 EP EP12814249.4A patent/EP2734240B1/en active Active
- 2012-07-16 CA CA3205596A patent/CA3205596A1/en active Pending
-
2014
- 2014-01-17 US US14/158,357 patent/US9453226B2/en active Active
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