JP2014528700A5 - - Google Patents

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Publication number
JP2014528700A5
JP2014528700A5 JP2014521695A JP2014521695A JP2014528700A5 JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5 JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5
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JP
Japan
Prior art keywords
inhibitor
composition
composition according
seq
stranded rna
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JP2014521695A
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English (en)
Japanese (ja)
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JP2014528700A (ja
JP6313203B2 (ja
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Priority claimed from PCT/US2012/046928 external-priority patent/WO2013012806A2/en
Publication of JP2014528700A publication Critical patent/JP2014528700A/ja
Publication of JP2014528700A5 publication Critical patent/JP2014528700A5/ja
Application granted granted Critical
Publication of JP6313203B2 publication Critical patent/JP6313203B2/ja
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JP2014521695A 2011-07-18 2012-07-16 Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤 Active JP6313203B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161508867P 2011-07-18 2011-07-18
US61/508,867 2011-07-18
US201161543038P 2011-10-04 2011-10-04
US61/543,038 2011-10-04
PCT/US2012/046928 WO2013012806A2 (en) 2011-07-18 2012-07-16 Protection of cells from alu-rna-induced degenereation and inhibitors for protecting cells

Publications (3)

Publication Number Publication Date
JP2014528700A JP2014528700A (ja) 2014-10-30
JP2014528700A5 true JP2014528700A5 (enExample) 2015-08-20
JP6313203B2 JP6313203B2 (ja) 2018-04-18

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ID=47558691

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014521695A Active JP6313203B2 (ja) 2011-07-18 2012-07-16 Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤

Country Status (9)

Country Link
US (1) US9453226B2 (enExample)
EP (2) EP2734240B1 (enExample)
JP (1) JP6313203B2 (enExample)
CN (1) CN103889461B (enExample)
AU (1) AU2012284223B2 (enExample)
CA (2) CA2842034C (enExample)
ES (1) ES2907620T3 (enExample)
PT (1) PT3366302T (enExample)
WO (1) WO2013012806A2 (enExample)

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WO2013169382A1 (en) * 2012-05-07 2013-11-14 DePuy Synthes Products, LLC Methods and devices for treating intervertebral disc disease
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US9441223B2 (en) 2012-09-05 2016-09-13 Cold Spring Harbor Laboratory, LLC Transposable elements, TDP-43, and neurodegenerative disorders
US10981961B2 (en) 2013-03-11 2021-04-20 University Of Florida Research Foundation, Incorporated Delivery of card protein as therapy for occular inflammation
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WO2015095609A1 (en) * 2013-12-19 2015-06-25 The J. David Gladstone Institute Inhibition of interferon-gamma-inducible protein 16 (ifi16)
WO2015127094A1 (en) 2014-02-19 2015-08-27 University Of Florida Research Foundation, Inc. Delivery of nrf2 as therapy for protection against reactive oxygen species
EP4050020A1 (en) * 2014-03-11 2022-08-31 University of Florida Research Foundation, Inc. Aav-expressed m013 protein as an anti-inflammatroy therapeutic for use in a method of treating inflammatory ocular disease
WO2016022914A1 (en) * 2014-08-08 2016-02-11 Moderna Therapeutics, Inc. Compositions and methods for the treatment of ophthalmic diseases and conditions
US11219623B2 (en) 2015-02-26 2022-01-11 University Of Kentucky Research Foundation Inflammasome inhibition for the treatment of Parkinson's disease, Alzheimer's disease and multiple sclerosis
PT4215527T (pt) 2015-02-26 2025-01-07 Univ Kentucky Res Found Composições e métodos para tratar a degradação retinal
CN108350046B (zh) 2015-09-03 2022-04-01 在本-古里安大学的B．G．内盖夫科技与应用有限公司 Vdac1衍生肽的类似物
EP3373939A4 (en) * 2015-11-10 2019-06-26 B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University MEDIUM AND METHOD FOR REDUCING TUMORIGENITY OF CANCER STEM CELLS
EP3377630A4 (en) 2015-11-16 2020-01-01 Olix Pharmaceuticals, Inc. Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3
CN108779463B (zh) 2016-02-02 2022-05-24 奥利克斯医药有限公司 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘
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WO2017214553A1 (en) * 2016-06-09 2017-12-14 The General Hospital Corporation Modulating the cellular stress response
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
US20190185820A1 (en) * 2016-08-26 2019-06-20 The Regents Of The University Of California Compositions and Methods for Inhibiting Stem Cell Aging
DK3558335T3 (da) 2016-12-23 2023-07-24 Casp Aid Inc Caspase-1 inhibition and uses thereof for prevention and treatment of neurological conditions
US11591600B2 (en) 2017-02-10 2023-02-28 OliX Pharmaceuticals. Inc. Long double-stranded RNA for RNA interference
GB2561540A (en) 2017-03-13 2018-10-24 Nodthera Ltd Chemical compounds
EP3607063A4 (en) * 2017-04-03 2021-01-13 Duke University COMPOSITIONS AND METHODS FOR DIFFERENTIAL INDUCTION OF CELLULAR DEATH AND INTERFERON EXPRESSION
WO2019074884A2 (en) * 2017-10-10 2019-04-18 University Of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND GEOGRAPHIC ATROPHY
BR112020025018A2 (pt) * 2018-06-27 2021-03-23 Children's Medical Center Corporation compostos para inibição de inflamação
KR102138256B1 (ko) * 2018-09-13 2020-08-13 한국과학기술연구원 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물
US20210348164A1 (en) * 2018-10-09 2021-11-11 University Of Virginia Patent Foundation Endogenous cytoplasmic alu complementary dna in age-related macular degeneration
CN110305957B (zh) * 2019-08-22 2022-07-29 中国水产科学研究院淡水渔业研究中心 一种鉴定黄颡鱼脂肪肝程度的试剂盒及其鉴定方法
WO2021041317A1 (en) * 2019-08-23 2021-03-04 University Of Virginia Patent Foundation Ddx17 and nlrc4 targeting for inflammatory diseases
CN115484986A (zh) * 2020-01-06 2022-12-16 海阳制药 用于预防或治疗黄斑变性的含有细胞可渗透的核酸复合物作为活性成分的组合物
EP4103177A4 (en) * 2020-02-11 2024-03-27 University of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR THE TREATMENT AND/OR PREVENTION OF EYE DISEASES
CN111358950A (zh) * 2020-03-20 2020-07-03 厦门大学 Caspase-1及ASC/Caspase-8作为靶点的应用
US20240011030A1 (en) * 2020-08-10 2024-01-11 Novartis Ag Treatments for retinal degenerative diseases
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CN115969844B (zh) * 2021-12-28 2024-04-02 首都医科大学附属北京同仁医院 Nox2特异性抑制剂在制备视网膜变性药物中的应用

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