JP2019507775A5 - - Google Patents
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- Publication number
- JP2019507775A5 JP2019507775A5 JP2018546897A JP2018546897A JP2019507775A5 JP 2019507775 A5 JP2019507775 A5 JP 2019507775A5 JP 2018546897 A JP2018546897 A JP 2018546897A JP 2018546897 A JP2018546897 A JP 2018546897A JP 2019507775 A5 JP2019507775 A5 JP 2019507775A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical composition
- subject
- composition according
- rheumatoid arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 12
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 8
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 8
- 206010003246 arthritis Diseases 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229940071643 prefilled syringe Drugs 0.000 claims 1
- 238000004062 sedimentation Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022170275A JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305253.3 | 2016-03-07 | ||
| EP16305253.3A EP3216461A1 (en) | 2016-03-07 | 2016-03-07 | Compositions and methods for treating rheumatoid arthritis |
| EP16170664.3 | 2016-05-20 | ||
| EP16170664 | 2016-05-20 | ||
| EP16306111.2 | 2016-09-05 | ||
| EP16306111 | 2016-09-05 | ||
| PCT/US2017/021149 WO2017155990A1 (en) | 2016-03-07 | 2017-03-07 | Compositions and methods for treating rheumatoid arthritis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022170275A Division JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507775A JP2019507775A (ja) | 2019-03-22 |
| JP2019507775A5 true JP2019507775A5 (enExample) | 2020-04-09 |
| JP7166925B2 JP7166925B2 (ja) | 2022-11-08 |
Family
ID=58387910
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546897A Active JP7166925B2 (ja) | 2016-03-07 | 2017-03-07 | 関節リウマチを処置するための組成物及び方法 |
| JP2022170275A Active JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022170275A Active JP7745529B2 (ja) | 2016-03-07 | 2022-10-25 | 関節リウマチを処置するための組成物及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20190100585A1 (enExample) |
| EP (1) | EP3426295A1 (enExample) |
| JP (2) | JP7166925B2 (enExample) |
| KR (2) | KR20230093522A (enExample) |
| CN (1) | CN109069642A (enExample) |
| AU (2) | AU2017229364A1 (enExample) |
| BR (1) | BR112018067851A2 (enExample) |
| CA (1) | CA3016880A1 (enExample) |
| CL (1) | CL2018002559A1 (enExample) |
| CR (1) | CR20180465A (enExample) |
| EA (1) | EA201892005A1 (enExample) |
| IL (2) | IL261515B2 (enExample) |
| MX (2) | MX2018010815A (enExample) |
| PH (1) | PH12018501894A1 (enExample) |
| SG (2) | SG11201807614SA (enExample) |
| TN (1) | TN2018000312A1 (enExample) |
| TW (3) | TWI819435B (enExample) |
| WO (1) | WO2017155990A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| IL297354A (en) * | 2017-11-30 | 2022-12-01 | Bio Thera Solutions Ltd | A liquid preparation of a humanized antibody for the treatment of 6-il-related disease |
| CN112955222A (zh) * | 2018-08-29 | 2021-06-11 | 里珍纳龙药品有限公司 | 用于治疗患有类风湿性关节炎的个体的方法和组合物 |
| TW202521583A (zh) | 2019-01-31 | 2025-06-01 | 法商賽諾菲生物技術公司 | 用於治療幼年原發性關節炎之組成物及方法 |
| MA55760A (fr) * | 2019-04-24 | 2022-03-02 | Regeneron Pharma | Procédés de diagnostic et de traitement de la polyarthrite rhumatoïde |
| JP2022534794A (ja) * | 2019-06-04 | 2022-08-03 | サノフィ・バイオテクノロジー | 関節リウマチを有する対象における疼痛を治療するための組成物および方法 |
| WO2023020563A1 (en) * | 2021-08-18 | 2023-02-23 | Bio-Thera Solutions, Ltd. | Liquid formulations comprising high concentrations humanized antibodies for treating il-6 related diseases |
| WO2026047197A1 (en) | 2024-08-30 | 2026-03-05 | Sanofi Biotechnology | Differential biomarkers for anti-interleukin-6 and anti-tumor necrosis factor-α treatment response in rheumatoid arthritis |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215534A (en) | 1991-12-02 | 1993-06-01 | Lawrence De Harde | Safety syringe system |
| CA2385745C (en) * | 2001-06-08 | 2015-02-17 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| RS52176B (sr) | 2006-06-02 | 2012-08-31 | Regeneron Pharmaceuticals Inc. | Antitela visokog afiniteta prema humanom il-6 receptoru |
| GB0718684D0 (en) * | 2007-09-24 | 2007-10-31 | Roche Products Ltd | Treatment method |
| JO3417B1 (ar) * | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| US9427531B2 (en) | 2010-06-28 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
| TWI589299B (zh) * | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
| US9248242B2 (en) | 2012-04-20 | 2016-02-02 | Safety Syringes, Inc. | Anti-needle stick safety device for injection device |
| US20140155827A1 (en) | 2012-12-03 | 2014-06-05 | Mylan, Inc. | Medicament information system and method |
| WO2015077582A1 (en) * | 2013-11-22 | 2015-05-28 | Sanofi Biotechnology | Compositions for the treatment of rheumatoid arthritis and methods of using same |
-
2017
- 2017-03-07 TW TW110146922A patent/TWI819435B/zh active
- 2017-03-07 TN TNP/2018/000312A patent/TN2018000312A1/en unknown
- 2017-03-07 TW TW106107363A patent/TWI747885B/zh active
- 2017-03-07 US US16/082,841 patent/US20190100585A1/en active Pending
- 2017-03-07 SG SG11201807614SA patent/SG11201807614SA/en unknown
- 2017-03-07 BR BR112018067851A patent/BR112018067851A2/pt not_active Application Discontinuation
- 2017-03-07 CN CN201780028050.2A patent/CN109069642A/zh active Pending
- 2017-03-07 CR CR20180465A patent/CR20180465A/es unknown
- 2017-03-07 AU AU2017229364A patent/AU2017229364A1/en not_active Abandoned
- 2017-03-07 EP EP17712604.2A patent/EP3426295A1/en active Pending
- 2017-03-07 JP JP2018546897A patent/JP7166925B2/ja active Active
- 2017-03-07 TW TW112135625A patent/TW202419103A/zh unknown
- 2017-03-07 WO PCT/US2017/021149 patent/WO2017155990A1/en not_active Ceased
- 2017-03-07 SG SG10202012182YA patent/SG10202012182YA/en unknown
- 2017-03-07 KR KR1020237019726A patent/KR20230093522A/ko not_active Ceased
- 2017-03-07 IL IL261515A patent/IL261515B2/en unknown
- 2017-03-07 CA CA3016880A patent/CA3016880A1/en active Pending
- 2017-03-07 KR KR1020187028624A patent/KR20180114955A/ko not_active Ceased
- 2017-03-07 IL IL308539A patent/IL308539A/en unknown
- 2017-03-07 MX MX2018010815A patent/MX2018010815A/es unknown
- 2017-03-07 EA EA201892005A patent/EA201892005A1/ru unknown
-
2018
- 2018-09-05 PH PH12018501894A patent/PH12018501894A1/en unknown
- 2018-09-07 MX MX2023014841A patent/MX2023014841A/es unknown
- 2018-09-07 CL CL2018002559A patent/CL2018002559A1/es unknown
-
2022
- 2022-10-25 JP JP2022170275A patent/JP7745529B2/ja active Active
-
2024
- 2024-05-07 AU AU2024203011A patent/AU2024203011A1/en active Pending
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