JP2014527979A - 増殖性疾患を治療するためのストリゴラクトンおよびストリゴラクトンアナログの使用 - Google Patents

増殖性疾患を治療するためのストリゴラクトンおよびストリゴラクトンアナログの使用 Download PDF

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JP2014527979A
JP2014527979A JP2014531375A JP2014531375A JP2014527979A JP 2014527979 A JP2014527979 A JP 2014527979A JP 2014531375 A JP2014531375 A JP 2014531375A JP 2014531375 A JP2014531375 A JP 2014531375A JP 2014527979 A JP2014527979 A JP 2014527979A
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methyl
cells
strigolactone
dihydro
dihydrofuran
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Japanese (ja)
Inventor
カプルニク，ヨラム
コルタイ，ヒナニット
ヤーデン，ロニット
プランディ，クリスティーナ
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Georgetown University
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Georgetown University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2014531375A 2011-09-21 2012-09-20 増殖性疾患を治療するためのストリゴラクトンおよびストリゴラクトンアナログの使用 Pending JP2014527979A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161537062P 2011-09-21 2011-09-21
US61/537,062 2011-09-21
US201261614965P 2012-03-23 2012-03-23
US61/614,965 2012-03-23
PCT/IL2012/050381 WO2013042124A1 (en) 2011-09-21 2012-09-20 Use of strigolactones and strigolactone analogs for treating proliferative conditions

Publications (1)

Publication Number Publication Date
JP2014527979A true JP2014527979A (ja) 2014-10-23

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ID=47913975

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JP2014531375A Pending JP2014527979A (ja) 2011-09-21 2012-09-20 増殖性疾患を治療するためのストリゴラクトンおよびストリゴラクトンアナログの使用

Country Status (7)

Country Link
US (1) US10208007B2 (enExample)
EP (1) EP2758392B1 (enExample)
JP (1) JP2014527979A (enExample)
CN (1) CN104053655A (enExample)
CA (1) CA2849343C (enExample)
IN (1) IN2014CN02680A (enExample)
WO (1) WO2013042124A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016530295A (ja) 2013-09-06 2016-09-29 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｃｙｒ６１及びｖｅｇｆ媒介性の状態の治療
EP3294063A4 (en) * 2015-05-14 2018-12-05 The State of Israel, Ministry of Agriculture and Rural Development, Agricultural Research Organisation, Volcani Center Plant hormone application
GB201615544D0 (en) * 2016-09-13 2016-10-26 Syngenta Participations Ag Plant Growth regulator compounds
CN108675974B (zh) * 2018-05-07 2020-04-07 南开大学 一类独脚金内酯衍生物及其制备方法和用途
CN108558796B (zh) * 2018-05-07 2020-04-07 南开大学 一类羟亚甲基氢化茚酮衍生物及其制备方法和用途
WO2020095260A1 (en) * 2018-11-08 2020-05-14 Universita' Degli Studi Di Torino Strigolactones for use in preventing and/or treating infections caused by viruses of the herpesviridae family
CN117843651B (zh) * 2024-01-03 2024-09-10 盐城工学院 一种含有三氟甲基季碳中心的四氢呋喃并[3,2-b]吲哚啉类化合物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077177A2 (fr) * 2004-02-10 2005-08-25 Universite Paul Sabatier Toulouse Iii Modulateurs de developpement des champignons mycorhiziens a arbuscules, et applications
JP2010529975A (ja) * 2007-06-15 2010-09-02 バイエル・クロツプサイエンス・エス・アー ストリゴラクトン誘導体と殺菌剤化合物を含んでいる殺有害生物剤組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200904331A (en) 2007-06-15 2009-02-01 Bayer Cropscience Sa Pesticidal composition comprising a strigolactone derivative and an insecticide compound
EP2248421A1 (en) * 2009-05-07 2010-11-10 GMI - Gregor-Mendel-Institut für Molekulare Pflanzenbiologie GmbH Accumulation of biomass in plants
FI20106119A0 (fi) * 2010-10-27 2010-10-27 Sirtuin Valley Oy Energia-aineenvaihduntaan vaikuttava koostumus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077177A2 (fr) * 2004-02-10 2005-08-25 Universite Paul Sabatier Toulouse Iii Modulateurs de developpement des champignons mycorhiziens a arbuscules, et applications
JP2010529975A (ja) * 2007-06-15 2010-09-02 バイエル・クロツプサイエンス・エス・アー ストリゴラクトン誘導体と殺菌剤化合物を含んでいる殺有害生物剤組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6016018937; Ｅｕｒ．　Ｊ．　Ｏｒｇ．　Ｃｈｅｍ，　２０１１　Ｊｕｌ，　Ｖｏｌ．２０１１，　ｐ．３７８１-３７９３ *
JPN6016018941; ＡＣＳ　Ｓｙｍｐ．　ｓｅｒ．，　１９９１，　Ｖｏｌ．４４３，　ｐ．２７８-２８７ *
JPN6016018944; Ｊ．Ｃ．Ｓ．　Ｃｈｅｍ．　Ｃｏｍｍ．，　１９７４，　Ｖｏｌ．１３，　ｐ．５１２-５１３ *

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WO2013042124A8 (en) 2013-07-25
WO2013042124A1 (en) 2013-03-28
EP2758392B1 (en) 2019-09-18
US20140323563A1 (en) 2014-10-30
CA2849343C (en) 2020-12-15
CA2849343A1 (en) 2013-03-28
CN104053655A (zh) 2014-09-17
IN2014CN02680A (enExample) 2015-07-03
EP2758392A1 (en) 2014-07-30
EP2758392A4 (en) 2015-05-20
US10208007B2 (en) 2019-02-19

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