CA2849343C - Use of strigolactones and strigolactone analogs for treating proliferative conditions - Google Patents

Use of strigolactones and strigolactone analogs for treating proliferative conditions Download PDF

Info

Publication number
CA2849343C
CA2849343C CA2849343A CA2849343A CA2849343C CA 2849343 C CA2849343 C CA 2849343C CA 2849343 A CA2849343 A CA 2849343A CA 2849343 A CA2849343 A CA 2849343A CA 2849343 C CA2849343 C CA 2849343C
Authority
CA
Canada
Prior art keywords
cells
cancer
methyl
strigolactone
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2849343A
Other languages
English (en)
French (fr)
Other versions
CA2849343A1 (en
Inventor
Yoram Kapulnik
Hinanit KOLTAI
Ronit YARDEN
Cristina PRANDI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agricultural Research Organization of Israel Ministry of Agriculture
Georgetown University
Original Assignee
Agricultural Research Organization of Israel Ministry of Agriculture
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agricultural Research Organization of Israel Ministry of Agriculture , Georgetown University filed Critical Agricultural Research Organization of Israel Ministry of Agriculture
Publication of CA2849343A1 publication Critical patent/CA2849343A1/en
Application granted granted Critical
Publication of CA2849343C publication Critical patent/CA2849343C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2849343A 2011-09-21 2012-09-20 Use of strigolactones and strigolactone analogs for treating proliferative conditions Expired - Fee Related CA2849343C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161537062P 2011-09-21 2011-09-21
US61/537,062 2011-09-21
US201261614965P 2012-03-23 2012-03-23
US61/614,965 2012-03-23
PCT/IL2012/050381 WO2013042124A1 (en) 2011-09-21 2012-09-20 Use of strigolactones and strigolactone analogs for treating proliferative conditions

Publications (2)

Publication Number Publication Date
CA2849343A1 CA2849343A1 (en) 2013-03-28
CA2849343C true CA2849343C (en) 2020-12-15

Family

ID=47913975

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2849343A Expired - Fee Related CA2849343C (en) 2011-09-21 2012-09-20 Use of strigolactones and strigolactone analogs for treating proliferative conditions

Country Status (7)

Country Link
US (1) US10208007B2 (enExample)
EP (1) EP2758392B1 (enExample)
JP (1) JP2014527979A (enExample)
CN (1) CN104053655A (enExample)
CA (1) CA2849343C (enExample)
IN (1) IN2014CN02680A (enExample)
WO (1) WO2013042124A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016530295A (ja) 2013-09-06 2016-09-29 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｃｙｒ６１及びｖｅｇｆ媒介性の状態の治療
EP3294063A4 (en) * 2015-05-14 2018-12-05 The State of Israel, Ministry of Agriculture and Rural Development, Agricultural Research Organisation, Volcani Center Plant hormone application
GB201615544D0 (en) * 2016-09-13 2016-10-26 Syngenta Participations Ag Plant Growth regulator compounds
CN108675974B (zh) * 2018-05-07 2020-04-07 南开大学 一类独脚金内酯衍生物及其制备方法和用途
CN108558796B (zh) * 2018-05-07 2020-04-07 南开大学 一类羟亚甲基氢化茚酮衍生物及其制备方法和用途
WO2020095260A1 (en) * 2018-11-08 2020-05-14 Universita' Degli Studi Di Torino Strigolactones for use in preventing and/or treating infections caused by viruses of the herpesviridae family
CN117843651B (zh) * 2024-01-03 2024-09-10 盐城工学院 一种含有三氟甲基季碳中心的四氢呋喃并[3,2-b]吲哚啉类化合物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2865897B1 (fr) * 2004-02-10 2006-06-09 Univ Toulouse Modulateurs de developpement des champignons mycorhiziens a arbuscules, et applications.
TW200904330A (en) 2007-06-15 2009-02-01 Bayer Cropscience Sa Pesticidal composition comprising a strigolactone derivative and a fungicide compound
TW200904331A (en) 2007-06-15 2009-02-01 Bayer Cropscience Sa Pesticidal composition comprising a strigolactone derivative and an insecticide compound
EP2248421A1 (en) * 2009-05-07 2010-11-10 GMI - Gregor-Mendel-Institut für Molekulare Pflanzenbiologie GmbH Accumulation of biomass in plants
FI20106119A0 (fi) * 2010-10-27 2010-10-27 Sirtuin Valley Oy Energia-aineenvaihduntaan vaikuttava koostumus

Also Published As

Publication number Publication date
JP2014527979A (ja) 2014-10-23
WO2013042124A8 (en) 2013-07-25
WO2013042124A1 (en) 2013-03-28
EP2758392B1 (en) 2019-09-18
US20140323563A1 (en) 2014-10-30
CA2849343A1 (en) 2013-03-28
CN104053655A (zh) 2014-09-17
IN2014CN02680A (enExample) 2015-07-03
EP2758392A1 (en) 2014-07-30
EP2758392A4 (en) 2015-05-20
US10208007B2 (en) 2019-02-19

Similar Documents

Publication Publication Date Title
CA2849343C (en) Use of strigolactones and strigolactone analogs for treating proliferative conditions
Taylor et al. The use of natural products to target cancer stem cells
Hong et al. Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
EP2925307B1 (en) Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition
Lu et al. Duloxetine attenuates paclitaxel-induced peripheral nerve injury by inhibiting p53-related pathways
Hur et al. Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro
Yan et al. Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice
Liu et al. NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway
US10238631B2 (en) Sesquiterpene derivatives and their use in inflammation or cancer treatment
Nakagawa-Goto et al. Novel sesquiterpene lactone analogues as potent anti-breast cancer agents
Ma et al. IPM712, a vanillin derivative as potential antitumor agents, displays better antitumor activity in colorectal cancers cell lines
Awale et al. Targeting pancreatic cancer with novel plumbagin derivatives: Design, synthesis, molecular mechanism, in vitro and in vivo evaluation
Gao et al. Juniperus communis suppresses melanoma tumorigenesis by inhibiting tumor growth and inducing apoptosis
Li et al. Synthesis and biological properties of polyamine modified flavonoids as hepatocellular carcinoma inhibitors
Shan et al. First total synthesis, antitumor evaluation and target identification of mornaphthoate E: a new tubulin inhibitor template acting on PI3K/Akt signaling pathway
Yamazaki et al. Targeting pancreatic cancer with novel nicolaioidesin C derivatives: Molecular mechanism, in vitro, and in vivo evaluations
AU2015352041B2 (en) Titled extracts of Cynara scolymus and uses thereof
US8580847B2 (en) Antrocin containing pharmaceutical compositions for inhibiting cancer cells
ITRM20130502A1 (it) Estratto di filipendula vulgaris e suoi usi
CN107501219A (zh) 不对称姜黄色素类化合物及其在制备抗胃癌药物中的应用
Wang Dietary Compound Diosmetin Chemosensitizes Breast Cancer Stem Cells by Suppressing HMGB1-mediated Autophagy
CN106581012B (zh) 一种抗癌药物组合物及其制剂和制备方法
KR101416505B1 (ko) 마타이레시놀을 포함하는 혈관신생 억제용 약제학적 조성물
US20110263700A1 (en) Antrocin containing pharmaceutical compositions for inhibiting cancer cells
US20180221329A1 (en) Cis- and trans-suffruticosol d as therapeutic agents

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180621

MKLA Lapsed

Effective date: 20210920