JP2014527071A - Ｈ−ホスホネートによるナノ粒子ｐｅｇの改変 - Google Patents

Ｈ−ホスホネートによるナノ粒子ｐｅｇの改変 Download PDF

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Publication number
JP2014527071A
JP2014527071A JP2014528610A JP2014528610A JP2014527071A JP 2014527071 A JP2014527071 A JP 2014527071A JP 2014528610 A JP2014528610 A JP 2014528610A JP 2014528610 A JP2014528610 A JP 2014528610A JP 2014527071 A JP2014527071 A JP 2014527071A
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group
compound
agent
peg
agents
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JP2014527071A5 (enExample
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トーマス イー． ロジャーズ，
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Mallinckrodt Inc
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Mallinckrodt Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y10S977/836—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
JP2014528610A 2011-08-31 2012-08-30 Ｈ−ホスホネートによるナノ粒子ｐｅｇの改変 Pending JP2014527071A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161529694P 2011-08-31 2011-08-31
US61/529,694 2011-08-31
PCT/US2012/053197 WO2013033438A2 (en) 2011-08-31 2012-08-30 Nanoparticle peg modification with h-phosphonates

Publications (2)

Publication Number Publication Date
JP2014527071A true JP2014527071A (ja) 2014-10-09
JP2014527071A5 JP2014527071A5 (enExample) 2015-10-15

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JP2014528610A Pending JP2014527071A (ja) 2011-08-31 2012-08-30 Ｈ−ホスホネートによるナノ粒子ｐｅｇの改変

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Country Link
US (2) US8889657B2 (enExample)
EP (1) EP2750712A2 (enExample)
JP (1) JP2014527071A (enExample)
KR (1) KR20140067070A (enExample)
CN (1) CN103930135A (enExample)
BR (1) BR112014004544A2 (enExample)
CA (1) CA2845845A1 (enExample)
IL (1) IL231215A0 (enExample)
WO (1) WO2013033438A2 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536845A (ja) * 2017-10-05 2020-12-17 ソニー株式会社 プログラマブルな樹枝状薬物
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
JP2024012419A (ja) * 2018-10-01 2024-01-30 ヨハネス グーテンベルグ－ウニヴェリジテート マインツ ポリサルコシンを含むｒｎａ粒子
US12076407B2 (en) 2018-01-12 2024-09-03 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
US12098161B2 (en) 2017-10-05 2024-09-24 Sony Group Corporation Programmable polymeric drugs
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
US12270812B2 (en) 2016-04-06 2025-04-08 Sony Group Corporation Ultra bright dimeric or polymeric dyes with spacing linker groups
US12275851B2 (en) 2018-03-21 2025-04-15 Sony Group Corporation Polymeric tandem dyes with linker groups
US12359071B2 (en) 2019-09-26 2025-07-15 Sony Group Corporation Polymeric tandem dyes with linker groups
US12391833B2 (en) 2018-06-27 2025-08-19 Sony Group Corporation Polymeric dyes with linker groups comprising deoxyribose
US12473433B2 (en) 2020-12-07 2025-11-18 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
CA2892529C (en) 2012-11-26 2023-04-25 Moderna Therapeutics, Inc. Terminally modified rna
WO2014152211A1 (en) 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
WO2016011226A1 (en) 2014-07-16 2016-01-21 Moderna Therapeutics, Inc. Chimeric polynucleotides
US20170210788A1 (en) 2014-07-23 2017-07-27 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
DK3350157T3 (da) 2015-09-17 2022-02-14 Modernatx Inc Forbindelser og sammensætninger til intracellulær afgivelse af terapeutiske midler
WO2017067592A1 (en) 2015-10-21 2017-04-27 Biontech Ag Cytotoxic immunostimulating particles and uses thereof
MA52645B1 (fr) 2015-10-22 2022-06-30 Modernatx Inc Vaccins contre le virus respiratoire
MA46316A (fr) 2015-10-22 2021-03-24 Modernatx Inc Vaccin contre le cytomégalovirus humain
KR20180096592A (ko) 2015-10-22 2018-08-29 모더나티엑스, 인크. 호흡기 세포융합 바이러스 백신
MX2018004918A (es) 2015-10-22 2019-04-01 Modernatx Inc Vacuna del virus herpes simple.
CA3003103A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Broad spectrum influenza virus vaccine
CN117731769A (zh) 2015-10-22 2024-03-22 摩登纳特斯有限公司 用于水痘带状疱疹病毒(vzv)的核酸疫苗
MD3386484T2 (ro) 2015-12-10 2022-11-30 Modernatx Inc Compoziții și metode de livrare a unor agenți terapeutici
AU2016377681B2 (en) 2015-12-22 2021-05-13 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
EP4039699A1 (en) 2015-12-23 2022-08-10 ModernaTX, Inc. Methods of using ox40 ligand encoding polynucleotides
US20190241658A1 (en) 2016-01-10 2019-08-08 Modernatx, Inc. Therapeutic mRNAs encoding anti CTLA-4 antibodies
KR102530707B1 (ko) 2016-04-01 2023-05-11 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
EP3455300A1 (en) 2016-05-11 2019-03-20 Sony Corporation Ultra bright dimeric or polymeric dyes
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
US10072032B2 (en) * 2016-09-19 2018-09-11 Afton Chemical Corporation AminoBisPhosphonate antiwear additives
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
AU2018234692B2 (en) 2017-03-15 2022-06-02 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
ES2911186T3 (es) 2017-03-15 2022-05-18 Modernatx Inc Formas cristalinas de aminolípidos
EP3625345B1 (en) 2017-05-18 2023-05-24 ModernaTX, Inc. Modified messenger rna comprising functional rna elements
WO2018213731A1 (en) 2017-05-18 2018-11-22 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
EP3638292A1 (en) 2017-06-14 2020-04-22 ModernaTX, Inc. Polynucleotides encoding coagulation factor viii
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
US11786607B2 (en) 2017-06-15 2023-10-17 Modernatx, Inc. RNA formulations
MX2020002348A (es) 2017-08-31 2020-10-08 Modernatx Inc Métodos de elaboración de nanopartículas lipídicas.
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
WO2019104152A1 (en) 2017-11-22 2019-05-31 Modernatx, Inc. Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
EP3714045A1 (en) 2017-11-22 2020-09-30 Modernatx, Inc. Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia
US11939601B2 (en) 2017-11-22 2024-03-26 Modernatx, Inc. Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria
US11802146B2 (en) 2018-01-05 2023-10-31 Modernatx, Inc. Polynucleotides encoding anti-chikungunya virus antibodies
US20190262793A1 (en) * 2018-02-28 2019-08-29 Southwest Research Institute Polymer-Encapsulated Polyhemoglobin-Based Oxygen Carrier
WO2019200171A1 (en) 2018-04-11 2019-10-17 Modernatx, Inc. Messenger rna comprising functional rna elements
EP3796893A1 (en) 2018-05-23 2021-03-31 Modernatx, Inc. Delivery of dna
US20220184185A1 (en) 2018-07-25 2022-06-16 Modernatx, Inc. Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
US20220110966A1 (en) 2018-09-02 2022-04-14 Modernatx, Inc. Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency
WO2020056161A1 (en) 2018-09-12 2020-03-19 University Of Florida Research Foundation, Inc. Slow-cycling cell-rna based nanoparticle vaccine to treat cancer
WO2020056147A2 (en) 2018-09-13 2020-03-19 Modernatx, Inc. Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease
MA53608A (fr) 2018-09-13 2021-07-21 Modernatx Inc Polynucléotides codant pour les sous-unités e1-alpha, e1-beta et e2 du complexe alpha-cétoacide déshydrogénase à chaîne ramifiée pour le traitement de la leucinose
CA3112398A1 (en) 2018-09-14 2020-03-19 Modernatx, Inc. Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
CA3113025A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Peg lipids and uses thereof
EP4509118A3 (en) 2018-09-19 2025-05-14 ModernaTX, Inc. High-purity peg lipids and uses thereof
US12263248B2 (en) 2018-09-19 2025-04-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US12090235B2 (en) 2018-09-20 2024-09-17 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
US20220152225A1 (en) 2018-09-27 2022-05-19 Modernatx, Inc. Polynucleotides encoding arginase 1 for the treatment of arginase deficiency
WO2020069718A1 (en) * 2018-10-01 2020-04-09 Johannes Gutenberg-Universität Mainz Rna particles comprising polysarcosine
US20220001026A1 (en) 2018-11-08 2022-01-06 Modernatx, Inc. Use of mrna encoding ox40l to treat cancer in human patients
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EP3965806A1 (en) 2019-05-08 2022-03-16 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
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US20220387628A1 (en) 2019-06-24 2022-12-08 Modernatx, Inc. Messenger rna comprising functional rna elements and uses thereof
CA3154618A1 (en) 2019-09-19 2021-03-25 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
US20230235298A1 (en) 2020-06-01 2023-07-27 Modernatx, Inc. Phenylalanine hydroxylase variants and uses thereof
US20230272378A1 (en) 2020-06-12 2023-08-31 University Of Rochester ENCODING AND EXPRESSION OF ACE-tRNAs
AU2021377895A1 (en) 2020-11-13 2023-06-15 Modernatx, Inc. Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
WO2022204380A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
JP2024512026A (ja) 2021-03-24 2024-03-18 モデルナティエックス インコーポレイテッド オルニチントランスカルバミラーゼ欠損症の治療を目的とした脂質ナノ粒子及びオルニチントランスカルバミラーゼをコードするポリヌクレオチド
WO2022204369A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
WO2022204390A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
US20240207374A1 (en) 2021-03-24 2024-06-27 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
EP4355882A2 (en) 2021-06-15 2024-04-24 Modernatx, Inc. Engineered polynucleotides for cell-type or microenvironment-specific expression
US20240376445A1 (en) 2021-06-22 2024-11-14 Modernatx, Inc. Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
US20250017867A1 (en) 2021-10-01 2025-01-16 Modernatx, Inc. Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
AU2023215397A1 (en) 2022-02-07 2024-08-22 University Of Rochester Optimized sequences for enhanced trna expression or/and nonsense mutation suppression.
US20250327041A1 (en) 2022-02-24 2025-10-23 Io Biotech Aps Nucleotide delivery of cancer therapy
WO2023177904A1 (en) 2022-03-18 2023-09-21 Modernatx, Inc. Sterile filtration of lipid nanoparticles and filtration analysis thereof for biological applications
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WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas

Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB792595A (en) * 1954-03-05 1958-04-02 Ciba Ltd New organic compounds containing nitrogen and phosphorus and their manufacture
GB1128086A (en) * 1966-10-27 1968-09-25 Pure Chem Ltd Improvements relating to hydroxy-containing phosphonates and polyurethanes
US3974209A (en) * 1971-08-04 1976-08-10 Monsanto Company Substituted tertiary amines and processes for preparing the same
JPS58129429A (ja) * 1982-01-23 1983-08-02 アグフア−ゲヴエルト・アクチエンゲゼルシヤフト 有機染料で染色可能な層を含有する写真材料
JPS6233197A (ja) * 1985-07-24 1987-02-13 メルク　エンド　カムパニ−　インコ−ポレ−テツド 酵素阻害剤
JPH07278166A (ja) * 1994-03-15 1995-10-24 Hoechst Ag テクネチウムまたはレニウム錯体製造のためのアミノジアルキル燐酸化物をベースとする非環式キレート化剤
WO1999019334A1 (en) * 1997-10-15 1999-04-22 Monsanto Company Selective functionalization of sodium glycinate
WO2002062398A2 (en) * 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
WO2004089356A2 (en) * 2003-04-03 2004-10-21 Semafore Pharmaceuticals Inc. Targeted bone marrow protection agents
JP2006514887A (ja) * 2002-12-20 2006-05-18 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インサイチュ変性ナノ粒子の製造および使用
JP2006523237A (ja) * 2003-04-03 2006-10-12 セマフォア ファーマシューティカルズ， インコーポレイテッド Ｐｉ−３キナーゼインヒビタープロドラッグ
JP2006525423A (ja) * 2003-05-05 2006-11-09 ビーエーエスエフ　アクチェンゲゼルシャフト リン−酸素酸のアルコキシ含有エステルおよびエステル塩、およびこれらの腐食防止剤としての使用方法
JP2007518746A (ja) * 2004-01-23 2007-07-12 エムツェーエス マイクロ キャリアー システムズ ゲーエムベーハー 脂質由来ビスホスホン酸
JP2008532971A (ja) * 2005-03-08 2008-08-21 チバ ホールディング インコーポレーテッド 特定のホスホネートにより被覆された金属酸化物ナノ粒子
WO2009066513A1 (ja) * 2007-11-19 2009-05-28 The University Of Tokyo 標的核酸を位置選択的に切断する方法
WO2010013086A1 (en) * 2008-08-01 2010-02-04 Centre National De La Recherche Scientifique Phosphorylated dendrimers as antiinflammatory drugs
JP2010535701A (ja) * 2003-04-25 2010-11-25 ギリアード サイエンシーズ， インコーポレイテッド 抗癌ホスホネートアナログ
WO2011097563A1 (en) * 2010-02-08 2011-08-11 Board Of Regents Of The University Of Nebraska Biomineral and metal binding liposomes, their synthesis, and methods of use thereof
WO2011101520A2 (es) * 2010-02-18 2011-08-25 Universidad De Alcalá De Henares (Uah) Dendrimeros carbosilanos y su uso como antivirales
JP2014511356A (ja) * 2011-01-28 2014-05-15 ベイジン・コンランズ・ファーマシューティカル・カンパニー・リミテッド リン含有置換基を有するキノリン系化合物及びその製造方法、並びに該化合物を含有する薬物組成物及び使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE514095C (de) * 1927-07-24 1930-12-11 Knoll Akt Ges Chemische Fabrik Verfahren zur Herstellung von Estern der Sterine mit Sauerstoffsaeuren des Phosphors
US4568432A (en) 1984-12-28 1986-02-04 Monsanto Company Process for preparing glyphosate and glyphosate derivatives
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US6054608A (en) 1997-05-05 2000-04-25 Monsanto Company Method for preparing formylphosphonic acid
JP3799435B2 (ja) * 1998-04-13 2006-07-19 三共有機合成株式会社 安定化された抗菌性樹脂組成物
US7833992B2 (en) * 2001-05-18 2010-11-16 Merck Sharpe & Dohme Conjugates and compositions for cellular delivery
DE10049074A1 (de) 2000-10-02 2002-04-18 Andreas Kage Verfahren zur Selektion hochaffin an ein Target bindender Nukleinsäuren
US7420000B2 (en) * 2003-09-10 2008-09-02 University Of Southern California Amino phosphonate and amino bis-phosphonate derivatives
WO2006078646A2 (en) 2005-01-18 2006-07-27 Caltagirone Gaetano T A class of supramolecular drug molecules and methods of identification and use thereof
CN105152939A (zh) * 2008-11-10 2015-12-16 阿尔尼拉姆医药品有限公司 用于递送治疗剂的脂质和组合物
JP5381269B2 (ja) * 2009-04-15 2014-01-08 コニカミノルタ株式会社 光学フィルム、光学フィルムの製造方法、偏光板及び液晶表示装置
JO3131B1 (ar) * 2010-04-27 2017-09-20 Glaxosmithkline Llc مركبات كيميائية

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB792595A (en) * 1954-03-05 1958-04-02 Ciba Ltd New organic compounds containing nitrogen and phosphorus and their manufacture
GB1128086A (en) * 1966-10-27 1968-09-25 Pure Chem Ltd Improvements relating to hydroxy-containing phosphonates and polyurethanes
US3974209A (en) * 1971-08-04 1976-08-10 Monsanto Company Substituted tertiary amines and processes for preparing the same
JPS58129429A (ja) * 1982-01-23 1983-08-02 アグフア−ゲヴエルト・アクチエンゲゼルシヤフト 有機染料で染色可能な層を含有する写真材料
JPS6233197A (ja) * 1985-07-24 1987-02-13 メルク　エンド　カムパニ−　インコ−ポレ−テツド 酵素阻害剤
JPH07278166A (ja) * 1994-03-15 1995-10-24 Hoechst Ag テクネチウムまたはレニウム錯体製造のためのアミノジアルキル燐酸化物をベースとする非環式キレート化剤
WO1999019334A1 (en) * 1997-10-15 1999-04-22 Monsanto Company Selective functionalization of sodium glycinate
WO2002062398A2 (en) * 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
JP2006514887A (ja) * 2002-12-20 2006-05-18 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インサイチュ変性ナノ粒子の製造および使用
JP2006523237A (ja) * 2003-04-03 2006-10-12 セマフォア ファーマシューティカルズ， インコーポレイテッド Ｐｉ−３キナーゼインヒビタープロドラッグ
WO2004089356A2 (en) * 2003-04-03 2004-10-21 Semafore Pharmaceuticals Inc. Targeted bone marrow protection agents
JP2010535701A (ja) * 2003-04-25 2010-11-25 ギリアード サイエンシーズ， インコーポレイテッド 抗癌ホスホネートアナログ
JP2006525423A (ja) * 2003-05-05 2006-11-09 ビーエーエスエフ　アクチェンゲゼルシャフト リン−酸素酸のアルコキシ含有エステルおよびエステル塩、およびこれらの腐食防止剤としての使用方法
JP2007518746A (ja) * 2004-01-23 2007-07-12 エムツェーエス マイクロ キャリアー システムズ ゲーエムベーハー 脂質由来ビスホスホン酸
JP2008532971A (ja) * 2005-03-08 2008-08-21 チバ ホールディング インコーポレーテッド 特定のホスホネートにより被覆された金属酸化物ナノ粒子
WO2009066513A1 (ja) * 2007-11-19 2009-05-28 The University Of Tokyo 標的核酸を位置選択的に切断する方法
WO2010013086A1 (en) * 2008-08-01 2010-02-04 Centre National De La Recherche Scientifique Phosphorylated dendrimers as antiinflammatory drugs
WO2011097563A1 (en) * 2010-02-08 2011-08-11 Board Of Regents Of The University Of Nebraska Biomineral and metal binding liposomes, their synthesis, and methods of use thereof
WO2011101520A2 (es) * 2010-02-18 2011-08-25 Universidad De Alcalá De Henares (Uah) Dendrimeros carbosilanos y su uso como antivirales
JP2014511356A (ja) * 2011-01-28 2014-05-15 ベイジン・コンランズ・ファーマシューティカル・カンパニー・リミテッド リン含有置換基を有するキノリン系化合物及びその製造方法、並びに該化合物を含有する薬物組成物及び使用

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN5014010222; ＢＡＲＯＵＤＡ　ＥＬＥＮＩ: ＣＲＹＳＴＡＬ　ＧＲＯＷＴＨ　ＡＮＤ　ＤＥＳＩＧＮ Ｖ７　Ｎ２, 20070101, Ｐ３２１-３２７ *
JPN5014010223; ＣＨＯＩ　ＳＵＮＧ-ＷＯＯＫ: ＪＯＵＲＮＡＬ　ＯＦ　ＣＯＮＴＲＯＬＬＥＤ　ＲＥＬＥＡＳＥ Ｖ１２２　Ｎ１, 20070822, Ｐ２４-３０, ＥＬＳＥＶＩＥＲ *
JPN6016013474; 'Ｄｅｒｉｖａｔｉｖｅｓ　ｏｆ　ａｍｉｎｏｍｅｔｈｙｌｐｈｏｓｐｈｏｎｉｃ　ａｃｉｄ' Ｒｅｓｅａｒｃｈ　Ｄｉｓｃｌｏｓｕｒｅ １７７, 1979, ｐｐ．　５０-５２ *
JPN6016013476; Ｆｌｏｃｈ，　Ｖｉｒｇｉｎｉｅ　ｅｔ　ａｌ．: 'Ｐｈｏｓｐｈｏｎｏｌｉｐｉｄｓ　ａｓ　ｎｏｎ-ｖｉｒａｌ　ｖｅｃｔｏｒｓ　ｆｏｒ　ｇｅｎｅ　ｔｈｅｒａｐｙ' Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ ３３（１２）, 1998, ｐｐ．　９２３-９３４ *
JPN6016013479; Ｃｈｅｒｋａｓｏｖ，　Ｒ．　Ａ．　ｅｔ　ａｌ．: 'Ｌｉｑｕｉｄ　Ｅｘｔｒａｃｔｉｏｎ　ｏｆ　Ｎｏｂｌｅ　Ｍｅｔａｌ　Ｉｏｎｓ　ｗｉｔｈ　Ｂｉｓ（alpha-ａｍｉｎｏｐｈｏｓｐｈｏｎａｔｅｓ）' Ｒｕｓｓｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｇｅｎｅｒａｌ　Ｃｈｅｍｉｓｔｒｙ ７６（３）, 2006, ｐｐ．　４１７-４２０ *
JPN6016013481; Ｈｓｕ， Ｙｕａｎ-Ｙａｏ ｅｔ ａｌ．: 'Ｏｒｇａｎｏｐｈｏｓｐｈｏｒｕｓ ｃｏｍｐｏｕｎｄｓ． ＩＩＩ． Ｄｉａｌｋｙｌ Ｎ，Ｎ-ｄｉｓｕｂｓｔｉｔｕｔｅｄ ａｍｉｎｏｍｅｔｈｙｌｐｈｏｓｐｈｏｎａｔｅｓ ａｎｄ ｔｈｅｉｒ ｄｅｒ' Ａｃｔａ Ｃｈｉｍｉｃａ Ｓｉｎｉｃａ ３０（６）, 1964, ｐｐ． ５２６-５３２ *
JPN7016000913; ＤＤ ２８２４７０ Ａ５ , 19900912 *

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US12461106B2 (en) 2016-04-06 2025-11-04 Sony Group Corporation Ultra bright dimeric or polymeric dyes with spacing linker groups
JP7403744B2 (ja) 2017-10-05 2023-12-25 ソニーグループ株式会社 プログラマブルな樹枝状薬物
US12290571B2 (en) 2017-10-05 2025-05-06 Sony Group Corporation Programmable dendritic drugs
JP2020536845A (ja) * 2017-10-05 2020-12-17 ソニー株式会社 プログラマブルな樹枝状薬物
US12098161B2 (en) 2017-10-05 2024-09-24 Sony Group Corporation Programmable polymeric drugs
US12145956B2 (en) 2017-10-05 2024-11-19 Sony Group Corporation Programmable polymeric drugs
US12076407B2 (en) 2018-01-12 2024-09-03 Sony Group Corporation Polymers with rigid spacing groups comprising biologically active compounds
US12194104B2 (en) 2018-01-12 2025-01-14 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
US12275851B2 (en) 2018-03-21 2025-04-15 Sony Group Corporation Polymeric tandem dyes with linker groups
US12319817B2 (en) 2018-03-21 2025-06-03 Sony Group Corporation Polymeric tandem dyes with linker groups
US12391833B2 (en) 2018-06-27 2025-08-19 Sony Group Corporation Polymeric dyes with linker groups comprising deoxyribose
JP2024012419A (ja) * 2018-10-01 2024-01-30 ヨハネス グーテンベルグ－ウニヴェリジテート マインツ ポリサルコシンを含むｒｎａ粒子
US12359071B2 (en) 2019-09-26 2025-07-15 Sony Group Corporation Polymeric tandem dyes with linker groups
US12473433B2 (en) 2020-12-07 2025-11-18 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes

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