|
CH652145A5
(de)
|
1982-01-22 |
1985-10-31 |
Sandoz Ag |
Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
|
|
US5672347A
(en)
|
1984-07-05 |
1997-09-30 |
Genentech, Inc. |
Tumor necrosis factor antagonists and their use
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
US4965198A
(en)
|
1985-12-24 |
1990-10-23 |
Konica Corporation |
Monoclonal antibody and method of manufacturing hybridoma producing the same
|
|
DE3631229A1
(de)
|
1986-09-13 |
1988-03-24 |
Basf Ag |
Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
|
|
DK590387A
(da)
|
1986-11-13 |
1988-05-14 |
Otsuka Pharma Co Ltd |
Antistoffer mod interleukin-1
|
|
US5034316A
(en)
|
1987-03-30 |
1991-07-23 |
The Regents Of The University Of California |
In vitro human monoclonal IgG rheumatoid factor autoantibody
|
|
FR2640146B1
(fr)
|
1988-12-08 |
1993-12-24 |
Commissariat A Energie Atomique |
Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
JPH04504253A
(ja)
|
1989-03-27 |
1992-07-30 |
セントカー・インコーポレーテツド |
IgM抗体の安定化のための配合物
|
|
GB9122820D0
(en)
|
1991-10-28 |
1991-12-11 |
Wellcome Found |
Stabilised antibodies
|
|
JPH08502300A
(ja)
|
1992-10-14 |
1996-03-12 |
スターリング ウィンスロップ アイエヌシー. |
治療および診断像形成組成物および方法
|
|
DE69427928T3
(de)
|
1993-03-05 |
2012-05-10 |
Bayer Healthcare Llc |
Humane monoklonale anti-TNF alpha Antikörper
|
|
EP0659766A1
(en)
|
1993-11-23 |
1995-06-28 |
Schering-Plough |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
|
US5959085A
(en)
|
1993-11-23 |
1999-09-28 |
Schering Corporation |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
|
GB9509620D0
(en)
|
1995-05-12 |
1995-07-05 |
Nat Blood Authority |
Transepithelial transport of molecular species
|
|
WO1997002479A2
(en)
|
1995-06-30 |
1997-01-23 |
Yale University |
Human monoclonal anti-tumor antibodies
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
SE9802402D0
(sv)
|
1998-07-03 |
1998-07-03 |
Karolinska Innovations Ab |
Method of diagnosing cardiovascular disease and early atherosclerosis
|
|
US20030040617A9
(en)
|
1999-03-12 |
2003-02-27 |
Rosen Craig A. |
Nucleic acids, proteins and antibodies
|
|
US20030232054A1
(en)
|
2000-01-25 |
2003-12-18 |
Tang Y. Tom |
Novel nucleic acids and polypeptides
|
|
US6623736B2
(en)
|
2000-05-02 |
2003-09-23 |
Edward L. Tobinick |
Interleukin antagonists for the treatment of neurological, retinal and muscular disorders
|
|
AU2007202323C1
(en)
|
2000-06-29 |
2012-04-12 |
Abbvie Inc. |
Dual specificity antibodies and methods of making and using
|
|
US20040086507A1
(en)
|
2000-10-19 |
2004-05-06 |
Kenya Shitara |
Antibody inhibiting vplf activity
|
|
US20030026806A1
(en)
|
2000-10-27 |
2003-02-06 |
Amgen Inc. |
Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
|
|
US7273888B2
(en)
|
2001-11-16 |
2007-09-25 |
Als Therapy Development Foundation, Inc. |
Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis
|
|
ME00204B
(me)
|
2002-09-06 |
2011-02-10 |
Medarex Llc |
Terapijsko, humano, monoklonsko anti-il-1r1antitijelo
|
|
JP4450644B2
(ja)
|
2003-03-03 |
2010-04-14 |
日本化薬株式会社 |
Amf類を有効成分とする医薬製剤
|
|
US20040224893A1
(en)
|
2003-05-06 |
2004-11-11 |
Li-Hsien Wang |
Methods of using IL-1 antagonists to treat neointimal hyperplasia
|
|
HN2004000285A
(es)
|
2003-08-04 |
2006-04-27 |
Pfizer Prod Inc |
ANTICUERPOS DIRIGIDOS A c-MET
|
|
US7799327B2
(en)
|
2003-12-24 |
2010-09-21 |
Henry John Smith |
Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment
|
|
US7105183B2
(en)
|
2004-02-03 |
2006-09-12 |
The Regents Of The University Of California |
Chlorite in the treatment of neurodegenerative disease
|
|
WO2006001967A2
(en)
|
2004-05-25 |
2006-01-05 |
Sloan-Kettering Institute For Cancer Research |
Migrastatin analogs in the treatment of cancer
|
|
US20050276807A1
(en)
|
2004-06-15 |
2005-12-15 |
Advanced Biotherapy, Inc. |
Treatment of acne
|
|
US7718674B2
(en)
|
2004-09-27 |
2010-05-18 |
Bridge Pharma, Inc. |
Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
|
|
CA2591148A1
(en)
|
2004-12-09 |
2006-06-15 |
Centocor, Inc. |
Anti-integrin immunoconjugates, methods and uses
|
|
CN101253409A
(zh)
|
2005-08-02 |
2008-08-27 |
埃克斯生物科技公司 |
使用IL-1α自身抗体诊断、治疗和预防血管疾病
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US20090215992A1
(en)
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
|
AU2006298767B2
(en)
|
2005-09-28 |
2013-01-10 |
Cytos Biotechnology Ag |
Interleukin-1 conjugates and uses thereof
|
|
BRPI0709977A2
(pt)
|
2006-04-14 |
2011-08-02 |
Novartis Ag |
uso de anticorpos de il-1 para o tratamento de distúrbios oftálmicos
|
|
JP2009537507A
(ja)
|
2006-05-15 |
2009-10-29 |
エクスバイオテク インコーポレーティッド |
アテローム性動脈硬化症に対して保護的な自己抗体を誘導するIL−1α免疫法
|
|
US20110008282A1
(en)
|
2006-05-15 |
2011-01-13 |
Xbiotech, Inc. |
IL-1alpha immunization induces autoantibodies protective against atherosclerosis
|
|
ES2374845T3
(es)
|
2006-05-22 |
2012-02-22 |
Xbiotech, Inc |
Tratamiento de cáncer con anticuerpos anti-il-1.
|
|
CL2007001536A1
(es)
|
2006-05-30 |
2008-01-25 |
Genentech Inc |
Anticuerpos anti-cd22; polinucleotidos que los codifica; vector y celula huesped que los comprende; metodo de fabricacion; metodo de deteccion del anticuerpo en una muestra biologica; inmunoconjugado que comprende al anticuerpo; composicion que lo comprende y su uso para tratar trastornos proliferativos de celulas b.
|
|
WO2008082651A2
(en)
|
2006-12-29 |
2008-07-10 |
Abbott Laboratories |
Dual-specific il-1a/ il-1b antibodies
|
|
EP3632444A3
(en)
|
2008-04-15 |
2020-08-26 |
SARcode Bioscience Inc. |
Topical lfa-1 antagonists for use in localized treatment of immune related disorders
|
|
NZ590033A
(en)
*
|
2008-05-30 |
2011-08-26 |
Xbiotech Inc |
Interleukin-1alpha antibodies and methods of use
|
|
CA2737056C
(en)
|
2008-09-12 |
2018-10-30 |
Xbiotech Inc. |
Targeting pathogenic monocytes
|
|
SG172855A1
(en)
*
|
2009-01-29 |
2011-08-29 |
Abbott Lab |
Il-1 binding proteins
|
|
CN102655880A
(zh)
|
2009-10-15 |
2012-09-05 |
雅培制药有限公司 |
Il-1结合蛋白
|
|
PT2582391T
(pt)
|
2010-06-18 |
2019-01-11 |
Xbiotech Inc |
Tratamento da artrite
|
|
RU2013110030A
(ru)
|
2010-08-23 |
2014-09-27 |
ИксБиотеч, Инк. |
Лечение неопластических заболеваний
|
|
US9724409B2
(en)
|
2011-04-01 |
2017-08-08 |
Xbiotech, Inc. |
Treatment of inflammatory skin disease
|
|
CN103442733A
(zh)
|
2011-04-01 |
2013-12-11 |
埃克斯生物科技公司 |
皮肤病学病状的治疗
|
|
PT2750709T
(pt)
|
2011-09-23 |
2018-11-22 |
Xbiotech Inc |
Tratamento da caquexia
|
|
US20130195877A1
(en)
|
2012-01-31 |
2013-08-01 |
Xbiotech, Inc. |
Treatment of cachexia by targeting interleukin-1 beta
|
|
US9545441B2
(en)
|
2012-09-18 |
2017-01-17 |
Xbiotech, Inc. |
Treatment of diabetes
|
|
EP4628162A3
(en)
|
2012-10-04 |
2025-12-03 |
XBiotech Inc. |
Treating vascular disease and complications thereof
|
|
EP2903643A4
(en)
|
2012-10-04 |
2016-06-15 |
Xbiotech Inc |
TREATMENT OF PSYCHIATRIC DISEASES
|