JP2008534503A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008534503A5 JP2008534503A5 JP2008503069A JP2008503069A JP2008534503A5 JP 2008534503 A5 JP2008534503 A5 JP 2008534503A5 JP 2008503069 A JP2008503069 A JP 2008503069A JP 2008503069 A JP2008503069 A JP 2008503069A JP 2008534503 A5 JP2008534503 A5 JP 2008534503A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- use according
- disorder
- clomiphene
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
- 208000035475 disorder Diseases 0.000 claims 16
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 9
- 201000003585 eunuchism Diseases 0.000 claims 8
- 208000037106 male hypogonadism Diseases 0.000 claims 8
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 230000037182 bone density Effects 0.000 claims 2
- 229960003608 clomifene Drugs 0.000 claims 2
- 208000000509 infertility Diseases 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 231100000535 infertility Toxicity 0.000 claims 2
- 208000006132 lipodystrophy Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000036765 blood level Effects 0.000 claims 1
- 230000036314 physical performance Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000035936 sexual power Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66429005P | 2005-03-22 | 2005-03-22 | |
| US60/664,290 | 2005-03-22 | ||
| PCT/US2006/010022 WO2006102232A2 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246454A Division JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534503A JP2008534503A (ja) | 2008-08-28 |
| JP2008534503A5 true JP2008534503A5 (enExample) | 2009-03-12 |
| JP5785680B2 JP5785680B2 (ja) | 2015-09-30 |
Family
ID=37024477
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503069A Expired - Fee Related JP5785680B2 (ja) | 2005-03-22 | 2006-03-17 | トランス−クロミフェン用の投与レジメン |
| JP2014246454A Expired - Fee Related JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
| JP2017221743A Pending JP2018024712A (ja) | 2005-03-22 | 2017-11-17 | トランス−クロミフェン用の投与レジメン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246454A Expired - Fee Related JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
| JP2017221743A Pending JP2018024712A (ja) | 2005-03-22 | 2017-11-17 | トランス−クロミフェン用の投与レジメン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8247456B2 (enExample) |
| EP (2) | EP1865938A4 (enExample) |
| JP (3) | JP5785680B2 (enExample) |
| KR (1) | KR20070114187A (enExample) |
| CN (1) | CN101163467B (enExample) |
| AU (1) | AU2006227243B2 (enExample) |
| BR (1) | BRPI0609389A2 (enExample) |
| CA (2) | CA3071412A1 (enExample) |
| MX (1) | MX2007010659A (enExample) |
| NZ (1) | NZ560551A (enExample) |
| PL (1) | PL383444A1 (enExample) |
| RU (1) | RU2413508C2 (enExample) |
| WO (1) | WO2006102232A2 (enExample) |
| ZA (1) | ZA200707774B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
| US7759360B2 (en) | 2001-07-09 | 2010-07-20 | Repros Therapeutics Inc. | Methods and materials for the treatment of testosterone deficiency in men |
| RU2413508C2 (ru) | 2005-03-22 | 2011-03-10 | Репрос Терапьютикс Инк. | Режимы дозирования транс-кломифена |
| MY148330A (en) | 2006-10-31 | 2013-03-29 | Basf Se | Regulation of a process for producing water-absorbing polymer particles in a heated gas phase |
| CA2806526C (en) | 2007-10-16 | 2014-12-30 | Repros Therapeutics Inc. | Trans-clomiphen for type 2 diabetes |
| TW201500041A (zh) * | 2008-11-07 | 2015-01-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| UA113291C2 (xx) * | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| CA2881604C (en) * | 2011-08-09 | 2021-09-14 | Kenneth W. Adams | Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males |
| US9161940B2 (en) * | 2012-02-14 | 2015-10-20 | Repros Therapeutics Inc. | Selective estrogen receptor modulators with short half-lives and uses thereof |
| JP2015508825A (ja) * | 2012-02-29 | 2015-03-23 | レプロス セラピューティクス インコーポレイティド | アンドロゲン欠乏症を治療するための併用療法 |
| JP6341910B2 (ja) | 2012-05-31 | 2018-06-13 | レプロス セラピューティクス インコーポレイティド | 抗プロゲスチンの経膣送達用製剤およびその送達方法 |
| AU2013338311A1 (en) * | 2012-11-02 | 2015-05-14 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
| ES2688821T3 (es) | 2012-11-02 | 2018-11-07 | Repros Therapeutics Inc. | Métodos y composiciones para tratar afecciones dependientes de la progesterona |
| JP6417409B2 (ja) * | 2013-06-05 | 2018-11-07 | レプロス セラピューティクス インコーポレイティド | 骨塩密度を増加させる薬剤としてのトランス−クロミフェン及びその類似体 |
| KR20180112048A (ko) * | 2016-02-25 | 2018-10-11 | 아스펜 파크 파마슈티컬스 인코포레이티드 | 클로미펜 이성질체들의 경구 제형 및 이차 생식선 기능저하증 치료를 위하여 이들을 사용하는 방법 |
| US10364212B2 (en) | 2016-04-22 | 2019-07-30 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061733A (en) * | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| DE3660489D1 (en) | 1985-06-08 | 1988-09-15 | Asta Pharma Ag | Derivatives of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl) ethane |
| US4820736A (en) * | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| GB8926171D0 (en) * | 1989-11-20 | 1990-01-10 | Applied Research Systems | Treatment of infertility |
| JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| JPH10501814A (ja) | 1994-06-17 | 1998-02-17 | ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ | 生物的作用物質用のイン・シツゲル形成デリバリービヒクルおよびその使用方法 |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| CA2228610C (en) | 1995-08-17 | 2008-06-03 | Heidi Rolfes | Controlled release products |
| US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| IL120262A (en) * | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
| DE69730982T2 (de) | 1996-10-28 | 2005-09-01 | General Mills, Inc., Minneapolis | Einbettung und einkapselung von teilchen zur kontrollierten abgabe |
| EP0973818B1 (en) * | 1997-04-03 | 2004-10-13 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same |
| US6653297B1 (en) * | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| RU2200732C2 (ru) * | 1997-08-12 | 2003-03-20 | Глэксо Вэллкам Инк. | Производные трифенилэтилена, способы лечения и профилактики остеопороза, рака груди и сердечно-сосудистого заболевания |
| US6342250B1 (en) * | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
| US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| EP1100330A4 (en) | 1998-07-30 | 2004-04-14 | Stoller Ets | TREATMENT OF PLANTS WITH SALICYLIC ACID AND ORGANIC AMINES |
| EP1102753B1 (en) * | 1998-08-07 | 2007-02-28 | Novartis Vaccines and Diagnostics, Inc. | Pyrazoles as estrogen receptor modulators |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| HK1048269B (zh) * | 1999-06-11 | 2006-01-13 | 沃特森药物公司 | 非口服雄激素类固醇用於制备改善性激素结合球蛋白水平升高的药物 |
| AU6132700A (en) * | 1999-09-30 | 2001-04-05 | Chienna B.V. | Polymers loaded with bioactive agents |
| US6258802B1 (en) * | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
| US20020004065A1 (en) * | 2000-01-20 | 2002-01-10 | David Kanios | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| US7067557B2 (en) | 2000-05-26 | 2006-06-27 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| AU2001261684B2 (en) | 2000-05-26 | 2006-01-12 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| ATE278421T1 (de) * | 2000-08-11 | 2004-10-15 | Wyeth Corp | Verfahren zur behandlung eines östrogenrezeptor positives karzinoms |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US6743448B2 (en) * | 2000-12-11 | 2004-06-01 | Abraham H. Kryger | Topical testosterone formulations and associated methods |
| WO2003005459A1 (en) * | 2001-07-04 | 2003-01-16 | Nichia Corporation | Nitride semiconductor device |
| US7173064B2 (en) * | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
| US7759360B2 (en) * | 2001-07-09 | 2010-07-20 | Repros Therapeutics Inc. | Methods and materials for the treatment of testosterone deficiency in men |
| US6645974B2 (en) * | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
| WO2003026568A2 (en) * | 2001-09-21 | 2003-04-03 | Merck & Co., Inc. | Androstanes as androgen receptor modulators |
| US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US7105679B2 (en) * | 2001-12-19 | 2006-09-12 | Kanojia Ramesh M | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| JP4312522B2 (ja) | 2003-06-30 | 2009-08-12 | 株式会社リコー | 現像剤補給方法、現像剤補給装置、及び、画像形成装置 |
| US20080242726A1 (en) * | 2004-07-14 | 2008-10-02 | Podolski Joseph S | Trans-Clomiphene for the Treatment of Benign Prostate Hypertrophy, Porstate Cancer, Hypogonadism Elevated Triglycerides and High Cholesterol |
| BRPI0606528A8 (pt) * | 2005-02-04 | 2018-03-13 | Repros Therapeutics Inc | composição para uso no fabrico de medicamentos de tratamento da infertilidade masculina e uso da mesma |
| JP2008537538A (ja) * | 2005-02-11 | 2008-09-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆ拮抗剤及び降圧剤の治療的組み合わせ |
| RU2413508C2 (ru) | 2005-03-22 | 2011-03-10 | Репрос Терапьютикс Инк. | Режимы дозирования транс-кломифена |
| JP2009503096A (ja) | 2005-08-05 | 2009-01-29 | リプロス セラピューティクス インコーポレイテッド | クロミフェンを用いる女性不妊症を処置するための方法および組成物 |
| EP1829534A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
| CA2806526C (en) | 2007-10-16 | 2014-12-30 | Repros Therapeutics Inc. | Trans-clomiphen for type 2 diabetes |
-
2006
- 2006-03-17 RU RU2007138867/15A patent/RU2413508C2/ru active
- 2006-03-17 EP EP06738985A patent/EP1865938A4/en not_active Ceased
- 2006-03-17 WO PCT/US2006/010022 patent/WO2006102232A2/en not_active Ceased
- 2006-03-17 PL PL383444A patent/PL383444A1/pl unknown
- 2006-03-17 US US11/815,542 patent/US8247456B2/en not_active Expired - Fee Related
- 2006-03-17 NZ NZ560551A patent/NZ560551A/en not_active IP Right Cessation
- 2006-03-17 CN CN2006800089841A patent/CN101163467B/zh not_active Expired - Fee Related
- 2006-03-17 CA CA3071412A patent/CA3071412A1/en not_active Abandoned
- 2006-03-17 BR BRPI0609389-2A patent/BRPI0609389A2/pt active Search and Examination
- 2006-03-17 AU AU2006227243A patent/AU2006227243B2/en not_active Ceased
- 2006-03-17 JP JP2008503069A patent/JP5785680B2/ja not_active Expired - Fee Related
- 2006-03-17 EP EP11153365A patent/EP2392322A3/en not_active Withdrawn
- 2006-03-17 KR KR1020077021707A patent/KR20070114187A/ko not_active Ceased
- 2006-03-17 MX MX2007010659A patent/MX2007010659A/es active IP Right Grant
- 2006-03-17 CA CA002597700A patent/CA2597700A1/en not_active Abandoned
-
2007
- 2007-09-11 ZA ZA200707774A patent/ZA200707774B/xx unknown
-
2012
- 2012-08-20 US US13/590,045 patent/US8519004B2/en not_active Expired - Fee Related
-
2014
- 2014-12-05 JP JP2014246454A patent/JP6270281B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-17 JP JP2017221743A patent/JP2018024712A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008534503A5 (enExample) | ||
| NZ606825A (en) | Methods and compositions for treating complement-associated disorders | |
| EA201590166A1 (ru) | Комбинированная терапия для лечения рассеянного склероза | |
| NZ604029A (en) | Methods of treating bladder cancer | |
| SG169233A1 (en) | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation | |
| NZ611628A (en) | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients | |
| MY161593A (en) | Oral formulations of cytidine analogs and methods of use thereof | |
| ZA200802811B (en) | Therapy for the treatment of disease | |
| MX344476B (es) | Metodos de tratar trastornos pulmonares con formulaciones de amikacina liposomal. | |
| MX2010002392A (es) | Composiciones de brimonidina mejoradas para tratar eritema. | |
| EA201270221A1 (ru) | Лечение болезни крона с применением лаквинимода | |
| TW200806318A (en) | Uses of anti-insulin-like growth factor I receptor antibodies | |
| JP2010505850A5 (enExample) | ||
| EA201492010A1 (ru) | Применение высокой дозы лахинимода для лечения рассеянного склероза | |
| NZ587202A (en) | Methods for measuring a patient response upon administration of a drug and compositions thereof | |
| NZ595376A (en) | Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration | |
| RU2014150942A (ru) | Лечение побочных эффектов в виде моторных и двигательных расстройств, связанных с лечением болезни паркинсона | |
| RU2012124268A (ru) | Бензимидазольные соединения и их применения | |
| NZ591525A (en) | Methods of treatment of complicated skin and skin structure infections using single doses of oritavancin | |
| MX2011011459A (es) | Formulacion de clavulanato para neuroproteccion y tratamiento de trastornos neurodegenerativos. | |
| MX350195B (es) | Analogos de cistamina para el tratamiento de la enfermedad de parkinson. | |
| RU2007138867A (ru) | Режимы дозирования транс-кломифена | |
| JP2011500589A5 (enExample) | ||
| MX2013003523A (es) | Composicion farmaceutica de dosis baja. | |
| JP2016505050A5 (enExample) |