JP2008534503A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008534503A5 JP2008534503A5 JP2008503069A JP2008503069A JP2008534503A5 JP 2008534503 A5 JP2008534503 A5 JP 2008534503A5 JP 2008503069 A JP2008503069 A JP 2008503069A JP 2008503069 A JP2008503069 A JP 2008503069A JP 2008534503 A5 JP2008534503 A5 JP 2008534503A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- use according
- disorder
- clomiphene
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
- 208000035475 disorder Diseases 0.000 claims 16
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 9
- 201000003585 eunuchism Diseases 0.000 claims 8
- 208000037106 male hypogonadism Diseases 0.000 claims 8
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 230000037182 bone density Effects 0.000 claims 2
- 229960003608 clomifene Drugs 0.000 claims 2
- 208000000509 infertility Diseases 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 231100000535 infertility Toxicity 0.000 claims 2
- 208000006132 lipodystrophy Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000036765 blood level Effects 0.000 claims 1
- 230000036314 physical performance Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000035936 sexual power Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66429005P | 2005-03-22 | 2005-03-22 | |
| US60/664,290 | 2005-03-22 | ||
| PCT/US2006/010022 WO2006102232A2 (en) | 2005-03-22 | 2006-03-17 | Dosing regimes for trans-clomiphene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246454A Division JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008534503A JP2008534503A (ja) | 2008-08-28 |
| JP2008534503A5 true JP2008534503A5 (enExample) | 2009-03-12 |
| JP5785680B2 JP5785680B2 (ja) | 2015-09-30 |
Family
ID=37024477
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503069A Expired - Fee Related JP5785680B2 (ja) | 2005-03-22 | 2006-03-17 | トランス−クロミフェン用の投与レジメン |
| JP2014246454A Expired - Fee Related JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
| JP2017221743A Pending JP2018024712A (ja) | 2005-03-22 | 2017-11-17 | トランス−クロミフェン用の投与レジメン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246454A Expired - Fee Related JP6270281B2 (ja) | 2005-03-22 | 2014-12-05 | トランス−クロミフェン用の投与レジメン |
| JP2017221743A Pending JP2018024712A (ja) | 2005-03-22 | 2017-11-17 | トランス−クロミフェン用の投与レジメン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8247456B2 (enExample) |
| EP (2) | EP1865938A4 (enExample) |
| JP (3) | JP5785680B2 (enExample) |
| KR (1) | KR20070114187A (enExample) |
| CN (1) | CN101163467B (enExample) |
| AU (1) | AU2006227243B2 (enExample) |
| BR (1) | BRPI0609389A2 (enExample) |
| CA (2) | CA2597700A1 (enExample) |
| MX (1) | MX2007010659A (enExample) |
| NZ (1) | NZ560551A (enExample) |
| PL (1) | PL383444A1 (enExample) |
| RU (1) | RU2413508C2 (enExample) |
| WO (1) | WO2006102232A2 (enExample) |
| ZA (1) | ZA200707774B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1289075C (zh) | 2001-07-09 | 2006-12-13 | 佐纳根有限公司 | 富含反式克罗米酚的克罗米酚组合物的用途 |
| US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
| NZ560551A (en) | 2005-03-22 | 2010-02-26 | Repros Therapeutics Inc | Dosing regimes for trans-clomiphene |
| BRPI0717756B1 (pt) | 2006-10-31 | 2018-01-30 | Basf Se | Processo para a produção de partículas poliméricas absorventes de água |
| MX2010004195A (es) * | 2007-10-16 | 2010-06-02 | Repros Therapeutics Inc | Trans-clomifeno para el sindrome metabolico. |
| TWI458478B (zh) * | 2008-11-07 | 2014-11-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| UA113291C2 (xx) * | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| WO2013020215A1 (en) * | 2011-08-09 | 2013-02-14 | Adams Kenneth W | Use of aromatase inhibitor or estrogen blocker for increasing spermatogenesis or testosterone levels in males |
| AU2013221478B2 (en) * | 2012-02-14 | 2017-06-01 | Repros Therapeutics Inc. | Selective estrogen receptor modulators with short half-lives and uses thereof |
| MX2014009322A (es) * | 2012-02-29 | 2014-11-10 | Repros Therapeutics Inc | Terapia de combinacion para el tratamiento de la deficiencia androgenica. |
| CA2872644A1 (en) | 2012-05-31 | 2013-12-05 | Allergan Pharmaceuticals International Limited | Formulations and methods for vaginal delivery of antiprogestins |
| CN104994877A (zh) * | 2012-11-02 | 2015-10-21 | 利普生物药剂公司 | 用于癌症治疗的反式-克罗米芬 |
| US9545411B2 (en) | 2012-11-02 | 2017-01-17 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| HK1223318A1 (zh) * | 2013-06-05 | 2017-07-28 | Repros Therapeutics Inc. | 作爲提高骨矿物质密度的药剂的反式克罗米芬和它的类似物 |
| JP2019506425A (ja) * | 2016-02-25 | 2019-03-07 | アスペン パーク ファーマシューティカルズ，インコーポレイティド | クロミフェン異性体の経口剤形および続発性性腺機能低下症を治療するために経口剤形を使用する方法 |
| CN108463453A (zh) | 2016-04-22 | 2018-08-28 | 意大利合成制造有限公司 | 用于制备具有针状晶体习性的柠檬酸恩氯米芬的方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061733A (en) * | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| EP0206021B1 (de) | 1985-06-08 | 1988-08-10 | ASTA Pharma AG | Neue Derivate des 1,1,2,2-Tetramethyl-1,2-bis-(2-fluor-4-hydroxyphenyl)-ethans |
| US4820736A (en) * | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| GB8926171D0 (en) * | 1989-11-20 | 1990-01-10 | Applied Research Systems | Treatment of infertility |
| JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| WO1995035093A1 (en) | 1994-06-17 | 1995-12-28 | University Of Nebraska Board Of Regents | In situ gel-forming delivery vehicle for bio-affecting substances, and method of use |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| CA2228610C (en) | 1995-08-17 | 2008-06-03 | Heidi Rolfes | Controlled release products |
| US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| IL120262A (en) * | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
| ATE277739T1 (de) * | 1996-10-28 | 2004-10-15 | Gen Mills Inc | Einbettung und einkapselung von teilchen zur kontrollierten abgabe |
| JP4496316B2 (ja) * | 1997-04-03 | 2010-07-07 | エーザイ インコーポレイテッド | 生分解性テレフタレートポリエステル−ポリホスフェートポリマー、組成物、物品、並びにその製造及び使用方法 |
| US6653297B1 (en) * | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| RU2200732C2 (ru) * | 1997-08-12 | 2003-03-20 | Глэксо Вэллкам Инк. | Производные трифенилэтилена, способы лечения и профилактики остеопороза, рака груди и сердечно-сосудистого заболевания |
| US6342250B1 (en) * | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
| US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| NZ510201A (en) | 1998-07-30 | 2002-10-25 | Stoller Ets | Treatment of plants with salicylic acid and organic amines |
| DE69935335T2 (de) * | 1998-08-07 | 2007-11-22 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Pyrazole als modulatoren des östrogenrezeptors |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| JP5184727B2 (ja) * | 1999-06-11 | 2013-04-17 | ワトソン ファーマシューティカルズ， インコーポレイテッド | 女性への非経口アンドロゲンステロイドの投与 |
| CA2321321A1 (en) * | 1999-09-30 | 2001-03-30 | Isotis B.V. | Polymers loaded with bioactive agents |
| US6258802B1 (en) * | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
| US20020004065A1 (en) * | 2000-01-20 | 2002-01-10 | David Kanios | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| WO2001091744A1 (en) * | 2000-05-26 | 2001-12-06 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| US7067557B2 (en) * | 2000-05-26 | 2006-06-27 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
| ATE278421T1 (de) * | 2000-08-11 | 2004-10-15 | Wyeth Corp | Verfahren zur behandlung eines östrogenrezeptor positives karzinoms |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US6743448B2 (en) * | 2000-12-11 | 2004-06-01 | Abraham H. Kryger | Topical testosterone formulations and associated methods |
| US6872986B2 (en) * | 2001-07-04 | 2005-03-29 | Nichia Corporation | Nitride semiconductor device |
| US7173064B2 (en) * | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
| CN1289075C (zh) * | 2001-07-09 | 2006-12-13 | 佐纳根有限公司 | 富含反式克罗米酚的克罗米酚组合物的用途 |
| US6645974B2 (en) * | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
| EP1429779A2 (en) * | 2001-09-21 | 2004-06-23 | Merck & Co., Inc. | Androstanes as androgen receptor modulators |
| US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US7105679B2 (en) * | 2001-12-19 | 2006-09-12 | Kanojia Ramesh M | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| JP4312522B2 (ja) | 2003-06-30 | 2009-08-12 | 株式会社リコー | 現像剤補給方法、現像剤補給装置、及び、画像形成装置 |
| EP1776098A1 (en) | 2004-07-14 | 2007-04-25 | Repros Therapeutics Inc. | Trans-clomiphene for the treatment of benign prostate hypertrophy, prostate cancer, hypogonadism, elevated triglycerides and high cholesterol |
| WO2006084153A2 (en) * | 2005-02-04 | 2006-08-10 | Repros Therapeutics Inc. | Methods and materials with trans-clomiphene for the treatment of male infertility |
| EP1853298A2 (en) * | 2005-02-11 | 2007-11-14 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
| NZ560551A (en) | 2005-03-22 | 2010-02-26 | Repros Therapeutics Inc | Dosing regimes for trans-clomiphene |
| US20080306035A1 (en) | 2005-08-05 | 2008-12-11 | Repros Therapeutics Inc. | Methods and Compositions for Treating Female Infertility Using Clomiphene |
| EP1829534A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
| MX2010004195A (es) | 2007-10-16 | 2010-06-02 | Repros Therapeutics Inc | Trans-clomifeno para el sindrome metabolico. |
-
2006
- 2006-03-17 NZ NZ560551A patent/NZ560551A/en not_active IP Right Cessation
- 2006-03-17 JP JP2008503069A patent/JP5785680B2/ja not_active Expired - Fee Related
- 2006-03-17 MX MX2007010659A patent/MX2007010659A/es active IP Right Grant
- 2006-03-17 BR BRPI0609389-2A patent/BRPI0609389A2/pt active Search and Examination
- 2006-03-17 RU RU2007138867/15A patent/RU2413508C2/ru active
- 2006-03-17 WO PCT/US2006/010022 patent/WO2006102232A2/en not_active Ceased
- 2006-03-17 AU AU2006227243A patent/AU2006227243B2/en not_active Ceased
- 2006-03-17 EP EP06738985A patent/EP1865938A4/en not_active Ceased
- 2006-03-17 CA CA002597700A patent/CA2597700A1/en not_active Abandoned
- 2006-03-17 EP EP11153365A patent/EP2392322A3/en not_active Withdrawn
- 2006-03-17 CN CN2006800089841A patent/CN101163467B/zh not_active Expired - Fee Related
- 2006-03-17 KR KR1020077021707A patent/KR20070114187A/ko not_active Ceased
- 2006-03-17 US US11/815,542 patent/US8247456B2/en not_active Expired - Fee Related
- 2006-03-17 CA CA3071412A patent/CA3071412A1/en not_active Abandoned
- 2006-03-17 PL PL383444A patent/PL383444A1/pl unknown
-
2007
- 2007-09-11 ZA ZA200707774A patent/ZA200707774B/xx unknown
-
2012
- 2012-08-20 US US13/590,045 patent/US8519004B2/en not_active Expired - Fee Related
-
2014
- 2014-12-05 JP JP2014246454A patent/JP6270281B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-17 JP JP2017221743A patent/JP2018024712A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ606825A (en) | Methods and compositions for treating complement-associated disorders | |
| EA201590166A1 (ru) | Комбинированная терапия для лечения рассеянного склероза | |
| NZ604029A (en) | Methods of treating bladder cancer | |
| IL189546A0 (en) | Therapy for the treatment of disease | |
| SG169233A1 (en) | Pharmaceutical compositions comprising apomorphine for pulmonary inhalation | |
| NZ611628A (en) | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients | |
| MY161593A (en) | Oral formulations of cytidine analogs and methods of use thereof | |
| MX344476B (es) | Metodos de tratar trastornos pulmonares con formulaciones de amikacina liposomal. | |
| MX2010002392A (es) | Composiciones de brimonidina mejoradas para tratar eritema. | |
| EA201270221A1 (ru) | Лечение болезни крона с применением лаквинимода | |
| TW200501983A (en) | Uses of anti-insulin-like growth factor I receptor antibodies | |
| NZ585856A (en) | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease | |
| JP2010505850A5 (enExample) | ||
| EA201492010A1 (ru) | Применение высокой дозы лахинимода для лечения рассеянного склероза | |
| NZ595376A (en) | Dental anesthetic comprising tetracaine and a vasoconstrictor for intranasal administration | |
| NZ587202A (en) | Methods for measuring a patient response upon administration of a drug and compositions thereof | |
| RU2012124268A (ru) | Бензимидазольные соединения и их применения | |
| RU2014150942A (ru) | Лечение побочных эффектов в виде моторных и двигательных расстройств, связанных с лечением болезни паркинсона | |
| NZ591525A (en) | Methods of treatment of complicated skin and skin structure infections using single doses of oritavancin | |
| RU2014113334A (ru) | Применение ингибитора ароматазы для лечения гипогонадизма и родственных заболеваний | |
| MX350195B (es) | Analogos de cistamina para el tratamiento de la enfermedad de parkinson. | |
| RU2007138867A (ru) | Режимы дозирования транс-кломифена | |
| WO2012042197A3 (en) | Low dose pharmaceutical composition comprising zanamivir | |
| JP2011500589A5 (enExample) | ||
| JP2016505050A5 (enExample) |