JP2014526246A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014526246A5 JP2014526246A5 JP2014529633A JP2014529633A JP2014526246A5 JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5 JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5
- Authority
- JP
- Japan
- Prior art keywords
- filter
- sample
- virus
- population
- parvovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 24
- 238000001914 filtration Methods 0.000 claims 5
- 241000125945 Protoparvovirus Species 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 239000004627 regenerated cellulose Substances 0.000 claims 4
- 241000701447 unidentified baculovirus Species 0.000 claims 4
- 210000002845 virion Anatomy 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 claims 3
- 238000011210 chromatographic step Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- -1 polytetrafluoroethylene Polymers 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 239000000020 Nitrocellulose Substances 0.000 claims 1
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920001220 nitrocellulos Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 238000011045 prefiltration Methods 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532176P | 2011-09-08 | 2011-09-08 | |
| US61/532,176 | 2011-09-08 | ||
| EP11180594 | 2011-09-08 | ||
| EP11180594.1 | 2011-09-08 | ||
| PCT/NL2012/050619 WO2013036118A1 (en) | 2011-09-08 | 2012-09-07 | Removal of contaminating viruses from aav preparations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Division JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526246A JP2014526246A (ja) | 2014-10-06 |
| JP2014526246A5 true JP2014526246A5 (enExample) | 2015-10-01 |
| JP6198278B2 JP6198278B2 (ja) | 2017-09-20 |
Family
ID=47832422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529633A Expired - Fee Related JP6198278B2 (ja) | 2011-09-08 | 2012-09-07 | Ａａｖ調製物からの混入ウイルスの除去 |
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9840694B2 (enExample) |
| EP (3) | EP2744895B1 (enExample) |
| JP (2) | JP6198278B2 (enExample) |
| KR (1) | KR101961347B1 (enExample) |
| CN (2) | CN107502597A (enExample) |
| AU (1) | AU2012304993B2 (enExample) |
| BR (1) | BR112014005255A2 (enExample) |
| CA (1) | CA2847604A1 (enExample) |
| DK (1) | DK2744895T3 (enExample) |
| EA (1) | EA027511B1 (enExample) |
| ES (1) | ES2558168T3 (enExample) |
| HU (1) | HUE026579T2 (enExample) |
| IL (1) | IL231398A (enExample) |
| MX (1) | MX349601B (enExample) |
| PL (1) | PL2744895T3 (enExample) |
| PT (1) | PT2744895E (enExample) |
| SI (1) | SI2744895T1 (enExample) |
| WO (1) | WO2013036118A1 (enExample) |
| ZA (1) | ZA201401714B (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6198278B2 (ja) | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
| CN105745326A (zh) | 2013-10-24 | 2016-07-06 | 优尼科Ip有限公司 | 用于基因治疗神经疾病的aav-5假型载体 |
| US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| SG10202007103TA (en) | 2014-11-05 | 2020-09-29 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| CN112375760A (zh) | 2014-11-14 | 2021-02-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| KR20230169197A (ko) | 2014-11-14 | 2023-12-15 | 보이저 테라퓨틱스, 인크. | 근위축성 측삭 경화증(als)을 치료하는 조성물 및 방법 |
| EP3591070B1 (en) * | 2014-11-28 | 2022-12-21 | uniQure IP B.V. | Dna impurities in a composition comprising a parvoviral virion |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| HUE043842T2 (hu) | 2014-12-24 | 2019-09-30 | Uniqure Ip Bv | RNAi-indukált huntingtin gén szuppresszió |
| EP3054007A1 (en) * | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| IL297576B2 (en) | 2016-05-18 | 2024-02-01 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| CN117904112A (zh) | 2016-05-18 | 2024-04-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| EP3506817A4 (en) | 2016-08-30 | 2020-07-22 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| CN119491003A (zh) | 2017-05-05 | 2025-02-21 | 沃雅戈治疗公司 | 治疗亨廷顿病的组合物和方法 |
| CA3061652A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CA3070087A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | Trajectory array guide system |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| AU2018352236B2 (en) | 2017-10-16 | 2025-04-10 | The Curators Of The University Of Missouri | Treatment of amyotrophic lateral sclerosis (ALS) |
| IL275838B2 (en) | 2018-01-17 | 2024-11-01 | Meiragtx Uk Ii Ltd | A modified raav capsid protein for gene therapy |
| CN112424359A (zh) | 2018-05-15 | 2021-02-26 | 沃雅戈治疗公司 | 用于治疗帕金森氏病的组合物和方法 |
| WO2020053258A1 (en) | 2018-09-12 | 2020-03-19 | Uniqure Ip B.V. | Rnai induced c9orf72 suppression for the treatment of als/ftd |
| SG11202103151RA (en) | 2018-09-28 | 2021-04-29 | Voyager Therapeutics Inc | Frataxin expression constructs having engineered promoters and methods of use thereof |
| CN112912518A (zh) * | 2018-10-15 | 2021-06-04 | 再生生物股份有限公司 | 用于测量复制缺陷型病毒载体和病毒的感染性的方法 |
| CA3119721A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | A companion diagnostic to monitor the effects of gene therapy |
| WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| AU2019382824A1 (en) | 2018-11-19 | 2021-06-03 | Uniqure Ip B.V. | Method and means to deliver miRNA to target cells |
| US20200199625A1 (en) | 2018-11-19 | 2020-06-25 | Uniqure Ip B.V. | RNAi induced reduction of ataxin-3 for the treatment of Spinocerebellar ataxia type 3 |
| WO2020150556A1 (en) * | 2019-01-18 | 2020-07-23 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| EP3924364A1 (en) | 2019-02-15 | 2021-12-22 | Sangamo Therapeutics, Inc. | Compositions and methods for producing recombinant aav |
| WO2020219897A1 (en) * | 2019-04-24 | 2020-10-29 | Biogen Ma Inc. | Methods for production of recombinant adeno-associated viruses |
| JP7681277B2 (ja) | 2019-07-15 | 2025-05-22 | メイラグティーエックス ユーケー アイアイ リミティド | 関節炎疾患の治療のための修飾ａａｖキャプシドタンパク質 |
| EP4031148A1 (en) | 2019-09-16 | 2022-07-27 | uniQure IP B.V. | Targeting misspliced transcripts in genetic disorders |
| US20230020565A1 (en) | 2019-12-04 | 2023-01-19 | Sangamo Therapeutics, Inc. | Novel compositions and methods for producing recombinant aav |
| CN114829371A (zh) * | 2019-12-12 | 2022-07-29 | Emd密理博公司 | 使用透析过滤缓冲液强化的病毒过滤 |
| EP4097239A2 (en) * | 2020-01-29 | 2022-12-07 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| EP4112735A4 (en) * | 2020-02-28 | 2023-09-06 | Asahi Kasei Medical Co., Ltd. | Method for evaluating viral clearance performance |
| EP4133074A1 (en) | 2020-04-07 | 2023-02-15 | uniQure IP B.V. | Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof |
| CN115427561B (zh) | 2021-03-09 | 2024-06-04 | 辉大(上海)生物科技有限公司 | 工程化CRISPR/Cas13系统及其用途 |
| US20240157306A1 (en) * | 2021-03-30 | 2024-05-16 | 3M Innovative Properties Company | Hollow-fiber membrane and method making thereof |
| CN117120152A (zh) * | 2021-03-30 | 2023-11-24 | 3M创新有限公司 | 包含聚砜和聚噁唑啉的中空纤维膜及其制造方法 |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| CA3219847A1 (en) | 2021-06-02 | 2022-12-08 | Sander Jan Hendrik Van Deventer | Adeno-associated virus vectors modified to bind high-density lipoprotein |
| US20250382611A1 (en) | 2021-06-21 | 2025-12-18 | Uniqure Biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| EP4359010A1 (en) | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Improved lysis procedures |
| WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| WO2023198663A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of snca |
| CN119032174A (zh) | 2022-04-12 | 2024-11-26 | 优尼科生物制药有限公司 | ApoE的核酸调节 |
| EP4508215A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Novel systems for nucleic acid regulation |
| EP4508214A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of c9orf72 |
| US20240209324A1 (en) * | 2022-12-22 | 2024-06-27 | Cytiva Us Llc | Virus separation |
| AU2024256392A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| AU2024258047A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs |
| AU2024313758A1 (en) | 2023-06-23 | 2026-01-08 | Uniqure Biopharma B.V. | Novel fragile x constructs |
| WO2025051805A1 (en) | 2023-09-04 | 2025-03-13 | Uniqure Biopharma B.V. | Novel neurotropic recombinant adeno-associated virus particles |
| WO2025078602A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Nucleic acid regulation of msh3 in repeat expansion disorders |
| WO2025078606A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Further novel systems for nucleic acid regulation |
| WO2025078598A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Novel nucleic acid regulation of huntingtin gene |
| WO2025114524A1 (en) | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
| WO2025219443A1 (en) | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US6066324A (en) | 1994-10-07 | 2000-05-23 | Loyola University Of Chicago | Carboxyl terminal of papilloma virus L1 region is not required for formation of virus-like particles |
| DE19709186C2 (de) | 1997-03-06 | 1999-10-14 | Medigene Ag | Filtrationsverfahren zur Trennung von Viren |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| EP1135468B1 (en) | 1998-11-10 | 2010-01-06 | University Of North Carolina At Chapel Hill | Virus vectors and methods of making and administering the same |
| US6593123B1 (en) * | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| WO2003074714A1 (en) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
| US20050009168A1 (en) * | 2003-05-12 | 2005-01-13 | Robbins Joan Marie | Methods and apparatus for Adeno associated virus purification |
| CA2655957C (en) * | 2006-06-21 | 2016-05-03 | Amsterdam Molecular Therapeutics (Amt) B.V. | Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav in insect cells |
| US20080299545A1 (en) * | 2007-03-06 | 2008-12-04 | Shuyuan Zhang | Chromatographic methods for assessing adenovirus purity |
| US20100323429A1 (en) * | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| ES2693194T3 (es) * | 2009-06-16 | 2018-12-10 | Genzyme Corporation | Métodos mejorados para la purificación de vectores de AAV recombinantes |
| JP2013517798A (ja) * | 2010-01-28 | 2013-05-20 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター |
| JP6198278B2 (ja) * | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
-
2012
- 2012-09-07 JP JP2014529633A patent/JP6198278B2/ja not_active Expired - Fee Related
- 2012-09-07 PL PL12758663T patent/PL2744895T3/pl unknown
- 2012-09-07 CA CA2847604A patent/CA2847604A1/en not_active Abandoned
- 2012-09-07 EP EP12758663.4A patent/EP2744895B1/en active Active
- 2012-09-07 KR KR1020147009146A patent/KR101961347B1/ko not_active Expired - Fee Related
- 2012-09-07 BR BR112014005255A patent/BR112014005255A2/pt active Search and Examination
- 2012-09-07 ES ES12758663.4T patent/ES2558168T3/es active Active
- 2012-09-07 AU AU2012304993A patent/AU2012304993B2/en not_active Ceased
- 2012-09-07 CN CN201710697343.1A patent/CN107502597A/zh active Pending
- 2012-09-07 SI SI201230372T patent/SI2744895T1/sl unknown
- 2012-09-07 CN CN201280049899.5A patent/CN103857790B/zh not_active Expired - Fee Related
- 2012-09-07 WO PCT/NL2012/050619 patent/WO2013036118A1/en not_active Ceased
- 2012-09-07 US US14/343,884 patent/US9840694B2/en not_active Expired - Fee Related
- 2012-09-07 EP EP18191023.3A patent/EP3425044A1/en not_active Withdrawn
- 2012-09-07 PT PT127586634T patent/PT2744895E/pt unknown
- 2012-09-07 HU HUE12758663A patent/HUE026579T2/en unknown
- 2012-09-07 EP EP15186937.7A patent/EP2990477B8/en not_active Revoked
- 2012-09-07 DK DK12758663.4T patent/DK2744895T3/en active
- 2012-09-07 MX MX2014002733A patent/MX349601B/es active IP Right Grant
- 2012-09-07 EA EA201490583A patent/EA027511B1/ru not_active IP Right Cessation
-
2014
- 2014-03-06 IL IL231398A patent/IL231398A/en active IP Right Grant
- 2014-03-07 ZA ZA2014/01714A patent/ZA201401714B/en unknown
-
2017
- 2017-06-27 JP JP2017125458A patent/JP6624690B2/ja not_active Expired - Fee Related
- 2017-12-08 US US15/836,220 patent/US10253301B2/en not_active Expired - Fee Related
-
2019
- 2019-03-20 US US16/359,593 patent/US20190218523A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014526246A5 (enExample) | ||
| WO2012025943A4 (en) | Method for purifying water by contacting water with a porous rice husk ash and clay mixture and apparatus therefor | |
| JP6730949B2 (ja) | 生体高分子ユニットおよびウイルスを液体から分離するための方法 | |
| JP2006515227A5 (enExample) | ||
| JP6522001B2 (ja) | 中空糸濾過膜 | |
| JP2009125071A (ja) | 膜イオン交換クロマトグラフィーのための媒体 | |
| KR101642608B1 (ko) | 바이러스 및 박테리아 필터용 여재 및 이의 제조방법 | |
| JP2010227757A (ja) | 複合分離膜 | |
| US20030201229A1 (en) | Process for prefiltration of a protein solution | |
| CN112892229A (zh) | 一种病毒复合过滤膜及其制备方法 | |
| CN206463797U (zh) | 一种具有多种功能的简化净水工艺的膜元件 | |
| Hwang et al. | Effects of membrane compositions and operating conditions on the filtration and backwashing performance of the activated carbon polymer composite membranes | |
| EP3444029A1 (de) | Proteinreinigungsvorrichtung | |
| JP2012254410A (ja) | 浄水カートリッジおよび浄水器 | |
| EP1624950B1 (en) | Process for prefiltration of a protein solution | |
| CN206121528U (zh) | 一种抗菌除病毒、吸附重金属离子的中空纤维膜复合滤芯 | |
| CN210915611U (zh) | 复合滤芯及净水系统 | |
| KR101466249B1 (ko) | 제습-정수 장치 | |
| JP5516835B2 (ja) | 多段積多層平膜 | |
| JP2015216906A (ja) | 分離容器およびウイルスの濃縮・精製方法 | |
| WO2020051215A1 (en) | Tangential flow filters having extractables adsorber | |
| JP2011092801A (ja) | 浄水フィルタ及び該浄水フィルタを備えた浄水器 | |
| CN202912774U (zh) | 一种净水滤芯及净水器 | |
| CN202289878U (zh) | 一种错流微滤器 | |
| CN212440798U (zh) | 一种高通量聚合膜结构 |