JP2014526246A5 - - Google Patents
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- Publication number
- JP2014526246A5 JP2014526246A5 JP2014529633A JP2014529633A JP2014526246A5 JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5 JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014529633 A JP2014529633 A JP 2014529633A JP 2014526246 A5 JP2014526246 A5 JP 2014526246A5
- Authority
- JP
- Japan
- Prior art keywords
- filter
- sample
- virus
- population
- parvovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 24
- 238000001914 filtration Methods 0.000 claims 5
- 241000125945 Protoparvovirus Species 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 239000004627 regenerated cellulose Substances 0.000 claims 4
- 241000701447 unidentified baculovirus Species 0.000 claims 4
- 210000002845 virion Anatomy 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 claims 3
- 238000011210 chromatographic step Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- -1 polytetrafluoroethylene Polymers 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 239000000020 Nitrocellulose Substances 0.000 claims 1
- 239000002033 PVDF binder Substances 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004695 Polyether sulfone Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229920001220 nitrocellulos Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920006393 polyether sulfone Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 238000011045 prefiltration Methods 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532176P | 2011-09-08 | 2011-09-08 | |
| US61/532,176 | 2011-09-08 | ||
| EP11180594.1 | 2011-09-08 | ||
| EP11180594 | 2011-09-08 | ||
| PCT/NL2012/050619 WO2013036118A1 (en) | 2011-09-08 | 2012-09-07 | Removal of contaminating viruses from aav preparations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Division JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526246A JP2014526246A (ja) | 2014-10-06 |
| JP2014526246A5 true JP2014526246A5 (enExample) | 2015-10-01 |
| JP6198278B2 JP6198278B2 (ja) | 2017-09-20 |
Family
ID=47832422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529633A Expired - Fee Related JP6198278B2 (ja) | 2011-09-08 | 2012-09-07 | Ａａｖ調製物からの混入ウイルスの除去 |
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017125458A Expired - Fee Related JP6624690B2 (ja) | 2011-09-08 | 2017-06-27 | Ａａｖ調製物からの混入ウイルスの除去 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9840694B2 (enExample) |
| EP (3) | EP2744895B1 (enExample) |
| JP (2) | JP6198278B2 (enExample) |
| KR (1) | KR101961347B1 (enExample) |
| CN (2) | CN107502597A (enExample) |
| AU (1) | AU2012304993B2 (enExample) |
| BR (1) | BR112014005255A2 (enExample) |
| CA (1) | CA2847604A1 (enExample) |
| DK (1) | DK2744895T3 (enExample) |
| EA (1) | EA027511B1 (enExample) |
| ES (1) | ES2558168T3 (enExample) |
| HU (1) | HUE026579T2 (enExample) |
| IL (1) | IL231398A (enExample) |
| MX (1) | MX349601B (enExample) |
| PL (1) | PL2744895T3 (enExample) |
| PT (1) | PT2744895E (enExample) |
| SI (1) | SI2744895T1 (enExample) |
| WO (1) | WO2013036118A1 (enExample) |
| ZA (1) | ZA201401714B (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2847604A1 (en) * | 2011-09-08 | 2013-03-14 | Uniqure Ip B.V. | Removal of contaminating viruses from aav preparations |
| WO2015060722A1 (en) | 2013-10-24 | 2015-04-30 | Uniqure Ip B.V. | Aav-5 pseudotyped vector for gene therapy for neurological diseases |
| US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| WO2016073693A2 (en) | 2014-11-05 | 2016-05-12 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
| CA2975583A1 (en) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| US11021762B2 (en) * | 2014-11-28 | 2021-06-01 | Uniqure Ip B.V. | DNA impurities in a composition comprising a parvoviral virion |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| LT3237618T (lt) | 2014-12-24 | 2019-07-10 | Uniqure Ip B.V. | Rnri sukeltas hantingtino geno slopinimas |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| IL262784B2 (en) | 2016-05-18 | 2023-10-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
| SG11201809643UA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| WO2018044933A1 (en) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| WO2018204786A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| MX2019013172A (es) | 2017-05-05 | 2020-09-07 | Voyager Therapeutics Inc | Composiciones y metodos para tratar la enfermedad de huntington. |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
| MX2020003042A (es) | 2017-09-29 | 2020-11-18 | Voyager Therapeutics Inc | Rescate del fenotipo neurológico central y periférico de la ataxia de friedreich mediante administración intravenosa. |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
| BR112020014625A2 (pt) | 2018-01-17 | 2020-12-08 | Meiragtx Uk Ii Limited | Proteína de capsídeo de raav modificada para terapia gênica |
| EP3794126A1 (en) | 2018-05-15 | 2021-03-24 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| WO2020053258A1 (en) | 2018-09-12 | 2020-03-19 | Uniqure Ip B.V. | Rnai induced c9orf72 suppression for the treatment of als/ftd |
| SG11202103151RA (en) | 2018-09-28 | 2021-04-29 | Voyager Therapeutics Inc | Frataxin expression constructs having engineered promoters and methods of use thereof |
| AU2019362833A1 (en) * | 2018-10-15 | 2021-04-29 | Regenxbio Inc. | Method for measuring the infectivity of replication defective viral vectors and viruses |
| CA3120177A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | Method and means to deliver mirna to target cells |
| WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| EP3884050A1 (en) | 2018-11-19 | 2021-09-29 | uniQure IP B.V. | Rnai induced reduction of ataxin-3 for the treatment of spinocerebellar ataxia type 3 |
| CA3119721A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | A companion diagnostic to monitor the effects of gene therapy |
| CA3125770A1 (en) * | 2019-01-18 | 2020-07-23 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| JP2022520647A (ja) | 2019-02-15 | 2022-03-31 | サンガモ セラピューティクス， インコーポレイテッド | 組み換えａａｖ生産のための組成物および方法 |
| WO2020219897A1 (en) * | 2019-04-24 | 2020-10-29 | Biogen Ma Inc. | Methods for production of recombinant adeno-associated viruses |
| RS66255B1 (sr) | 2019-07-15 | 2024-12-31 | Meiragtx Uk Ii Ltd | Modifikovani proteini aav kapsida za lečenje artritične bolesti |
| EP4031148A1 (en) | 2019-09-16 | 2022-07-27 | uniQure IP B.V. | Targeting misspliced transcripts in genetic disorders |
| KR20220110781A (ko) | 2019-12-04 | 2022-08-09 | 상가모 테라퓨틱스, 인코포레이티드 | 재조합 aav를 생산하기 위한 신규 조성물 및 방법 |
| KR20220097990A (ko) * | 2019-12-12 | 2022-07-08 | 이엠디 밀리포어 코포레이션 | 정용여과 완충제를 사용한 강화된 바이러스 여과 |
| US20230242939A1 (en) * | 2020-01-29 | 2023-08-03 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| WO2021172573A1 (ja) * | 2020-02-28 | 2021-09-02 | 旭化成メディカル株式会社 | ウイルスクリアランス性能の評価方法 |
| EP4133074A1 (en) | 2020-04-07 | 2023-02-15 | uniQure IP B.V. | Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof |
| WO2022188797A1 (en) | 2021-03-09 | 2022-09-15 | Huigene Therapeutics Co., Ltd. | Engineered crispr/cas13 system and uses thereof |
| EP4313379A1 (en) * | 2021-03-30 | 2024-02-07 | 3M Innovative Properties Company | Hollow-fiber membrane comprising polysulfone and polyoxazoline and method making thereof |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| US20240374755A1 (en) | 2021-06-02 | 2024-11-14 | Uniqure Biopharma B.V. | Adeno-associated virus vectors modified to bind High-Density Lipoprotein |
| EP4359525A1 (en) | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| US20240287545A1 (en) | 2021-06-21 | 2024-08-29 | Uniqure Biopharma B.V. | Improved lysis procedures |
| WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| EP4508216A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of snca |
| EP4508213A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of apoe |
| WO2023198702A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of c9orf72 |
| WO2023198662A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Novel systems for nucleic acid regulation |
| US20240209324A1 (en) * | 2022-12-22 | 2024-06-27 | Cytiva Us Llc | Virus separation |
| WO2024218192A1 (en) | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs |
| WO2024218204A1 (en) | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| WO2024261220A1 (en) | 2023-06-23 | 2024-12-26 | Uniqure Biopharma B.V. | Novel fragile x constructs |
| WO2025051805A1 (en) | 2023-09-04 | 2025-03-13 | Uniqure Biopharma B.V. | Novel neurotropic recombinant adeno-associated virus particles |
| WO2025078602A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Nucleic acid regulation of msh3 in repeat expansion disorders |
| WO2025078606A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Further novel systems for nucleic acid regulation |
| WO2025078598A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Novel nucleic acid regulation of huntingtin gene |
| WO2025114524A1 (en) | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
| WO2025219443A1 (en) | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| AU4270196A (en) | 1994-10-07 | 1996-05-02 | Lutz Gissmann | Papilloma virus-like particles, fusion proteins and process for producing the same |
| DE19709186C2 (de) | 1997-03-06 | 1999-10-14 | Medigene Ag | Filtrationsverfahren zur Trennung von Viren |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| CA2348382C (en) | 1998-11-10 | 2013-09-17 | The University Of North Carolina At Chapel Hill | Chimeric parvovirus vectors and methods of making and administering the same |
| US6593123B1 (en) * | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| WO2003074714A1 (en) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
| US20050009168A1 (en) * | 2003-05-12 | 2005-01-13 | Robbins Joan Marie | Methods and apparatus for Adeno associated virus purification |
| AU2007261806B2 (en) * | 2006-06-21 | 2013-08-15 | Uniqure Ip B.V. | Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV in insect cells |
| WO2008109721A1 (en) * | 2007-03-06 | 2008-09-12 | Introgen Therapeutics, Inc. | Chromatographic methods for assessing adenovirus purity |
| US20100323429A1 (en) * | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| HUE054940T2 (hu) * | 2009-06-16 | 2021-10-28 | Genzyme Corp | Javított eljárások rekombináns AAV-vektorok tisztítására |
| CN102947453A (zh) * | 2010-01-28 | 2013-02-27 | 费城儿童医院 | 用于病毒载体纯化的可扩缩生产平台和用于基因治疗中的如此纯化的病毒载体 |
| CA2847604A1 (en) | 2011-09-08 | 2013-03-14 | Uniqure Ip B.V. | Removal of contaminating viruses from aav preparations |
-
2012
- 2012-09-07 CA CA2847604A patent/CA2847604A1/en not_active Abandoned
- 2012-09-07 US US14/343,884 patent/US9840694B2/en active Active
- 2012-09-07 HU HUE12758663A patent/HUE026579T2/en unknown
- 2012-09-07 PL PL12758663T patent/PL2744895T3/pl unknown
- 2012-09-07 DK DK12758663.4T patent/DK2744895T3/en active
- 2012-09-07 ES ES12758663.4T patent/ES2558168T3/es active Active
- 2012-09-07 KR KR1020147009146A patent/KR101961347B1/ko not_active Expired - Fee Related
- 2012-09-07 EP EP12758663.4A patent/EP2744895B1/en active Active
- 2012-09-07 BR BR112014005255A patent/BR112014005255A2/pt active Search and Examination
- 2012-09-07 CN CN201710697343.1A patent/CN107502597A/zh active Pending
- 2012-09-07 SI SI201230372T patent/SI2744895T1/sl unknown
- 2012-09-07 WO PCT/NL2012/050619 patent/WO2013036118A1/en not_active Ceased
- 2012-09-07 MX MX2014002733A patent/MX349601B/es active IP Right Grant
- 2012-09-07 EP EP18191023.3A patent/EP3425044A1/en not_active Withdrawn
- 2012-09-07 JP JP2014529633A patent/JP6198278B2/ja not_active Expired - Fee Related
- 2012-09-07 AU AU2012304993A patent/AU2012304993B2/en not_active Ceased
- 2012-09-07 CN CN201280049899.5A patent/CN103857790B/zh not_active Expired - Fee Related
- 2012-09-07 PT PT127586634T patent/PT2744895E/pt unknown
- 2012-09-07 EA EA201490583A patent/EA027511B1/ru not_active IP Right Cessation
- 2012-09-07 EP EP15186937.7A patent/EP2990477B8/en not_active Revoked
-
2014
- 2014-03-06 IL IL231398A patent/IL231398A/en active IP Right Grant
- 2014-03-07 ZA ZA2014/01714A patent/ZA201401714B/en unknown
-
2017
- 2017-06-27 JP JP2017125458A patent/JP6624690B2/ja not_active Expired - Fee Related
- 2017-12-08 US US15/836,220 patent/US10253301B2/en not_active Expired - Fee Related
-
2019
- 2019-03-20 US US16/359,593 patent/US20190218523A1/en not_active Abandoned
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