PL2744895T3 - Usuwanie zanieczyszczających wirusów z preparatów aav - Google Patents
Usuwanie zanieczyszczających wirusów z preparatów aavInfo
- Publication number
- PL2744895T3 PL2744895T3 PL12758663T PL12758663T PL2744895T3 PL 2744895 T3 PL2744895 T3 PL 2744895T3 PL 12758663 T PL12758663 T PL 12758663T PL 12758663 T PL12758663 T PL 12758663T PL 2744895 T3 PL2744895 T3 PL 2744895T3
- Authority
- PL
- Poland
- Prior art keywords
- removal
- contaminating viruses
- aav preparations
- aav
- preparations
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/16—Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/08—Polysaccharides
- B01D71/10—Cellulose; Modified cellulose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2623—Ion-Exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2649—Filtration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14351—Methods of production or purification of viral material
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Water Supply & Treatment (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532176P | 2011-09-08 | 2011-09-08 | |
| EP11180594 | 2011-09-08 | ||
| PCT/NL2012/050619 WO2013036118A1 (en) | 2011-09-08 | 2012-09-07 | Removal of contaminating viruses from aav preparations |
| EP12758663.4A EP2744895B1 (en) | 2011-09-08 | 2012-09-07 | Removal of contaminating viruses from aav preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2744895T3 true PL2744895T3 (pl) | 2016-04-29 |
Family
ID=47832422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12758663T PL2744895T3 (pl) | 2011-09-08 | 2012-09-07 | Usuwanie zanieczyszczających wirusów z preparatów aav |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9840694B2 (enExample) |
| EP (3) | EP2744895B1 (enExample) |
| JP (2) | JP6198278B2 (enExample) |
| KR (1) | KR101961347B1 (enExample) |
| CN (2) | CN107502597A (enExample) |
| AU (1) | AU2012304993B2 (enExample) |
| BR (1) | BR112014005255A2 (enExample) |
| CA (1) | CA2847604A1 (enExample) |
| DK (1) | DK2744895T3 (enExample) |
| EA (1) | EA027511B1 (enExample) |
| ES (1) | ES2558168T3 (enExample) |
| HU (1) | HUE026579T2 (enExample) |
| IL (1) | IL231398A (enExample) |
| MX (1) | MX349601B (enExample) |
| PL (1) | PL2744895T3 (enExample) |
| PT (1) | PT2744895E (enExample) |
| SI (1) | SI2744895T1 (enExample) |
| WO (1) | WO2013036118A1 (enExample) |
| ZA (1) | ZA201401714B (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6198278B2 (ja) | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
| CN105745326A (zh) | 2013-10-24 | 2016-07-06 | 优尼科Ip有限公司 | 用于基因治疗神经疾病的aav-5假型载体 |
| US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| SG10202007103TA (en) | 2014-11-05 | 2020-09-29 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| CN112375760A (zh) | 2014-11-14 | 2021-02-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| KR20230169197A (ko) | 2014-11-14 | 2023-12-15 | 보이저 테라퓨틱스, 인크. | 근위축성 측삭 경화증(als)을 치료하는 조성물 및 방법 |
| EP3591070B1 (en) * | 2014-11-28 | 2022-12-21 | uniQure IP B.V. | Dna impurities in a composition comprising a parvoviral virion |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| HUE043842T2 (hu) | 2014-12-24 | 2019-09-30 | Uniqure Ip Bv | RNAi-indukált huntingtin gén szuppresszió |
| EP3054007A1 (en) * | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| IL297576B2 (en) | 2016-05-18 | 2024-02-01 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
| CN117904112A (zh) | 2016-05-18 | 2024-04-19 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| EP3506817A4 (en) | 2016-08-30 | 2020-07-22 | The Regents of The University of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| CN119491003A (zh) | 2017-05-05 | 2025-02-21 | 沃雅戈治疗公司 | 治疗亨廷顿病的组合物和方法 |
| CA3061652A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CA3070087A1 (en) | 2017-07-17 | 2019-01-24 | Voyager Therapeutics, Inc. | Trajectory array guide system |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| AU2018352236B2 (en) | 2017-10-16 | 2025-04-10 | The Curators Of The University Of Missouri | Treatment of amyotrophic lateral sclerosis (ALS) |
| IL275838B2 (en) | 2018-01-17 | 2024-11-01 | Meiragtx Uk Ii Ltd | A modified raav capsid protein for gene therapy |
| CN112424359A (zh) | 2018-05-15 | 2021-02-26 | 沃雅戈治疗公司 | 用于治疗帕金森氏病的组合物和方法 |
| WO2020053258A1 (en) | 2018-09-12 | 2020-03-19 | Uniqure Ip B.V. | Rnai induced c9orf72 suppression for the treatment of als/ftd |
| SG11202103151RA (en) | 2018-09-28 | 2021-04-29 | Voyager Therapeutics Inc | Frataxin expression constructs having engineered promoters and methods of use thereof |
| CN112912518A (zh) * | 2018-10-15 | 2021-06-04 | 再生生物股份有限公司 | 用于测量复制缺陷型病毒载体和病毒的感染性的方法 |
| CA3119721A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Ip B.V. | A companion diagnostic to monitor the effects of gene therapy |
| WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| AU2019382824A1 (en) | 2018-11-19 | 2021-06-03 | Uniqure Ip B.V. | Method and means to deliver miRNA to target cells |
| US20200199625A1 (en) | 2018-11-19 | 2020-06-25 | Uniqure Ip B.V. | RNAi induced reduction of ataxin-3 for the treatment of Spinocerebellar ataxia type 3 |
| WO2020150556A1 (en) * | 2019-01-18 | 2020-07-23 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| EP3924364A1 (en) | 2019-02-15 | 2021-12-22 | Sangamo Therapeutics, Inc. | Compositions and methods for producing recombinant aav |
| WO2020219897A1 (en) * | 2019-04-24 | 2020-10-29 | Biogen Ma Inc. | Methods for production of recombinant adeno-associated viruses |
| JP7681277B2 (ja) | 2019-07-15 | 2025-05-22 | メイラグティーエックス ユーケー アイアイ リミティド | 関節炎疾患の治療のための修飾ａａｖキャプシドタンパク質 |
| EP4031148A1 (en) | 2019-09-16 | 2022-07-27 | uniQure IP B.V. | Targeting misspliced transcripts in genetic disorders |
| US20230020565A1 (en) | 2019-12-04 | 2023-01-19 | Sangamo Therapeutics, Inc. | Novel compositions and methods for producing recombinant aav |
| CN114829371A (zh) * | 2019-12-12 | 2022-07-29 | Emd密理博公司 | 使用透析过滤缓冲液强化的病毒过滤 |
| EP4097239A2 (en) * | 2020-01-29 | 2022-12-07 | Voyager Therapeutics, Inc. | Methods and systems for producing aav particles |
| EP4112735A4 (en) * | 2020-02-28 | 2023-09-06 | Asahi Kasei Medical Co., Ltd. | Method for evaluating viral clearance performance |
| EP4133074A1 (en) | 2020-04-07 | 2023-02-15 | uniQure IP B.V. | Gene constructs for silencing angiopoietin-like 3 (angptl3) and uses thereof |
| CN115427561B (zh) | 2021-03-09 | 2024-06-04 | 辉大(上海)生物科技有限公司 | 工程化CRISPR/Cas13系统及其用途 |
| US20240157306A1 (en) * | 2021-03-30 | 2024-05-16 | 3M Innovative Properties Company | Hollow-fiber membrane and method making thereof |
| CN117120152A (zh) * | 2021-03-30 | 2023-11-24 | 3M创新有限公司 | 包含聚砜和聚噁唑啉的中空纤维膜及其制造方法 |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| CA3219847A1 (en) | 2021-06-02 | 2022-12-08 | Sander Jan Hendrik Van Deventer | Adeno-associated virus vectors modified to bind high-density lipoprotein |
| US20250382611A1 (en) | 2021-06-21 | 2025-12-18 | Uniqure Biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| EP4359010A1 (en) | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Improved lysis procedures |
| WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| WO2023198663A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of snca |
| CN119032174A (zh) | 2022-04-12 | 2024-11-26 | 优尼科生物制药有限公司 | ApoE的核酸调节 |
| EP4508215A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Novel systems for nucleic acid regulation |
| EP4508214A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of c9orf72 |
| US20240209324A1 (en) * | 2022-12-22 | 2024-06-27 | Cytiva Us Llc | Virus separation |
| AU2024256392A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| AU2024258047A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs |
| AU2024313758A1 (en) | 2023-06-23 | 2026-01-08 | Uniqure Biopharma B.V. | Novel fragile x constructs |
| WO2025051805A1 (en) | 2023-09-04 | 2025-03-13 | Uniqure Biopharma B.V. | Novel neurotropic recombinant adeno-associated virus particles |
| WO2025078602A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Nucleic acid regulation of msh3 in repeat expansion disorders |
| WO2025078606A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Further novel systems for nucleic acid regulation |
| WO2025078598A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Novel nucleic acid regulation of huntingtin gene |
| WO2025114524A1 (en) | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
| WO2025219443A1 (en) | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
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| US20080299545A1 (en) * | 2007-03-06 | 2008-12-04 | Shuyuan Zhang | Chromatographic methods for assessing adenovirus purity |
| US20100323429A1 (en) * | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| ES2693194T3 (es) * | 2009-06-16 | 2018-12-10 | Genzyme Corporation | Métodos mejorados para la purificación de vectores de AAV recombinantes |
| JP2013517798A (ja) * | 2010-01-28 | 2013-05-20 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | ウイルスベクター精製における拡張可能な製造プラットフォームおよび遺伝子治療における使用のための高純度ウイルスベクター |
| JP6198278B2 (ja) * | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
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2012
- 2012-09-07 JP JP2014529633A patent/JP6198278B2/ja not_active Expired - Fee Related
- 2012-09-07 PL PL12758663T patent/PL2744895T3/pl unknown
- 2012-09-07 CA CA2847604A patent/CA2847604A1/en not_active Abandoned
- 2012-09-07 EP EP12758663.4A patent/EP2744895B1/en active Active
- 2012-09-07 KR KR1020147009146A patent/KR101961347B1/ko not_active Expired - Fee Related
- 2012-09-07 BR BR112014005255A patent/BR112014005255A2/pt active Search and Examination
- 2012-09-07 ES ES12758663.4T patent/ES2558168T3/es active Active
- 2012-09-07 AU AU2012304993A patent/AU2012304993B2/en not_active Ceased
- 2012-09-07 CN CN201710697343.1A patent/CN107502597A/zh active Pending
- 2012-09-07 SI SI201230372T patent/SI2744895T1/sl unknown
- 2012-09-07 CN CN201280049899.5A patent/CN103857790B/zh not_active Expired - Fee Related
- 2012-09-07 WO PCT/NL2012/050619 patent/WO2013036118A1/en not_active Ceased
- 2012-09-07 US US14/343,884 patent/US9840694B2/en not_active Expired - Fee Related
- 2012-09-07 EP EP18191023.3A patent/EP3425044A1/en not_active Withdrawn
- 2012-09-07 PT PT127586634T patent/PT2744895E/pt unknown
- 2012-09-07 HU HUE12758663A patent/HUE026579T2/en unknown
- 2012-09-07 EP EP15186937.7A patent/EP2990477B8/en not_active Revoked
- 2012-09-07 DK DK12758663.4T patent/DK2744895T3/en active
- 2012-09-07 MX MX2014002733A patent/MX349601B/es active IP Right Grant
- 2012-09-07 EA EA201490583A patent/EA027511B1/ru not_active IP Right Cessation
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2014
- 2014-03-06 IL IL231398A patent/IL231398A/en active IP Right Grant
- 2014-03-07 ZA ZA2014/01714A patent/ZA201401714B/en unknown
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2017
- 2017-06-27 JP JP2017125458A patent/JP6624690B2/ja not_active Expired - Fee Related
- 2017-12-08 US US15/836,220 patent/US10253301B2/en not_active Expired - Fee Related
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2019
- 2019-03-20 US US16/359,593 patent/US20190218523A1/en not_active Abandoned
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