|
US4916135A
(en)
|
1989-05-08 |
1990-04-10 |
Hoechst Roussel Pharmaceuticals Inc. |
N-heteroaryl-4-quinolinamines
|
|
US5710158A
(en)
|
1991-05-10 |
1998-01-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
PT100905A
(pt)
|
1991-09-30 |
1994-02-28 |
Eisai Co Ltd |
Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
|
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
JP2994165B2
(ja)
*
|
1992-06-26 |
1999-12-27 |
ゼネカ・リミテッド |
キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
|
|
GB9510757D0
(en)
*
|
1994-09-19 |
1995-07-19 |
Wellcome Found |
Therapeuticaly active compounds
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US6046206A
(en)
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
|
|
ID19609A
(id)
|
1996-07-13 |
1998-07-23 |
Glaxo Group Ltd |
Senyawa-senyawa heterosiklik
|
|
AU3969697A
(en)
|
1996-08-01 |
1998-02-25 |
Dow Agrosciences Llc |
Quinolinium derivatives having fungicidal activity
|
|
KR100567649B1
(ko)
*
|
1996-09-25 |
2006-04-05 |
아스트라제네카 유케이 리미티드 |
혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
ATE232205T1
(de)
|
1998-10-01 |
2003-02-15 |
Astrazeneca Ab |
Chinolin- und chinazolin derivate und ihre verwendung als inhibitoren von krankheiten, bei denen cytokine beteiligt wird
|
|
GB2345486A
(en)
|
1999-01-11 |
2000-07-12 |
Glaxo Group Ltd |
Heteroaromatic protein tyrosine kinase inhibitors
|
|
US7709479B1
(en)
|
1999-09-21 |
2010-05-04 |
Astrazeneca |
Quinazoline derivatives and their use as pharmaceuticals
|
|
US6977259B2
(en)
|
2000-01-28 |
2005-12-20 |
Astrazeneca Ab |
Quinoline derivatives and their use as aurora 2 kinase inhibitors
|
|
EP1257546A1
(en)
|
2000-02-17 |
2002-11-20 |
Amgen Inc. |
Kinase inhibitors
|
|
US6521618B2
(en)
|
2000-03-28 |
2003-02-18 |
Wyeth |
3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
|
|
US6589758B1
(en)
*
|
2000-05-19 |
2003-07-08 |
Amgen Inc. |
Crystal of a kinase-ligand complex and methods of use
|
|
WO2002012226A1
(en)
|
2000-08-09 |
2002-02-14 |
Astrazeneca Ab |
Quinoline derivatives having vegf inhibiting activity
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
GB0025782D0
(en)
|
2000-10-20 |
2000-12-06 |
Pfizer Ltd |
Use of inhibitors
|
|
GB0104422D0
(en)
|
2001-02-22 |
2001-04-11 |
Glaxo Group Ltd |
Quinoline derivative
|
|
MXPA03008659A
(es)
|
2001-03-23 |
2005-04-08 |
Bayer Ag |
Inhibidores de rho-cinasa.
|
|
US20030125344A1
(en)
|
2001-03-23 |
2003-07-03 |
Bayer Corporation |
Rho-kinase inhibitors
|
|
SE0101675D0
(sv)
|
2001-05-11 |
2001-05-11 |
Astrazeneca Ab |
Novel composition
|
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
WO2003026664A1
(en)
|
2001-09-26 |
2003-04-03 |
Bayer Corporation |
2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
|
|
DE60234125D1
(de)
|
2001-12-24 |
2009-12-03 |
Astrazeneca Ab |
E inhibitoren
|
|
US7645878B2
(en)
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
|
AU2003255482A1
(en)
*
|
2002-10-02 |
2004-04-23 |
Merck Patent Gmbh |
Use of 4 amino-quinazolines as anti cancer agents
|
|
AU2003286711A1
(en)
|
2002-10-25 |
2004-05-13 |
Vertex Pharmaceuticals Incorporated |
Indazolinone compositions useful as kinase inhibitors
|
|
US20040122161A1
(en)
|
2002-12-21 |
2004-06-24 |
Paul Charles W. |
Hot melt adhesive based on acrylic block copolymers
|
|
ES2290529T3
(es)
|
2002-12-24 |
2008-02-16 |
Astrazeneca Ab |
Derivados de fosfonooxiquinazolina y su uso farmaceutico.
|
|
TWI328009B
(en)
|
2003-05-21 |
2010-08-01 |
Glaxo Group Ltd |
Quinoline derivatives as phosphodiesterase inhibitors
|
|
CA2527017A1
(en)
|
2003-05-27 |
2004-12-09 |
Pfizer Products Inc. |
Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors
|
|
NZ544472A
(en)
|
2003-07-03 |
2009-04-30 |
Myriad Genetics Inc |
Compounds and therapeutical use thereof
|
|
ES2305844T3
(es)
|
2003-09-16 |
2008-11-01 |
Astrazeneca Ab |
Derivados de quinazolina como inhibidores de tirosina cinasa.
|
|
PT2213661E
(pt)
|
2003-09-26 |
2011-12-15 |
Exelixis Inc |
Moduladores de c-met e métodos de uso
|
|
EA009994B1
(ru)
|
2003-12-23 |
2008-06-30 |
Пфайзер Инк. |
Новые хинолиновые производные
|
|
EP1734040A4
(en)
|
2004-03-23 |
2007-11-28 |
Banyu Pharma Co Ltd |
SUBSTITUTED CHINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE
|
|
WO2005115145A2
(en)
|
2004-05-20 |
2005-12-08 |
Wyeth |
Quinone substituted quinazoline and quinoline kinase inhibitors
|
|
CA2567080A1
(en)
|
2004-05-27 |
2005-12-15 |
Vertex Pharmaceuticals Incorporated |
Ice inhibitors for the treatment of autoinflammatory diseases
|
|
EP1781293A1
(en)
|
2004-06-04 |
2007-05-09 |
Amphora Discovery Corporation |
Quinoline- and isoquinoline-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
|
|
FR2873695A1
(fr)
|
2004-07-30 |
2006-02-03 |
Palumed Sa |
Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
|
|
MX2007007645A
(es)
|
2004-12-22 |
2007-08-06 |
Bayer Schering Pharma Ag |
Derivado de quinolina, su uso, preparacion y medicamento que lo contiene.
|
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
US20080161305A1
(en)
|
2005-04-06 |
2008-07-03 |
Exelixis, Inc. |
C-Met Modulators and Methods of Use
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
EP1746096A1
(en)
|
2005-07-15 |
2007-01-24 |
4Sc Ag |
2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
|
|
ITMI20052008A1
(it)
|
2005-10-21 |
2007-04-22 |
Ctg Pharma S R L |
Nuovi antimalarici derivati della 4-aminochinolina
|
|
FR2902100A1
(fr)
|
2006-06-13 |
2007-12-14 |
Sanofi Aventis Sa |
Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
|
|
US7511063B2
(en)
|
2006-08-16 |
2009-03-31 |
Schering Corporation |
High affinity quinoline-based kinase ligands
|
|
JP2008063278A
(ja)
|
2006-09-07 |
2008-03-21 |
Fujifilm Finechemicals Co Ltd |
１−ピリジン−４−イル−インドール類の製造方法
|
|
CN101535279B
(zh)
|
2006-09-11 |
2015-05-20 |
柯瑞斯公司 |
含锌结合基的喹唑啉基egfr抑制剂
|
|
EP2061772A4
(en)
|
2006-09-11 |
2011-06-29 |
Curis Inc |
MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
|
|
AU2007296745B2
(en)
|
2006-09-11 |
2011-12-01 |
Curis, Inc. |
Quinazoline based EGFR inhibitors
|
|
TW200829555A
(en)
|
2006-11-10 |
2008-07-16 |
Astrazeneca Ab |
Chemical compounds
|
|
US8148532B2
(en)
|
2007-03-14 |
2012-04-03 |
Guoqing Paul Chen |
Spiro substituted compounds as angiogenesis inhibitors
|
|
US8163923B2
(en)
|
2007-03-14 |
2012-04-24 |
Advenchen Laboratories, Llc |
Spiro substituted compounds as angiogenesis inhibitors
|
|
US20080234267A1
(en)
|
2007-03-20 |
2008-09-25 |
Karen Elizabeth Lackey |
Compounds and Methods of Treatment
|
|
WO2008119771A2
(en)
|
2007-03-30 |
2008-10-09 |
Clanotech Ab |
Quinoline-s-carboxylic acid derivatives as tyrosine kinase inhibitors
|
|
KR20100015886A
(ko)
|
2007-04-23 |
2010-02-12 |
사노피-아벤티스 |
Ｐ2ｙ12 길항제로서의 퀴놀린-카복스아미드 유도체
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
CA2964162C
(en)
|
2007-06-01 |
2019-12-31 |
Wyeth Llc |
Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles having mutation in the bcrabl gene
|
|
CN101362719B
(zh)
|
2007-08-06 |
2012-04-18 |
北京师范大学 |
喹啉类衍生物以及包含其的组合物
|
|
US7939546B2
(en)
|
2007-10-12 |
2011-05-10 |
Supergen, Inc. |
Quinoline derivatives for modulating DNA methylation
|
|
US7790746B2
(en)
|
2007-10-12 |
2010-09-07 |
Supergen, Inc. |
Quinoline derivatives for modulating DNA methylation
|
|
WO2009073746A1
(en)
|
2007-12-07 |
2009-06-11 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Apparatus for countercurrent chromatography
|
|
EP2072502A1
(de)
*
|
2007-12-20 |
2009-06-24 |
Bayer Schering Pharma Aktiengesellschaft |
Sulfoximid-substituierte Chinolin- und Chinazolinderivate als Kinase-Inhibitoren
|
|
GB0801416D0
(en)
|
2008-01-25 |
2008-03-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
RU2601892C2
(ru)
*
|
2008-03-06 |
2016-11-10 |
Дженентек, Инк. |
Комбинированная терапия антагонистами с-мет и egfr
|
|
MX2011004050A
(es)
*
|
2008-10-17 |
2011-05-10 |
Genentech Inc |
Metodo de tratamiento.
|
|
DE102008062566A1
(de)
|
2008-12-16 |
2010-06-17 |
Bayer Schering Pharma Aktiengesellschaft |
Aminosäureester-Prodrugs und ihre Verwendung
|
|
PH12012500097A1
(en)
|
2009-07-21 |
2011-01-27 |
Shanghai Inst Organic Chem |
Potent small molecule inhibitors of autophagy, and methods of use thereof
|
|
US20130005726A1
(en)
*
|
2010-03-08 |
2013-01-03 |
Derek Abbott |
Compositions and methods for treating inflammatory disorders
|
|
EP2552211A4
(en)
|
2010-03-26 |
2013-10-23 |
Glaxo Group Ltd |
INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
|
|
JP2013523658A
(ja)
|
2010-03-26 |
2013-06-17 |
グラクソ グループ リミテッド |
キナーゼ阻害剤としてのピラゾリル‐ピリミジン
|
|
US20130018039A1
(en)
|
2010-03-31 |
2013-01-17 |
Bodmer Vera Q |
Imidazolyl-imidazoles as kinase inhibitors
|
|
EP2566477B1
(en)
|
2010-05-07 |
2015-09-02 |
GlaxoSmithKline Intellectual Property Development Limited |
Amino-quinolines as kinase inhibitors
|
|
UY33549A
(es)
|
2010-08-10 |
2012-01-31 |
Glaxo Group Ltd |
Quinolil aminas como agentes inhibidores de las quinasas
|
|
US8609672B2
(en)
|
2010-08-27 |
2013-12-17 |
University Of The Pacific |
Piperazinylpyrimidine analogues as protein kinase inhibitors
|
|
WO2012118632A1
(en)
|
2011-02-28 |
2012-09-07 |
Ning Xi |
Substituted quinoline compounds and methods of use
|
|
SG192769A1
(en)
|
2011-03-04 |
2013-09-30 |
Glaxosmithkline Ip No 2 Ltd |
Amino-quinolines as kinase inhibitors
|
|
TWI547494B
(zh)
*
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
AR092530A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
AR092529A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
RU2662810C2
(ru)
|
2013-02-21 |
2018-07-31 |
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
Хиназолины в качестве ингибиторов киназы
|