JP2015528508A5 - - Google Patents
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- Publication number
- JP2015528508A5 JP2015528508A5 JP2015532064A JP2015532064A JP2015528508A5 JP 2015528508 A5 JP2015528508 A5 JP 2015528508A5 JP 2015532064 A JP2015532064 A JP 2015532064A JP 2015532064 A JP2015532064 A JP 2015532064A JP 2015528508 A5 JP2015528508 A5 JP 2015528508A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazol
- dimethyl
- alkoxy
- amine
- quinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- -1 cyano, hydroxyl Chemical group 0.000 claims 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 4
- QODPGRHWJBWTJC-UHFFFAOYSA-N 6-tert-butylsulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-(2-methoxyethoxy)quinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OCCOC)=CC2=NC=CC=1NC1=NNC(C)=C1C QODPGRHWJBWTJC-UHFFFAOYSA-N 0.000 claims 3
- 208000009766 Blau syndrome Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- BFDDPFRPBQXQBX-GFCCVEGCSA-N (2r)-1-[6-tert-butylsulfonyl-4-[(4,5-dimethyl-1h-pyrazol-3-yl)amino]quinolin-7-yl]oxypropan-2-ol Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OC[C@H](O)C)=CC2=NC=CC=1NC1=NNC(C)=C1C BFDDPFRPBQXQBX-GFCCVEGCSA-N 0.000 claims 1
- BFDDPFRPBQXQBX-LBPRGKRZSA-N (2s)-1-[6-tert-butylsulfonyl-4-[(4,5-dimethyl-1h-pyrazol-3-yl)amino]quinolin-7-yl]oxypropan-2-ol Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OC[C@@H](O)C)=CC2=NC=CC=1NC1=NNC(C)=C1C BFDDPFRPBQXQBX-LBPRGKRZSA-N 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- HOTBTVYQQMHEBB-UHFFFAOYSA-N 1-[6-tert-butylsulfonyl-4-[(4,5-dimethyl-1h-pyrazol-3-yl)amino]quinolin-7-yl]oxy-2-methylpropan-2-ol Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(OCC(C)(C)O)=C(S(=O)(=O)C(C)(C)C)C=C12 HOTBTVYQQMHEBB-UHFFFAOYSA-N 0.000 claims 1
- HZDJLSITORIPGT-UHFFFAOYSA-N 2-[4-[(4,5-dimethyl-1h-pyrazol-3-yl)amino]-7-methoxyquinolin-6-yl]sulfonyl-2-methylpropan-1-ol Chemical compound C=12C=C(S(=O)(=O)C(C)(C)CO)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C HZDJLSITORIPGT-UHFFFAOYSA-N 0.000 claims 1
- LSTLSXLHIRBYFQ-UHFFFAOYSA-N 2-[4-[(4,5-dimethyl-1h-pyrazol-3-yl)amino]-7-methoxyquinolin-6-yl]sulfonylethanol Chemical compound C=12C=C(S(=O)(=O)CCO)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C LSTLSXLHIRBYFQ-UHFFFAOYSA-N 0.000 claims 1
- HRBKEPLXBIHJME-UHFFFAOYSA-N 2-[6-tert-butylsulfonyl-4-[(4,5-dimethyl-1h-pyrazol-3-yl)amino]quinolin-7-yl]oxyethanol Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(OCCO)=C(S(=O)(=O)C(C)(C)C)C=C12 HRBKEPLXBIHJME-UHFFFAOYSA-N 0.000 claims 1
- OVPZGUMHWDAVSH-UHFFFAOYSA-N 6-(2,2-dimethyloxan-4-yl)sulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-methoxyquinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C3CC(C)(C)OCC3)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C OVPZGUMHWDAVSH-UHFFFAOYSA-N 0.000 claims 1
- SHJUBFAKVSHFJQ-OCZCAGDBSA-N 6-[(2r,6s)-2,6-dimethyloxan-4-yl]sulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-methoxyquinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C3C[C@@H](C)O[C@@H](C)C3)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C SHJUBFAKVSHFJQ-OCZCAGDBSA-N 0.000 claims 1
- QWECBUNTPLWDBL-UHFFFAOYSA-N 6-tert-butylsulfonyl-4-[(4,5-dimethyl-1H-pyrazol-3-yl)amino]quinolin-7-ol Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(O)=C(S(=O)(=O)C(C)(C)C)C=C12 QWECBUNTPLWDBL-UHFFFAOYSA-N 0.000 claims 1
- PLYPDBCKMUBDTF-UHFFFAOYSA-N 6-tert-butylsulfonyl-7-(2,2-difluoroethoxy)-n-(4,5-dimethyl-1h-pyrazol-3-yl)quinolin-4-amine Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(OCC(F)F)=C(S(=O)(=O)C(C)(C)C)C=C12 PLYPDBCKMUBDTF-UHFFFAOYSA-N 0.000 claims 1
- DPILGXGHKJEOAS-UHFFFAOYSA-N 6-tert-butylsulfonyl-7-(difluoromethoxy)-n-(4,5-dimethyl-1h-pyrazol-3-yl)quinolin-4-amine Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(OC(F)F)=C(S(=O)(=O)C(C)(C)C)C=C12 DPILGXGHKJEOAS-UHFFFAOYSA-N 0.000 claims 1
- DPSNWHXNCQBYAH-UHFFFAOYSA-N 6-tert-butylsulfonyl-7-methoxy-n-[4-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl]quinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OC)=CC2=NC=CC=1NC1=NNC(C(F)(F)F)=C1C DPSNWHXNCQBYAH-UHFFFAOYSA-N 0.000 claims 1
- LSBUSOIHRLJSJM-UHFFFAOYSA-N 6-tert-butylsulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-(2,2,2-trifluoroethoxy)quinolin-4-amine Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(OCC(F)(F)F)=C(S(=O)(=O)C(C)(C)C)C=C12 LSBUSOIHRLJSJM-UHFFFAOYSA-N 0.000 claims 1
- VENUDGUYMCDYAB-UHFFFAOYSA-N 6-tert-butylsulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-(3-methoxypropoxy)quinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OCCCOC)=CC2=NC=CC=1NC1=NNC(C)=C1C VENUDGUYMCDYAB-UHFFFAOYSA-N 0.000 claims 1
- UVCJVWDOTPZNJM-UHFFFAOYSA-N 6-tert-butylsulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-ethoxyquinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OCC)=CC2=NC=CC=1NC1=NNC(C)=C1C UVCJVWDOTPZNJM-UHFFFAOYSA-N 0.000 claims 1
- SNLKRSSBDMHRFL-UHFFFAOYSA-N 6-tert-butylsulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-fluoroquinolin-4-amine Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(F)=C(S(=O)(=O)C(C)(C)C)C=C12 SNLKRSSBDMHRFL-UHFFFAOYSA-N 0.000 claims 1
- LHPFRDAGGDMRMZ-UHFFFAOYSA-N 6-tert-butylsulfonyl-n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-methoxyquinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C(C)(C)C)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C LHPFRDAGGDMRMZ-UHFFFAOYSA-N 0.000 claims 1
- SVARURAGDUBTCW-UHFFFAOYSA-N 7-(difluoromethoxy)-n-(4,5-dimethyl-1h-pyrazol-3-yl)-6-(oxan-4-ylsulfonyl)quinolin-4-amine Chemical compound CC1=C(C)NN=C1NC1=CC=NC2=CC(OC(F)F)=C(S(=O)(=O)C3CCOCC3)C=C12 SVARURAGDUBTCW-UHFFFAOYSA-N 0.000 claims 1
- GMWIWJMSCHALJV-UHFFFAOYSA-N 7-methoxy-n-[4-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl]-6-(oxan-4-ylsulfonyl)quinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C3CCOCC3)C(OC)=CC2=NC=CC=1NC1=NNC(C(F)(F)F)=C1C GMWIWJMSCHALJV-UHFFFAOYSA-N 0.000 claims 1
- LHUXIXHXMCIUBN-UHFFFAOYSA-N 7-methoxy-n-[4-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl]-6-propan-2-ylsulfonylquinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C(C)C)C(OC)=CC2=NC=CC=1NC1=NNC(C(F)(F)F)=C1C LHUXIXHXMCIUBN-UHFFFAOYSA-N 0.000 claims 1
- 208000007082 Alcoholic Fatty Liver Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 108090000426 Caspase-1 Proteins 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 101001109137 Homo sapiens Receptor-interacting serine/threonine-protein kinase 2 Proteins 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 102100022502 Receptor-interacting serine/threonine-protein kinase 2 Human genes 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 208000026594 alcoholic fatty liver disease Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- UTGFZERHPKWOOY-UHFFFAOYSA-N n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-methoxy-6-(2-methoxyethylsulfonyl)quinolin-4-amine Chemical compound C1=CN=C2C=C(OC)C(S(=O)(=O)CCOC)=CC2=C1NC1=NNC(C)=C1C UTGFZERHPKWOOY-UHFFFAOYSA-N 0.000 claims 1
- GTRTXSSFSXXYFL-UHFFFAOYSA-N n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-methoxy-6-(4-methyloxan-4-yl)sulfonylquinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C3(C)CCOCC3)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C GTRTXSSFSXXYFL-UHFFFAOYSA-N 0.000 claims 1
- CXRQMMOWWNSBTM-UHFFFAOYSA-N n-(4,5-dimethyl-1h-pyrazol-3-yl)-7-methoxy-6-(oxan-4-ylsulfonyl)quinolin-4-amine Chemical compound C=12C=C(S(=O)(=O)C3CCOCC3)C(OC)=CC2=NC=CC=1NC1=NNC(C)=C1C CXRQMMOWWNSBTM-UHFFFAOYSA-N 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- VLCMRTMCMQJSKM-UHFFFAOYSA-N phenyl-[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone Chemical compound C=1C=CC=CC=1C(=O)C1=CN=C2C(C(F)(F)F)=CC=CC2=C1C1=CC=CC=C1 VLCMRTMCMQJSKM-UHFFFAOYSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700536P | 2012-09-13 | 2012-09-13 | |
| US61/700,536 | 2012-09-13 | ||
| US201361767378P | 2013-02-21 | 2013-02-21 | |
| US61/767,378 | 2013-02-21 | ||
| PCT/US2013/059600 WO2014043437A1 (en) | 2012-09-13 | 2013-09-13 | Amino-quinolines as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528508A JP2015528508A (ja) | 2015-09-28 |
| JP2015528508A5 true JP2015528508A5 (https=) | 2016-07-14 |
| JP6258331B2 JP6258331B2 (ja) | 2018-01-10 |
Family
ID=50278701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532064A Expired - Fee Related JP6258331B2 (ja) | 2012-09-13 | 2013-09-13 | キナーゼ阻害剤としてのアミノ−キノリン |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9216965B2 (https=) |
| EP (1) | EP2895167B1 (https=) |
| JP (1) | JP6258331B2 (https=) |
| KR (1) | KR20150053920A (https=) |
| CN (1) | CN104602692B (https=) |
| AR (1) | AR092530A1 (https=) |
| AU (1) | AU2013315387B2 (https=) |
| BR (1) | BR112015004967A2 (https=) |
| CA (1) | CA2883155A1 (https=) |
| CL (1) | CL2015000615A1 (https=) |
| CR (1) | CR20150133A (https=) |
| DO (1) | DOP2015000059A (https=) |
| EA (1) | EA027984B1 (https=) |
| ES (1) | ES2713172T3 (https=) |
| IL (1) | IL237158A0 (https=) |
| MX (1) | MX2015003275A (https=) |
| PE (1) | PE20150774A1 (https=) |
| PH (1) | PH12015500345A1 (https=) |
| SG (1) | SG11201500973WA (https=) |
| TW (1) | TW201425307A (https=) |
| WO (1) | WO2014043437A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| US9604963B2 (en) | 2011-03-04 | 2017-03-28 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基－喹啉類 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| CA2902132C (en) | 2013-02-21 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| JP6740354B2 (ja) | 2015-10-05 | 2020-08-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法 |
| CN107158385B (zh) * | 2016-03-14 | 2020-07-14 | 苏州大学 | Rip3抑制剂在制备抗血小板血栓药物中的用途 |
| AU2017253560B2 (en) | 2016-04-20 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Conjugates comprising RIPK2 inhibitors |
| WO2020094613A1 (en) | 2018-11-06 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nod2 inhibitors for the treatment of hereditary periodic fevers |
| CN114014890A (zh) * | 2021-03-12 | 2022-02-08 | 爱科诺生物医药(香港)有限公司 | 具有rip2激酶抑制活性的化合物，包含其的药物组合物，及其应用 |
| WO2025078493A1 (en) | 2023-10-11 | 2025-04-17 | Institut National de la Santé et de la Recherche Médicale | Local administration of ripk2 inhibitors for the curative treatment of allergic asthma |
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| US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| US6046206A (en) | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
| AR007857A1 (es) | 1996-07-13 | 1999-11-24 | Glaxo Group Ltd | Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen. |
| WO1998005647A1 (en) | 1996-08-01 | 1998-02-12 | Dow Agrosciences Llc | Quinolinium derivatives having fungicidal activity |
| WO1998013350A1 (en) | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
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| CA2384291A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline derivatives and their use as pharmaceuticals |
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| WO2002012226A1 (en) | 2000-08-09 | 2002-02-14 | Astrazeneca Ab | Quinoline derivatives having vegf inhibiting activity |
| GB0104422D0 (en) | 2001-02-22 | 2001-04-11 | Glaxo Group Ltd | Quinoline derivative |
| SE0101675D0 (sv) | 2001-05-11 | 2001-05-11 | Astrazeneca Ab | Novel composition |
| US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| WO2003026664A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
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| TWI275390B (en) * | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| AU2003286711A1 (en) | 2002-10-25 | 2004-05-13 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| US20040122161A1 (en) | 2002-12-21 | 2004-06-24 | Paul Charles W. | Hot melt adhesive based on acrylic block copolymers |
| SI1847539T1 (sl) | 2002-12-24 | 2010-01-29 | Astrazeneca Ab | Kinazolinski derivati |
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-
2013
- 2013-09-11 TW TW102132714A patent/TW201425307A/zh unknown
- 2013-09-11 AR ARP130103248A patent/AR092530A1/es unknown
- 2013-09-13 KR KR1020157006177A patent/KR20150053920A/ko not_active Withdrawn
- 2013-09-13 WO PCT/US2013/059600 patent/WO2014043437A1/en not_active Ceased
- 2013-09-13 EA EA201590552A patent/EA027984B1/ru not_active IP Right Cessation
- 2013-09-13 MX MX2015003275A patent/MX2015003275A/es unknown
- 2013-09-13 EP EP13836616.6A patent/EP2895167B1/en active Active
- 2013-09-13 SG SG11201500973WA patent/SG11201500973WA/en unknown
- 2013-09-13 US US14/396,559 patent/US9216965B2/en not_active Expired - Fee Related
- 2013-09-13 ES ES13836616T patent/ES2713172T3/es active Active
- 2013-09-13 CA CA2883155A patent/CA2883155A1/en not_active Abandoned
- 2013-09-13 CN CN201380045559.XA patent/CN104602692B/zh not_active Expired - Fee Related
- 2013-09-13 AU AU2013315387A patent/AU2013315387B2/en not_active Ceased
- 2013-09-13 PE PE2015000276A patent/PE20150774A1/es not_active Application Discontinuation
- 2013-09-13 BR BR112015004967A patent/BR112015004967A2/pt active Search and Examination
- 2013-09-13 JP JP2015532064A patent/JP6258331B2/ja not_active Expired - Fee Related
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2015
- 2015-02-09 IL IL237158A patent/IL237158A0/en unknown
- 2015-02-17 PH PH12015500345A patent/PH12015500345A1/en unknown
- 2015-03-12 CL CL2015000615A patent/CL2015000615A1/es unknown
- 2015-03-13 DO DO2015000059A patent/DOP2015000059A/es unknown
- 2015-03-13 CR CR20150133A patent/CR20150133A/es unknown
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