JP2015529681A5 - - Google Patents
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- Publication number
- JP2015529681A5 JP2015529681A5 JP2015532068A JP2015532068A JP2015529681A5 JP 2015529681 A5 JP2015529681 A5 JP 2015529681A5 JP 2015532068 A JP2015532068 A JP 2015532068A JP 2015532068 A JP2015532068 A JP 2015532068A JP 2015529681 A5 JP2015529681 A5 JP 2015529681A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- hydrate
- compound
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- -1 Dihydrogen phosphate 2-((4- (benzo [d] thiazol-5-ylamino) -6- (tert-butylsulfonyl) quinazolin-7-yl) oxy) ethyl hydrochloride monohydrate Chemical compound 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 208000009766 Blau syndrome Diseases 0.000 claims 2
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- LMLSTUCUPVCKEU-UHFFFAOYSA-N O.O.O.O.O.O.[Ca] Chemical compound O.O.O.O.O.O.[Ca] LMLSTUCUPVCKEU-UHFFFAOYSA-N 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 2
- 159000000007 calcium salts Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- MJLYDVMFNHZMLV-UHFFFAOYSA-N 2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinazolin-7-yl]oxyethyl dihydrogen phosphate Chemical compound C1=C2SC=NC2=CC(NC2=C3C=C(C(=CC3=NC=N2)OCCOP(O)(O)=O)S(=O)(=O)C(C)(C)C)=C1 MJLYDVMFNHZMLV-UHFFFAOYSA-N 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 101001109137 Homo sapiens Receptor-interacting serine/threonine-protein kinase 2 Proteins 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 102100022502 Receptor-interacting serine/threonine-protein kinase 2 Human genes 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 1
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000003774 sarcomatosis Diseases 0.000 claims 1
- 159000000000 sodium salts Chemical group 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 150000004684 trihydrates Chemical class 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700422P | 2012-09-13 | 2012-09-13 | |
| US61/700,422 | 2012-09-13 | ||
| US201361767387P | 2013-02-21 | 2013-02-21 | |
| US61/767,387 | 2013-02-21 | ||
| PCT/US2013/059619 WO2014043446A1 (en) | 2012-09-13 | 2013-09-13 | Prodrugs of amino quinazoline kinase inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529681A JP2015529681A (ja) | 2015-10-08 |
| JP2015529681A5 true JP2015529681A5 (https=) | 2016-10-20 |
| JP6246813B2 JP6246813B2 (ja) | 2017-12-13 |
Family
ID=50278703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532068A Expired - Fee Related JP6246813B2 (ja) | 2012-09-13 | 2013-09-13 | アミノキナゾリンキナーゼ阻害剤のプロドラッグ |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US9586953B2 (https=) |
| EP (2) | EP2895174B1 (https=) |
| JP (1) | JP6246813B2 (https=) |
| KR (1) | KR102101527B1 (https=) |
| CN (1) | CN104619327B (https=) |
| AR (1) | AR092529A1 (https=) |
| AU (1) | AU2013315396B2 (https=) |
| BR (1) | BR112015005694A2 (https=) |
| CA (1) | CA2886467C (https=) |
| CL (1) | CL2015000614A1 (https=) |
| CR (1) | CR20150132A (https=) |
| CY (1) | CY1120236T1 (https=) |
| DK (1) | DK2895174T3 (https=) |
| DO (1) | DOP2015000060A (https=) |
| EA (1) | EA028146B1 (https=) |
| ES (1) | ES2663237T3 (https=) |
| HK (1) | HK1251222A1 (https=) |
| HR (1) | HRP20180411T1 (https=) |
| HU (1) | HUE036347T2 (https=) |
| IL (1) | IL237263B (https=) |
| LT (1) | LT2895174T (https=) |
| ME (1) | ME02985B (https=) |
| MX (1) | MX371356B (https=) |
| NZ (1) | NZ628452A (https=) |
| PE (1) | PE20150635A1 (https=) |
| PH (1) | PH12015500363A1 (https=) |
| PL (1) | PL2895174T3 (https=) |
| PT (1) | PT2895174T (https=) |
| RS (1) | RS57144B1 (https=) |
| SG (1) | SG11201501139RA (https=) |
| SI (1) | SI2895174T1 (https=) |
| SM (1) | SMT201800158T1 (https=) |
| TW (1) | TWI592417B (https=) |
| WO (1) | WO2014043446A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9604963B2 (en) | 2011-03-04 | 2017-03-28 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基－喹啉類 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| CA2902132C (en) | 2013-02-21 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| EP3439658B1 (en) * | 2016-04-04 | 2021-11-24 | ChemoCentryx, Inc. | Soluble c5ar antagonists |
| AU2017327539B2 (en) | 2016-09-15 | 2020-12-24 | Boehringer Ingelheim International Gmbh | Heteroaryl carboxamide compounds as inhibitors of RIPK2 |
| WO2020043122A1 (zh) * | 2018-08-28 | 2020-03-05 | 南京明德新药研发有限公司 | 作为rip2激酶抑制剂的喹唑啉类衍生物 |
| WO2020094613A1 (en) | 2018-11-06 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nod2 inhibitors for the treatment of hereditary periodic fevers |
| CN114014890A (zh) * | 2021-03-12 | 2022-02-08 | 爱科诺生物医药(香港)有限公司 | 具有rip2激酶抑制活性的化合物，包含其的药物组合物，及其应用 |
| WO2025078493A1 (en) * | 2023-10-11 | 2025-04-17 | Institut National de la Santé et de la Recherche Médicale | Local administration of ripk2 inhibitors for the curative treatment of allergic asthma |
| WO2025092821A1 (zh) * | 2023-11-01 | 2025-05-08 | 成都赜灵生物医药科技有限公司 | 喹唑啉衍生物类ripk2抑制剂及其用途 |
Family Cites Families (87)
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| EP2566477B1 (en) | 2010-05-07 | 2015-09-02 | GlaxoSmithKline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
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| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| RU2568258C2 (ru) | 2011-02-28 | 2015-11-20 | Саншайн Лейк Фарма Ко., Лтд | Замещенные соединения хинолина и способы их использования |
| US9604963B2 (en) | 2011-03-04 | 2017-03-28 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) * | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基－喹啉類 |
| CA2902132C (en) | 2013-02-21 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
-
2013
- 2013-09-11 AR ARP130103247A patent/AR092529A1/es unknown
- 2013-09-11 TW TW102132715A patent/TWI592417B/zh not_active IP Right Cessation
- 2013-09-13 RS RS20180281A patent/RS57144B1/sr unknown
- 2013-09-13 LT LTEP13837571.2T patent/LT2895174T/lt unknown
- 2013-09-13 WO PCT/US2013/059619 patent/WO2014043446A1/en not_active Ceased
- 2013-09-13 ES ES13837571.2T patent/ES2663237T3/es active Active
- 2013-09-13 HU HUE13837571A patent/HUE036347T2/hu unknown
- 2013-09-13 SG SG11201501139RA patent/SG11201501139RA/en unknown
- 2013-09-13 BR BR112015005694A patent/BR112015005694A2/pt active Search and Examination
- 2013-09-13 EP EP13837571.2A patent/EP2895174B1/en active Active
- 2013-09-13 JP JP2015532068A patent/JP6246813B2/ja not_active Expired - Fee Related
- 2013-09-13 AU AU2013315396A patent/AU2013315396B2/en not_active Ceased
- 2013-09-13 SI SI201330964T patent/SI2895174T1/en unknown
- 2013-09-13 ME MEP-2018-80A patent/ME02985B/me unknown
- 2013-09-13 MX MX2015003276A patent/MX371356B/es active IP Right Grant
- 2013-09-13 KR KR1020157006176A patent/KR102101527B1/ko not_active Expired - Fee Related
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