EA027984B1 - Аминохинолины в качестве ингибиторов rip2 киназы - Google Patents
Аминохинолины в качестве ингибиторов rip2 киназы Download PDFInfo
- Publication number
- EA027984B1 EA027984B1 EA201590552A EA201590552A EA027984B1 EA 027984 B1 EA027984 B1 EA 027984B1 EA 201590552 A EA201590552 A EA 201590552A EA 201590552 A EA201590552 A EA 201590552A EA 027984 B1 EA027984 B1 EA 027984B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tert
- butylsulfonyl
- dimethyl
- pyrazol
- mmol
- Prior art date
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Landscapes
- Health & Medical Sciences (AREA)
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- Biomedical Technology (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700536P | 2012-09-13 | 2012-09-13 | |
| US201361767378P | 2013-02-21 | 2013-02-21 | |
| PCT/US2013/059600 WO2014043437A1 (en) | 2012-09-13 | 2013-09-13 | Amino-quinolines as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| EA201590552A1 EA201590552A1 (ru) | 2015-06-30 |
| EA027984B1 true EA027984B1 (ru) | 2017-09-29 |
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| EA201590552A EA027984B1 (ru) | 2012-09-13 | 2013-09-13 | Аминохинолины в качестве ингибиторов rip2 киназы |
Country Status (21)
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| US (1) | US9216965B2 (https=) |
| EP (1) | EP2895167B1 (https=) |
| JP (1) | JP6258331B2 (https=) |
| KR (1) | KR20150053920A (https=) |
| CN (1) | CN104602692B (https=) |
| AR (1) | AR092530A1 (https=) |
| AU (1) | AU2013315387B2 (https=) |
| BR (1) | BR112015004967A2 (https=) |
| CA (1) | CA2883155A1 (https=) |
| CL (1) | CL2015000615A1 (https=) |
| CR (1) | CR20150133A (https=) |
| DO (1) | DOP2015000059A (https=) |
| EA (1) | EA027984B1 (https=) |
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| IL (1) | IL237158A0 (https=) |
| MX (1) | MX2015003275A (https=) |
| PE (1) | PE20150774A1 (https=) |
| PH (1) | PH12015500345A1 (https=) |
| SG (1) | SG11201500973WA (https=) |
| TW (1) | TW201425307A (https=) |
| WO (1) | WO2014043437A1 (https=) |
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| UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| US9604963B2 (en) | 2011-03-04 | 2017-03-28 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基－喹啉類 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| CA2902132C (en) | 2013-02-21 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| JP6740354B2 (ja) | 2015-10-05 | 2020-08-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法 |
| CN107158385B (zh) * | 2016-03-14 | 2020-07-14 | 苏州大学 | Rip3抑制剂在制备抗血小板血栓药物中的用途 |
| AU2017253560B2 (en) | 2016-04-20 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Conjugates comprising RIPK2 inhibitors |
| WO2020094613A1 (en) | 2018-11-06 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nod2 inhibitors for the treatment of hereditary periodic fevers |
| CN114014890A (zh) * | 2021-03-12 | 2022-02-08 | 爱科诺生物医药(香港)有限公司 | 具有rip2激酶抑制活性的化合物，包含其的药物组合物，及其应用 |
| WO2025078493A1 (en) | 2023-10-11 | 2025-04-17 | Institut National de la Santé et de la Recherche Médicale | Local administration of ripk2 inhibitors for the curative treatment of allergic asthma |
Citations (3)
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| US20030212276A1 (en) * | 2002-04-30 | 2003-11-13 | Wyeth Holdings Corporation | Process for the preparation of 7-substituted-3 quinolinecarbonitriles |
| US20120041024A1 (en) * | 2010-08-10 | 2012-02-16 | Adam Kenneth Charnley | Quinolyl amines as kinase inhibitors |
| US20120219522A1 (en) * | 2011-02-28 | 2012-08-30 | Dr. Ning XI | Substituted quinoline compounds and methods of use |
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| US20130018039A1 (en) | 2010-03-31 | 2013-01-17 | Bodmer Vera Q | Imidazolyl-imidazoles as kinase inhibitors |
| EP2566477B1 (en) | 2010-05-07 | 2015-09-02 | GlaxoSmithKline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| US9604963B2 (en) | 2011-03-04 | 2017-03-28 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基－喹啉類 |
| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| CA2902132C (en) | 2013-02-21 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
-
2013
- 2013-09-11 TW TW102132714A patent/TW201425307A/zh unknown
- 2013-09-11 AR ARP130103248A patent/AR092530A1/es unknown
- 2013-09-13 KR KR1020157006177A patent/KR20150053920A/ko not_active Withdrawn
- 2013-09-13 WO PCT/US2013/059600 patent/WO2014043437A1/en not_active Ceased
- 2013-09-13 EA EA201590552A patent/EA027984B1/ru not_active IP Right Cessation
- 2013-09-13 MX MX2015003275A patent/MX2015003275A/es unknown
- 2013-09-13 EP EP13836616.6A patent/EP2895167B1/en active Active
- 2013-09-13 SG SG11201500973WA patent/SG11201500973WA/en unknown
- 2013-09-13 US US14/396,559 patent/US9216965B2/en not_active Expired - Fee Related
- 2013-09-13 ES ES13836616T patent/ES2713172T3/es active Active
- 2013-09-13 CA CA2883155A patent/CA2883155A1/en not_active Abandoned
- 2013-09-13 CN CN201380045559.XA patent/CN104602692B/zh not_active Expired - Fee Related
- 2013-09-13 AU AU2013315387A patent/AU2013315387B2/en not_active Ceased
- 2013-09-13 PE PE2015000276A patent/PE20150774A1/es not_active Application Discontinuation
- 2013-09-13 BR BR112015004967A patent/BR112015004967A2/pt active Search and Examination
- 2013-09-13 JP JP2015532064A patent/JP6258331B2/ja not_active Expired - Fee Related
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2015
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- 2015-02-17 PH PH12015500345A patent/PH12015500345A1/en unknown
- 2015-03-12 CL CL2015000615A patent/CL2015000615A1/es unknown
- 2015-03-13 DO DO2015000059A patent/DOP2015000059A/es unknown
- 2015-03-13 CR CR20150133A patent/CR20150133A/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030212276A1 (en) * | 2002-04-30 | 2003-11-13 | Wyeth Holdings Corporation | Process for the preparation of 7-substituted-3 quinolinecarbonitriles |
| US20120041024A1 (en) * | 2010-08-10 | 2012-02-16 | Adam Kenneth Charnley | Quinolyl amines as kinase inhibitors |
| US20120219522A1 (en) * | 2011-02-28 | 2012-08-30 | Dr. Ning XI | Substituted quinoline compounds and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015528508A (ja) | 2015-09-28 |
| PH12015500345A1 (en) | 2015-04-20 |
| AR092530A1 (es) | 2015-04-22 |
| EP2895167A4 (en) | 2016-03-16 |
| MX2015003275A (es) | 2015-07-06 |
| CN104602692A (zh) | 2015-05-06 |
| JP6258331B2 (ja) | 2018-01-10 |
| ES2713172T3 (es) | 2019-05-20 |
| CN104602692B (zh) | 2017-06-23 |
| EP2895167B1 (en) | 2018-12-05 |
| AU2013315387A1 (en) | 2015-02-26 |
| WO2014043437A1 (en) | 2014-03-20 |
| US9216965B2 (en) | 2015-12-22 |
| TW201425307A (zh) | 2014-07-01 |
| BR112015004967A2 (pt) | 2020-04-22 |
| PE20150774A1 (es) | 2015-05-28 |
| CR20150133A (es) | 2015-05-04 |
| SG11201500973WA (en) | 2015-04-29 |
| IL237158A0 (en) | 2015-04-30 |
| CA2883155A1 (en) | 2014-03-20 |
| KR20150053920A (ko) | 2015-05-19 |
| US20150094333A1 (en) | 2015-04-02 |
| DOP2015000059A (es) | 2015-05-15 |
| EP2895167A1 (en) | 2015-07-22 |
| EA201590552A1 (ru) | 2015-06-30 |
| CL2015000615A1 (es) | 2015-08-28 |
| AU2013315387B2 (en) | 2016-09-08 |
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