JP2014524747A5 - - Google Patents
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- JP2014524747A5 JP2014524747A5 JP2014520591A JP2014520591A JP2014524747A5 JP 2014524747 A5 JP2014524747 A5 JP 2014524747A5 JP 2014520591 A JP2014520591 A JP 2014520591A JP 2014520591 A JP2014520591 A JP 2014520591A JP 2014524747 A5 JP2014524747 A5 JP 2014524747A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- factor
- collection
- detergent
- ctab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000003599 detergent Substances 0.000 description 14
- 241000700605 Viruses Species 0.000 description 9
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 125000002091 cationic group Chemical group 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000007928 solubilization Effects 0.000 description 4
- 238000005063 solubilization Methods 0.000 description 4
- 229920001429 chelating resin Polymers 0.000 description 3
- 238000005352 clarification Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 101710084021 Large envelope protein Proteins 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011027 product recovery Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509630P | 2011-07-20 | 2011-07-20 | |
| EP11174660 | 2011-07-20 | ||
| EP11174660.8 | 2011-07-20 | ||
| US61/509,630 | 2011-07-20 | ||
| PCT/EP2012/063045 WO2013010797A1 (en) | 2011-07-20 | 2012-07-04 | Process for producing viral antigen and vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524747A JP2014524747A (ja) | 2014-09-25 |
| JP2014524747A5 true JP2014524747A5 (https=) | 2016-11-04 |
| JP6275641B2 JP6275641B2 (ja) | 2018-02-07 |
Family
ID=45094875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520591A Expired - Fee Related JP6275641B2 (ja) | 2011-07-20 | 2012-07-04 | ウイルス抗原およびワクチンの製造方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2734619B1 (https=) |
| JP (1) | JP6275641B2 (https=) |
| KR (2) | KR20160096215A (https=) |
| CN (1) | CN103827296B (https=) |
| AU (1) | AU2012286098C1 (https=) |
| BR (1) | BR112014001049A2 (https=) |
| CA (1) | CA2841604C (https=) |
| ES (1) | ES2653197T3 (https=) |
| MX (1) | MX2014000753A (https=) |
| RU (1) | RU2565827C2 (https=) |
| TW (1) | TW201311896A (https=) |
| WO (1) | WO2013010797A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104524563A (zh) * | 2014-12-12 | 2015-04-22 | 普莱柯生物工程股份有限公司 | 疫苗组合物及其制备方法和应用 |
| WO2019121846A1 (en) | 2017-12-19 | 2019-06-27 | CSL Behring Lengnau AG | Protein purification and virus inactivation with alkyl glycosides |
| JP7360594B2 (ja) * | 2017-12-28 | 2023-10-13 | 共立製薬株式会社 | ワクチン製剤、並びに魚類のイリドウイルス感染症予防方法 |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| IL279295B2 (en) | 2018-06-12 | 2026-03-01 | Kentucky Bioprocessing Inc | Purification and cross-linking of virus and antigen |
| US11999975B2 (en) * | 2018-07-04 | 2024-06-04 | Probiogen Ag | Method for purifying an enveloped virus |
| US12123028B2 (en) | 2018-11-15 | 2024-10-22 | Bayer Healthcare Llc | Viral inactivation methods for continuous manufacturing of antibodies |
| RU2710239C1 (ru) * | 2019-06-14 | 2019-12-25 | Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства | Способ получения антигена или антигенов для производства противогриппозной вакцины и вакцина на его основе |
| MX2022005513A (es) * | 2019-11-07 | 2022-06-08 | Seqirus Uk Ltd | Composiciones y metodos para producir una vacuna viral con tama?o de particula reducido. |
| KR102546626B1 (ko) * | 2020-04-29 | 2023-06-21 | 에스케이바이오사이언스(주) | 인플루엔자 바이러스 항원 정제 조건 신속 확인 시험 |
| JP7779858B2 (ja) * | 2020-04-29 | 2025-12-03 | エスケー バイオサイエンス カンパニー リミテッド | 使い捨て培養工程システムを用いたインフルエンザウイルス生産方法及びインフルエンザウイルス抗原精製条件の迅速確認試験 |
| CN112309502B (zh) * | 2020-10-14 | 2024-09-20 | 深圳市新合生物医疗科技有限公司 | 一种计算肿瘤新抗原负荷的方法及系统 |
| JP2023141423A (ja) * | 2022-03-24 | 2023-10-05 | 国立大学法人 東京大学 | ウイルスの精製方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140762A (en) * | 1974-01-14 | 1979-02-20 | Sandoz Ltd. | Influenza sub-unit vaccine |
| US4240762A (en) * | 1979-03-12 | 1980-12-23 | Johnston Pump Company | Seal-aligning rigid coupling assembly |
| SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| US7262045B2 (en) * | 2003-02-25 | 2007-08-28 | Medimmune Vaccines, Inc. | Methods of producing influenza vaccine compositions |
| RU2283139C1 (ru) * | 2005-03-21 | 2006-09-10 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Способ получения антигенов для вакцины против вирусов гриппа |
| EP1982727A1 (en) * | 2007-04-17 | 2008-10-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for purification of viral proteins |
| AU2008293513B2 (en) * | 2007-08-28 | 2013-11-21 | Alachua Government Services, Inc. | Method for producing viral vaccines |
| WO2009115917A2 (en) * | 2008-03-18 | 2009-09-24 | Novartis Ag | Improvements in preparation of influenza virus vaccine antigens |
| CN102215865B (zh) * | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
| RU2547587C2 (ru) * | 2008-09-24 | 2015-04-10 | Медиммун, Ллк | Способы культивирования клеток, размножения и очистки вирусов |
| GB0918830D0 (en) * | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
-
2012
- 2012-07-04 CA CA2841604A patent/CA2841604C/en not_active Expired - Fee Related
- 2012-07-04 MX MX2014000753A patent/MX2014000753A/es not_active Application Discontinuation
- 2012-07-04 ES ES12734892.8T patent/ES2653197T3/es active Active
- 2012-07-04 KR KR1020167020663A patent/KR20160096215A/ko not_active Withdrawn
- 2012-07-04 EP EP12734892.8A patent/EP2734619B1/en active Active
- 2012-07-04 BR BR112014001049A patent/BR112014001049A2/pt not_active IP Right Cessation
- 2012-07-04 JP JP2014520591A patent/JP6275641B2/ja not_active Expired - Fee Related
- 2012-07-04 AU AU2012286098A patent/AU2012286098C1/en not_active Ceased
- 2012-07-04 KR KR1020147001348A patent/KR20140038530A/ko not_active Ceased
- 2012-07-04 RU RU2014101484/10A patent/RU2565827C2/ru not_active IP Right Cessation
- 2012-07-04 WO PCT/EP2012/063045 patent/WO2013010797A1/en not_active Ceased
- 2012-07-04 CN CN201280035724.9A patent/CN103827296B/zh not_active Expired - Fee Related
- 2012-07-19 TW TW101126141A patent/TW201311896A/zh unknown
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