JP2014520523A5 - - Google Patents
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- JP2014520523A5 JP2014520523A5 JP2014517958A JP2014517958A JP2014520523A5 JP 2014520523 A5 JP2014520523 A5 JP 2014520523A5 JP 2014517958 A JP2014517958 A JP 2014517958A JP 2014517958 A JP2014517958 A JP 2014517958A JP 2014520523 A5 JP2014520523 A5 JP 2014520523A5
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- 210000000130 stem cell Anatomy 0.000 claims 17
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1111503.7A GB201111503D0 (en) | 2011-07-06 | 2011-07-06 | Heart failure (HF) MSC subtype |
| GB1111500.3 | 2011-07-06 | ||
| GB1111503.7 | 2011-07-06 | ||
| GBGB1111505.2A GB201111505D0 (en) | 2011-07-06 | 2011-07-06 | MI MSC subtype |
| GB1111505.2 | 2011-07-06 | ||
| GBGB1111509.4A GB201111509D0 (en) | 2011-07-06 | 2011-07-06 | Orthopedic MSC subtype |
| GB1111509.4 | 2011-07-06 | ||
| GBGB1111500.3A GB201111500D0 (en) | 2011-07-06 | 2011-07-06 | Wet age-related macular degeneration MSC subtype |
| PCT/GB2012/051600 WO2013005053A2 (en) | 2011-07-06 | 2012-07-06 | Progenitor cells of mesodermal lineage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017144116A Division JP2017225451A (ja) | 2011-07-06 | 2017-07-26 | 中胚葉系列の前駆細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520523A JP2014520523A (ja) | 2014-08-25 |
| JP2014520523A5 true JP2014520523A5 (cg-RX-API-DMAC7.html) | 2015-07-16 |
| JP6607675B2 JP6607675B2 (ja) | 2019-11-20 |
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ID=46513785
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517958A Active JP6607675B2 (ja) | 2011-07-06 | 2012-07-06 | 中胚葉系列の前駆細胞 |
| JP2017144116A Pending JP2017225451A (ja) | 2011-07-06 | 2017-07-26 | 中胚葉系列の前駆細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017144116A Pending JP2017225451A (ja) | 2011-07-06 | 2017-07-26 | 中胚葉系列の前駆細胞 |
Country Status (19)
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| CN (2) | CN107746830A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2012279995C1 (cg-RX-API-DMAC7.html) |
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| HR (1) | HRP20181152T1 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2013005053A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120087933A1 (en) | 2010-10-08 | 2012-04-12 | Samson Tom | Enhanced msc preparations |
| EP2782555B1 (en) | 2011-11-23 | 2019-03-13 | Cell Therapy Limited | Platelet lysate gel |
| CN106255884B (zh) * | 2013-10-04 | 2019-01-11 | 赛尔爱迪尔私人有限公司 | 用于细胞治疗的生物标志物 |
| GB201408712D0 (en) * | 2014-05-16 | 2014-07-02 | Univ Leuven Kath | Mesodermal progenitor cells |
| GB201410504D0 (en) | 2014-06-12 | 2014-07-30 | Cell Therapy Ltd | Immuno-modulaltory progenitor (IMP) cell |
| US20170248596A1 (en) * | 2014-08-29 | 2017-08-31 | Becton, Dickinson And Company | Methods and compositions for obtaining a tuberculosis assessment in a subject |
| WO2016131430A1 (en) * | 2015-02-20 | 2016-08-25 | Shih-Chieh Hung | Use of mesenchymal stem cells in treating osteoarthritis |
| EP3091084A1 (en) * | 2015-05-08 | 2016-11-09 | Université Catholique De Louvain | Methods for assessing the purity of a mesenchymal stem cells preparation |
| GB201513996D0 (en) * | 2015-08-07 | 2015-09-23 | Cell Therapy Ltd | Immuno-oncology mesodermal progenitor (IOMP) cell |
| CN108138136B (zh) * | 2015-09-11 | 2022-02-11 | 安斯泰来制药株式会社 | 制造肾前体细胞的方法 |
| GB201518263D0 (en) | 2015-10-15 | 2015-12-02 | Oxford Bioelectronics Ltd | Method |
| CN105483206B (zh) * | 2016-01-06 | 2019-09-13 | 北京汉氏联合生物技术股份有限公司 | 一种用vcam-1检测msc促内皮细胞增殖能力的方法 |
| JP7219211B2 (ja) * | 2016-08-29 | 2023-02-07 | ハッケンサック ユニヴァーシティ メディカル センター | ヒトにおける血小板様細胞を含有する血液の血小板に富む画分の幹細胞性により成体細胞を再プログラミングするための組成物および方法 |
| IL264815B2 (en) * | 2016-08-29 | 2024-09-01 | Univ Hackensack Medical Center | Preparations and methods for reprogramming cells of an adult with a platelet-rich fraction of blood containing platelet-like cells |
| WO2019102268A1 (en) | 2017-11-22 | 2019-05-31 | Mesoblast International Sarl | Cellular compositions and methods of treatment i |
| JP7009977B2 (ja) * | 2017-12-25 | 2022-01-26 | 国立大学法人東海国立大学機構 | 被検体の血中ｖｅｇｆ－ａに関する測定値を用いた心疾患の重症度及び予後予測を行うための方法、装置及びコンピュータプログラム |
| CN108715834B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种富含cd41+、cd81+微囊的血小板裂解液制备方法 |
| CN108715833B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种负载血小板裂解液的微球制备方法 |
| PL3880217T3 (pl) * | 2018-11-14 | 2024-05-20 | Onderzoeks en Ontwikkelingsfonds Rode Kruis-Vlaanderen | Sposoby otrzymywania materiału uwalnianego z płytek krwi |
| CN109329270A (zh) * | 2018-11-19 | 2019-02-15 | 成都清科生物科技有限公司 | 一种静脉回输用间充质干细胞保存液及其制备方法 |
| GB201900554D0 (en) | 2019-01-15 | 2019-03-06 | Cell Therapy Ltd | Mesodermal killer (mk) cell |
| AU2020209441B2 (en) | 2019-01-15 | 2025-07-31 | Cell Therapy Limited | Mesodermal killer (MK) cell |
| US20220160776A1 (en) * | 2019-01-28 | 2022-05-26 | Mesoblast International Sárl | Method for treating or preventing gastrointestinal bleeding |
| CN113811295A (zh) * | 2019-05-15 | 2021-12-17 | 永生公司 | 高浓度细胞包装和运送 |
| CN110237094B (zh) * | 2019-07-30 | 2023-10-03 | 天晴干细胞股份有限公司 | 一种底层血小板因子贴及sPL血小板因子凝胶贴膜的制备方法 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8801537D0 (sv) | 1988-04-26 | 1988-04-26 | Ellco Food Ab | Cellodlingsmedium samt forfarande for dess framstellning |
| RU2138162C1 (ru) | 1997-04-17 | 1999-09-27 | Суханов Владимир Александрович | Способ криоконсервации богатой тромбоцитами плазмы |
| DE69837491T2 (de) | 1997-07-03 | 2008-01-17 | Osiris Therapeutics, Inc. | Menschliche mesenchymale stammzellen aus peripherem blut |
| AU9127098A (en) | 1997-09-04 | 1999-03-22 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
| US6387367B1 (en) | 1998-05-29 | 2002-05-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| DK1226233T3 (da) | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
| JP2003055237A (ja) * | 2001-08-15 | 2003-02-26 | Japan Science & Technology Corp | 骨再生促進剤 |
| AUPR703601A0 (en) | 2001-08-15 | 2001-09-06 | Peter Maccallum Cancer Institute, The | Identification and isolation of somatic stem cells and uses thereof |
| US20050118714A1 (en) | 2002-02-19 | 2005-06-02 | Chul-Won Ha | Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood and differentation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues |
| KR100534215B1 (ko) | 2003-11-11 | 2005-12-08 | (주)히스토스템 | 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법 |
| DE102005011570A1 (de) | 2004-04-13 | 2005-11-03 | Man Roland Druckmaschinen Ag | Prägeeinrichtung für Bedruckstoffe mit strukturierter Oberfläche in einer Bogendruckmaschine |
| ATE494360T1 (de) | 2004-07-20 | 2011-01-15 | Univ Case Western Reserve | Neue zellpopulationen und deren anwendungen |
| CN102391981B (zh) | 2004-09-24 | 2014-08-20 | 麦索布莱斯特公司 | 多能扩增间充质前体细胞子代(memp)及其应用 |
| AU2005287855B2 (en) | 2004-09-24 | 2011-06-16 | Mesoblast, Inc. | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) |
| WO2006108229A1 (en) | 2005-04-12 | 2006-10-19 | Angioblast Systems, Inc. | Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase |
| KR100679642B1 (ko) * | 2005-11-16 | 2007-02-06 | 주식회사 알앤엘바이오 | 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제 |
| EP1795588A1 (en) | 2005-12-07 | 2007-06-13 | Cellerix, S.L. | Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease |
| EP1971679B1 (en) | 2006-01-13 | 2013-04-10 | Osiris Therapeutics, Inc. | Mesenchymal stem cells expressing tnf- receptor |
| EP1845154A1 (en) | 2006-04-12 | 2007-10-17 | RNL Bio Co., Ltd. | Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same |
| CN101516385B (zh) | 2006-07-12 | 2013-07-10 | 成血管细胞系统公司 | 过量新血管化的治疗 |
| US20090253151A1 (en) | 2006-09-01 | 2009-10-08 | Stempeutics Research Private Limited | Self-Renewing Master Adult Pluripotent Stem Cells |
| WO2008097828A2 (en) | 2007-02-02 | 2008-08-14 | St. Jude Children's Research Hospital | Method for isolating mesenchymal stromal cells |
| WO2008129563A2 (en) | 2007-04-23 | 2008-10-30 | Stempeutics Research Private Limited, | Human mesenchymal stem cells and preparation thereof |
| US20090053182A1 (en) | 2007-05-25 | 2009-02-26 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| US9095562B2 (en) * | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
| EP2014294A1 (en) | 2007-07-13 | 2009-01-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of CD200 as a mesenchymal stem cells marker |
| WO2009044943A1 (en) | 2007-10-01 | 2009-04-09 | Seoul National University Industry Foundation | Various human dental stem cells having a mineralization ability and the method for culturing them |
| MX2010000393A (es) | 2007-11-09 | 2010-05-19 | Rnl Bio Co Ltd | Metodo para el aislamiento y cultivo de celulas madre adultas derivadas del epitelio amniotico humano. |
| WO2009069991A2 (en) * | 2007-11-30 | 2009-06-04 | Rnl Bio Co., Ltd. | Cellular therapeutic agent for incontinence of urine comprising stem cells originated from decidua or adipose |
| EP2297305A4 (en) | 2008-05-15 | 2013-03-13 | Univ Miami | ISOLATION OF STEM CELL PROCESSORS AND EXPANSION UNDER NON-TERMS OF CONDITION |
| CN102076844B (zh) | 2008-06-30 | 2013-08-07 | 成血管细胞系统公司 | 采用组合疗法的眼病和过度血管新生的治疗 |
| WO2010017216A2 (en) | 2008-08-04 | 2010-02-11 | Allocure | Mesenchymal stromal cell populations and methods of isolating and using same |
| ES2707274T3 (es) | 2008-08-18 | 2019-04-03 | Mesoblast Inc | Uso de la proteína beta de shock térmico de 90 kDa como marcador para la identificación y/o enriquecimiento de las células precursoras mesenquimales multipotenciales adultas |
| WO2010021412A1 (ja) * | 2008-08-22 | 2010-02-25 | 財団法人ヒューマンサイエンス振興財団 | 脳梗塞治療材及び脳組織再生方法 |
| WO2010033605A2 (en) | 2008-09-16 | 2010-03-25 | Mayo Foundation For Medical Education And Research | Compositions containing platelet contents |
| EP2186883A1 (en) | 2008-11-04 | 2010-05-19 | Fresenius Medical Care | An isolated multipotent mesenchymal stem cell from human adult glomeruli (hGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney |
| CN104546912B (zh) | 2008-11-20 | 2019-11-08 | 中胚有限公司 | 用于治疗胰功能异常的方法 |
| JP5647230B2 (ja) | 2009-04-28 | 2014-12-24 | アントロジェン カンパニー リミテッドＡｎｔｅｒｏｇｅｎ Ｃｏ．， Ｌｔｄ． | 瘻孔治療のための自家及び同種異系の脂肪由来間質幹細胞組成物 |
| EP2488187A4 (en) | 2009-10-13 | 2014-03-26 | Allocure Inc | ASSAY FOR PREDICTING THE THERAPEUTIC EFFECT OF MECHANICAL CYCLES AND METHOD OF USE THEREOF |
| ES2358146B1 (es) | 2009-10-22 | 2012-03-23 | Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud En Sevilla | Uso de células mesenquimales nestina positivas para el mantenimiento de la hematopoyesis. |
| US20120269779A1 (en) | 2009-10-30 | 2012-10-25 | Allocure, Inc. | Mesenchymal stromal cell populations and methods of using same |
| CN102048756B (zh) | 2009-11-04 | 2014-02-19 | 中国医学科学院基础医学研究所 | 人脂肪来源的间充质干细胞在肾脏、眼底疾病中的用途 |
| US8703487B2 (en) | 2009-12-01 | 2014-04-22 | The Regents Of The University Of California | Compositions and methods for making and using bone marrow mesenchymal stem cells and erythroid progenitor cells |
| EP2506867B1 (en) * | 2009-12-02 | 2014-10-08 | Cardio3 Biosciences S.A. | Pharmaceutical compositions for the stimulation of stem cells. |
| AU2011274255B2 (en) | 2010-07-02 | 2016-05-05 | Mesoblast, Inc. | Treatment of T-cell mediated immune disorders |
| AU2011293144B2 (en) | 2010-08-27 | 2015-04-23 | Hare, Joshua M | Bone marrow derived CD271 precursor cells for cardiac repair |
| US20120087933A1 (en) | 2010-10-08 | 2012-04-12 | Samson Tom | Enhanced msc preparations |
| ES2384790B1 (es) | 2010-12-10 | 2013-05-20 | Instituto De Salud Carlos Iii | Células madre mesenquimales aisladas a partir de sangre periférica. |
| US20120288480A1 (en) | 2011-02-22 | 2012-11-15 | Taipei Medical University | Cell population comprising orbital fat-derived stem cells (ofscs) and their isolation and applications |
| CN102078644A (zh) * | 2011-03-08 | 2011-06-01 | 吉林大学 | 一种简便高效的自体富血小板血浆提取装置及提取方法 |
| ES2833076T3 (es) | 2011-05-19 | 2021-06-14 | Mesoblast Inc | Métodos para el tratamiento de la obesidad y/o el síndrome metabólico |
| ES2716015T3 (es) | 2011-06-03 | 2019-06-07 | Mesoblast Inc | Procedimiento para tratar los efectos de un accidente cerebrovascular |
| CA2837895C (en) | 2011-06-03 | 2021-07-27 | Mesoblast, Inc. | Methods of treating or preventing neurological diseases |
| ES3013463T3 (en) | 2011-07-04 | 2025-04-14 | Mesoblast Inc | Treating or preventing rheumatic disease |
| WO2013033777A1 (en) | 2011-09-09 | 2013-03-14 | Mesoblast, Inc | Methods for increasing osteoblastic function |
| AU2013219945B2 (en) | 2012-02-13 | 2017-12-07 | Gamida-Cell Ltd. | Culturing of mesenchymal stem cells |
| WO2013151725A1 (en) | 2012-04-05 | 2013-10-10 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
| US20130273011A1 (en) | 2012-04-17 | 2013-10-17 | Medistem, Inc. | Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome |
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