JP2014518853A - 新規な二環式窒素含有ヘテロアリールtgr5受容体調節因子 - Google Patents
新規な二環式窒素含有ヘテロアリールtgr5受容体調節因子 Download PDFInfo
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- JP2014518853A JP2014518853A JP2014508573A JP2014508573A JP2014518853A JP 2014518853 A JP2014518853 A JP 2014518853A JP 2014508573 A JP2014508573 A JP 2014508573A JP 2014508573 A JP2014508573 A JP 2014508573A JP 2014518853 A JP2014518853 A JP 2014518853A
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- alkyl
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- hydrogen
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- 0 CCC(C1)=C1c1c(*C)c(C)c(*C#C)c(C)c1C Chemical compound CCC(C1)=C1c1c(*C)c(C)c(*C#C)c(C)c1C 0.000 description 8
- NUVCHIRBNLDKJQ-UHFFFAOYSA-N Brc1c2OCCNc2ccc1 Chemical compound Brc1c2OCCNc2ccc1 NUVCHIRBNLDKJQ-UHFFFAOYSA-N 0.000 description 1
- QUYHDDXMHIYZIT-UHFFFAOYSA-N Brc1cccc2c1CCCCN2 Chemical compound Brc1cccc2c1CCCCN2 QUYHDDXMHIYZIT-UHFFFAOYSA-N 0.000 description 1
- MRCNSASXYAUKIC-UHFFFAOYSA-N CC(C(Nc(cccc1Br)c1O)=O)Br Chemical compound CC(C(Nc(cccc1Br)c1O)=O)Br MRCNSASXYAUKIC-UHFFFAOYSA-N 0.000 description 1
- AKNNMKHMPDPNDH-UHFFFAOYSA-N CC(C)(C)OC(NCCCOc1cc(C[n]2ncc(-c3c(CCCN4C(CCCOc5c(C)c(C)ccc5)=O)c4ccc3)c2)ccc1)=O Chemical compound CC(C)(C)OC(NCCCOc1cc(C[n]2ncc(-c3c(CCCN4C(CCCOc5c(C)c(C)ccc5)=O)c4ccc3)c2)ccc1)=O AKNNMKHMPDPNDH-UHFFFAOYSA-N 0.000 description 1
- UTNNBJFUQKCVNK-UHFFFAOYSA-N CC(C)(C)OC(c1cc(Cl)c(C[n]2ncc(-c(cccc3N(C4)C(OCCOc5cccc(Cl)c5C)=O)c3OCC4=O)c2)c(F)c1)=O Chemical compound CC(C)(C)OC(c1cc(Cl)c(C[n]2ncc(-c(cccc3N(C4)C(OCCOc5cccc(Cl)c5C)=O)c3OCC4=O)c2)c(F)c1)=O UTNNBJFUQKCVNK-UHFFFAOYSA-N 0.000 description 1
- JNWUGHGDWOYTJC-UHFFFAOYSA-N CC(C)(CO)[n]1ncc(-c2c(CCCN3C(CCCOc4c(C)c(C)ccc4)=O)c3ccc2)c1 Chemical compound CC(C)(CO)[n]1ncc(-c2c(CCCN3C(CCCOc4c(C)c(C)ccc4)=O)c3ccc2)c1 JNWUGHGDWOYTJC-UHFFFAOYSA-N 0.000 description 1
- ZSHCCBGNWQXLKG-UHFFFAOYSA-N COC(c1cc(CN(C=C(C=C2)Br)C2=O)ccc1)=O Chemical compound COC(c1cc(CN(C=C(C=C2)Br)C2=O)ccc1)=O ZSHCCBGNWQXLKG-UHFFFAOYSA-N 0.000 description 1
- YBACRFASCQUNML-UHFFFAOYSA-N COc1ccc(CN(c2cccc(Br)c2C=C2)C2=O)cc1 Chemical compound COc1ccc(CN(c2cccc(Br)c2C=C2)C2=O)cc1 YBACRFASCQUNML-UHFFFAOYSA-N 0.000 description 1
- HMCAYFBGOBOVHC-UHFFFAOYSA-N Cc(c(Cl)ccc1)c1OCC1(CC1)C(N1c2cccc(Br)c2CCC1)=O Chemical compound Cc(c(Cl)ccc1)c1OCC1(CC1)C(N1c2cccc(Br)c2CCC1)=O HMCAYFBGOBOVHC-UHFFFAOYSA-N 0.000 description 1
- QBTFIUKQPOFNLD-UHFFFAOYSA-N Cc(c(F)ccc1)c1OCCOC(N1c2cccc(-c3c[n](Cc4cccc(NC(NCS(O)(=O)=O)=O)c4)nc3)c2C(C2)C2C1)=O Chemical compound Cc(c(F)ccc1)c1OCCOC(N1c2cccc(-c3c[n](Cc4cccc(NC(NCS(O)(=O)=O)=O)c4)nc3)c2C(C2)C2C1)=O QBTFIUKQPOFNLD-UHFFFAOYSA-N 0.000 description 1
- YOKVZRVBNZDQLG-UHFFFAOYSA-N Cc1cccc(OCCCC(N2c3cccc(-c4c[n](CCC(OC)OC)nc4)c3CCC2)=O)c1C Chemical compound Cc1cccc(OCCCC(N2c3cccc(-c4c[n](CCC(OC)OC)nc4)c3CCC2)=O)c1C YOKVZRVBNZDQLG-UHFFFAOYSA-N 0.000 description 1
- FESBMWPEIUCOGZ-UHFFFAOYSA-N Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5cc(Br)ccc5)nc4)c3CCC2)=O)c1C Chemical compound Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5cc(Br)ccc5)nc4)c3CCC2)=O)c1C FESBMWPEIUCOGZ-UHFFFAOYSA-N 0.000 description 1
- XKAYOSALSOPLLQ-UHFFFAOYSA-N Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5cc(OCCOS(C)(=O)=O)ccc5)nc4)c3CCC2)=O)c1C Chemical compound Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5cc(OCCOS(C)(=O)=O)ccc5)nc4)c3CCC2)=O)c1C XKAYOSALSOPLLQ-UHFFFAOYSA-N 0.000 description 1
- MNJIARFVECPDCC-UHFFFAOYSA-N Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5cccc(O)c5)nc4)c3CCC2)=O)c1C Chemical compound Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5cccc(O)c5)nc4)c3CCC2)=O)c1C MNJIARFVECPDCC-UHFFFAOYSA-N 0.000 description 1
- YBHAWCDJUSXCGP-UHFFFAOYSA-N Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5nc(S(C)(=O)=O)ncc5)nc4)c3CCC2)=O)c1C Chemical compound Cc1cccc(OCCCC(N2c3cccc(-c4c[n](Cc5nc(S(C)(=O)=O)ncc5)nc4)c3CCC2)=O)c1C YBHAWCDJUSXCGP-UHFFFAOYSA-N 0.000 description 1
- TUVDATPQORXJER-UHFFFAOYSA-N Cc1cccc(OCCCC(N2c3cccc(-c4ccnc(N5CCNCC5)c4)c3CCC2)=O)c1C Chemical compound Cc1cccc(OCCCC(N2c3cccc(-c4ccnc(N5CCNCC5)c4)c3CCC2)=O)c1C TUVDATPQORXJER-UHFFFAOYSA-N 0.000 description 1
- PWJRNRWQFLQDIS-UHFFFAOYSA-N O=C(N1c2cccc(Br)c2CCC1)Cl Chemical compound O=C(N1c2cccc(Br)c2CCC1)Cl PWJRNRWQFLQDIS-UHFFFAOYSA-N 0.000 description 1
- JRSQZZAMBSRRPL-UHFFFAOYSA-N O=C1Nc(cccc2Br)c2SC1 Chemical compound O=C1Nc(cccc2Br)c2SC1 JRSQZZAMBSRRPL-UHFFFAOYSA-N 0.000 description 1
- XLNXYWXWOLFEOD-UHFFFAOYSA-N O=C1Nc2cccc(Br)c2C=C1 Chemical compound O=C1Nc2cccc(Br)c2C=C1 XLNXYWXWOLFEOD-UHFFFAOYSA-N 0.000 description 1
- NYQRTVLRKQEZLO-UHFFFAOYSA-N OC(c1cccc(C[n]2ncc(-c3c(CCCN4C(CCCC(c(cc5)ccc5Cl)(F)F)=O)c4ccc3)c2)c1)=O Chemical compound OC(c1cccc(C[n]2ncc(-c3c(CCCN4C(CCCC(c(cc5)ccc5Cl)(F)F)=O)c4ccc3)c2)c1)=O NYQRTVLRKQEZLO-UHFFFAOYSA-N 0.000 description 1
- JYGRLCRHEGTISO-UHFFFAOYSA-N OS(CNC(c1cc(C[n]2ncc(-c3c(CCCN4C(CCCC(c(cc5)ccc5Cl)(F)F)=O)c4ccc3)c2)ccc1)=O)(=O)=O Chemical compound OS(CNC(c1cc(C[n]2ncc(-c3c(CCCN4C(CCCC(c(cc5)ccc5Cl)(F)F)=O)c4ccc3)c2)ccc1)=O)(=O)=O JYGRLCRHEGTISO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D221/04—Ortho- or peri-condensed ring systems
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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| US201161479917P | 2011-04-28 | 2011-04-28 | |
| US61/479,917 | 2011-04-28 | ||
| PCT/US2012/035327 WO2012149236A1 (en) | 2011-04-28 | 2012-04-27 | Novel bicyclic nitrogen containing heteroaryl tgr5 receptor modulators |
Publications (2)
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| JP2014518853A true JP2014518853A (ja) | 2014-08-07 |
| JP2014518853A5 JP2014518853A5 (enExample) | 2015-06-18 |
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| TW (1) | TW201247627A (enExample) |
| WO (1) | WO2012149236A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020512332A (ja) * | 2017-03-22 | 2020-04-23 | シンジェンタ パーティシペーションズ アーゲー | 殺有害生物的に活性なシクロプロピルメチルアミド誘導体 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| RU2720237C2 (ru) | 2013-11-18 | 2020-04-28 | Форма Терапеутикс, Инк. | Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет |
| DK3071203T3 (da) | 2013-11-18 | 2021-03-15 | Forma Therapeutics Inc | Tetrahydroquinolinsammensætninger som bet-bromdomæne-inhibitorer |
| WO2015089800A1 (en) * | 2013-12-19 | 2015-06-25 | Eli Lilly And Company | Fluorophenyl pyrazol compounds |
| EP3188730B1 (en) | 2014-09-05 | 2019-05-01 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| EP3188731B1 (en) | 2014-09-05 | 2019-04-03 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| EP3188732B1 (en) * | 2014-09-05 | 2019-07-24 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
| AU2015335783B2 (en) | 2014-10-24 | 2019-10-03 | Bristol-Myers Squibb Company | Tricyclic atropisomer compounds |
| HUE050706T2 (hu) | 2014-10-24 | 2020-12-28 | Bristol Myers Squibb Co | Indol karboxamid vegyületek, amelyek hasznosak kináz inhibitorokként |
| WO2018005794A2 (en) * | 2016-07-01 | 2018-01-04 | Venenum Biodesign Llc | Novel non-systemic tgr5 agonists |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ,インク. | Gpr119アゴニスト |
| CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ,インク. | Ampkアクチベーター |
| CN114199812A (zh) * | 2021-12-28 | 2022-03-18 | 南通联亚药业有限公司 | 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法 |
| JP2025510646A (ja) | 2022-03-14 | 2025-04-15 | スラップ ファーマシューティカルズ エルエルシー | 多環式化合物 |
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| JPH07242663A (ja) * | 1994-03-01 | 1995-09-19 | Yoshitomi Pharmaceut Ind Ltd | ベンゾオキサジン化合物 |
| JP2006063064A (ja) * | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| WO2010016552A1 (ja) * | 2008-08-07 | 2010-02-11 | 武田薬品工業株式会社 | 過敏性腸症候群治療薬 |
| WO2010107768A1 (en) * | 2009-03-18 | 2010-09-23 | Schering Corporation | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase |
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| DE69026708T2 (de) * | 1989-10-20 | 1997-04-03 | Otsuka Pharma Co Ltd | Benzoheterozyklische verbindungen |
| GB9307527D0 (en) * | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| US7989461B2 (en) * | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| AU2007325315A1 (en) | 2006-11-28 | 2008-06-05 | Kalypsys Inc | Heterocyclic modulators of TGR5 |
| US20090035306A1 (en) | 2006-11-29 | 2009-02-05 | Kalypsys, Inc. | Quinazolinone modulators of tgr5 |
| WO2008097976A1 (en) | 2007-02-09 | 2008-08-14 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| WO2009026241A1 (en) | 2007-08-23 | 2009-02-26 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
| WO2010016846A1 (en) | 2008-08-08 | 2010-02-11 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 for treatment of disease |
| PE20110574A1 (es) * | 2008-10-29 | 2011-08-11 | Hoffmann La Roche | Derivados de fenilamida y de piridilamida como agonistas de gpbar1 |
| ES2592452T3 (es) | 2008-11-19 | 2016-11-30 | Intercept Pharmaceuticals, Inc. | Moduladores de TGR5 y métodos de uso de los mismos |
| US8785488B2 (en) | 2009-02-12 | 2014-07-22 | Exelixis Patent Company Llc | Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity |
| EP2509960A1 (en) | 2009-12-11 | 2012-10-17 | Exelixis, Inc. | Tgr5 agonists |
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2012
- 2012-04-27 US US14/113,593 patent/US9062028B2/en active Active
- 2012-04-27 JP JP2014508573A patent/JP2014518853A/ja active Pending
- 2012-04-27 CN CN201280031836.7A patent/CN103619817A/zh active Pending
- 2012-04-27 EP EP12723982.0A patent/EP2702042A1/en not_active Withdrawn
- 2012-04-27 WO PCT/US2012/035327 patent/WO2012149236A1/en not_active Ceased
- 2012-04-27 TW TW101115262A patent/TW201247627A/zh unknown
Patent Citations (5)
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| JPH07242663A (ja) * | 1994-03-01 | 1995-09-19 | Yoshitomi Pharmaceut Ind Ltd | ベンゾオキサジン化合物 |
| JP2006063064A (ja) * | 2004-07-27 | 2006-03-09 | Takeda Chem Ind Ltd | 受容体作動剤 |
| WO2010016552A1 (ja) * | 2008-08-07 | 2010-02-11 | 武田薬品工業株式会社 | 過敏性腸症候群治療薬 |
| WO2010107768A1 (en) * | 2009-03-18 | 2010-09-23 | Schering Corporation | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase |
| WO2010107765A1 (en) * | 2009-03-18 | 2010-09-23 | Schering Corporation | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020512332A (ja) * | 2017-03-22 | 2020-04-23 | シンジェンタ パーティシペーションズ アーゲー | 殺有害生物的に活性なシクロプロピルメチルアミド誘導体 |
| JP7149955B2 (ja) | 2017-03-22 | 2022-10-07 | シンジェンタ パーティシペーションズ アーゲー | 殺有害生物的に活性なシクロプロピルメチルアミド誘導体 |
Also Published As
| Publication number | Publication date |
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| US9062028B2 (en) | 2015-06-23 |
| WO2012149236A1 (en) | 2012-11-01 |
| TW201247627A (en) | 2012-12-01 |
| EP2702042A1 (en) | 2014-03-05 |
| CN103619817A (zh) | 2014-03-05 |
| US20140080788A1 (en) | 2014-03-20 |
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