JP2014518377A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014518377A5 JP2014518377A5 JP2014513712A JP2014513712A JP2014518377A5 JP 2014518377 A5 JP2014518377 A5 JP 2014518377A5 JP 2014513712 A JP2014513712 A JP 2014513712A JP 2014513712 A JP2014513712 A JP 2014513712A JP 2014518377 A5 JP2014518377 A5 JP 2014518377A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- jcv
- determined
- vla
- therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090001123 antibodies Proteins 0.000 claims description 129
- 102000004965 antibodies Human genes 0.000 claims description 129
- 241000701460 JC polyomavirus Species 0.000 claims description 71
- 238000002560 therapeutic procedure Methods 0.000 claims description 71
- 206010036807 Progressive multifocal leukoencephalopathy Diseases 0.000 claims description 70
- 230000002401 inhibitory effect Effects 0.000 claims description 64
- 239000000523 sample Substances 0.000 claims description 61
- 239000012472 biological sample Substances 0.000 claims description 31
- 239000011541 reaction mixture Substances 0.000 claims description 24
- 239000003018 immunosuppressive agent Substances 0.000 claims description 20
- 239000000758 substrate Substances 0.000 claims description 19
- 238000004166 bioassay Methods 0.000 claims description 18
- 238000002650 immunosuppressive therapy Methods 0.000 claims description 10
- 108010035649 Natalizumab Proteins 0.000 claims description 9
- 229960005027 natalizumab Drugs 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 7
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- 238000003018 immunoassay Methods 0.000 claims description 6
- 108010072051 Glatiramer Acetate Proteins 0.000 claims description 5
- 102000014150 Interferons Human genes 0.000 claims description 5
- 108010050904 Interferons Proteins 0.000 claims description 5
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-aminopentanedioic acid;(2S)-2-aminopropanoic acid;(2S)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims description 5
- 239000003246 corticosteroid Substances 0.000 claims description 5
- 229960003776 glatiramer acetate Drugs 0.000 claims description 5
- 229940079322 interferon Drugs 0.000 claims description 5
- 230000036462 Unbound Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000001861 immunosuppresant Effects 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 102000038129 antigens Human genes 0.000 claims description 3
- 108091007172 antigens Proteins 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000002965 ELISA Methods 0.000 claims description 2
- 238000009175 antibody therapy Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drugs Drugs 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims 2
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 1
- 230000002596 correlated Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 210000002966 Serum Anatomy 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
- 239000000463 material Substances 0.000 description 2
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-N,N-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161491810P | 2011-05-31 | 2011-05-31 | |
US61/491,810 | 2011-05-31 | ||
US201161508584P | 2011-07-15 | 2011-07-15 | |
US61/508,584 | 2011-07-15 | ||
US201161550257P | 2011-10-21 | 2011-10-21 | |
US61/550,257 | 2011-10-21 | ||
US201261636588P | 2012-04-20 | 2012-04-20 | |
US61/636,588 | 2012-04-20 | ||
PCT/US2012/040283 WO2012166971A2 (en) | 2011-05-31 | 2012-05-31 | Method of assessing risk of pml |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017144730A Division JP6663396B2 (ja) | 2011-05-31 | 2017-07-26 | Pmlの危険性を査定する方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014518377A JP2014518377A (ja) | 2014-07-28 |
JP2014518377A5 true JP2014518377A5 (US07794700-20100914-C00194.png) | 2015-07-23 |
JP6243838B2 JP6243838B2 (ja) | 2017-12-06 |
Family
ID=47260338
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014513712A Active JP6243838B2 (ja) | 2011-05-31 | 2012-05-31 | Pmlの危険性を査定する方法 |
JP2017144730A Active JP6663396B2 (ja) | 2011-05-31 | 2017-07-26 | Pmlの危険性を査定する方法 |
JP2020023062A Active JP7128221B2 (ja) | 2011-05-31 | 2020-02-14 | Pmlの危険性を査定する方法 |
JP2021168084A Active JP7353338B2 (ja) | 2011-05-31 | 2021-10-13 | Pmlの危険性を査定する方法 |
JP2023151467A Pending JP2023169307A (ja) | 2011-05-31 | 2023-09-19 | Pmlの危険性を査定する方法 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017144730A Active JP6663396B2 (ja) | 2011-05-31 | 2017-07-26 | Pmlの危険性を査定する方法 |
JP2020023062A Active JP7128221B2 (ja) | 2011-05-31 | 2020-02-14 | Pmlの危険性を査定する方法 |
JP2021168084A Active JP7353338B2 (ja) | 2011-05-31 | 2021-10-13 | Pmlの危険性を査定する方法 |
JP2023151467A Pending JP2023169307A (ja) | 2011-05-31 | 2023-09-19 | Pmlの危険性を査定する方法 |
Country Status (19)
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2676967T (lt) | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
KR20080104343A (ko) | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
CA2776756A1 (en) | 2009-10-11 | 2011-04-14 | Biogen Idec Ma Inc. | Anti-vla-4 related assays |
LT3339865T (lt) | 2010-01-11 | 2022-12-12 | Biogen Ma Inc. | Tyrimas, skirtas antikūnams prieš jc virusą nustatyti |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
JP6243838B2 (ja) | 2011-05-31 | 2017-12-06 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Pmlの危険性を査定する方法 |
EP3004334A4 (en) * | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
US20160223565A1 (en) * | 2013-09-18 | 2016-08-04 | The Johns Hopkins University | Bk virus serology assessment of progressive multifocal leukoencephalopathy (pml) risk |
EP3757224A3 (en) | 2014-02-27 | 2021-03-17 | Biogen MA Inc. | Method of assessing risk of pml |
MA40985A (fr) | 2014-11-17 | 2017-09-26 | Biogen Ma Inc | Méthodes de traitement de la sclérose en plaques |
EP3700931A1 (en) | 2017-10-26 | 2020-09-02 | Biogen MA Inc. | Extended interval dosing of natalizumab |
MX2023005596A (es) | 2020-11-14 | 2023-08-15 | Biogen Ma Inc | Regímenes de dosificación bifásica subcutánea para anticuerpos anti-vla-4. |
CA3215371A1 (en) | 2021-04-13 | 2022-10-20 | Shibeshih Mitiku BELACHEW | Compositions and methods for treating chronic active white matter lesions / radiologically isolated syndrome |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4517288A (en) | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
US4703017C1 (en) | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
US5763262A (en) | 1986-09-18 | 1998-06-09 | Quidel Corporation | Immunodiagnostic device |
EP0560411B1 (en) | 1987-04-27 | 2000-07-26 | Unilever N.V. | Specific binding assays |
US4943522A (en) | 1987-06-01 | 1990-07-24 | Quidel | Lateral flow, non-bibulous membrane assay protocols |
US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
US4818677A (en) | 1987-12-03 | 1989-04-04 | Monoclonal Antibodies, Inc. | Membrane assay using focused sample application |
AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
US5221616A (en) | 1988-07-15 | 1993-06-22 | Quidel Corporation | Prevention of spontaneous complement activation in mammalian biological fluids |
US5118630A (en) | 1988-11-04 | 1992-06-02 | Quidel Corporation | Method for determining periodic infertility in females |
US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
US6033665A (en) | 1989-09-27 | 2000-03-07 | Elan Pharmaceuticals, Inc. | Compositions and methods for modulating leukocyte adhesion to brain endothelial cells |
US5084828A (en) | 1989-09-29 | 1992-01-28 | Healthtech Services Corp. | Interactive medication delivery system |
US5252496A (en) | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
US5096837A (en) | 1990-02-08 | 1992-03-17 | Pacific Biotech, Inc. | Immunochromatographic assay and method of using same |
US5223220A (en) | 1990-03-27 | 1993-06-29 | Pacific Biotech, Inc. | Solid phase immunoassay device and method of making same |
US5118428A (en) | 1990-11-13 | 1992-06-02 | Quidel | Method to remove red blood cells from whole blood samples |
DE4139840B4 (de) | 1990-12-04 | 2005-06-02 | Quidel Corp., San Diego | Antigen-Zubereitung zum Nachweis von H. pylori |
EP0566695B1 (en) | 1991-01-11 | 1999-06-02 | Quidel Corporation | A one-step lateral flow assay and nonbibulous support used therein |
US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
US5225328A (en) | 1991-05-30 | 1993-07-06 | Quidel Corporation | Stable alkaline phosphatase compositions with color enhancement and their use in assays |
US5686315A (en) | 1991-06-14 | 1997-11-11 | Quidel Corporation | Assay device for one step detection of analyte |
WO1993015217A1 (en) | 1992-02-04 | 1993-08-05 | Quidel Corporation | Simplified extraction method for bacterial antigens using dried reagents |
US5541069A (en) | 1992-02-28 | 1996-07-30 | Quidel Corporation | Assay having improved dose response curve |
DE69329377T2 (de) | 1992-03-10 | 2001-04-05 | Quidel Corp., San Diego | Trennmittel für rote blutkörperchen bei untersuchungen mit spezifischer bindung |
NZ261259A (en) | 1993-01-12 | 1996-12-20 | Biogen Inc | Humanised recombinant anti-vla4 antibody and diagnostic compositions and medicaments |
US5415994A (en) | 1993-08-02 | 1995-05-16 | Quidel Corporation | Lateral flow medical diagnostic assay device with sample extraction means |
US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
US5434057A (en) | 1994-02-02 | 1995-07-18 | Quidel Corporation | Sperm motility assay and devices |
US5521102A (en) | 1994-08-08 | 1996-05-28 | Quidel Corporation | Controlled sensitivity immunochromatographic assay |
US5845255A (en) | 1994-10-28 | 1998-12-01 | Advanced Health Med-E-Systems Corporation | Prescription management system |
US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
US5712172A (en) | 1995-05-18 | 1998-01-27 | Wyntek Diagnostics, Inc. | One step immunochromatographic device and method of use |
US5804452A (en) | 1995-04-27 | 1998-09-08 | Quidel Corporation | One step urine creatinine assays |
US5786220A (en) | 1995-04-28 | 1998-07-28 | Quidel Corporation | Assays and devices for distinguishing between normal and abnormal pregnancy |
US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
US5773234A (en) | 1995-08-07 | 1998-06-30 | Quidel Corporation | Method and device for chlamydia detection |
DE19543553B4 (de) | 1995-11-22 | 2009-04-09 | Deutsches Primatenzentrum Gmbh | VP-Antigene des JC-Virus |
NZ512006A (en) | 1996-02-09 | 2005-05-27 | Abbott Biotech Ltd | Medical treatment with human TNF-alpha antibodies |
US6305377B1 (en) | 1996-12-12 | 2001-10-23 | Michael T. Portwood | System and method for improving compliance of a medical regimen |
US6229011B1 (en) | 1997-08-22 | 2001-05-08 | Hoffman-La Roche Inc. | N-aroylphenylalanine derivative VCAM-1 inhibitors |
US6306642B1 (en) | 1997-11-24 | 2001-10-23 | Quidel Corporation | Enzyme substrate delivery and product registration in one step enzyme immunoassays |
US6623981B2 (en) | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
US6014631A (en) | 1998-04-02 | 2000-01-11 | Merck-Medco Managed Care, Llc | Computer implemented patient medication review system and process for the managed care, health care and/or pharmacy industry |
US6045501A (en) | 1998-08-28 | 2000-04-04 | Celgene Corporation | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug |
US6407066B1 (en) | 1999-01-26 | 2002-06-18 | Elan Pharmaceuticals, Inc. | Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US7171371B2 (en) | 1999-09-03 | 2007-01-30 | Smg Trust | Method and system for providing pre and post operative support and care |
DK1232392T3 (da) | 1999-10-12 | 2003-07-28 | Connex Ges Zur Optimierung Von | Forbedret fremgangsmåde til påvisning af syreresistente bakterier af slægten Helicobacter i afføring |
US6388084B1 (en) | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
EP1242118B1 (en) | 1999-12-16 | 2009-11-11 | Biogen Idec MA Inc. | Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists |
CN1400968A (zh) | 2000-01-27 | 2003-03-05 | 美国氰胺公司 | 制备α-磺酰基异羟肟酸衍生物的方法 |
US20040248216A1 (en) | 2000-03-30 | 2004-12-09 | Yuko Seino | Method of examining cancer by assaying autoantibody against mdm2 and reagent therefor |
US6620626B1 (en) | 2000-08-09 | 2003-09-16 | Mission Research Corp. | Antigen detection device and method |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
DE60135147D1 (de) | 2000-10-17 | 2008-09-11 | Besst Test Aps | Nen biologischen zelle in einer körperflüssigkeitsprobe |
US6315720B1 (en) | 2000-10-23 | 2001-11-13 | Celgene Corporation | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug |
US6485460B2 (en) | 2001-01-12 | 2002-11-26 | Bracco Diagnostics, Inc. | Tamper evident syringe barrel |
EP1419387B1 (en) | 2001-08-20 | 2012-01-04 | Proteome Systems Ltd. | Diagnostic testing process |
WO2003016902A1 (en) | 2001-08-20 | 2003-02-27 | Proteome Systems Intellectual Property Pty Ltd | Diagnostic testing process and apparatus |
US6605602B1 (en) | 2001-09-28 | 2003-08-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method of treating BK virus nephropathy |
CA2478547C (en) * | 2001-12-03 | 2011-09-20 | Abgenix, Inc. | Identification of high affinity molecules by limited dilution screening |
US20040009169A1 (en) | 2002-02-25 | 2004-01-15 | Julie Taylor | Administration of agents for the treatment of inflammation |
TWI281470B (en) | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
TW200307671A (en) | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
AU2003243642A1 (en) | 2002-06-21 | 2004-01-06 | Mckesson Automation Inc. | Closed loop medication use system and method |
WO2005052567A1 (en) | 2003-11-24 | 2005-06-09 | Biogen Idec Ma Inc. | Methods for detecting half-antibodies using chip-based gel electrophoresis |
JP4672263B2 (ja) | 2004-01-27 | 2011-04-20 | デンカ生研株式会社 | 簡便な検出法、検出装置及び検出キットとその製法 |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
TWI556829B (zh) | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
US20050283385A1 (en) | 2004-06-21 | 2005-12-22 | The Permanente Medical Group, Inc. | Individualized healthcare management system |
KR101273614B1 (ko) | 2004-07-08 | 2013-06-12 | 엘란 파마슈티칼스, 인크. | 중합체 부분을 포함하는 다가 vla―4 길항제 |
CA2478458A1 (en) | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
CA2589379A1 (en) | 2004-12-03 | 2006-06-08 | Biogen Idec Ma Inc. | Delaying or preventing onset of multiple sclerosis |
WO2006112951A2 (en) | 2005-03-03 | 2006-10-26 | Seedlings Life Science Ventures, Llc | Method of risk management for patients undergoing natalizumab treatment |
EP1872136B9 (en) | 2005-04-04 | 2023-02-08 | Biogen MA Inc. | Methods and products for evaluating an immune response to a therapeutic protein |
US8785401B2 (en) * | 2005-07-08 | 2014-07-22 | Philadelphia Health & Education Corporation | Methods for treating diseases having an inflammatory component related to phospholipase A2 |
EA015388B1 (ru) | 2005-09-29 | 2011-08-30 | Элан Фамэсьютикэлс, Инк. | ПИРИМИДИНИЛАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ВКЛЮЧАЮЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО α4-ИНТЕГРИНАМИ |
NZ570679A (en) | 2006-02-27 | 2011-01-28 | Elan Pharm Inc | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated By VLA-4 |
LT2676967T (lt) * | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
WO2007100763A2 (en) | 2006-02-28 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds |
KR20080104343A (ko) | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
WO2008021954A2 (en) * | 2006-08-09 | 2008-02-21 | Biogen Idec Ma Inc. | Method for distribution of a drug |
TWI415845B (zh) * | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物 |
EP2089515A4 (en) | 2006-11-16 | 2011-02-23 | Novavax Inc | VIRUSUAL PARTICLES OF RESPIRATORY SYNZYTIAL VIRUS |
EP1933140B1 (en) | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Antibody detection method involving an oligonucleotide enhanced collodial gold signal |
TW200846363A (en) * | 2007-03-22 | 2008-12-01 | Urrma R & B | Novel human anti-R7V antibodies and uses thereof |
FR2919804B1 (fr) * | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
ES2781754T3 (es) * | 2008-11-07 | 2020-09-07 | Adaptive Biotechnologies Corp | Métodos para supervisar las condiciones por análisis de secuencia |
ES2842425T3 (es) | 2009-02-05 | 2021-07-14 | Biogen Ma Inc | Métodos para la detección del poliomavirus JC |
CN102326080B (zh) | 2009-02-20 | 2015-08-05 | 加利福尼亚大学董事会 | A+生物标志物的试验 |
LT3339865T (lt) * | 2010-01-11 | 2022-12-12 | Biogen Ma Inc. | Tyrimas, skirtas antikūnams prieš jc virusą nustatyti |
JP6243838B2 (ja) | 2011-05-31 | 2017-12-06 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Pmlの危険性を査定する方法 |
EP3004334A4 (en) * | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
-
2012
- 2012-05-31 JP JP2014513712A patent/JP6243838B2/ja active Active
- 2012-05-31 DK DK19169482.7T patent/DK3575792T3/da active
- 2012-05-31 KR KR1020137031996A patent/KR102039751B1/ko active IP Right Grant
- 2012-05-31 EP EP19169482.7A patent/EP3575792B1/en active Active
- 2012-05-31 HU HUE12792375A patent/HUE043339T2/hu unknown
- 2012-05-31 CA CA2836490A patent/CA2836490A1/en active Pending
- 2012-05-31 PT PT12792375T patent/PT2715352T/pt unknown
- 2012-05-31 HR HRP20230186TT patent/HRP20230186T1/hr unknown
- 2012-05-31 HU HUE19169482A patent/HUE061244T2/hu unknown
- 2012-05-31 PT PT191694827T patent/PT3575792T/pt unknown
- 2012-05-31 SI SI201231596T patent/SI2715352T1/sl unknown
- 2012-05-31 WO PCT/US2012/040283 patent/WO2012166971A2/en active Application Filing
- 2012-05-31 ES ES19169482T patent/ES2939482T3/es active Active
- 2012-05-31 AU AU2012262122A patent/AU2012262122B2/en active Active
- 2012-05-31 PL PL12792375T patent/PL2715352T3/pl unknown
- 2012-05-31 CN CN201280026045.5A patent/CN103635803A/zh active Pending
- 2012-05-31 EP EP22209669.5A patent/EP4187248A1/en active Pending
- 2012-05-31 LT LTEP12792375.3T patent/LT2715352T/lt unknown
- 2012-05-31 PL PL19169482.7T patent/PL3575792T3/pl unknown
- 2012-05-31 KR KR1020197031074A patent/KR102292563B1/ko active IP Right Grant
- 2012-05-31 FI FIEP19169482.7T patent/FI3575792T3/fi active
- 2012-05-31 KR KR1020217026042A patent/KR102473834B1/ko active IP Right Grant
- 2012-05-31 DK DK12792375.3T patent/DK2715352T3/da active
- 2012-05-31 ES ES12792375T patent/ES2729945T3/es active Active
- 2012-05-31 RS RS20230142A patent/RS63989B1/sr unknown
- 2012-05-31 RS RS20190690A patent/RS58967B1/sr unknown
- 2012-05-31 EP EP12792375.3A patent/EP2715352B1/en not_active Revoked
- 2012-05-31 SI SI201232024T patent/SI3575792T1/sl unknown
- 2012-05-31 LT LTEP19169482.7T patent/LT3575792T/lt unknown
-
2017
- 2017-07-26 JP JP2017144730A patent/JP6663396B2/ja active Active
-
2018
- 2018-12-05 US US16/211,154 patent/US12105090B2/en active Active
-
2019
- 2019-05-09 HR HRP20190860TT patent/HRP20190860T1/hr unknown
- 2019-06-03 CY CY20191100584T patent/CY1121981T1/el unknown
-
2020
- 2020-02-14 JP JP2020023062A patent/JP7128221B2/ja active Active
-
2021
- 2021-08-03 US US17/393,335 patent/US12066442B2/en active Active
- 2021-10-13 JP JP2021168084A patent/JP7353338B2/ja active Active
-
2023
- 2023-09-19 JP JP2023151467A patent/JP2023169307A/ja active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2014518377A5 (US07794700-20100914-C00194.png) | ||
Gorelik et al. | Anti‐JC virus antibodies: implications for PML risk stratification | |
AU2015217261B2 (en) | Assays for detecting the presence or amount of an anti-drug antibody | |
Bloem et al. | Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients | |
ES2729945T3 (es) | Procedimiento para valorar el riesgo de LMP | |
JP2019535015A5 (US07794700-20100914-C00194.png) | ||
Fialová et al. | Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis | |
JP2019530875A5 (US07794700-20100914-C00194.png) | ||
JP6756611B2 (ja) | 中和抗体を検出するための競合リガンド結合アッセイ | |
HRP20221390T1 (hr) | Analiza za antitijela jc virusa | |
JP2020522685A5 (US07794700-20100914-C00194.png) | ||
JP2013516633A5 (US07794700-20100914-C00194.png) | ||
EP2952896B1 (en) | Method for reducing false negatives in immunoassay for assaying biomembrane-derived specimen | |
JP2020537128A5 (US07794700-20100914-C00194.png) | ||
Plavina et al. | Multi-site analytical validation of an assay to detect anti-JCV antibodies in human serum and plasma | |
Jia et al. | Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B | |
Liu et al. | Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia | |
JP2015505371A5 (US07794700-20100914-C00194.png) | ||
Lodhia et al. | Updates in therapeutic drug monitoring in inflammatory bowel disease | |
McGrath et al. | Effect-based proteomic detection of growth promoter abuse | |
Kaysheva et al. | Mass spectrometric detection of the amino acid sequence polymorphism of the hepatitis C virus antigen | |
JP2013511728A5 (US07794700-20100914-C00194.png) | ||
JPWO2018181263A1 (ja) | 体液による抗原抗体反応阻害を防止する物質 | |
Lim et al. | On optimizing the blocking step of indirect enzyme-linked immunosorbent assay for Epstein-Barr virus serology | |
JP2015025787A (ja) | ハプテンの測定方法 |