HRP20230186T1 - METODA PROCJENE RIZIKA OD PML-a - Google Patents
METODA PROCJENE RIZIKA OD PML-a Download PDFInfo
- Publication number
- HRP20230186T1 HRP20230186T1 HRP20230186TT HRP20230186T HRP20230186T1 HR P20230186 T1 HRP20230186 T1 HR P20230186T1 HR P20230186T T HRP20230186T T HR P20230186TT HR P20230186 T HRP20230186 T HR P20230186T HR P20230186 T1 HRP20230186 T1 HR P20230186T1
- Authority
- HR
- Croatia
- Prior art keywords
- patient
- jcv antibody
- determined
- therapy
- antibody titer
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 11
- 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 claims 7
- 230000005764 inhibitory process Effects 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 5
- 238000002560 therapeutic procedure Methods 0.000 claims 5
- 238000002650 immunosuppressive therapy Methods 0.000 claims 4
- 229960005027 natalizumab Drugs 0.000 claims 4
- 239000011541 reaction mixture Substances 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 229960002170 azathioprine Drugs 0.000 claims 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 2
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical group O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 2
- 229960001156 mitoxantrone Drugs 0.000 claims 2
- 229940014456 mycophenolate Drugs 0.000 claims 2
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 2
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 2
- 239000013641 positive control Substances 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Claims (9)
1. Metoda procjene pacijentovog rizika od razvoja progresivne multifokalne leukoencefalopatije (PML), metoda sadrži:
i) utvrđivanje, u uzorku seruma ili plazme pacijenta, titra anti-JC virusa (JCV) antitijela, pri čemu se titar anti-JCV antitijela određuje ELISA testom koji sadrži sljedeće korake:
(a) formiranje reakcijske mješavine koja se sastoji od alikvota uzorka i supstrata na koji su odložene visoko pročišćene čestice slične virusima (HPVLP), i
(b) detektiranje razine anti-JCV antitijela vezanog za navedeni supstrat na kojem se nalazi HPVLP-ovi;
pri čemu se titar anti-JCV antitijela izražava kao vrijednost indeksa, pri čemu se vrijednost indeksa određuje normalizacijom vrijednosti optičke gustoće (OD) uzorka na granični kalibrator podešen da ima nOD od 1, i pozitivna kontrola je podešena da ima nOD od 1.3; pri čemu se granični kalibrator i pozitivna kontrola sadrže mješavinu seruma pozitivnog na anti-JCV antitijela i seruma negativnog na anti-JCV antitijela, i pri čemu negativna kontrola sadrži serum negativan na anti-JCV antitijela i ima nOD od 0.1;
i
ii) utvrđivanje bolesnika s visokim rizikom od razvoja PML-a ako se utvrdi da je vrijednost indeksa anti-JCV antitijela > 1.5.
2. Metoda prema zahtjevu 1, naznačena time što
titar anti-JCV antitijela je izražen kao vrijednost indeksa za prvu reakcijsku mješavinu koja sadrži prvi alikvot uzorka seruma ili plazme pacijenta i supstrat na koji je odložen HPVLP; i
u drugom koraku, % inhibicije koji ukazuje na stupanj do kojeg inkubacija s HPVLP-om topive faze smanjuje razinu nevezanog anti-JCV antitijela koje se veže na HPVLP raspoređeno na supstrat u usporedbi s prvom reakcijskom mješavinom, određuje se u drugu reakcijsku mješavinu koja sadrži drugi alikvot uzorka seruma ili plazme pacijenta i supstrat na koji je odložen HPVLP; i
utvrđivanje pacijenta s visokim rizikom od razvoja PML-a ako se utvrdi da je vrijednost indeksa anti-JCV antitijela > 1.5, i % inhibicije > 70 %.
3. Metoda prema zahtjevu 1 ili zahtjevu 2, naznačena time što se titar anti-JCV antitijela ili % inhibicije određuje prije primjene natalizumaba.
4. Metoda prema bilo kojem od zahtjeva 1 do 3, naznačena time što se titar anti-JCV antitijela ili % inhibicije određuje nakon što je pacijent započeo liječenje s natalizumabom.
5. Metoda prema bilo kojem od zahtjeva 1 do 4, koja nadalje sadrži:
(a) utvrđivanje je li pacijent primao terapiju natalizumabom dulje od 24 mjeseca; ili
(b) utvrđivanje je li pacijent primio terapiju imunosupresivima koji nisu anti-VLA-4, pri čemu je terapija imunosupresivima koji nisu anti-VLA-4 odabrana između mitoksantrona, metotreksata, azatioprina, ciklofosfamida, mikofenolata, anti-CD20 terapije, anti -CD11a terapije, i mikofenolat mofetila.
6. Metoda prema bilo kojem od zahtjeva 1 do 5, naznačena time što se titar anti-JCV antitijela ili % inhibicije ponovno testira u intervalima od 6 ili 12 mjeseci.
7. Metoda prema zahtjevu 6, naznačena time što povećanje titra anti-JCV antitijela ili % inhibicije ukazuje na povećanje pacijentovog rizika od razvoja PML-a.
8. Metoda prema bilo kojem od zahtjeva 1 do 7, naznačena time što pacijent ima multiplu sklerozu.
9. Metoda prema bilo kojem od zahtjeva 1 do 8, naznačena time što se za pacijenta za kojeg je utvrđeno da ima visok rizik od razvoja PML-a utvrđuje da ima veći rizik od razvoja PML-a ako je pacijent primao natalizumab dulje od 24 mjeseca i prethodno nije primao terapiju imunosupresivima koji nisu anti-VLA-4, pri čemu je terapija imunosupresivima koji nisu anti-VLA-4 odabrana između mitoksantrona, metotreksata, azatioprina, ciklofosfamida, mikofenolat, anti-CD20 terapije, anti-CD11a terapije, i mikofenolat mofetila.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161491810P | 2011-05-31 | 2011-05-31 | |
US201161508584P | 2011-07-15 | 2011-07-15 | |
US201161550257P | 2011-10-21 | 2011-10-21 | |
US201261636588P | 2012-04-20 | 2012-04-20 | |
EP19169482.7A EP3575792B1 (en) | 2011-05-31 | 2012-05-31 | Method of assessing risk of pml |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20230186T1 true HRP20230186T1 (hr) | 2023-03-31 |
Family
ID=47260338
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20230186TT HRP20230186T1 (hr) | 2011-05-31 | 2012-05-31 | METODA PROCJENE RIZIKA OD PML-a |
HRP20190860TT HRP20190860T1 (hr) | 2011-05-31 | 2019-05-09 | POSTUPAK PROCJENJIVANJA RIZIKA OD PML-a |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190860TT HRP20190860T1 (hr) | 2011-05-31 | 2019-05-09 | POSTUPAK PROCJENJIVANJA RIZIKA OD PML-a |
Country Status (19)
Country | Link |
---|---|
US (2) | US20190227064A1 (hr) |
EP (3) | EP2715352B1 (hr) |
JP (5) | JP6243838B2 (hr) |
KR (3) | KR102292563B1 (hr) |
CN (1) | CN103635803A (hr) |
AU (1) | AU2012262122B2 (hr) |
CA (1) | CA2836490A1 (hr) |
CY (1) | CY1121981T1 (hr) |
DK (2) | DK3575792T3 (hr) |
ES (2) | ES2939482T3 (hr) |
FI (1) | FI3575792T3 (hr) |
HR (2) | HRP20230186T1 (hr) |
HU (2) | HUE043339T2 (hr) |
LT (2) | LT3575792T (hr) |
PL (2) | PL2715352T3 (hr) |
PT (2) | PT3575792T (hr) |
RS (2) | RS58967B1 (hr) |
SI (2) | SI2715352T1 (hr) |
WO (1) | WO2012166971A2 (hr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
EP1991267B1 (en) | 2006-03-03 | 2017-12-20 | Biogen MA Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
WO2011044553A1 (en) | 2009-10-11 | 2011-04-14 | Biogen Idec Ma Inc. | Anti-vla-4 related assays |
EP4152004A1 (en) | 2010-01-11 | 2023-03-22 | Biogen MA Inc. | Assay for jc virus antibodies |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
CN103635803A (zh) | 2011-05-31 | 2014-03-12 | 比奥根艾迪克Ma公司 | 评估进行性多灶性白质脑病风险的方法 |
EP3004334A4 (en) * | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
WO2015042254A1 (en) * | 2013-09-18 | 2015-03-26 | The Johns Hopkins University | Bk virus serology assessment of progressive multifocal leukoencephalopathy (pml) risk |
EP3110976B1 (en) * | 2014-02-27 | 2020-05-13 | Biogen MA Inc. | Method of assessing risk of pml |
MA40985A (fr) | 2014-11-17 | 2017-09-26 | Biogen Ma Inc | Méthodes de traitement de la sclérose en plaques |
JP2021501152A (ja) | 2017-10-26 | 2021-01-14 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | ナタリズマブの延長間隔投与 |
AU2021378813A1 (en) | 2020-11-14 | 2023-06-22 | Biogen Ma Inc. | Biphasic subcutaneous dosing regimens for anti-vla-4 antibodies |
CA3215371A1 (en) | 2021-04-13 | 2022-10-20 | Shibeshih Mitiku BELACHEW | Compositions and methods for treating chronic active white matter lesions / radiologically isolated syndrome |
Family Cites Families (21)
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NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
DE19543553B4 (de) | 1995-11-22 | 2009-04-09 | Deutsches Primatenzentrum Gmbh | VP-Antigene des JC-Virus |
SI9720020B (en) | 1996-02-09 | 2001-12-31 | Basf Ag | Human antibodies that bind human TNF alpha |
BR0107862A (pt) | 2000-01-27 | 2002-11-05 | American Cyanamid Co | Método para a preparação de derivados do ácido alfa-sulfonil hidroxâmico |
US7972775B2 (en) * | 2005-03-03 | 2011-07-05 | Seedlings Life Science Ventures, Llc | Method of risk management for patients undergoing Natalizumab treatment |
EP1915613A4 (en) * | 2005-07-08 | 2008-11-05 | Philadelphia Health & Educatio | METHOD FOR MONITORING THE NEUROINFLAMMATORY DESTRUCTION OF NEURONS AND FOR THE TREATMENT OF DISEASES COMPRISING A COMPOSITION COMPONENT RELATED TO PHOSPHOLIPASE A2 |
HUE047230T2 (hu) | 2006-02-28 | 2020-04-28 | Biogen Ma Inc | Gyulladásos és autoimmun betegségek natalizumabbal való kezelésének módszerei |
WO2008021954A2 (en) * | 2006-08-09 | 2008-02-21 | Biogen Idec Ma Inc. | Method for distribution of a drug |
TWI415845B (zh) * | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物 |
FR2919804B1 (fr) * | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
EP2719774B8 (en) * | 2008-11-07 | 2020-04-22 | Adaptive Biotechnologies Corporation | Methods of monitoring conditions by sequence analysis |
EP4152004A1 (en) * | 2010-01-11 | 2023-03-22 | Biogen MA Inc. | Assay for jc virus antibodies |
CN103635803A (zh) | 2011-05-31 | 2014-03-12 | 比奥根艾迪克Ma公司 | 评估进行性多灶性白质脑病风险的方法 |
EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
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2012
- 2012-05-31 CN CN201280026045.5A patent/CN103635803A/zh active Pending
- 2012-05-31 LT LTEP19169482.7T patent/LT3575792T/lt unknown
- 2012-05-31 ES ES19169482T patent/ES2939482T3/es active Active
- 2012-05-31 EP EP12792375.3A patent/EP2715352B1/en not_active Revoked
- 2012-05-31 HU HUE12792375A patent/HUE043339T2/hu unknown
- 2012-05-31 KR KR1020197031074A patent/KR102292563B1/ko active IP Right Grant
- 2012-05-31 SI SI201231596T patent/SI2715352T1/sl unknown
- 2012-05-31 PT PT191694827T patent/PT3575792T/pt unknown
- 2012-05-31 KR KR1020217026042A patent/KR102473834B1/ko active IP Right Grant
- 2012-05-31 HU HUE19169482A patent/HUE061244T2/hu unknown
- 2012-05-31 ES ES12792375T patent/ES2729945T3/es active Active
- 2012-05-31 JP JP2014513712A patent/JP6243838B2/ja active Active
- 2012-05-31 LT LTEP12792375.3T patent/LT2715352T/lt unknown
- 2012-05-31 AU AU2012262122A patent/AU2012262122B2/en active Active
- 2012-05-31 RS RS20190690A patent/RS58967B1/sr unknown
- 2012-05-31 RS RS20230142A patent/RS63989B1/sr unknown
- 2012-05-31 PL PL12792375T patent/PL2715352T3/pl unknown
- 2012-05-31 DK DK19169482.7T patent/DK3575792T3/da active
- 2012-05-31 KR KR1020137031996A patent/KR102039751B1/ko active IP Right Grant
- 2012-05-31 CA CA2836490A patent/CA2836490A1/en active Pending
- 2012-05-31 FI FIEP19169482.7T patent/FI3575792T3/fi active
- 2012-05-31 PL PL19169482.7T patent/PL3575792T3/pl unknown
- 2012-05-31 DK DK12792375.3T patent/DK2715352T3/da active
- 2012-05-31 SI SI201232024T patent/SI3575792T1/sl unknown
- 2012-05-31 PT PT12792375T patent/PT2715352T/pt unknown
- 2012-05-31 WO PCT/US2012/040283 patent/WO2012166971A2/en active Application Filing
- 2012-05-31 EP EP19169482.7A patent/EP3575792B1/en active Active
- 2012-05-31 EP EP22209669.5A patent/EP4187248A1/en active Pending
- 2012-05-31 HR HRP20230186TT patent/HRP20230186T1/hr unknown
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2017
- 2017-07-26 JP JP2017144730A patent/JP6663396B2/ja active Active
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2018
- 2018-12-05 US US16/211,154 patent/US20190227064A1/en not_active Abandoned
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2019
- 2019-05-09 HR HRP20190860TT patent/HRP20190860T1/hr unknown
- 2019-06-03 CY CY20191100584T patent/CY1121981T1/el unknown
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2020
- 2020-02-14 JP JP2020023062A patent/JP7128221B2/ja active Active
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2021
- 2021-08-03 US US17/393,335 patent/US20220011310A1/en active Pending
- 2021-10-13 JP JP2021168084A patent/JP7353338B2/ja active Active
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2023
- 2023-09-19 JP JP2023151467A patent/JP2023169307A/ja active Pending
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