JP2014517692A - ヘパラン−ｎ−スルファターゼを精製するためのプロセス - Google Patents

ヘパラン−ｎ−スルファターゼを精製するためのプロセス Download PDF

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Publication number
JP2014517692A
JP2014517692A JP2014511591A JP2014511591A JP2014517692A JP 2014517692 A JP2014517692 A JP 2014517692A JP 2014511591 A JP2014511591 A JP 2014511591A JP 2014511591 A JP2014511591 A JP 2014511591A JP 2014517692 A JP2014517692 A JP 2014517692A
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Prior art keywords
hns
heparan
sulfatase
column
resin
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JP2014511591A
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Japanese (ja)
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JP2014517692A5 (enExample
Inventor
デイビッド ニコルス，
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シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド
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Publication of JP2014517692A publication Critical patent/JP2014517692A/ja
Publication of JP2014517692A5 publication Critical patent/JP2014517692A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2014511591A 2011-05-19 2012-05-18 ヘパラン−ｎ−スルファターゼを精製するためのプロセス Ceased JP2014517692A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488090P 2011-05-19 2011-05-19
US61/488,090 2011-05-19
PCT/US2012/038630 WO2012159053A1 (en) 2011-05-19 2012-05-18 Process for purifying heparan-n-sulfatase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016214041A Division JP2017029170A (ja) 2011-05-19 2016-11-01 ヘパラン−ｎ−スルファターゼを精製するためのプロセス

Publications (2)

Publication Number Publication Date
JP2014517692A true JP2014517692A (ja) 2014-07-24
JP2014517692A5 JP2014517692A5 (enExample) 2015-07-02

Family

ID=47177365

Family Applications (2)

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JP2014511591A Ceased JP2014517692A (ja) 2011-05-19 2012-05-18 ヘパラン−ｎ−スルファターゼを精製するためのプロセス
JP2016214041A Pending JP2017029170A (ja) 2011-05-19 2016-11-01 ヘパラン−ｎ−スルファターゼを精製するためのプロセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016214041A Pending JP2017029170A (ja) 2011-05-19 2016-11-01 ヘパラン−ｎ−スルファターゼを精製するためのプロセス

Country Status (8)

Country Link
US (1) US20120329133A1 (enExample)
EP (2) EP2709654A4 (enExample)
JP (2) JP2014517692A (enExample)
AR (1) AR086445A1 (enExample)
CA (1) CA2836599A1 (enExample)
HK (1) HK1214960A1 (enExample)
TW (1) TW201307563A (enExample)
WO (1) WO2012159053A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524092A (ja) * 2002-04-26 2005-08-11 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
JP2011509674A (ja) * 2008-01-18 2011-03-31 バイオマリン ファーマシューティカル インコーポレイテッド 高度にリン酸化された活性なヒトリソソームスルファターゼ酵素の製造およびそれの使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ521732A (en) * 2000-03-22 2004-05-28 Octagene Gmbh Production of recombinant blood clotting factors in human cell lines and factor VIII muteins
ATE494367T1 (de) * 2002-12-18 2011-01-15 Hoffmann La Roche Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität
AU2005211775B2 (en) * 2004-02-06 2009-10-08 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
EP1828239B1 (en) * 2004-12-10 2011-08-24 ZymoGenetics, Inc. Fgf18 production in prokaryotic hosts
US8076462B2 (en) * 2007-04-02 2011-12-13 Kyowa Hakko Kirin Co., Ltd Method for producing antithrombin composition
CN103260637B (zh) * 2010-06-25 2016-04-06 夏尔人类遗传性治疗公司 乙酰肝素n-硫酸酯酶cns递送的方法和组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524092A (ja) * 2002-04-26 2005-08-11 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
JP2011509674A (ja) * 2008-01-18 2011-03-31 バイオマリン ファーマシューティカル インコーポレイテッド 高度にリン酸化された活性なヒトリソソームスルファターゼ酵素の製造およびそれの使用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOCHEM. J., 1978, VOL. 181, PP. 677-684, JPN6016016509, ISSN: 0003308882 *
BIOCHEM. J., 1998, VOL. 329, PP. 145-150, JPN6016016506, ISSN: 0003308880 *
MOL. GENET. METAB., 2004, VOL. 83, PP. 239-245, JPN6016016505, ISSN: 0003308879 *
MOL. GENET. METAB., 2007, VOL. 90, PP. 313-328, JPN6016016508, ISSN: 0003308881 *

Also Published As

Publication number Publication date
JP2017029170A (ja) 2017-02-09
TW201307563A (zh) 2013-02-16
AR086445A1 (es) 2013-12-11
US20120329133A1 (en) 2012-12-27
EP2709654A4 (en) 2014-11-12
HK1214960A1 (en) 2016-08-12
WO2012159053A1 (en) 2012-11-22
EP2929892A1 (en) 2015-10-14
CA2836599A1 (en) 2012-11-22
EP2709654A1 (en) 2014-03-26
EP2929892B1 (en) 2018-07-04

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