AR086445A1 - Proceso para purificar heparan-n-sulfatasa - Google Patents
Proceso para purificar heparan-n-sulfatasaInfo
- Publication number
- AR086445A1 AR086445A1 ARP120101760A ARP120101760A AR086445A1 AR 086445 A1 AR086445 A1 AR 086445A1 AR P120101760 A ARP120101760 A AR P120101760A AR P120101760 A ARP120101760 A AR P120101760A AR 086445 A1 AR086445 A1 AR 086445A1
- Authority
- AR
- Argentina
- Prior art keywords
- sulfatase
- heparan
- chromatography resin
- adsorbed
- contacting
- Prior art date
Links
- 108010089932 heparan sulfate sulfatase Proteins 0.000 title abstract 10
- 238000000034 method Methods 0.000 title abstract 2
- 239000012539 chromatography resin Substances 0.000 abstract 8
- 238000005571 anion exchange chromatography Methods 0.000 abstract 2
- 238000005277 cation exchange chromatography Methods 0.000 abstract 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 abstract 1
- 229920002971 Heparan sulfate Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488090P | 2011-05-19 | 2011-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086445A1 true AR086445A1 (es) | 2013-12-11 |
Family
ID=47177365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101760A AR086445A1 (es) | 2011-05-19 | 2012-05-18 | Proceso para purificar heparan-n-sulfatasa |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120329133A1 (enExample) |
| EP (2) | EP2709654A4 (enExample) |
| JP (2) | JP2014517692A (enExample) |
| AR (1) | AR086445A1 (enExample) |
| CA (1) | CA2836599A1 (enExample) |
| HK (1) | HK1214960A1 (enExample) |
| TW (1) | TW201307563A (enExample) |
| WO (1) | WO2012159053A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11584777B2 (en) | 2017-08-31 | 2023-02-21 | Green Cross Corporation | Method for purifying a sulfatase protein |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ521732A (en) * | 2000-03-22 | 2004-05-28 | Octagene Gmbh | Production of recombinant blood clotting factors in human cell lines and factor VIII muteins |
| KR100788093B1 (ko) * | 2002-04-26 | 2007-12-21 | 제넨테크, 인크. | 단백질의 비친화성 정제 |
| ATE494367T1 (de) * | 2002-12-18 | 2011-01-15 | Hoffmann La Roche | Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität |
| AU2005211775B2 (en) * | 2004-02-06 | 2009-10-08 | Biomarin Pharmaceutical Inc. | Manufacture of highly phosphorylated lysosomal enzymes and uses thereof |
| EP1828239B1 (en) * | 2004-12-10 | 2011-08-24 | ZymoGenetics, Inc. | Fgf18 production in prokaryotic hosts |
| US8076462B2 (en) * | 2007-04-02 | 2011-12-13 | Kyowa Hakko Kirin Co., Ltd | Method for producing antithrombin composition |
| SI3219795T1 (sl) | 2008-01-18 | 2024-10-30 | Biomarin Pharmaceutical Inc. | Izdelava akitvnih visoko fosforiliranih humanih encimov lizomske sulfataze in njihova uporaba |
| CN103260637B (zh) * | 2010-06-25 | 2016-04-06 | 夏尔人类遗传性治疗公司 | 乙酰肝素n-硫酸酯酶cns递送的方法和组合物 |
-
2012
- 2012-05-17 TW TW101117561A patent/TW201307563A/zh unknown
- 2012-05-18 WO PCT/US2012/038630 patent/WO2012159053A1/en not_active Ceased
- 2012-05-18 US US13/475,568 patent/US20120329133A1/en not_active Abandoned
- 2012-05-18 CA CA2836599A patent/CA2836599A1/en not_active Abandoned
- 2012-05-18 EP EP12785579.9A patent/EP2709654A4/en not_active Withdrawn
- 2012-05-18 EP EP15166651.8A patent/EP2929892B1/en active Active
- 2012-05-18 AR ARP120101760A patent/AR086445A1/es unknown
- 2012-05-18 JP JP2014511591A patent/JP2014517692A/ja not_active Ceased
-
2016
- 2016-03-15 HK HK16102969.5A patent/HK1214960A1/en unknown
- 2016-11-01 JP JP2016214041A patent/JP2017029170A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017029170A (ja) | 2017-02-09 |
| TW201307563A (zh) | 2013-02-16 |
| JP2014517692A (ja) | 2014-07-24 |
| US20120329133A1 (en) | 2012-12-27 |
| EP2709654A4 (en) | 2014-11-12 |
| HK1214960A1 (en) | 2016-08-12 |
| WO2012159053A1 (en) | 2012-11-22 |
| EP2929892A1 (en) | 2015-10-14 |
| CA2836599A1 (en) | 2012-11-22 |
| EP2709654A1 (en) | 2014-03-26 |
| EP2929892B1 (en) | 2018-07-04 |
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Legal Events
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| FB | Suspension of granting procedure |