JP2014516080A - 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 - Google Patents

一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 Download PDF

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JP2014516080A
JP2014516080A JP2014514630A JP2014514630A JP2014516080A JP 2014516080 A JP2014516080 A JP 2014516080A JP 2014514630 A JP2014514630 A JP 2014514630A JP 2014514630 A JP2014514630 A JP 2014514630A JP 2014516080 A JP2014516080 A JP 2014516080A
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pharmaceutically active
particles
poly
polymer
particle diameter
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JP2014516080A5 (enExample
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デイビッド エフ． カウンツ，
ドナルド ピー． コックス，
アヌプ ケイ． ダム，
マイケル イー． スタルへイマー，
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エスティーアイ ファーマ， エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014514630A 2011-06-08 2012-06-07 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 Withdrawn JP2014516080A (ja)

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US201161494659P 2011-06-08 2011-06-08
US61/494,659 2011-06-08
PCT/US2012/041331 WO2012170676A1 (en) 2011-06-08 2012-06-07 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration

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JP2014516080A true JP2014516080A (ja) 2014-07-07
JP2014516080A5 JP2014516080A5 (enExample) 2015-05-28

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JP2017094634A Pending JP2017137354A (ja) 2011-06-08 2017-05-11 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤

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US (3) US10463611B2 (enExample)
EP (1) EP2717860A4 (enExample)
JP (2) JP2014516080A (enExample)
CA (1) CA2835293C (enExample)
WO (1) WO2012170676A1 (enExample)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
JP2017137354A (ja) * 2011-06-08 2017-08-10 エスティーアイ ファーマ， エルエルシー 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤
WO2022080798A1 (ko) * 2020-10-12 2022-04-21 뉴지랩테라퓨틱스 주식회사 나파모스타트 또는 이의 약제학적으로 허용가능한 염을 함유하는 방출 조절 제형 및 이의 제조방법
TWI765913B (zh) * 2016-09-27 2022-06-01 德商拜耳製藥公司 結晶型的考布曲鈣（ｃａｌｃｏｂｕｔｒｏｌ）及其製備方法

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US20110020423A1 (en) 2009-07-22 2011-01-27 Puretech Ventures Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
TWI649100B (zh) 2013-06-17 2019-02-01 地平線罕見醫學製藥有限責任公司 延遲釋放型半胱胺珠粒調配物，以及其製備及使用方法
WO2015010194A1 (en) 2013-07-22 2015-01-29 Duchesnay Inc. Composition for the management of nausea and vomiting
US9452181B2 (en) 2013-07-22 2016-09-27 Duchesnay Inc. Composition for the management of nausea and vomiting
CN107108442A (zh) 2014-11-14 2017-08-29 燿石治疗公司 用于制备α,ω‑二羧酸封端的二烷醚的方法和中间体
WO2017055935A1 (en) * 2015-09-30 2017-04-06 Symed Labs Limited Amorphous co-precipitates of flibanserin
US10143665B2 (en) 2015-11-17 2018-12-04 Horizon Orphan Llc Methods for storing cysteamine formulations and related methods of treatment
CN106866546A (zh) * 2015-12-10 2017-06-20 常州爱诺新睿医药技术有限公司 氟班色林或其药学上可接受的盐与药用辅料的固体分散体及其制备方法
WO2018047013A1 (en) * 2016-09-12 2018-03-15 St Ip Holding Ag Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same
CA3036630A1 (en) 2016-09-12 2018-03-15 St Ip Holding Ag Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione, taste-modified formulations, and methods of making and using same
WO2018047002A1 (en) * 2016-09-12 2018-03-15 St Ip Holding Ag Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same
EP3509642A1 (en) 2016-09-12 2019-07-17 ST IP Holding AG Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same
US11202760B2 (en) 2016-09-30 2021-12-21 Xenamed Corp. Compositions of midodrine and methods of using the same
IL269884B2 (en) * 2017-04-18 2023-09-01 Gemphire Therapeutics Inc Gamkaban its accepted pharmaceutical salts, their compositions and methods of their use
US12213953B2 (en) 2017-12-22 2025-02-04 Xenamed Corp. Extended release midodrine hydrochloride compositions and methods of use
AU2019346626B2 (en) 2018-09-28 2022-06-02 Karuna Therapeutics, Inc. Compositions and methods for treating disorders ameliorated by muscarinic receptor activation
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
US20210022994A1 (en) * 2019-07-22 2021-01-28 Lupin Holdings, B.V. Sustained release trepostinil-compound microparticle compositions
JOP20220209A1 (ar) * 2020-03-09 2023-01-30 Sushma Paul Berlia تركيبات الإطلاق المحكوم مشتملة على الدروتافيرين أو ملحه
US11135220B1 (en) 2020-04-08 2021-10-05 St Ip Holding Ag Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
WO2022192195A1 (en) * 2021-03-09 2022-09-15 Ensysce Biosciences Inc. Modified release compositions of nafamostat and methods of using same

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WO2005046652A1 (en) * 2003-11-12 2005-05-26 Lek Pharmaceuticals D.D. Controlled release ketoprofen formulation
JP2006522099A (ja) * 2003-04-04 2006-09-28 ファルマシア コーポレーション 複合粒状体からなる経口徐放性圧縮錠
JP2007039353A (ja) * 2005-08-02 2007-02-15 Shionogi & Co Ltd 徐放性顆粒剤
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US20100305163A1 (en) * 2009-05-20 2010-12-02 Pramod Dattatray Yedurkar Pharmaceutical formulations comprising nsaid and proton pump inhibitor drugs

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JPS63107917A (ja) * 1986-08-01 1988-05-12 エ−ピ−エス　リサ−チ　リミテツド イブプロフエン徐放性製剤およびその製造方法
JPH01250314A (ja) * 1987-10-22 1989-10-05 Aps Res Ltd 徐放性製剤
US5431922A (en) * 1991-03-05 1995-07-11 Bristol-Myers Squibb Company Method for administration of buspirone
JPH05201867A (ja) * 1991-08-12 1993-08-10 Euro Celtique Sa スフェロイド製剤
JP2009019056A (ja) * 1998-10-01 2009-01-29 Elan Pharma Internatl Ltd 徐放性ナノ粒子組成物
JP2006522099A (ja) * 2003-04-04 2006-09-28 ファルマシア コーポレーション 複合粒状体からなる経口徐放性圧縮錠
WO2005046652A1 (en) * 2003-11-12 2005-05-26 Lek Pharmaceuticals D.D. Controlled release ketoprofen formulation
JP2007039353A (ja) * 2005-08-02 2007-02-15 Shionogi & Co Ltd 徐放性顆粒剤
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017137354A (ja) * 2011-06-08 2017-08-10 エスティーアイ ファーマ， エルエルシー 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤
TWI765913B (zh) * 2016-09-27 2022-06-01 德商拜耳製藥公司 結晶型的考布曲鈣（ｃａｌｃｏｂｕｔｒｏｌ）及其製備方法
WO2022080798A1 (ko) * 2020-10-12 2022-04-21 뉴지랩테라퓨틱스 주식회사 나파모스타트 또는 이의 약제학적으로 허용가능한 염을 함유하는 방출 조절 제형 및 이의 제조방법

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US20220047505A1 (en) 2022-02-17
WO2012170676A1 (en) 2012-12-13
US10463611B2 (en) 2019-11-05
US11191719B2 (en) 2021-12-07
CA2835293A1 (en) 2012-12-13
JP2017137354A (ja) 2017-08-10
CA2835293C (en) 2020-08-18
EP2717860A1 (en) 2014-04-16
US20140154313A1 (en) 2014-06-05
US20200000719A1 (en) 2020-01-02
EP2717860A4 (en) 2014-11-05

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