JP2014515383A5 - - Google Patents
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- Publication number
- JP2014515383A5 JP2014515383A5 JP2014513136A JP2014513136A JP2014515383A5 JP 2014515383 A5 JP2014515383 A5 JP 2014515383A5 JP 2014513136 A JP2014513136 A JP 2014513136A JP 2014513136 A JP2014513136 A JP 2014513136A JP 2014515383 A5 JP2014515383 A5 JP 2014515383A5
- Authority
- JP
- Japan
- Prior art keywords
- aqueous ophthalmic
- mass
- volume
- polyvinyl alcohol
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 238000009472 formulation Methods 0.000 claims 8
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000003169 prostaglandin F2α derivatives Chemical class 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229960002470 bimatoprost Drugs 0.000 claims 2
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 2
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical class CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 claims 1
- WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 claims 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 1
- 229960001222 carteolol Drugs 0.000 claims 1
- LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- XXUPXHKCPIKWLR-JHUOEJJVSA-N isopropyl unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC(C)C XXUPXHKCPIKWLR-JHUOEJJVSA-N 0.000 claims 1
- 229960001160 latanoprost Drugs 0.000 claims 1
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 229960003712 propranolol Drugs 0.000 claims 1
- 239000003087 receptor blocking agent Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229960004458 tafluprost Drugs 0.000 claims 1
- WSNODXPBBALQOF-VEJSHDCNSA-N tafluprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COC1=CC=CC=C1 WSNODXPBBALQOF-VEJSHDCNSA-N 0.000 claims 1
- 229960005221 timolol maleate Drugs 0.000 claims 1
- 229960002368 travoprost Drugs 0.000 claims 1
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 1
- 229950008081 unoprostone isopropyl Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11167894 | 2011-05-27 | ||
| EP11167894.2 | 2011-05-27 | ||
| PCT/EP2012/059831 WO2012163827A2 (en) | 2011-05-27 | 2012-05-25 | Ophthalmic preparation comprising a pgf2alpha analogue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014515383A JP2014515383A (ja) | 2014-06-30 |
| JP2014515383A5 true JP2014515383A5 (enExample) | 2014-08-07 |
Family
ID=46168493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513136A Pending JP2014515383A (ja) | 2011-05-27 | 2012-05-25 | ＰＧＦ２α類似体を含む眼科用製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140088107A1 (enExample) |
| EP (1) | EP2714007A2 (enExample) |
| JP (1) | JP2014515383A (enExample) |
| KR (1) | KR20140053894A (enExample) |
| CA (1) | CA2837240A1 (enExample) |
| EA (1) | EA201301332A1 (enExample) |
| IL (1) | IL229182A0 (enExample) |
| WO (1) | WO2012163827A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3973954A1 (en) * | 2013-10-15 | 2022-03-30 | Pharmathen S.A. | Preservative free pharmaceutical compositions for ophthalmic administration |
| GR1008330B (el) * | 2013-10-17 | 2014-10-20 | "Φαρματεν Α.Β.Ε.Ε.", | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση εχoν βελτιωμενες φυσικες ιδιοτητες και ογκο σταγονας |
| GR1008483B (el) * | 2013-12-23 | 2015-05-12 | Rafarm Α.Ε.Β.Ε., | Οφθαλμικη φαρμακευτικη συνθεση και μεθοδος για την παρασκευη αυτης |
| PL3103439T3 (pl) * | 2015-06-09 | 2019-12-31 | Medproject Pharma-Entwicklungs- Und Vertriebsgesellschaft Mbh | Zdolny do tworzenia kropli oftalmiczny żel bimatoprostu |
| GR1009006B (el) | 2016-04-01 | 2017-04-04 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χρηση περιεχον βιματοπροστη και τιμολολη |
| GR1009040B (el) | 2016-04-19 | 2017-05-19 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο οφθαλμικο σκευασμα ελευθερο συντηρητικου |
| JP6855026B1 (ja) * | 2020-11-09 | 2021-04-07 | 東亜薬品株式会社 | タフルプロスト点眼液 |
| US12042502B2 (en) | 2022-03-21 | 2024-07-23 | Somerset Therapeutics, Llc | Enhanced penetration ophthalmic compositions of bimatoprost and timolol |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01290623A (ja) * | 1988-05-16 | 1989-11-22 | Transfite Sa | 乾性眼症候郡の治療のための点眼液 |
| TWI298257B (en) * | 2001-05-31 | 2008-07-01 | Allergan Inc | Hypotensive lipid and timolol compositions and methods of using same |
| FR2833268B1 (fr) * | 2001-12-12 | 2005-07-08 | Fabre Pierre Dermo Cosmetique | Nouvelle association contenant un poloxamer et de l'acide chondroitine sulfurique et/ou une glycoproteine et son utilisation |
| JP4850513B2 (ja) * | 2003-07-03 | 2012-01-11 | 株式会社メニコン | 点眼用組成物 |
| KR101118935B1 (ko) * | 2003-08-21 | 2012-03-13 | 가부시키가이샤 아루떼꾸 우에노 | 안과용 조성물 |
| ES2331313T3 (es) * | 2003-11-07 | 2009-12-29 | Senju Pharmaceutical Co., Ltd. | Composicion farmaceutica que contiene prostaglandina. |
| US20050276867A1 (en) * | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Stabilized compositions comprising a therapeutically active agent and an oxidizing preservative |
| US7851504B2 (en) * | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
| MX2009000885A (es) * | 2006-07-25 | 2009-02-05 | Osmotica Corp | Soluciones oftalmicas. |
| JP2008120764A (ja) * | 2006-11-15 | 2008-05-29 | Nippon Tenganyaku Kenkyusho:Kk | プロスタグランジン水性点眼剤 |
| FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
| BRPI0909797A2 (pt) * | 2008-03-07 | 2017-08-22 | Sun Pharma Advanced Res Co Ltd | Composição oftálmica |
| EP2269612A4 (en) * | 2008-04-23 | 2013-07-31 | Otsuka Pharma Co Ltd | EYE DROP PREPARATION AND ITS USE |
| TW201109325A (en) * | 2009-07-30 | 2011-03-16 | Wakamoto Pharma Co Ltd | Aqueous composition for eye drops |
| EP2389939A1 (en) * | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
-
2012
- 2012-05-25 EA EA201301332A patent/EA201301332A1/ru unknown
- 2012-05-25 JP JP2014513136A patent/JP2014515383A/ja active Pending
- 2012-05-25 WO PCT/EP2012/059831 patent/WO2012163827A2/en not_active Ceased
- 2012-05-25 EP EP12723695.8A patent/EP2714007A2/en not_active Withdrawn
- 2012-05-25 KR KR1020137031286A patent/KR20140053894A/ko not_active Withdrawn
- 2012-05-25 CA CA2837240A patent/CA2837240A1/en not_active Abandoned
-
2013
- 2013-10-31 IL IL229182A patent/IL229182A0/en unknown
- 2013-11-25 US US14/089,473 patent/US20140088107A1/en not_active Abandoned
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