|
WO2011044187A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
EP2485920B1
(en)
|
2009-10-08 |
2016-04-27 |
Merck Sharp & Dohme Corp. |
Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
|
|
EP2694489B1
(en)
|
2011-04-07 |
2017-09-06 |
Merck Sharp & Dohme Corp. |
C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
EP2694521B1
(en)
|
2011-04-07 |
2015-11-25 |
Merck Sharp & Dohme Corp. |
Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
CN103874496A
(zh)
|
2011-08-22 |
2014-06-18 |
默沙东公司 |
作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途
|
|
UA113438C2
(xx)
|
2012-05-24 |
2017-01-25 |
|
5-аміно$1,4]тіазини як інгібітори бета-секретази 1
|
|
WO2014059185A1
(en)
|
2012-10-12 |
2014-04-17 |
Amgen Inc. |
Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
|
|
WO2014093190A1
(en)
|
2012-12-14 |
2014-06-19 |
Merck Sharp & Dohme Corp. |
Bace inhibitors of iminothiadiazine dioxides
|
|
EP2934539B1
(en)
*
|
2012-12-20 |
2019-03-27 |
Merck Sharp & Dohme Corp. |
C5, c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors
|
|
WO2014099788A1
(en)
*
|
2012-12-21 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
C5-spiro iminothiadiazine dioxides as bace inhibitors
|
|
US9309263B2
(en)
|
2013-01-29 |
2016-04-12 |
Amgen Inc. |
Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof
|
|
WO2014134341A1
(en)
|
2013-03-01 |
2014-09-04 |
Amgen Inc. |
Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
MX374512B
(es)
|
2013-03-08 |
2025-03-06 |
Amgen Inc |
Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y métodos de uso.
|
|
US9428476B2
(en)
|
2013-03-15 |
2016-08-30 |
Merck Sharp & Dohme Corp. |
S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use
|
|
WO2014150331A1
(en)
|
2013-03-15 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use
|
|
WO2014150344A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
C2-azaspiro iminothiazine dioxides as bace inhibitors
|
|
WO2015017407A1
(en)
|
2013-07-30 |
2015-02-05 |
Amgen Inc. |
Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta- secretase
|
|
WO2015094930A1
(en)
*
|
2013-12-18 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
C-6 spirocarbocyclic iminothiadiazine dioxides as bace inhibitors, compositions, and their use
|
|
WO2015095104A1
(en)
*
|
2013-12-18 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Iminothiadiazepane dioxide compounds as bace inhibitors, compositions, and their use
|
|
EP2918171A1
(en)
*
|
2014-03-14 |
2015-09-16 |
University of Vienna |
Novel plant growth regulators and their use in modulating organ number
|
|
CN106459088A
(zh)
|
2014-04-10 |
2017-02-22 |
辉瑞公司 |
2‑氨基‑6‑甲基‑4，4a，5，6‑四氢吡喃并[3，4‑d][1，3]噻嗪‑8a(8H)‑基‑1，3‑噻唑‑4‑基酰胺
|
|
US9732088B2
(en)
|
2014-06-02 |
2017-08-15 |
Merck Sharp & Dohme Corp. |
C2-carbocyclic iminothiazine dioxides as BACE inhibitors, compositions, and their use
|
|
US10047102B2
(en)
|
2014-07-25 |
2018-08-14 |
Hoffmann-La Roche Inc. |
Pyridyl-triazabicycles
|
|
US9957269B2
(en)
|
2014-09-12 |
2018-05-01 |
Merck Sharp & Dohme Corp. |
S-imino-S-oxo iminothiazine compounds as bace inhibitors, compositions, and their use
|
|
WO2016118404A1
(en)
|
2015-01-20 |
2016-07-28 |
Merck Sharp & Dohme Corp. |
Iminothiadiazine dioxides bearing an amine-linked substituent as bace inhibitors, compositions, and their use
|
|
EP3271355B1
(en)
|
2015-03-20 |
2020-07-29 |
H. Hoffnabb-La Roche Ag |
Bace1 inhibitors
|
|
ES2942308T3
(es)
*
|
2015-04-21 |
2023-05-31 |
Allgenesis Biotherapeutics Inc |
Compuestos y su uso como inhibidores de BACE1
|
|
WO2017024180A1
(en)
|
2015-08-06 |
2017-02-09 |
Amgen Inc. |
Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
JP2018531923A
(ja)
|
2015-09-24 |
2018-11-01 |
ファイザー・インク |
Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド
|
|
WO2017051303A1
(en)
|
2015-09-24 |
2017-03-30 |
Pfizer Inc. |
Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
|
|
WO2017070089A1
(en)
|
2015-10-19 |
2017-04-27 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
SG10202004618TA
(en)
|
2015-11-19 |
2020-06-29 |
Incyte Corp |
Heterocyclic compounds as immunomodulators
|
|
WO2017095759A1
(en)
|
2015-12-04 |
2017-06-08 |
Merck Sharp & Dohme Corp. |
C5-c6-carbocyclic fused iminothiadiazine dioxides as bace inhibitors, compositions, and their use
|
|
MA44075A
(fr)
*
|
2015-12-17 |
2021-05-19 |
Incyte Corp |
Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1
|
|
AU2016379372A1
(en)
|
2015-12-22 |
2018-08-02 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
AR108396A1
(es)
|
2016-05-06 |
2018-08-15 |
Incyte Corp |
Compuestos heterocíclicos como inmunomoduladores
|
|
WO2017205464A1
(en)
|
2016-05-26 |
2017-11-30 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
HUE060256T2
(hu)
|
2016-06-20 |
2023-02-28 |
Incyte Corp |
Heterociklusos vegyületek mint immunmodulátorok
|
|
EP3484866B1
(en)
|
2016-07-14 |
2022-09-07 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
WO2018044783A1
(en)
|
2016-08-29 |
2018-03-08 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
MX394391B
(es)
|
2016-12-15 |
2025-03-24 |
Amgen Inc |
Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso.
|
|
CA3047290A1
(en)
|
2016-12-15 |
2018-06-21 |
Amgen Inc. |
1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
|
|
CA3047288A1
(en)
|
2016-12-15 |
2018-06-21 |
Amgen Inc. |
Thiazine derivatives as beta-secretase inhibitors and methods of use
|
|
EP3555085B1
(en)
|
2016-12-15 |
2020-12-02 |
Amgen Inc. |
Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
|
|
AU2017376441B2
(en)
|
2016-12-15 |
2021-10-14 |
Amgen Inc. |
Oxazine derivatives as beta-secretase inhibitors and methods of use
|
|
ES2874756T3
(es)
|
2016-12-22 |
2021-11-05 |
Incyte Corp |
Derivados de triazolo[1,5-A]piridina como inmunomoduladores
|
|
WO2018119221A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Pyridine derivatives as immunomodulators
|
|
JP7101678B2
(ja)
|
2016-12-22 |
2022-07-15 |
インサイト・コーポレイション |
免疫調節剤としての複素環式化合物
|
|
LT3558990T
(lt)
|
2016-12-22 |
2022-12-27 |
Incyte Corporation |
Tetrahidroimidazo[4,5-c]piridino dariniai kaip pd-l1 internalizavimo induktoriai
|
|
US20180179202A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
AU2018346597B2
(en)
|
2017-10-06 |
2023-07-13 |
Forma Therapeutics, Inc. |
Inhibiting Ubiquitin Specific Peptidase 30
|
|
CN111511732A
(zh)
*
|
2017-12-21 |
2020-08-07 |
豪夫迈·罗氏有限公司 |
放射性标记化合物
|
|
EP3765459A1
(en)
|
2018-03-13 |
2021-01-20 |
Shire Human Genetic Therapies, Inc. |
Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
|
|
SMT202500157T1
(it)
|
2018-03-30 |
2025-05-12 |
Incyte Corp |
Composti eterociclici come immunomodulatori
|
|
AU2019258575A1
(en)
|
2018-04-27 |
2020-10-29 |
Shionogi & Co., Ltd. |
Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
|
|
HUE061503T2
(hu)
|
2018-05-11 |
2023-07-28 |
Incyte Corp |
Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok
|
|
JP7449242B2
(ja)
|
2018-05-17 |
2024-03-13 |
フォーマ セラピューティクス，インコーポレイテッド |
ユビキチン特異的ペプチダーゼ３０（ｕｓｐ３０）阻害剤として有用な縮合二環化合物
|
|
CN108997328B
(zh)
*
|
2018-09-06 |
2021-06-08 |
广东东阳光药业有限公司 |
亚氨基噻二嗪二氧化物衍生物及其用途
|
|
JP7530889B2
(ja)
|
2018-10-05 |
2024-08-08 |
フォーマ セラピューティクス，インコーポレイテッド |
ユビキチン特異的プロテアーゼ３０（ｕｓｐ３０）阻害剤として作用する縮合ピロリン
|
|
JP7665593B2
(ja)
|
2019-08-09 |
2025-04-21 |
インサイト・コーポレイション |
Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
|
|
WO2021032935A1
(en)
*
|
2019-08-21 |
2021-02-25 |
Kalvista Pharmaceuticals Limited |
Enzyme inhibitors
|
|
DK4031547T3
(da)
|
2019-09-18 |
2024-09-09 |
Takeda Pharmaceuticals Co |
Plasmakallikreininhibitorer og anvendelser deraf
|
|
EP4031245A1
(en)
|
2019-09-18 |
2022-07-27 |
Takeda Pharmaceutical Company Limited |
Heteroaryl plasma kallikrein inhibitors
|
|
PE20221038A1
(es)
|
2019-09-30 |
2022-06-17 |
Incyte Corp |
Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores
|
|
CA3160131A1
(en)
|
2019-11-11 |
2021-05-20 |
Incyte Corporation |
Salts and crystalline forms of a pd-1/pd-l1 inhibitor
|
|
CR20230230A
(es)
|
2020-11-06 |
2023-07-27 |
Incyte Corp |
Proceso para hacer un inhibidor de pd-1/pdl1 y sales y formas cristalinas del mismo
|
|
WO2022099018A1
(en)
|
2020-11-06 |
2022-05-12 |
Incyte Corporation |
Process of preparing a pd-1/pd-l1 inhibitor
|
|
TW202233615A
(zh)
|
2020-11-06 |
2022-09-01 |
美商英塞特公司 |
Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
|
|
JP7605446B2
(ja)
|
2022-04-28 |
2024-12-24 |
第一三共株式会社 |
ベンゾトリアゾール化合物
|