|
WO2012088446A1
(en)
|
2010-12-22 |
2012-06-28 |
Board Of Trustees Of The Leland Stanford Junior University |
Superagonists and antagonists of interleukin-2
|
|
US9890218B2
(en)
|
2011-06-30 |
2018-02-13 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
US10450361B2
(en)
|
2013-03-15 |
2019-10-22 |
Momenta Pharmaceuticals, Inc. |
Methods related to CTLA4-Fc fusion proteins
|
|
US10464996B2
(en)
|
2013-05-13 |
2019-11-05 |
Momenta Pharmaceuticals, Inc. |
Methods for the treatment of neurodegeneration
|
|
KR20220148304A
(ko)
|
2013-08-08 |
2022-11-04 |
싸이튠 파마 |
병용 약학 조성물
|
|
HRP20231437T1
(hr)
|
2013-08-08 |
2024-02-16 |
Cytune Pharma |
Il-15 i il-15ralpha sushi domena na temelju modulokina
|
|
CN105722860A
(zh)
|
2013-09-24 |
2016-06-29 |
梅迪塞纳医疗股份有限公司 |
白介素-2融合蛋白及其应用
|
|
EP3058084A4
(en)
|
2013-10-16 |
2017-07-05 |
Momenta Pharmaceuticals, Inc. |
Sialylated glycoproteins
|
|
CN106164289A
(zh)
*
|
2014-01-02 |
2016-11-23 |
纪念斯隆凯特琳癌症中心 |
癌症对免疫疗法的反应的决定因素
|
|
CN106659757B
(zh)
|
2014-04-24 |
2022-01-28 |
利兰斯坦福初级大学董事会 |
白介素2的超级激动剂、部分激动剂和拮抗剂
|
|
CN105296433B
(zh)
|
2014-08-01 |
2018-02-09 |
中山康方生物医药有限公司 |
一种ctla4抗体、其药物组合物及其用途
|
|
US20170216403A1
(en)
|
2014-08-12 |
2017-08-03 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
|
EP3180018B1
(en)
|
2014-08-12 |
2019-07-24 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
|
|
AU2015330731B2
(en)
|
2014-10-10 |
2020-07-09 |
Idera Pharmaceuticals, Inc. |
Treatment of cancer using TLR9 agonist with checkpoint inhibitors
|
|
WO2016127052A1
(en)
|
2015-02-05 |
2016-08-11 |
Bristol-Myers Squibb Company |
Cxcl11 and smica as predictive biomarkers for efficacy of anti-ctla4 immunotherapy
|
|
EP4151231A1
(en)
*
|
2015-02-13 |
2023-03-22 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind ctla4
|
|
EP3263599A4
(en)
|
2015-02-16 |
2018-12-19 |
Pharma Foods International Co., Ltd. |
Anti-cancer agent and antimetastatic agent using fstl1, and concomitant drug for same
|
|
CN107849144B
(zh)
*
|
2015-05-29 |
2021-09-17 |
艾吉纳斯公司 |
抗-ctla-4抗体及其使用方法
|
|
NL2014935B1
(en)
*
|
2015-06-08 |
2017-02-03 |
Applied Immune Tech Ltd |
T cell receptor like antibodies having fine specificity.
|
|
CN108136025B
(zh)
|
2015-07-16 |
2022-09-06 |
比奥克斯塞尔医疗股份有限公司 |
一种使用免疫调节治疗癌症的新颖方法
|
|
HK1257840A1
(zh)
|
2015-09-01 |
2019-11-01 |
Agenus Inc. |
抗-pd-1抗体及其使用方法
|
|
WO2017084078A1
(en)
*
|
2015-11-19 |
2017-05-26 |
Zeling Cai |
Ctla-4 antibodies and uses thereof
|
|
MX2018007089A
(es)
|
2015-12-14 |
2019-01-30 |
Macrogenics Inc |
Moleculas biespecificas que tienen inmunorreactividad con pd-1 y ctla-4, y metodos de uso de las mismas.
|
|
IL310404A
(en)
*
|
2015-12-15 |
2024-03-01 |
Oncoc4 Inc |
Chimeric and humanized anti-human ctla4 monoclonal antibodies and uses thereof
|
|
WO2017120612A1
(en)
|
2016-01-10 |
2017-07-13 |
Modernatx, Inc. |
Therapeutic mrnas encoding anti ctla-4 antibodies
|
|
WO2017160754A1
(en)
|
2016-03-15 |
2017-09-21 |
Mersana Therapeutics,Inc. |
Napi2b-targeted antibody-drug conjugates and methods of use thereof
|
|
TW201735949A
(zh)
|
2016-03-24 |
2017-10-16 |
千禧製藥公司 |
治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法
|
|
MA44483A
(fr)
|
2016-03-24 |
2019-01-30 |
Millennium Pharm Inc |
Procédés pour traiter des événements indésirables gastro-intestinaux d'origine immunitaire dans des traitements oncologiques immunitaires
|
|
US11542332B2
(en)
|
2016-03-26 |
2023-01-03 |
Bioatla, Inc. |
Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
|
|
EA039322B1
(ru)
*
|
2016-04-15 |
2022-01-13 |
Эйдженус Инк. |
Антитела против ctla-4 и способы их применения
|
|
AU2017268399B2
(en)
|
2016-05-18 |
2023-01-12 |
Modernatx, Inc. |
mRNA combination therapy for the treatment of cancer
|
|
BR112018076281A2
(pt)
|
2016-06-20 |
2019-03-26 |
Kymab Limited |
imunocitocina, uso de uma imunocitocina, método, composição farmacêutica, método para tratar uma doença proliferativa em um animal, ácido nucleico, vetor, hospedeiro e anticorpo ou fragmento do mesmo
|
|
CA3029426A1
(en)
|
2016-06-30 |
2018-01-04 |
Oncorus, Inc. |
Pseudotyped oncolytic viral delivery of therapeutic polypeptides
|
|
KR20190086431A
(ko)
*
|
2016-08-17 |
2019-07-22 |
오르비스 헬스 솔루션즈 엘엘씨 |
종양-표적화 비드 벡터 및 그의 사용 방법
|
|
CN106967172B
(zh)
|
2016-08-23 |
2019-01-08 |
康方药业有限公司 |
抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途
|
|
CN106977602B
(zh)
|
2016-08-23 |
2018-09-25 |
中山康方生物医药有限公司 |
一种抗pd1单克隆抗体、其药物组合物及其用途
|
|
WO2018035710A1
(en)
*
|
2016-08-23 |
2018-03-01 |
Akeso Biopharma, Inc. |
Anti-ctla4 antibodies
|
|
CN107815468B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
CN107815467B
(zh)
|
2016-08-31 |
2021-03-16 |
百奥赛图(北京)医药科技股份有限公司 |
人源化基因改造动物模型的制备方法及应用
|
|
WO2018041121A1
(en)
|
2016-08-31 |
2018-03-08 |
Beijing Biocytogen Co., Ltd |
Genetically modified non-human animal with human or chimeric ctla-4
|
|
KR20230133934A
(ko)
|
2016-10-11 |
2023-09-19 |
아게누스 인코포레이티드 |
항-lag-3 항체 및 이의 사용 방법
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
KR102504605B1
(ko)
*
|
2016-12-07 |
2023-03-02 |
아게누스 인코포레이티드 |
항-ctla-4 항체 및 이의 사용 방법
|
|
WO2018112266A1
(en)
|
2016-12-14 |
2018-06-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13 superkine: immune cell targeting constructs and methods of use thereof
|
|
EP3568150A4
(en)
|
2017-01-10 |
2020-12-02 |
Xcella Biosciences, Inc. |
POLYTHERAPY FOR TUMOR TREATMENT WITH INTEGRIN-BOUND FC FUSION PROTEIN AND IMMUNE MODULATOR
|
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
|
CN110545844A
(zh)
*
|
2017-02-21 |
2019-12-06 |
瑞美德生物医药科技有限公司 |
使用结合细胞毒性t淋巴细胞抗原-4(ctla-4)的抗体的癌症治疗
|
|
CN116440257A
(zh)
*
|
2017-02-28 |
2023-07-18 |
百时美施贵宝公司 |
具有增强的adcc的抗ctla-4抗体增强对疫苗的免疫应答的用途
|
|
WO2018160538A1
(en)
|
2017-02-28 |
2018-09-07 |
Mersana Therapeutics, Inc. |
Combination therapies of her2-targeted antibody-drug conjugates
|
|
US20220411506A1
(en)
*
|
2017-03-15 |
2022-12-29 |
Suzhou Galaxy Biopharma Co., Ltd. |
Ctla4 antibody, pharmaceutical composition and use thereof
|
|
CN116478289A
(zh)
*
|
2017-05-19 |
2023-07-25 |
上海药明生物技术有限公司 |
一种新的ctla-4单克隆抗体
|
|
IL270743B2
(en)
*
|
2017-05-19 |
2024-09-01 |
Wuxi Biologics Shanghai Co Ltd |
Monoclonal antibodies to cytotoxic t-lymphocyte-associated protein 4 (ctla-4), compositions containing same and uses thereof
|
|
AU2018287317B2
(en)
|
2017-06-19 |
2024-06-20 |
Medicenna Therapeutics Inc. |
Uses and methods for IL-2 superagonists, agonists, and fusions thereof
|
|
TWI799432B
(zh)
*
|
2017-07-27 |
2023-04-21 |
美商再生元醫藥公司 |
抗ctla-4抗體及其用途
|
|
US20200172618A1
(en)
*
|
2017-07-28 |
2020-06-04 |
Gene Signal International Sa |
Cd9p-1-targeting antibody and uses thereof
|
|
WO2019020807A1
(en)
*
|
2017-07-28 |
2019-01-31 |
Gene Signal International Sa |
CD9P-1 TARGETING ANTIBODIES AND USES THEREOF
|
|
EP3684812A4
(en)
*
|
2017-09-21 |
2021-09-08 |
Eucure (Beijing) Biopharma Co., Ltd |
ANTI-CTLA4 ANTIBODIES AND USES THEREOF
|
|
US11638760B2
(en)
|
2017-11-27 |
2023-05-02 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
ES2965187T3
(es)
|
2017-12-20 |
2024-04-11 |
Harbour Biomed Shanghai Co Ltd |
Anticuerpos que unen CTLA-4 y sus usos
|
|
WO2019126691A1
(en)
|
2017-12-21 |
2019-06-27 |
Mersana Therapeutics, Inc. |
Pyrrolobenzodiazepine antibody conjugates
|
|
WO2019133847A1
(en)
|
2017-12-29 |
2019-07-04 |
Oncorus, Inc. |
Oncolytic viral delivery of therapeutic polypeptides
|
|
CA3102097A1
(en)
|
2018-06-01 |
2019-12-05 |
The Board Of Trustees Of The Leland Stanford Junior Unversity |
Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof
|
|
CN112638375A
(zh)
|
2018-06-15 |
2021-04-09 |
旗舰创业创新五公司 |
通过后细胞信号传导因子的调节来增加免疫活性
|
|
CN110760002A
(zh)
*
|
2018-07-25 |
2020-02-07 |
南京金斯瑞生物科技有限公司 |
人源化抗人ctla4单克隆抗体及其制备方法和用途
|
|
WO2020023702A1
(en)
|
2018-07-25 |
2020-01-30 |
AskGene Pharma, Inc. |
Novel il-21 prodrugs and methods of use thereof
|
|
JP7397874B2
(ja)
|
2018-08-30 |
2023-12-13 |
エイチシーダブリュー バイオロジックス インコーポレイテッド |
多鎖キメラポリペプチドおよびその使用
|
|
US11672826B2
(en)
|
2018-08-30 |
2023-06-13 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
SG11202101780WA
(en)
|
2018-08-30 |
2021-03-30 |
Hcw Biologics Inc |
Single-chain chimeric polypeptides and uses thereof
|
|
JP7557882B2
(ja)
|
2018-09-28 |
2024-09-30 |
マサチューセッツ インスティテュート オブ テクノロジー |
コラーゲンに局在化される免疫調節分子およびその方法
|
|
CA3117050A1
(en)
|
2018-10-29 |
2020-05-07 |
Mersana Therapeutics, Inc. |
Cysteine engineered antibody-drug conjugates with peptide-containing linkers
|
|
AU2019371223B2
(en)
*
|
2018-10-31 |
2022-03-17 |
Bioatla, Inc. |
Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
|
|
CA3123338A1
(en)
|
2018-12-21 |
2020-06-25 |
Ose Immunotherapeutics |
Bifunctional anti-pd-1/il-7 molecule
|
|
CN113490687A
(zh)
|
2018-12-26 |
2021-10-08 |
西利欧发展公司 |
抗ctla4抗体和其使用方法
|
|
AU2019413366B2
(en)
*
|
2018-12-27 |
2025-06-05 |
Gigagen, Inc. |
Anti-CTLA-4 binding proteins and methods of use thereof
|
|
EP3914289A1
(en)
|
2019-01-23 |
2021-12-01 |
Massachusetts Institute of Technology |
Combination immunotherapy dosing regimen for immune checkpoint blockade
|
|
WO2020165374A1
(en)
|
2019-02-14 |
2020-08-20 |
Ose Immunotherapeutics |
Bifunctional molecule comprising il-15ra
|
|
MA55805A
(fr)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V Inc |
Métodes de modulation de l'activité immunitaire
|
|
TWI869398B
(zh)
*
|
2019-05-10 |
2025-01-11 |
英商拜西克爾德有限公司 |
治療癌症之方法
|
|
US11845801B2
(en)
|
2019-06-12 |
2023-12-19 |
AskGene Pharma, Inc. |
IL-15 prodrugs and methods of use thereof
|
|
EP3987010A1
(en)
|
2019-06-21 |
2022-04-27 |
HCW Biologics, Inc. |
Multi-chain chimeric polypeptides and uses thereof
|
|
WO2020263399A1
(en)
|
2019-06-26 |
2020-12-30 |
Massachusetts Institute Of Technology |
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
|
|
CA3145347A1
(en)
|
2019-07-15 |
2021-01-21 |
Intervet International B.V. |
Caninized antibodies to human and canine ctla-4
|
|
AU2020312686A1
(en)
*
|
2019-07-15 |
2022-02-03 |
Intervet International B.V. |
Caninized antibodies against canine CTLA-4
|
|
CN110467675B
(zh)
*
|
2019-09-19 |
2020-08-14 |
合源生物科技(天津)有限公司 |
一种ctla-4单克隆抗体6f1及其用于抗肿瘤的用途
|
|
US11459389B2
(en)
|
2019-10-24 |
2022-10-04 |
Massachusetts Institute Of Technology |
Monoclonal antibodies that bind human CD161
|
|
EP4076434A1
(en)
|
2019-12-17 |
2022-10-26 |
Flagship Pioneering Innovations V, Inc. |
Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
|
|
WO2021122866A1
(en)
|
2019-12-17 |
2021-06-24 |
Ose Immunotherapeutics |
Bifunctional molecules comprising an il-7 variant
|
|
KR20240035914A
(ko)
|
2019-12-27 |
2024-03-18 |
추가이 세이야쿠 가부시키가이샤 |
항ctla-4 항체 및 그의 사용
|
|
US12115191B2
(en)
|
2020-02-11 |
2024-10-15 |
Immunitybio, Inc. |
Methods of treating age-related and inflammatory diseases
|
|
WO2021163299A1
(en)
|
2020-02-11 |
2021-08-19 |
HCW Biologics, Inc. |
Chromatography resin and uses thereof
|
|
KR20220140572A
(ko)
|
2020-02-11 |
2022-10-18 |
에이치씨더블유 바이올로직스, 인크. |
조절 t 세포를 활성화시키는 방법
|
|
WO2021216572A1
(en)
|
2020-04-20 |
2021-10-28 |
Massachusetts Institute Of Technology |
Lipid compositions for delivery of sting agonist compounds and uses thereof
|
|
BR112022021020A2
(pt)
|
2020-04-22 |
2023-02-14 |
Iovance Biotherapeutics Inc |
Método de fabricação de um produto de terapia celular, métodos de tratamento do paciente com o produto de terapia celular de expansão e fabricado, e, método de fabricação de um produto de terapia celular
|
|
EP4143231A1
(en)
|
2020-04-29 |
2023-03-08 |
HCW Biologics, Inc. |
Anti-cd26 proteins and uses thereof
|
|
WO2021247003A1
(en)
|
2020-06-01 |
2021-12-09 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
US12024545B2
(en)
|
2020-06-01 |
2024-07-02 |
HCW Biologics, Inc. |
Methods of treating aging-related disorders
|
|
IL298608A
(en)
|
2020-06-01 |
2023-01-01 |
Hcw Biologics Inc |
Methods of treating aging-related disorders
|
|
WO2021250594A1
(en)
*
|
2020-06-11 |
2021-12-16 |
Nantbio, Inc. |
Anti-ctla4 monoclonal antibodies and chimeric antigen receptors
|
|
CN116096906A
(zh)
|
2020-06-29 |
2023-05-09 |
旗舰创业创新五公司 |
工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
|
|
EP4175981A4
(en)
*
|
2020-07-02 |
2024-07-24 |
Gigagen, Inc. |
ANTI-CTLA-4 BINDING PROTEINS AND METHODS OF USE
|
|
WO2022112198A1
(en)
|
2020-11-24 |
2022-06-02 |
Worldwide Innovative Network |
Method to select the optimal immune checkpoint therapies
|
|
WO2022133169A1
(en)
|
2020-12-18 |
2022-06-23 |
Century Therapeutics, Inc. |
Chimeric antigen receptor systems with adaptable receptor specificity
|
|
WO2022169269A1
(ko)
*
|
2021-02-03 |
2022-08-11 |
주식회사 유틸렉스 |
항 ctla-4 항체 및 이의 용도
|
|
US20220325287A1
(en)
|
2021-03-31 |
2022-10-13 |
Flagship Pioneering Innovations V, Inc. |
Thanotransmission polypeptides and their use in treating cancer
|
|
MX2023011964A
(es)
|
2021-04-09 |
2024-01-08 |
Ose Immunotherapeutics |
Nuevo andamio para moléculas bifuncionales con propiedades mejoradas.
|
|
WO2022214652A1
(en)
|
2021-04-09 |
2022-10-13 |
Ose Immunotherapeutics |
Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
|
|
CA3221833A1
(en)
|
2021-06-25 |
2022-12-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-ctla-4 antibody
|
|
MX2023014453A
(es)
|
2021-06-25 |
2024-01-31 |
Chugai Pharmaceutical Co Ltd |
Uso de anticuerpos anti-antigeno 4 del linfocito t citotoxico (anti-ctla-4).
|
|
US12448451B2
(en)
|
2021-06-25 |
2025-10-21 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-CTLA-4 antibody and use thereof
|
|
JP2024525475A
(ja)
|
2021-06-29 |
2024-07-12 |
フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド |
タノトランスミッションを促進するように操作された免疫細胞及びその使用
|
|
JP2025508939A
(ja)
|
2022-03-02 |
2025-04-10 |
イミュニティーバイオ インコーポレイテッド |
膵臓癌の治療方法
|
|
CA3248034A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT
|
|
WO2024003360A1
(en)
|
2022-07-01 |
2024-01-04 |
Institut Curie |
Biomarkers and uses thereof for the treatment of neuroblastoma
|
|
WO2024028386A1
(en)
|
2022-08-02 |
2024-02-08 |
Ose Immunotherapeutics |
Multifunctional molecule directed against cd28
|
|
EP4598946A1
(en)
|
2022-10-05 |
2025-08-13 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
|
|
KR20250122544A
(ko)
|
2022-11-21 |
2025-08-13 |
이오반스 바이오테라퓨틱스, 인크. |
종양 침윤 림프구의 확장을 위한 2차원 공정 및 이를 통한 요법
|
|
US20240269251A1
(en)
|
2023-01-09 |
2024-08-15 |
Flagship Pioneering Innovations V, Inc. |
Genetic switches and their use in treating cancer
|
|
CN121358499A
(zh)
|
2023-03-30 |
2026-01-16 |
Ose免疫疗法 |
靶向活化的免疫细胞以表达免疫细胞增强分子的基于脂质的纳米粒及其用途
|
|
WO2024200826A1
(en)
|
2023-03-30 |
2024-10-03 |
Ose Immunotherapeutics |
Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell inhibiting molecule and use thereof
|
|
WO2025242835A1
(en)
|
2024-05-22 |
2025-11-27 |
Ose Immunotherapeutics |
Molecules comprising masking linkers and uses thereof for the treatment of cancer
|