JP2014512333A5 - - Google Patents
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- Publication number
- JP2014512333A5 JP2014512333A5 JP2013549539A JP2013549539A JP2014512333A5 JP 2014512333 A5 JP2014512333 A5 JP 2014512333A5 JP 2013549539 A JP2013549539 A JP 2013549539A JP 2013549539 A JP2013549539 A JP 2013549539A JP 2014512333 A5 JP2014512333 A5 JP 2014512333A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- metformin
- composition according
- compound
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 5
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 5
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 5
- 229960003105 metformin Drugs 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 3
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 3
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 3
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001280 Prediabetic State Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 239000012299 nitrogen atmosphere Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161461113P | 2011-01-12 | 2011-01-12 | |
| US61/461,113 | 2011-01-12 | ||
| US13/348,265 | 2012-01-11 | ||
| US13/348,265 US20120178813A1 (en) | 2011-01-12 | 2012-01-11 | Lipid-lowering antidiabetic agent |
| PCT/US2012/021070 WO2012097144A1 (en) | 2011-01-12 | 2012-01-12 | Lipid-lowering antidiabetic agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512333A JP2014512333A (ja) | 2014-05-22 |
| JP2014512333A5 true JP2014512333A5 (enExample) | 2015-03-12 |
| JP5911514B2 JP5911514B2 (ja) | 2016-04-27 |
Family
ID=46455756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549539A Expired - Fee Related JP5911514B2 (ja) | 2011-01-12 | 2012-01-12 | 脂質低下抗糖尿病薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20120178813A1 (enExample) |
| EP (1) | EP2663186A4 (enExample) |
| JP (1) | JP5911514B2 (enExample) |
| KR (1) | KR20140092228A (enExample) |
| CN (1) | CN103533833B (enExample) |
| AU (1) | AU2012205547B2 (enExample) |
| BR (1) | BR112013017845A2 (enExample) |
| CA (1) | CA2824192A1 (enExample) |
| EA (1) | EA201391028A1 (enExample) |
| IL (1) | IL227346A0 (enExample) |
| MX (1) | MX2013008131A (enExample) |
| WO (1) | WO2012097144A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| BR112015000368A2 (pt) * | 2012-07-10 | 2017-06-27 | Thetis Pharmaceuticals Llc | forma de tri-sais de metformina |
| US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
| WO2014080307A2 (en) * | 2012-11-21 | 2014-05-30 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| WO2014195810A2 (en) * | 2013-06-04 | 2014-12-11 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| SG11201509782TA (en) * | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| WO2015022613A1 (en) * | 2013-08-11 | 2015-02-19 | Mahesh Kandula | Compositions and methods for the treatment of diabetes and pre-diabetes |
| WO2015171516A1 (en) * | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions and methods relating to ionic salts of peptides |
| CN107074884A (zh) | 2014-06-18 | 2017-08-18 | 西蒂斯制药有限责任公司 | 活性剂的矿物质氨基酸复合物 |
| US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
| WO2016132186A1 (en) * | 2015-02-20 | 2016-08-25 | Mohan M Alapati | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome |
| WO2016151372A1 (en) * | 2015-03-21 | 2016-09-29 | Mohan M Alapati | Compositions and methods for the treatment of hyperglycemia and metabolic syndrome |
| KR102437682B1 (ko) | 2016-06-03 | 2022-08-29 | 테티스 파마수티컬스 엘엘씨 | 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법 |
| WO2019008101A1 (en) | 2017-07-06 | 2019-01-10 | Evonik Technochemie Gmbh | ENTERICALLY COATED SOLID DOSAGE FORM COMPRISING AMINO ACIDS SALTS OF OMEGA-3 FATTY ACIDS |
| KR102628351B1 (ko) | 2017-08-15 | 2024-01-25 | 에보니크 오퍼레이션즈 게엠베하 | 오메가-3 지방산 아미노산 염의 높은 활성 성분 함량을 갖는 정제 |
| US11497722B2 (en) * | 2017-12-18 | 2022-11-15 | Soochow University | Use of metformin salt in the treatment of cerebral infarction |
| KR102977459B1 (ko) | 2019-08-08 | 2026-06-16 | 에보니크 오퍼레이션즈 게엠베하 | 다중불포화 지방산 염의 제조를 위한 다운스트림 공정 |
| US20220287345A1 (en) | 2019-08-08 | 2022-09-15 | Evonik Operations Gmbh | Solubility enhancement of poorly soluble actives |
| CN113105367B (zh) | 2021-03-30 | 2022-08-02 | 广州大学 | 一类二甲双胍盐及其制备方法和应用 |
| CN115192625A (zh) * | 2022-06-30 | 2022-10-18 | 山东海赜生物科技有限公司 | 一种口服组合物 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| CN1416341B (zh) | 2000-02-04 | 2010-05-05 | 武田药品工业株式会社 | 稳定的乳液组合物 |
| US6491950B1 (en) | 2000-08-07 | 2002-12-10 | Kos Pharmaceuticals, Inc. | Controlled release pharmaceutical composition |
| US6667064B2 (en) | 2000-08-30 | 2003-12-23 | Pilot Therapeutics, Inc. | Composition and method for treatment of hypertriglyceridemia |
| US6689385B2 (en) * | 2000-11-03 | 2004-02-10 | Chronorx Llc | Formulations for the treatment of insulin resistance and type 2 diabetes mellitus |
| FR2818906B1 (fr) * | 2000-12-29 | 2004-04-02 | Dospharma | Association medicamenteuse d'une biguanine et d'un transporteur, par exemple de metformine et d'arginine |
| DE10102050A1 (de) | 2001-01-17 | 2002-07-18 | Basf Ag | Zubereitung zur Verbesserung der Nahrungsverwertung |
| JP4220247B2 (ja) | 2001-03-29 | 2009-02-04 | ビーエーエスエフ ソシエタス・ヨーロピア | 共役不飽和グリセリド混合物及びその製造方法 |
| JP4744081B2 (ja) | 2001-08-31 | 2011-08-10 | ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー | 植物抽出物を用いて障害を処置するための方法 |
| ITMI20012384A1 (it) | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| AU2003211131A1 (en) * | 2002-02-14 | 2003-09-04 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
| US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| WO2004004693A1 (en) * | 2002-07-05 | 2004-01-15 | Collgegium Pharmaceutical | Abuse-deterrent pharmaceutical compositions of opiods and other drugs |
| EP1558237A4 (en) * | 2002-09-27 | 2007-01-17 | Martek Biosciences Corp | IMPROVED BLOOD SUGAR CONTROL F RPRU-DIABETES AND / OR DIABETES TYPE II USING DOCOSAHEXAENSURE |
| ITMI20022394A1 (it) | 2002-11-13 | 2004-05-14 | Bracco Spa | Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche. |
| CA2516142A1 (en) * | 2003-03-18 | 2004-09-30 | Novartis Ag | Compositions comprising fatty acids and amino acids |
| EP1510208A1 (en) | 2003-08-22 | 2005-03-02 | Fournier Laboratories Ireland Limited | Pharmaceutical composition comprising a combination of metformin and statin |
| CA2543722C (en) | 2003-10-29 | 2011-01-04 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| US20080045559A1 (en) | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
| RU2006118801A (ru) * | 2003-10-31 | 2007-12-10 | Алза Корпорейшн (Us) | Композиции и лекарственные формы для усиления всасывания габапентина и прегабалина |
| EP1708707A1 (en) | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| US20060003976A1 (en) | 2004-06-04 | 2006-01-05 | Yuehua Zhang | Cholesterol/bile acid/bile acid derivative-modified therapeutic drug compounds |
| US20100021555A1 (en) * | 2004-10-15 | 2010-01-28 | Karl Geiringer | Compositions containing high omega-3 and low saturated fatty acid levels |
| EP1804815A2 (en) | 2004-10-29 | 2007-07-11 | Joan Campell-Tofte | Anti-diabetic extract isolated from rauvolfia vomitoria and citrus aurantium, and methods of using same |
| EP1898922A4 (en) | 2005-07-04 | 2012-03-14 | Ramu Krishnan | MEDICINE OR IMPROVED PHARMACEUTICAL COMPOUNDS AND PREPARATION THEREOF |
| EP1960356A2 (en) | 2005-11-03 | 2008-08-27 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
| AU2007213506A1 (en) * | 2006-02-07 | 2007-08-16 | Universitetet I Oslo | Omega 3 |
| EP1984355A2 (en) | 2006-02-16 | 2008-10-29 | Takeda Pharmaceutical Company Limited | Cyclic amine compound and use thereof for the prophylaxis or treatment of hypertension |
| US20090047340A1 (en) | 2006-03-29 | 2009-02-19 | Guilford F Timothy | Liposomal reduced glutathione and 1-arginine, including with other ingredient(s), capable of multipath administration for reversal and prevention of obesity and for mitochondrial biogenesis |
| CN101522658A (zh) | 2006-06-16 | 2009-09-02 | 因迪基恩药物公司 | 作为抗糖尿病药用于控制糖尿病高血糖症和糖尿病并发症的二甲双胍r-(+)硫辛酸盐 |
| US8399516B2 (en) | 2006-11-01 | 2013-03-19 | Pronova Biopharma Norge As | Alpha-substituted omega-3 lipids that are activators or modulators of the peroxisome proliferators-activated receptor (PPAR) |
| WO2008053340A1 (en) * | 2006-11-03 | 2008-05-08 | Pronova Biopharma Norge As | A combination product comprising at least one lipid substituted in the alpha position and at least one hypoglycemic agent |
| WO2008058274A2 (en) * | 2006-11-09 | 2008-05-15 | Children's Medical Center Corporation | Use of resolvins and docosatrienes and analogues thereof for the treatment of angiogenesis and ocular neovascularization |
| WO2008093984A1 (en) * | 2007-01-29 | 2008-08-07 | Hanall Pharmaceutical Company. Ltd | N, n- dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same |
| TW200904433A (en) | 2007-04-27 | 2009-02-01 | Takeda Pharmaceutical | Substituted imidazole compound and use thereof |
| US20090227560A1 (en) | 2007-04-27 | 2009-09-10 | Takanobu Kuroita | Substituted imidazole compound and use thereof |
| US20090054513A1 (en) * | 2007-08-22 | 2009-02-26 | Response Scientific, Inc. | Method of managing blood glucose levels, insulin levels and/or insulin receptor functionality in individuals with diabetes, polycystic ovarian syndrome and/or alzheimer's disease |
| JP5292404B2 (ja) * | 2007-09-21 | 2013-09-18 | ハンオル バイオファーマ カンパニー，リミテッド | Ｎ，ｎ−ジメチルイミドジカルボンイミド酸ジアミドのジカルボン酸塩、その製造方法、及びその薬剤学的組成物 |
| EP2202228B1 (en) | 2007-10-15 | 2014-12-10 | Takeda Pharmaceutical Company Limited | Amide compounds and use of the same |
| CA2723434C (en) | 2008-05-05 | 2018-01-23 | Oramed Ltd. | Methods and compositions for oral administration of exenatide |
| SG188117A1 (en) | 2008-06-19 | 2013-03-28 | Takeda Pharmaceutical | Heterocyclic compound and use thereof |
| CN107233337A (zh) * | 2009-04-29 | 2017-10-10 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| US20110052678A1 (en) | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
| US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
| WO2013192109A1 (en) | 2012-06-17 | 2013-12-27 | Matinas Biopharma, Inc. | Omega-3 pentaenoic acid compositions and methods of use |
-
2012
- 2012-01-11 US US13/348,265 patent/US20120178813A1/en not_active Abandoned
- 2012-01-12 BR BR112013017845A patent/BR112013017845A2/pt not_active IP Right Cessation
- 2012-01-12 CA CA2824192A patent/CA2824192A1/en not_active Abandoned
- 2012-01-12 EP EP12734013.1A patent/EP2663186A4/en not_active Withdrawn
- 2012-01-12 CN CN201280005222.1A patent/CN103533833B/zh not_active Expired - Fee Related
- 2012-01-12 JP JP2013549539A patent/JP5911514B2/ja not_active Expired - Fee Related
- 2012-01-12 EA EA201391028A patent/EA201391028A1/ru unknown
- 2012-01-12 WO PCT/US2012/021070 patent/WO2012097144A1/en not_active Ceased
- 2012-01-12 MX MX2013008131A patent/MX2013008131A/es not_active Application Discontinuation
- 2012-01-12 AU AU2012205547A patent/AU2012205547B2/en not_active Ceased
- 2012-01-12 KR KR20137018679A patent/KR20140092228A/ko not_active Withdrawn
-
2013
- 2013-06-21 US US13/923,829 patent/US8901107B2/en not_active Expired - Fee Related
- 2013-07-04 IL IL227346A patent/IL227346A0/en unknown
- 2013-12-20 US US14/136,843 patent/US9012507B2/en not_active Expired - Fee Related
-
2014
- 2014-10-27 US US14/524,721 patent/US9216951B2/en not_active Expired - Fee Related
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