JP2014510081A5 - - Google Patents
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- Publication number
- JP2014510081A5 JP2014510081A5 JP2013558154A JP2013558154A JP2014510081A5 JP 2014510081 A5 JP2014510081 A5 JP 2014510081A5 JP 2013558154 A JP2013558154 A JP 2013558154A JP 2013558154 A JP2013558154 A JP 2013558154A JP 2014510081 A5 JP2014510081 A5 JP 2014510081A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- item
- oral formulation
- seed extract
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000284 extract Substances 0.000 claims description 93
- 239000000203 mixture Substances 0.000 claims description 63
- 238000009472 formulation Methods 0.000 claims description 62
- 229940087603 Grape Seed Extract Drugs 0.000 claims description 49
- 235000002532 grape seed extract Nutrition 0.000 claims description 49
- 239000001717 vitis vinifera seed extract Substances 0.000 claims description 49
- 239000003795 chemical substances by application Substances 0.000 claims description 41
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims description 29
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims description 29
- ACTIUHUUMQJHFO-UPTCCGCDSA-N Coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 29
- 240000007817 Olea europaea Species 0.000 claims description 29
- 229940114496 Olive Leaf Extract Drugs 0.000 claims description 29
- 235000013399 edible fruits Nutrition 0.000 claims description 29
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims description 28
- AGBQKNBQESQNJD-SSDOTTSWSA-N Lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims description 27
- 235000019136 lipoic acid Nutrition 0.000 claims description 27
- 229960002663 thioctic acid Drugs 0.000 claims description 27
- 230000002503 metabolic Effects 0.000 claims description 19
- ZIUSSTSXXLLKKK-HWUZOJPISA-N Curcumin Natural products C1=C(O)C(OC)=CC(\C=C\C(\O)=C/C(=O)/C=C/C=2C=C(OC)C(O)=CC=2)=C1 ZIUSSTSXXLLKKK-HWUZOJPISA-N 0.000 claims description 18
- OAIJSZIZWZSQBC-LWRKPGOESA-N Lycopene Natural products CC(C)=CCC\C(C)=C/C=C/C(/C)=C\C=C\C(\C)=C/C=C/C=C(/C)\C=C\C=C(\C)/C=C/C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-LWRKPGOESA-N 0.000 claims description 18
- 102100017234 NFE2L2 Human genes 0.000 claims description 18
- 101710031938 NFE2L2 Proteins 0.000 claims description 18
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Resveratrol Natural products C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 16
- 230000002708 enhancing Effects 0.000 claims description 13
- 230000002605 anti-dotal Effects 0.000 claims description 12
- 239000000729 antidote Substances 0.000 claims description 12
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims description 9
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-β,β-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims description 9
- KBPHJBAIARWVSC-TWGKZGRNSA-N (3R,3'R,6'R)-β,ε-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=C[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-TWGKZGRNSA-N 0.000 claims description 9
- 229940109262 Curcumin Drugs 0.000 claims description 9
- 229960005375 Lutein Drugs 0.000 claims description 9
- KBPHJBAIARWVSC-NRHWGSPPSA-N Lutein Natural products O[C@H]1C=C(C)[C@H](/C=C/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=2C(C)(C)C[C@H](O)CC=2C)\C)/C)\C)/C)C(C)(C)C1 KBPHJBAIARWVSC-NRHWGSPPSA-N 0.000 claims description 9
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims description 9
- 240000004678 Panax pseudoginseng Species 0.000 claims description 9
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 9
- 229940109529 Pomegranate Extract Drugs 0.000 claims description 9
- 235000005805 Prunus cerasus Nutrition 0.000 claims description 9
- 244000207449 Prunus puddum Species 0.000 claims description 9
- 235000009226 Prunus puddum Nutrition 0.000 claims description 9
- JKQXZKUSFCKOGQ-PQJNXSRMSA-N Zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C/C=C/C(/C)=C\C=C\C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-PQJNXSRMSA-N 0.000 claims description 9
- 235000012754 curcumin Nutrition 0.000 claims description 9
- 239000004148 curcumin Substances 0.000 claims description 9
- 235000005035 ginseng Nutrition 0.000 claims description 9
- 235000008434 ginseng Nutrition 0.000 claims description 9
- 229940038487 grape extract Drugs 0.000 claims description 9
- 235000012680 lutein Nutrition 0.000 claims description 9
- 239000001656 lutein Substances 0.000 claims description 9
- 235000012661 lycopene Nutrition 0.000 claims description 9
- 239000001751 lycopene Substances 0.000 claims description 9
- 229960004999 lycopene Drugs 0.000 claims description 9
- 230000001737 promoting Effects 0.000 claims description 9
- 235000021283 resveratrol Nutrition 0.000 claims description 9
- 229940016667 resveratrol Drugs 0.000 claims description 9
- 235000020748 rosemary extract Nutrition 0.000 claims description 9
- 229940092258 rosemary extract Drugs 0.000 claims description 9
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims description 9
- 235000010930 zeaxanthin Nutrition 0.000 claims description 9
- 239000001775 zeaxanthin Substances 0.000 claims description 9
- 229940043269 zeaxanthin Drugs 0.000 claims description 9
- -1 elixirs Substances 0.000 claims description 8
- 238000001784 detoxification Methods 0.000 claims description 7
- 230000000051 modifying Effects 0.000 claims description 7
- 230000003078 antioxidant Effects 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 5
- 235000006708 antioxidants Nutrition 0.000 claims description 5
- 230000001413 cellular Effects 0.000 claims description 5
- 238000011084 recovery Methods 0.000 claims description 5
- 229940002508 Ginger extract Drugs 0.000 claims description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
- 235000020708 ginger extract Nutrition 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 108009000409 Autophagy Proteins 0.000 claims description 3
- 108010037462 Cyclooxygenase 2 Proteins 0.000 claims description 3
- 102100013242 GCLC Human genes 0.000 claims description 3
- 101710013903 GCLC Proteins 0.000 claims description 3
- 102100007612 GCLM Human genes 0.000 claims description 3
- 101710013901 GCLM Proteins 0.000 claims description 3
- 101710025738 GLN1-2 Proteins 0.000 claims description 3
- 102100004384 GPX1 Human genes 0.000 claims description 3
- 101700060799 GPX1 Proteins 0.000 claims description 3
- 101700034462 GPX4 Proteins 0.000 claims description 3
- 102100016553 GPX4 Human genes 0.000 claims description 3
- 101700011492 GPX6 Proteins 0.000 claims description 3
- 102100013241 GSR Human genes 0.000 claims description 3
- 101710013882 GSR Proteins 0.000 claims description 3
- 102100007618 GSTA1 Human genes 0.000 claims description 3
- 101700076345 GSTA1 Proteins 0.000 claims description 3
- 101700069553 GSTF1 Proteins 0.000 claims description 3
- 101700039936 HMOX1 Proteins 0.000 claims description 3
- 102100004067 HMOX1 Human genes 0.000 claims description 3
- 101700019517 HYR1 Proteins 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 101710045273 NANOS2 Proteins 0.000 claims description 3
- 101710045275 NANOS3 Proteins 0.000 claims description 3
- 101700049309 NOS2 Proteins 0.000 claims description 3
- 102100002496 NOS2 Human genes 0.000 claims description 3
- 101700006637 NOS3 Proteins 0.000 claims description 3
- 102100000871 NOS3 Human genes 0.000 claims description 3
- 101700067251 NQO1 Proteins 0.000 claims description 3
- 102100002509 NQO1 Human genes 0.000 claims description 3
- 102100015381 PTGS2 Human genes 0.000 claims description 3
- 102100006168 SQSTM1 Human genes 0.000 claims description 3
- 101710026644 SQSTM1 Proteins 0.000 claims description 3
- 102100016159 SRXN1 Human genes 0.000 claims description 3
- 101700046133 SRXN1 Proteins 0.000 claims description 3
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 claims description 3
- 102000008221 Superoxide Dismutase-1 Human genes 0.000 claims description 3
- 102100005716 UGT1A6 Human genes 0.000 claims description 3
- 101710034656 UGT1A6 Proteins 0.000 claims description 3
- 230000006877 autophagy Effects 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 210000001519 tissues Anatomy 0.000 claims description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 2
- 229940067606 Lecithin Drugs 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 235000013361 beverage Nutrition 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000006196 drop Substances 0.000 claims description 2
- 235000013305 food Nutrition 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 229920000591 gum Polymers 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 239000007937 lozenge Substances 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 235000012431 wafers Nutrition 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims 1
- 230000037396 body weight Effects 0.000 description 2
- 240000001055 Brassica oleracea var. italica Species 0.000 description 1
- 108009000578 Oxidative Stress Proteins 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000020687 goji berry extract Nutrition 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452478P | 2011-03-14 | 2011-03-14 | |
| US61/452,478 | 2011-03-14 | ||
| PCT/US2012/029136 WO2012125772A2 (en) | 2011-03-14 | 2012-03-14 | Oral formulations for promoting cellular purification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018035032A Division JP2018087246A (ja) | 2011-03-14 | 2018-02-28 | 細胞浄化を促進するための経口製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510081A JP2014510081A (ja) | 2014-04-24 |
| JP2014510081A5 true JP2014510081A5 (US20070167479A1-20070719-C00034.png) | 2015-04-30 |
| JP6625792B2 JP6625792B2 (ja) | 2019-12-25 |
Family
ID=46831336
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558154A Active JP6625792B2 (ja) | 2011-03-14 | 2012-03-14 | 細胞浄化を促進するための経口製剤 |
| JP2018035032A Withdrawn JP2018087246A (ja) | 2011-03-14 | 2018-02-28 | 細胞浄化を促進するための経口製剤 |
| JP2019121344A Pending JP2019154453A (ja) | 2011-03-14 | 2019-06-28 | 細胞浄化を促進するための経口製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018035032A Withdrawn JP2018087246A (ja) | 2011-03-14 | 2018-02-28 | 細胞浄化を促進するための経口製剤 |
| JP2019121344A Pending JP2019154453A (ja) | 2011-03-14 | 2019-06-28 | 細胞浄化を促進するための経口製剤 |
Country Status (7)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9492952B2 (en) | 2010-08-30 | 2016-11-15 | Endo-Surgery, Inc. | Super-hydrophilic structures |
| US20120143228A1 (en) | 2010-08-30 | 2012-06-07 | Agency For Science Technology And Research | Adhesive structure with stiff protrusions on adhesive surface |
| BR112014016029B1 (pt) | 2011-12-29 | 2020-05-19 | Agency Science Tech & Res | estrutura adesiva e processo para produzir uma estrutura adesiva |
| US8969648B2 (en) | 2012-04-06 | 2015-03-03 | Ethicon, Inc. | Blood clotting substrate and medical device |
| US8926881B2 (en) | 2012-04-06 | 2015-01-06 | DePuy Synthes Products, LLC | Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them |
| KR20200128438A (ko) | 2012-11-26 | 2020-11-12 | 액세스 비지니스 그룹 인터내셔날 엘엘씨 | 항산화 식이 보충제 및 관련 방법 |
| WO2015030293A1 (ko) * | 2013-08-30 | 2015-03-05 | 씨제이제일제당 (주) | 포도 및 오미자 복합 추출물을 포함하는 대사증후군 관련 질환의 예방 또는 치료용 조성물 |
| TWI679980B (zh) * | 2013-09-30 | 2019-12-21 | 日商日星股份有限公司 | 肥胖抑制組成物 |
| WO2016037971A1 (en) | 2014-09-08 | 2016-03-17 | Bios Line S.P.A. | Compositions comprising glucosinolates precursors of sulforaphane in combination with extracts of rosemary |
| CN104382983A (zh) * | 2014-11-28 | 2015-03-04 | 哈尔滨墨医生物技术有限公司 | 一种藏虫草提取物软胶囊及其制备方法 |
| FR3046935B1 (fr) * | 2016-01-21 | 2020-12-25 | Ly Eang Hay | Composition a visee detoxifiante pour administration par voie orale et son procede de preparation |
| JP2016121178A (ja) * | 2016-03-03 | 2016-07-07 | サンスター株式会社 | 抗酸化機能亢進剤 |
| KR102636383B1 (ko) | 2017-08-04 | 2024-02-14 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| JP2022521467A (ja) | 2019-02-05 | 2022-04-08 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| KR20210135507A (ko) | 2019-02-06 | 2021-11-15 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| US11541094B2 (en) | 2019-08-06 | 2023-01-03 | Healthrite Partners, LLC | Formulations for treating metabolic syndrome and increasing energy levels |
| US20210213095A1 (en) * | 2020-01-13 | 2021-07-15 | Lifevantage Corporation | Compositions and methods for activating cellular signaling pathways |
| AU2021347101A1 (en) | 2020-09-24 | 2023-04-13 | Mars, Incorporated | Food compositions and applications thereof |
| US11541116B1 (en) | 2022-01-07 | 2023-01-03 | Kojin Therapeutics, Inc. | Methods and compositions for inducing ferroptosis in vivo |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2346325A (en) * | 1999-02-02 | 2000-08-09 | Wassen Int Ltd | Formulation comprising a brassica extract or sulforaphane and resveratrol |
| US20040001817A1 (en) * | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
| WO2006043671A1 (ja) * | 2004-10-22 | 2006-04-27 | Kirin Beer Kabushiki Kaisha | 転写因子Ｎｒｆ２活性化剤およびその機能が付与された食品 |
| US20090069417A1 (en) * | 2005-10-11 | 2009-03-12 | Yoav Sharoni | Carotenoid oxidation products as chemopreventive and chemotherapeutic agents |
| US8017147B2 (en) * | 2008-04-07 | 2011-09-13 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
| US20080305096A1 (en) * | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
| JP2010539102A (ja) * | 2007-09-11 | 2010-12-16 | ジョスリン ダイアベティス センター インコーポレイテッド | 第ｉｉ相解毒及び抗酸化活性 |
| ES2592210T3 (es) * | 2009-04-17 | 2016-11-28 | Dsm Ip Assets B.V. | Combinaciones de hidroxitirosol para mejorar la función mitocondrial y producción de energía |
| KR101944441B1 (ko) * | 2010-05-24 | 2019-01-31 | 엔에스이 프로덕츠, 인크. | 노화의 효과를 중화시키기 위한 경구 제제 |
-
2012
- 2012-03-14 SG SG2013067640A patent/SG193370A1/en unknown
- 2012-03-14 SG SG10201703576WA patent/SG10201703576WA/en unknown
- 2012-03-14 JP JP2013558154A patent/JP6625792B2/ja active Active
- 2012-03-14 KR KR1020137026684A patent/KR102090836B1/ko active IP Right Grant
- 2012-03-14 EP EP12758097.5A patent/EP2686021B1/en active Active
- 2012-03-14 WO PCT/US2012/029136 patent/WO2012125772A2/en unknown
- 2012-03-14 CN CN201280023826.9A patent/CN103732258A/zh active Pending
- 2012-03-14 US US13/420,547 patent/US20130071369A1/en not_active Abandoned
-
2017
- 2017-08-13 US US15/675,761 patent/US20180078601A1/en not_active Abandoned
-
2018
- 2018-02-28 JP JP2018035032A patent/JP2018087246A/ja not_active Withdrawn
-
2019
- 2019-06-28 JP JP2019121344A patent/JP2019154453A/ja active Pending
-
2021
- 2021-03-29 US US17/216,443 patent/US20210290721A1/en active Pending
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