JP2014509653A5 - - Google Patents
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- JP2014509653A5 JP2014509653A5 JP2014502821A JP2014502821A JP2014509653A5 JP 2014509653 A5 JP2014509653 A5 JP 2014509653A5 JP 2014502821 A JP2014502821 A JP 2014502821A JP 2014502821 A JP2014502821 A JP 2014502821A JP 2014509653 A5 JP2014509653 A5 JP 2014509653A5
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- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
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- treatment
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000010099 disease Diseases 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 5
- 108040005185 1-phosphatidylinositol-3-kinase activity proteins Proteins 0.000 claims 5
- 102000003964 Histone deacetylases Human genes 0.000 claims 4
- 108090000353 Histone deacetylases Proteins 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000001404 mediated Effects 0.000 claims 4
- 230000002062 proliferating Effects 0.000 claims 4
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010017758 Gastric cancer Diseases 0.000 claims 2
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 2
- 206010020243 Hodgkin's disease Diseases 0.000 claims 2
- 208000007766 Kaposi Sarcoma Diseases 0.000 claims 2
- 206010024324 Leukaemias Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010025650 Malignant melanoma Diseases 0.000 claims 2
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 2
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 2
- 206010025310 Other lymphomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 2
- 208000003154 Papilloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 206010041823 Squamous cell carcinoma Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 201000011231 colorectal cancer Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161470849P | 2011-04-01 | 2011-04-01 | |
| US61/470,849 | 2011-04-01 | ||
| US201161559489P | 2011-11-14 | 2011-11-14 | |
| US61/559,489 | 2011-11-14 | ||
| PCT/US2012/031361 WO2012135571A1 (en) | 2011-04-01 | 2012-03-30 | Phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155625A Division JP6275784B2 (ja) | 2011-04-01 | 2016-08-08 | 亜鉛結合部分を有するホスホイノシチド３−キナーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509653A JP2014509653A (ja) | 2014-04-21 |
| JP2014509653A5 true JP2014509653A5 (US20070167479A1-20070719-C00034.png) | 2015-04-09 |
| JP6242331B2 JP6242331B2 (ja) | 2017-12-06 |
Family
ID=46931927
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014502821A Active JP6242331B2 (ja) | 2011-04-01 | 2012-03-30 | 亜鉛結合部分を有するホスホイノシチド３−キナーゼインヒビター |
| JP2016155625A Active JP6275784B2 (ja) | 2011-04-01 | 2016-08-08 | 亜鉛結合部分を有するホスホイノシチド３−キナーゼインヒビター |
| JP2018001910A Withdrawn JP2018052987A (ja) | 2011-04-01 | 2018-01-10 | 亜鉛結合部分を有するホスホイノシチド３−キナーゼインヒビター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155625A Active JP6275784B2 (ja) | 2011-04-01 | 2016-08-08 | 亜鉛結合部分を有するホスホイノシチド３−キナーゼインヒビター |
| JP2018001910A Withdrawn JP2018052987A (ja) | 2011-04-01 | 2018-01-10 | 亜鉛結合部分を有するホスホイノシチド３−キナーゼインヒビター |
Country Status (30)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI558710B (zh) | 2009-01-08 | 2016-11-21 | 古利斯股份有限公司 | 具有鋅連接部位的磷酸肌醇３－激酶抑制劑 |
| HUE028910T2 (en) | 2011-04-01 | 2017-01-30 | Curis Inc | Phosphonoinoside-3-kinase inhibitor with zinc-binding radical |
| AU2012339640B2 (en) | 2011-11-14 | 2017-01-05 | Ignyta, Inc. | Uracil derivatives as AXL and c-MET kinase inhibitors |
| CN104725301A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种1,2-二氢吡啶-2-酮衍生物的制备方法 |
| AU2016250972B2 (en) * | 2015-04-21 | 2019-01-17 | Chengdu Zenitar Biomedical Technology Co., Ltd. | Purinyl-n-hydroxyl pyrimidine formamide derivative, preparation methods and uses thereof |
| AU2017301012B2 (en) * | 2016-07-19 | 2020-07-09 | National Institute Of Plant Genome Research | Novel protein against fungal pathogens |
| CN109923117A (zh) * | 2016-11-02 | 2019-06-21 | 柯瑞斯公司 | 使用具有锌结合部分的磷酸肌醇3-激酶抑制剂的联合治疗 |
| AU2018360845B2 (en) * | 2017-11-06 | 2024-05-02 | Cold Spring Harbor Laboratory | Method and compositions for forming a copper-containing complex and uses thereof |
| EP3849554A4 (en) | 2018-09-11 | 2022-06-01 | Curis, Inc. | POLYTHERAPY WITH A PHOSPHOINONOSITIDE 3-KINASE INHIBITOR HAVING A ZINC-BINDING METAL |
| WO2023212574A1 (en) * | 2022-04-26 | 2023-11-02 | Olivia Szu Hsieh Lee Nakaya | Compositions and methods for modulating rhythmic activity of pacemaker cardiomyocytes |
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2012
- 2012-03-30 HU HUE12764605A patent/HUE028910T2/en unknown
- 2012-03-30 CA CA2830822A patent/CA2830822C/en active Active
- 2012-03-30 DK DK12764605.7T patent/DK2694075T3/en active
- 2012-03-30 EA EA201301114A patent/EA022434B9/ru unknown
- 2012-03-30 TW TW101111283A patent/TWI571469B/zh active
- 2012-03-30 CN CN201280026400.9A patent/CN103582483B/zh active Active
- 2012-03-30 PL PL12764605.7T patent/PL2694075T3/pl unknown
- 2012-03-30 AU AU2012236367A patent/AU2012236367B2/en active Active
- 2012-03-30 RS RS20160457A patent/RS54903B1/sr unknown
- 2012-03-30 ME MEP-2019-179A patent/ME03523B/me unknown
- 2012-03-30 JP JP2014502821A patent/JP6242331B2/ja active Active
- 2012-03-30 RS RSP20190842 patent/RS59219B1/sr unknown
- 2012-03-30 DK DK16166266.3T patent/DK3111938T3/da active
- 2012-03-30 PE PE2013002160A patent/PE20141382A1/es active IP Right Grant
- 2012-03-30 PL PL16166266T patent/PL3111938T3/pl unknown
- 2012-03-30 HU HUE16166266A patent/HUE045041T2/hu unknown
- 2012-03-30 KR KR1020137028748A patent/KR101902325B1/ko active IP Right Grant
- 2012-03-30 WO PCT/US2012/031361 patent/WO2012135571A1/en active Application Filing
- 2012-03-30 PT PT16166266T patent/PT3111938T/pt unknown
- 2012-03-30 ES ES12764605.7T patent/ES2577982T3/es active Active
- 2012-03-30 LT LTEP16166266.3T patent/LT3111938T/lt unknown
- 2012-03-30 MX MX2013011132A patent/MX340577B/es active IP Right Grant
- 2012-03-30 ME MEP-2016-116A patent/ME02451B/me unknown
- 2012-03-30 EP EP16166266.3A patent/EP3111938B1/en active Active
- 2012-03-30 SG SG2013070883A patent/SG193563A1/en unknown
- 2012-03-30 PT PT127646057T patent/PT2694075T/pt unknown
- 2012-03-30 SI SI201231625T patent/SI3111938T1/sl unknown
- 2012-03-30 KR KR1020187026847A patent/KR20180108848A/ko not_active Application Discontinuation
- 2012-03-30 CN CN201610034817.XA patent/CN105461736B/zh active Active
- 2012-03-30 EP EP12764605.7A patent/EP2694075B1/en active Active
- 2012-03-30 US US13/435,062 patent/US8710219B2/en active Active
- 2012-03-30 BR BR112013025340-1A patent/BR112013025340B1/pt active IP Right Grant
- 2012-03-30 SI SI201230597A patent/SI2694075T1/sl unknown
- 2012-03-30 SG SG10201602569RA patent/SG10201602569RA/en unknown
- 2012-03-30 ES ES16166266T patent/ES2733128T3/es active Active
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2013
- 2013-09-19 ZA ZA2013/07082A patent/ZA201307082B/en unknown
- 2013-09-29 IL IL228588A patent/IL228588A/en active IP Right Grant
- 2013-09-30 CL CL2013002823A patent/CL2013002823A1/es unknown
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2014
- 2014-03-05 US US14/197,769 patent/US9249156B2/en active Active
- 2014-08-11 HK HK14108192.3A patent/HK1194969A1/zh unknown
- 2014-08-21 ZA ZA2014/06167A patent/ZA201406167B/en unknown
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2015
- 2015-12-28 US US14/979,887 patent/US9657032B2/en active Active
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2016
- 2016-05-20 HR HRP20160545TT patent/HRP20160545T1/hr unknown
- 2016-06-16 SM SM201600179T patent/SMT201600179B/it unknown
- 2016-07-14 CY CY20161100683T patent/CY1117785T1/el unknown
- 2016-08-08 JP JP2016155625A patent/JP6275784B2/ja active Active
- 2016-10-30 IL IL248597A patent/IL248597B/en active IP Right Grant
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2017
- 2017-04-25 US US15/496,318 patent/US10111864B2/en active Active
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2018
- 2018-01-10 JP JP2018001910A patent/JP2018052987A/ja not_active Withdrawn
- 2018-10-03 US US16/150,845 patent/US10543197B2/en active Active
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2019
- 2019-06-17 HR HRP20191091TT patent/HRP20191091T1/hr unknown
- 2019-07-17 CY CY20191100760T patent/CY1121825T1/el unknown
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2020
- 2020-01-07 US US16/736,081 patent/US11135205B2/en active Active
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2021
- 2021-09-09 US US17/470,410 patent/US11654136B2/en active Active
