JP2014509604A5 - - Google Patents

Info

Publication number

JP2014509604A5

JP2014509604A5 JP2013558459A JP2013558459A JP2014509604A5 JP 2014509604 A5 JP2014509604 A5 JP 2014509604A5 JP 2013558459 A JP2013558459 A JP 2013558459A JP 2013558459 A JP2013558459 A JP 2013558459A JP 2014509604 A5 JP2014509604 A5 JP 2014509604A5

Authority

JP

Japan

Prior art keywords

group

conjugate molecule

seq

molecule according

tyrosine

Prior art date

2012-03-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 21
• 125000000129 anionic group Chemical group 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 9
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 7
• 235000001014 amino acid Nutrition 0.000 claims 7
• 150000001413 amino acids Chemical class 0.000 claims 7
• 108010041397 CD4 Antigens Proteins 0.000 claims 6
• CIQHWLTYGMYQQR-QMMMGPOBSA-N O(4')-sulfo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(OS(O)(=O)=O)C=C1 CIQHWLTYGMYQQR-QMMMGPOBSA-N 0.000 claims 6
• 125000000539 amino acid group Chemical group 0.000 claims 6
• LJHYWUVYIKCPGU-VIFPVBQESA-N (2s)-2-amino-3-[4-(carboxymethyl)phenyl]propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(CC(O)=O)C=C1 LJHYWUVYIKCPGU-VIFPVBQESA-N 0.000 claims 5
• YOFPFYYTUIARDI-LURJTMIESA-N (2s)-2-aminooctanedioic acid Chemical compound OC(=O)[C@@H](N)CCCCCC(O)=O YOFPFYYTUIARDI-LURJTMIESA-N 0.000 claims 5
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 5
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 5
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
• 235000003704 aspartic acid Nutrition 0.000 claims 4
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 4
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
• 229960004308 acetylcysteine Drugs 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 230000001588 bifunctional effect Effects 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• 235000013922 glutamic acid Nutrition 0.000 claims 2
• 239000004220 glutamic acid Substances 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• KOODSCBKXPPKHE-UHFFFAOYSA-N propanethioic s-acid Chemical compound CCC(S)=O KOODSCBKXPPKHE-UHFFFAOYSA-N 0.000 claims 2
• 208000030507 AIDS Diseases 0.000 claims 1
• 101710150620 Anionic peptide Proteins 0.000 claims 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• JCZLABDVDPYLRZ-AWEZNQCLSA-N biphenylalanine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1C1=CC=CC=C1 JCZLABDVDPYLRZ-AWEZNQCLSA-N 0.000 claims 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
• 150000003573 thiols Chemical class 0.000 claims 1
• -1 tyrosine sulfonates Chemical group 0.000 claims 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• UVPQESAVCPPSEX-UHFFFAOYSA-N CC(CC(N1CCC(NCCOCCC(C)=O)=O)=O)C1=O Chemical compound CC(CC(N1CCC(NCCOCCC(C)=O)=O)=O)C1=O UVPQESAVCPPSEX-UHFFFAOYSA-N 0.000 description 1