JP2014509319A5 - - Google Patents

Info

Publication number

JP2014509319A5

JP2014509319A5 JP2013553661A JP2013553661A JP2014509319A5 JP 2014509319 A5 JP2014509319 A5 JP 2014509319A5 JP 2013553661 A JP2013553661 A JP 2013553661A JP 2013553661 A JP2013553661 A JP 2013553661A JP 2014509319 A5 JP2014509319 A5 JP 2014509319A5

Authority

JP

Japan

Prior art keywords

cells

umbilical cord

cord tissue

pharmaceutical composition

hla

Prior art date

2012-02-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 25
• 210000001519 tissue Anatomy 0.000 claims 15
• 210000003954 umbilical cord Anatomy 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 239000003795 chemical substances by application Substances 0.000 claims 10
• 239000003814 drug Substances 0.000 claims 9
• 229940079593 drug Drugs 0.000 claims 9
• -1 PDGFr-α Proteins 0.000 claims 6
• 239000003446 ligand Substances 0.000 claims 6
• 102100022464 5'-nucleotidase Human genes 0.000 claims 3
• 102100022749 Aminopeptidase N Human genes 0.000 claims 3
• 102100032912 CD44 antigen Human genes 0.000 claims 3
• 102000009410 Chemokine receptor Human genes 0.000 claims 3
• 108050000299 Chemokine receptor Proteins 0.000 claims 3
• 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 3
• 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims 3
• 108010075704 HLA-A Antigens Proteins 0.000 claims 3
• 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
• 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
• 108010024164 HLA-G Antigens Proteins 0.000 claims 3
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
• 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 3
• 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 3
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 3
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 3
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 3
• 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 3
• 102000004890 Interleukin-8 Human genes 0.000 claims 3
• 108090001007 Interleukin-8 Proteins 0.000 claims 3
• 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 3
• 102000003729 Neprilysin Human genes 0.000 claims 3
• 108090000028 Neprilysin Proteins 0.000 claims 3
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 3
• 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 3
• 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 3
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 3
• 102100022647 Reticulon-1 Human genes 0.000 claims 3
• 101710122684 Reticulon-1 Proteins 0.000 claims 3
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 3
• 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 3
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 3
• 210000004369 blood Anatomy 0.000 claims 3
• 210000002798 bone marrow cell Anatomy 0.000 claims 3
• 210000002950 fibroblast Anatomy 0.000 claims 3
• 210000005260 human cell Anatomy 0.000 claims 3
• 238000002347 injection Methods 0.000 claims 3
• 239000007924 injection Substances 0.000 claims 3
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 3
• 229940096397 interleukin-8 Drugs 0.000 claims 3
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 3
• 210000002161 motor neuron Anatomy 0.000 claims 3
• 210000000653 nervous system Anatomy 0.000 claims 3
• 108010017842 Telomerase Proteins 0.000 claims 2
• 210000001130 astrocyte Anatomy 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000001802 infusion Methods 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• 210000002894 multi-fate stem cell Anatomy 0.000 claims 2
• 210000003061 neural cell Anatomy 0.000 claims 2
• 210000005155 neural progenitor cell Anatomy 0.000 claims 2
• 210000001178 neural stem cell Anatomy 0.000 claims 2
• 210000002569 neuron Anatomy 0.000 claims 2
• 235000016709 nutrition Nutrition 0.000 claims 2
• 210000004248 oligodendroglia Anatomy 0.000 claims 2
• 210000001778 pluripotent stem cell Anatomy 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000002513 implantation Methods 0.000 claims 1
• 238000007913 intrathecal administration Methods 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 230000000626 neurodegenerative effect Effects 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1