JP2014507470A5 - - Google Patents
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- Publication number
- JP2014507470A5 JP2014507470A5 JP2013557712A JP2013557712A JP2014507470A5 JP 2014507470 A5 JP2014507470 A5 JP 2014507470A5 JP 2013557712 A JP2013557712 A JP 2013557712A JP 2013557712 A JP2013557712 A JP 2013557712A JP 2014507470 A5 JP2014507470 A5 JP 2014507470A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- silica
- hydrogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 8
- 150000002431 hydrogen Chemical group 0.000 claims 7
- 125000000962 organic group Chemical group 0.000 claims 7
- -1 carboxylate ester Chemical class 0.000 claims 6
- 239000000377 silicon dioxide Substances 0.000 claims 6
- 108010024636 Glutathione Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229960003180 glutathione Drugs 0.000 claims 4
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 4
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical group OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 claims 2
- DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 claims 2
- GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical compound OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- RITKHVBHSGLULN-WHFBIAKZSA-N L-gamma-glutamyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(O)=O RITKHVBHSGLULN-WHFBIAKZSA-N 0.000 claims 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical group OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- 108010076986 Phytochelatins Proteins 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229910052792 caesium Inorganic materials 0.000 claims 2
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical group [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Chemical group SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052730 francium Inorganic materials 0.000 claims 2
- KLMCZVJOEAUDNE-UHFFFAOYSA-N francium atom Chemical group [Fr] KLMCZVJOEAUDNE-UHFFFAOYSA-N 0.000 claims 2
- 108010068906 gamma-glutamylcysteine Proteins 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical group OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 2
- 235000019136 lipoic acid Nutrition 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 239000011591 potassium Chemical group 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 229910052701 rubidium Inorganic materials 0.000 claims 2
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical group [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Chemical group 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229960002663 thioctic acid Drugs 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical group [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 229940068492 thiosalicylate Drugs 0.000 claims 2
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 231100000783 metal toxicity Toxicity 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000036542 oxidative stress Effects 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/041,798 US8575218B2 (en) | 2009-09-28 | 2011-03-07 | Thiol-containing compounds for the removal of elements from tissues and formulations therefor |
| US13/041,798 | 2011-03-07 | ||
| PCT/US2012/020418 WO2012121798A2 (en) | 2011-03-07 | 2012-01-06 | Thiol-containing compounds for the removal of elements from tissues and formulations therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507470A JP2014507470A (ja) | 2014-03-27 |
| JP2014507470A5 true JP2014507470A5 (enExample) | 2014-06-26 |
Family
ID=46798686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557712A Withdrawn JP2014507470A (ja) | 2011-03-07 | 2012-01-06 | 組織から元素を除去するチオール含有化合物およびその製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8575218B2 (enExample) |
| EP (1) | EP2683370A4 (enExample) |
| JP (1) | JP2014507470A (enExample) |
| CN (1) | CN103442706A (enExample) |
| AU (1) | AU2012226279A1 (enExample) |
| RU (1) | RU2013141994A (enExample) |
| WO (1) | WO2012121798A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8950583B2 (en) | 2008-12-06 | 2015-02-10 | Ermes Medical Company Limited | Method to remove heavy metals from a mammal |
| JP2013505963A (ja) * | 2009-09-28 | 2013-02-21 | ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデイション | 汚染された環境から元素を除去するチオール含有化合物およびその使用方法 |
| US8426368B2 (en) * | 2010-03-25 | 2013-04-23 | The University Of Kentucky Research Foundation | Method of ameliorating oxidative stress and supplementing the diet |
| GB2524831A (en) * | 2014-04-04 | 2015-10-07 | Ermes Medical Company Ltd | New pharmaceutical use |
| GB2526623A (en) | 2014-05-30 | 2015-12-02 | Ermes Medical Company Ltd | New pharmaceutical use |
| US9802889B2 (en) | 2014-12-02 | 2017-10-31 | Covalent Research Technologies, LLC | Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds |
| US20160367620A1 (en) | 2015-06-19 | 2016-12-22 | Harry B. Demopoulos | Glutathione |
| DK3493849T3 (en) | 2016-08-05 | 2022-03-07 | Emeramed Ltd | New uses of n, n-bis-2-mercaptoethyl isophthalamide |
| AU2019386979B2 (en) * | 2018-11-26 | 2023-03-16 | The Procter & Gamble Company | Solid pharmaceutical preparation containing lipoic acid and use thereof |
| US11174277B2 (en) | 2019-05-29 | 2021-11-16 | Alliance For Sustainable Energy, Llc | Sequestering compositions and materials |
| GB202005057D0 (en) | 2020-04-06 | 2020-05-20 | Emeramed Ltd | New Use |
| CN114642681B (zh) * | 2022-03-18 | 2023-08-29 | 中国科学院长春应用化学研究所 | 一种聚合物在顺铂解毒中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4039446A (en) * | 1972-06-28 | 1977-08-02 | Sumitomo Chemical Company, Limited | Heavy metal-binding agent process |
| US4281086A (en) * | 1978-12-11 | 1981-07-28 | The University Of Illinois Foundation | Polymer bound multidentate complexes |
| JPS57102852A (en) * | 1980-12-19 | 1982-06-26 | Shionogi & Co Ltd | Dicarboxylic acid diamide |
| DE3174885D1 (en) | 1981-02-03 | 1986-07-31 | Ici Plc | Process for the extraction of metal values and novel metal extractants |
| DE3231982A1 (de) * | 1982-08-27 | 1984-03-01 | Süd-Chemie AG, 8000 München | Thiolathaltiges mittel und verfahren zur entfernung von schwermetallionen aus verduennten waessrigen loesungen |
| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| US4751286A (en) * | 1985-11-19 | 1988-06-14 | The Johns Hopkins University | Protein label and drug delivery system |
| US5200473A (en) * | 1988-03-25 | 1993-04-06 | Jeanneret Gris Gilbert | Chelating resins and method for their use in the extraction of metal ions |
| US5073575A (en) * | 1988-08-26 | 1991-12-17 | The Regents Of The University Of California | Cadmium ion-chelating synthetic polymers and process thereof |
| US4969995A (en) * | 1988-08-26 | 1990-11-13 | The United States Of America As Represented By The United States Department Of Energy | Removal of metal ions from aqueous solution |
| US5173470A (en) * | 1991-08-09 | 1992-12-22 | Brigham Young University | Compositions and processes for removing, separating and concentrating desired ions from solutions using sulfur and aralkyl nitrogen containing ligands bonded to inorganic supports |
| US5494935A (en) * | 1992-01-17 | 1996-02-27 | University Of Utah Research Foundation | Methods for oral decorporation of metals |
| SE508881C2 (sv) * | 1994-03-02 | 1998-11-16 | Ctc Medical Ab | Preparat avsett att vid behandling av i tänder befintliga amalgamfyllningar och/eller vid inserering av nya amalgamfyllningar hämma frisättning av Hg från amalgamet och/eller oskadliggöra frisatt Hg |
| US5615862A (en) * | 1995-02-02 | 1997-04-01 | Gaudette; Robert M. | Metal precipitation composition for treating spent dry film stripping solution |
| US5766478A (en) * | 1995-05-30 | 1998-06-16 | The Regents Of The University Of California, Office Of Technology Transfer | Water-soluble polymers for recovery of metal ions from aqueous streams |
| US6126964A (en) * | 1996-01-04 | 2000-10-03 | Mirus Corporation | Process of making a compound by forming a polymer from a template drug |
| US6896899B2 (en) * | 1996-12-31 | 2005-05-24 | Antioxidant Pharmaceuticals Corp. | Pharmaceutical preparations of glutathione and methods of administration thereof |
| WO1999005302A1 (en) * | 1997-07-24 | 1999-02-04 | The Perkin-Elmer Corporation | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| US7087770B2 (en) * | 1998-05-16 | 2006-08-08 | Mirus Bio Corporation | Compound containing a labile disulfide bond |
| US6936729B2 (en) * | 1998-05-16 | 2005-08-30 | Mirus Bio Corporation | Compound containing a labile disulfide bond |
| US6586600B2 (en) * | 2000-12-06 | 2003-07-01 | University Of Kentucky Research Foundation | Multidentate sulfur-containing ligands |
| RS51031B (sr) * | 2001-04-30 | 2010-10-31 | Trommsdorff Gmbh & Co.Kg.Arzneimittel | Farmaceutski aktivni estri uridina |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US20060099239A1 (en) * | 2002-04-15 | 2006-05-11 | Coleman Henry D | Dietary supplement for promoting removal of heavy metals from the body |
| US6852369B1 (en) * | 2002-09-05 | 2005-02-08 | University Of Kentucky Research Foundation | Method for prevention of solid dissolution through covalent ligand bonding |
| US20060115555A1 (en) * | 2004-12-01 | 2006-06-01 | Foulger Sidney W | Nutritional supplements containing xanthone extracts |
| US9226885B2 (en) * | 2005-05-24 | 2016-01-05 | Allium Vitalis Incorporated | Personal care and medicinal products incorporating bound organosulfur groups |
| US9186376B2 (en) * | 2005-09-30 | 2015-11-17 | Patrick James Baggot | Maternal chelation for embryo, fetal, and infant benefit |
| US8950583B2 (en) * | 2008-12-06 | 2015-02-10 | Ermes Medical Company Limited | Method to remove heavy metals from a mammal |
| JP2013505963A (ja) * | 2009-09-28 | 2013-02-21 | ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデイション | 汚染された環境から元素を除去するチオール含有化合物およびその使用方法 |
| US8426368B2 (en) * | 2010-03-25 | 2013-04-23 | The University Of Kentucky Research Foundation | Method of ameliorating oxidative stress and supplementing the diet |
-
2011
- 2011-03-07 US US13/041,798 patent/US8575218B2/en active Active
-
2012
- 2012-01-06 WO PCT/US2012/020418 patent/WO2012121798A2/en not_active Ceased
- 2012-01-06 EP EP12754449.2A patent/EP2683370A4/en not_active Withdrawn
- 2012-01-06 AU AU2012226279A patent/AU2012226279A1/en not_active Abandoned
- 2012-01-06 CN CN2012800121240A patent/CN103442706A/zh active Pending
- 2012-01-06 JP JP2013557712A patent/JP2014507470A/ja not_active Withdrawn
- 2012-01-06 RU RU2013141994/04A patent/RU2013141994A/ru not_active Application Discontinuation
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