CN103442706A - 用于从组织中除去元素的包含巯基的化合物及其制剂 - Google Patents

用于从组织中除去元素的包含巯基的化合物及其制剂 Download PDF

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Publication number
CN103442706A
CN103442706A CN2012800121240A CN201280012124A CN103442706A CN 103442706 A CN103442706 A CN 103442706A CN 2012800121240 A CN2012800121240 A CN 2012800121240A CN 201280012124 A CN201280012124 A CN 201280012124A CN 103442706 A CN103442706 A CN 103442706A
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alkyl
hydrogen
carboxyl
aryl
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CN2012800121240A
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Chinese (zh)
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博伊德·E·黑利
大卫·A·阿特伍德
尼拉德里·N·古普塔
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University of Kentucky Research Foundation
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University of Kentucky Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/46—Removing components of defined structure
    • B01D53/64—Heavy metals or compounds thereof, e.g. mercury
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B01D2253/106—Silica or silicates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/25—Coated, impregnated or composite adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/60—Heavy metals or heavy metal compounds
    • B01D2257/602—Mercury or mercury compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B01D2258/0291—Flue gases from waste incineration plants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2012800121240A 2011-03-07 2012-01-06 用于从组织中除去元素的包含巯基的化合物及其制剂 Pending CN103442706A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/041,798 US8575218B2 (en) 2009-09-28 2011-03-07 Thiol-containing compounds for the removal of elements from tissues and formulations therefor
US13/041,798 2011-03-07
PCT/US2012/020418 WO2012121798A2 (en) 2011-03-07 2012-01-06 Thiol-containing compounds for the removal of elements from tissues and formulations therefor

Publications (1)

Publication Number Publication Date
CN103442706A true CN103442706A (zh) 2013-12-11

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Application Number Title Priority Date Filing Date
CN2012800121240A Pending CN103442706A (zh) 2011-03-07 2012-01-06 用于从组织中除去元素的包含巯基的化合物及其制剂

Country Status (7)

Country Link
US (1) US8575218B2 (enExample)
EP (1) EP2683370A4 (enExample)
JP (1) JP2014507470A (enExample)
CN (1) CN103442706A (enExample)
AU (1) AU2012226279A1 (enExample)
RU (1) RU2013141994A (enExample)
WO (1) WO2012121798A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN114642681A (zh) * 2022-03-18 2022-06-21 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

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US8950583B2 (en) 2008-12-06 2015-02-10 Ermes Medical Company Limited Method to remove heavy metals from a mammal
JP2013505963A (ja) * 2009-09-28 2013-02-21 ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデイション 汚染された環境から元素を除去するチオール含有化合物およびその使用方法
US8426368B2 (en) * 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet
GB2524831A (en) * 2014-04-04 2015-10-07 Ermes Medical Company Ltd New pharmaceutical use
GB2526623A (en) 2014-05-30 2015-12-02 Ermes Medical Company Ltd New pharmaceutical use
US9802889B2 (en) 2014-12-02 2017-10-31 Covalent Research Technologies, LLC Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
DK3493849T3 (en) 2016-08-05 2022-03-07 Emeramed Ltd New uses of n, n-bis-2-mercaptoethyl isophthalamide
AU2019386979B2 (en) * 2018-11-26 2023-03-16 The Procter & Gamble Company Solid pharmaceutical preparation containing lipoic acid and use thereof
US11174277B2 (en) 2019-05-29 2021-11-16 Alliance For Sustainable Energy, Llc Sequestering compositions and materials
GB202005057D0 (en) 2020-04-06 2020-05-20 Emeramed Ltd New Use

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US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法

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US6586600B2 (en) * 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
US20100227812A1 (en) * 2008-12-06 2010-09-09 Haley Boyd E Method of supplementing the diet and ameliorating oxidative stress
CN102612511A (zh) * 2009-09-28 2012-07-25 肯塔基大学研究基金会 用于从污染的环境中去除元素的含巯基化合物及其使用方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114642681A (zh) * 2022-03-18 2022-06-21 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用
CN114642681B (zh) * 2022-03-18 2023-08-29 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

Also Published As

Publication number Publication date
US20110160150A1 (en) 2011-06-30
AU2012226279A1 (en) 2013-09-19
RU2013141994A (ru) 2015-04-20
JP2014507470A (ja) 2014-03-27
EP2683370A1 (en) 2014-01-15
EP2683370A4 (en) 2014-10-15
WO2012121798A2 (en) 2012-09-13
US8575218B2 (en) 2013-11-05

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Application publication date: 20131211