JP2014507470A - 組織から元素を除去するチオール含有化合物およびその製剤 - Google Patents

組織から元素を除去するチオール含有化合物およびその製剤 Download PDF

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JP2014507470A
JP2014507470A JP2013557712A JP2013557712A JP2014507470A JP 2014507470 A JP2014507470 A JP 2014507470A JP 2013557712 A JP2013557712 A JP 2013557712A JP 2013557712 A JP2013557712 A JP 2013557712A JP 2014507470 A JP2014507470 A JP 2014507470A
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group
administration
hydrogen
alkyl
independently
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Japanese (ja)
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JP2014507470A5 (enExample
Inventor
ヘイリー，ボイド，イー．
アトウッド，デイヴィッド，エイ．
グプタ，ニラドリ，エヌ．
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University of Kentucky Research Foundation
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University of Kentucky Research Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/46—Removing components of defined structure
    • B01D53/64—Heavy metals or compounds thereof, e.g. mercury
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/10—Inorganic adsorbents
    • B01D2253/106—Silica or silicates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2253/00—Adsorbents used in seperation treatment of gases and vapours
    • B01D2253/25—Coated, impregnated or composite adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/60—Heavy metals or heavy metal compounds
    • B01D2257/602—Mercury or mercury compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2258/00—Sources of waste gases
    • B01D2258/02—Other waste gases
    • B01D2258/0283—Flue gases
    • B01D2258/0291—Flue gases from waste incineration plants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013557712A 2011-03-07 2012-01-06 組織から元素を除去するチオール含有化合物およびその製剤 Withdrawn JP2014507470A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/041,798 US8575218B2 (en) 2009-09-28 2011-03-07 Thiol-containing compounds for the removal of elements from tissues and formulations therefor
US13/041,798 2011-03-07
PCT/US2012/020418 WO2012121798A2 (en) 2011-03-07 2012-01-06 Thiol-containing compounds for the removal of elements from tissues and formulations therefor

Publications (2)

Publication Number Publication Date
JP2014507470A true JP2014507470A (ja) 2014-03-27
JP2014507470A5 JP2014507470A5 (enExample) 2014-06-26

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ID=46798686

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JP2013557712A Withdrawn JP2014507470A (ja) 2011-03-07 2012-01-06 組織から元素を除去するチオール含有化合物およびその製剤

Country Status (7)

Country Link
US (1) US8575218B2 (enExample)
EP (1) EP2683370A4 (enExample)
JP (1) JP2014507470A (enExample)
CN (1) CN103442706A (enExample)
AU (1) AU2012226279A1 (enExample)
RU (1) RU2013141994A (enExample)
WO (1) WO2012121798A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511307A (ja) * 2014-04-04 2017-04-20 エメレイムド リミテッド Ｎ，ｎ−ビス−２−メルカプトエチルイソフタルアミドの新規な使用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8950583B2 (en) 2008-12-06 2015-02-10 Ermes Medical Company Limited Method to remove heavy metals from a mammal
JP2013505963A (ja) * 2009-09-28 2013-02-21 ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデイション 汚染された環境から元素を除去するチオール含有化合物およびその使用方法
US8426368B2 (en) * 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet
GB2526623A (en) 2014-05-30 2015-12-02 Ermes Medical Company Ltd New pharmaceutical use
US9802889B2 (en) 2014-12-02 2017-10-31 Covalent Research Technologies, LLC Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
DK3493849T3 (en) 2016-08-05 2022-03-07 Emeramed Ltd New uses of n, n-bis-2-mercaptoethyl isophthalamide
AU2019386979B2 (en) * 2018-11-26 2023-03-16 The Procter & Gamble Company Solid pharmaceutical preparation containing lipoic acid and use thereof
US11174277B2 (en) 2019-05-29 2021-11-16 Alliance For Sustainable Energy, Llc Sequestering compositions and materials
GB202005057D0 (en) 2020-04-06 2020-05-20 Emeramed Ltd New Use
CN114642681B (zh) * 2022-03-18 2023-08-29 中国科学院长春应用化学研究所 一种聚合物在顺铂解毒中的应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039446A (en) * 1972-06-28 1977-08-02 Sumitomo Chemical Company, Limited Heavy metal-binding agent process
US4281086A (en) * 1978-12-11 1981-07-28 The University Of Illinois Foundation Polymer bound multidentate complexes
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide
DE3174885D1 (en) 1981-02-03 1986-07-31 Ici Plc Process for the extraction of metal values and novel metal extractants
DE3231982A1 (de) * 1982-08-27 1984-03-01 Süd-Chemie AG, 8000 München Thiolathaltiges mittel und verfahren zur entfernung von schwermetallionen aus verduennten waessrigen loesungen
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4751286A (en) * 1985-11-19 1988-06-14 The Johns Hopkins University Protein label and drug delivery system
US5200473A (en) * 1988-03-25 1993-04-06 Jeanneret Gris Gilbert Chelating resins and method for their use in the extraction of metal ions
US5073575A (en) * 1988-08-26 1991-12-17 The Regents Of The University Of California Cadmium ion-chelating synthetic polymers and process thereof
US4969995A (en) * 1988-08-26 1990-11-13 The United States Of America As Represented By The United States Department Of Energy Removal of metal ions from aqueous solution
US5173470A (en) * 1991-08-09 1992-12-22 Brigham Young University Compositions and processes for removing, separating and concentrating desired ions from solutions using sulfur and aralkyl nitrogen containing ligands bonded to inorganic supports
US5494935A (en) * 1992-01-17 1996-02-27 University Of Utah Research Foundation Methods for oral decorporation of metals
SE508881C2 (sv) * 1994-03-02 1998-11-16 Ctc Medical Ab Preparat avsett att vid behandling av i tänder befintliga amalgamfyllningar och/eller vid inserering av nya amalgamfyllningar hämma frisättning av Hg från amalgamet och/eller oskadliggöra frisatt Hg
US5615862A (en) * 1995-02-02 1997-04-01 Gaudette; Robert M. Metal precipitation composition for treating spent dry film stripping solution
US5766478A (en) * 1995-05-30 1998-06-16 The Regents Of The University Of California, Office Of Technology Transfer Water-soluble polymers for recovery of metal ions from aqueous streams
US6126964A (en) * 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
WO1999005302A1 (en) * 1997-07-24 1999-02-04 The Perkin-Elmer Corporation Conjugates of transporter peptides and nucleic acid analogs, and their use
US7087770B2 (en) * 1998-05-16 2006-08-08 Mirus Bio Corporation Compound containing a labile disulfide bond
US6936729B2 (en) * 1998-05-16 2005-08-30 Mirus Bio Corporation Compound containing a labile disulfide bond
US6586600B2 (en) * 2000-12-06 2003-07-01 University Of Kentucky Research Foundation Multidentate sulfur-containing ligands
RS51031B (sr) * 2001-04-30 2010-10-31 Trommsdorff Gmbh & Co.Kg.Arzneimittel Farmaceutski aktivni estri uridina
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20060099239A1 (en) * 2002-04-15 2006-05-11 Coleman Henry D Dietary supplement for promoting removal of heavy metals from the body
US6852369B1 (en) * 2002-09-05 2005-02-08 University Of Kentucky Research Foundation Method for prevention of solid dissolution through covalent ligand bonding
US20060115555A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplements containing xanthone extracts
US9226885B2 (en) * 2005-05-24 2016-01-05 Allium Vitalis Incorporated Personal care and medicinal products incorporating bound organosulfur groups
US9186376B2 (en) * 2005-09-30 2015-11-17 Patrick James Baggot Maternal chelation for embryo, fetal, and infant benefit
US8950583B2 (en) * 2008-12-06 2015-02-10 Ermes Medical Company Limited Method to remove heavy metals from a mammal
JP2013505963A (ja) * 2009-09-28 2013-02-21 ユニヴァーシティ オブ ケンタッキー リサーチ ファウンデイション 汚染された環境から元素を除去するチオール含有化合物およびその使用方法
US8426368B2 (en) * 2010-03-25 2013-04-23 The University Of Kentucky Research Foundation Method of ameliorating oxidative stress and supplementing the diet

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511307A (ja) * 2014-04-04 2017-04-20 エメレイムド リミテッド Ｎ，ｎ−ビス−２−メルカプトエチルイソフタルアミドの新規な使用

Also Published As

Publication number Publication date
CN103442706A (zh) 2013-12-11
US20110160150A1 (en) 2011-06-30
AU2012226279A1 (en) 2013-09-19
RU2013141994A (ru) 2015-04-20
EP2683370A1 (en) 2014-01-15
EP2683370A4 (en) 2014-10-15
WO2012121798A2 (en) 2012-09-13
US8575218B2 (en) 2013-11-05

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