JP2014506914A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014506914A5 JP2014506914A5 JP2013555938A JP2013555938A JP2014506914A5 JP 2014506914 A5 JP2014506914 A5 JP 2014506914A5 JP 2013555938 A JP2013555938 A JP 2013555938A JP 2013555938 A JP2013555938 A JP 2013555938A JP 2014506914 A5 JP2014506914 A5 JP 2014506914A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- sucrose
- composition according
- matrix
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229930006000 Sucrose Natural products 0.000 claims 17
- 239000005720 sucrose Substances 0.000 claims 17
- -1 sucrose fatty acid esters Chemical class 0.000 claims 14
- 239000011159 matrix material Substances 0.000 claims 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims 12
- 239000000194 fatty acid Substances 0.000 claims 12
- 229930195729 fatty acid Natural products 0.000 claims 12
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical group C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 claims 11
- 238000010521 absorption reaction Methods 0.000 claims 10
- 229960000452 diethylstilbestrol Drugs 0.000 claims 10
- 239000003623 enhancer Substances 0.000 claims 10
- 229920002959 polymer blend Polymers 0.000 claims 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 8
- 235000010443 alginic acid Nutrition 0.000 claims 7
- 229920000615 alginic acid Polymers 0.000 claims 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 239000000783 alginic acid Substances 0.000 claims 5
- 229960001126 alginic acid Drugs 0.000 claims 5
- 150000004781 alginic acids Chemical class 0.000 claims 5
- 239000002736 nonionic surfactant Substances 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 210000002307 prostate Anatomy 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 3
- 229920000136 polysorbate Polymers 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims 2
- 239000004373 Pullulan Substances 0.000 claims 2
- 229920001218 Pullulan Polymers 0.000 claims 2
- GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 claims 2
- ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 claims 2
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical group O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 229940116224 behenate Drugs 0.000 claims 2
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 claims 2
- 229960005233 cineole Drugs 0.000 claims 2
- 239000010649 ginger oil Substances 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 229940049964 oleate Drugs 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- 235000019423 pullulan Nutrition 0.000 claims 2
- 150000003505 terpenes Chemical class 0.000 claims 2
- 235000007586 terpenes Nutrition 0.000 claims 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical group CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920001219 Polysorbate 40 Polymers 0.000 claims 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 claims 1
- 229940124532 absorption promoter Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229930007050 cineol Natural products 0.000 claims 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 claims 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
- 239000001593 sorbitan monooleate Substances 0.000 claims 1
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 1
- 229940035049 sorbitan monooleate Drugs 0.000 claims 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000001570 sorbitan monopalmitate Substances 0.000 claims 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 239000001589 sorbitan tristearate Substances 0.000 claims 1
- 235000011078 sorbitan tristearate Nutrition 0.000 claims 1
- 229960004129 sorbitan tristearate Drugs 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/040,143 | 2011-03-03 | ||
| US13/040,143 US8900634B2 (en) | 2008-11-03 | 2011-03-03 | Diethylstilbestrol dosage form and methods of treatment using thereof |
| PCT/GB2012/050475 WO2012117257A1 (en) | 2011-03-03 | 2012-03-02 | Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199070A Division JP2017061465A (ja) | 2011-03-03 | 2016-10-07 | ジエチルスチルベストロール製剤、及び、前立腺又は乳癌の治療におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506914A JP2014506914A (ja) | 2014-03-20 |
| JP2014506914A5 true JP2014506914A5 (enExample) | 2015-03-19 |
| JP6059153B2 JP6059153B2 (ja) | 2017-01-11 |
Family
ID=45841525
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555938A Expired - Fee Related JP6059153B2 (ja) | 2011-03-03 | 2012-03-02 | ジエチルスチルベストロール製剤、及び、前立腺又は乳癌の治療におけるその使用 |
| JP2016199070A Withdrawn JP2017061465A (ja) | 2011-03-03 | 2016-10-07 | ジエチルスチルベストロール製剤、及び、前立腺又は乳癌の治療におけるその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199070A Withdrawn JP2017061465A (ja) | 2011-03-03 | 2016-10-07 | ジエチルスチルベストロール製剤、及び、前立腺又は乳癌の治療におけるその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8900634B2 (enExample) |
| EP (1) | EP2680813B1 (enExample) |
| JP (2) | JP6059153B2 (enExample) |
| KR (1) | KR101865776B1 (enExample) |
| CN (1) | CN103561720A (enExample) |
| AU (2) | AU2012223023B2 (enExample) |
| BR (1) | BR112013022438A2 (enExample) |
| CA (1) | CA2827892C (enExample) |
| ES (1) | ES2733282T3 (enExample) |
| RU (1) | RU2602296C2 (enExample) |
| SG (1) | SG192845A1 (enExample) |
| TW (1) | TWI548426B (enExample) |
| WO (1) | WO2012117257A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
| US8900634B2 (en) * | 2008-11-03 | 2014-12-02 | Nal Pharmaceuticals, Ltd. | Diethylstilbestrol dosage form and methods of treatment using thereof |
| MX2015004759A (es) * | 2012-10-15 | 2015-10-12 | Chamaeleo Pharma Bvba | Fosfestrol para uso en el tratamiento curativo o paliativo de cancer en mamiferos hembras. |
| EP2906206A1 (en) | 2012-10-15 | 2015-08-19 | CHAMAELEO Pharma Bvba | Sulfestrol for treating cancer |
| CA2888161A1 (en) | 2012-10-15 | 2014-04-24 | Chamaeleo Pharma Bvba | Fosfestrol for use in curative or palliative treatment of prostate cancer |
| SG11201610358XA (en) | 2014-06-24 | 2017-01-27 | Catherine Lee | Fast acting orally disintegrating film |
| CN105997857A (zh) * | 2016-06-29 | 2016-10-12 | 冯志清 | 一种用于治疗猪乳房炎的注射液 |
| WO2018091473A1 (en) | 2016-11-15 | 2018-05-24 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| KR101940401B1 (ko) * | 2017-06-12 | 2019-01-21 | 경상대학교산학협력단 | 맛이 차폐된 구강붕해필름 및 이의 제조방법 |
| WO2019028457A2 (en) * | 2017-08-04 | 2019-02-07 | University Of Houston System | FORMULATION OF NANOSUSPENSION OF DIETHYLSTILBESTROL INJECTABLE |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| WO2020030991A1 (en) * | 2018-08-09 | 2020-02-13 | Nal Pharmaceutical Group Limited | Dosage form for insertion into the mouth |
| CN113133983B (zh) * | 2020-01-20 | 2023-12-12 | 鲁南制药集团股份有限公司 | 一种治疗前列腺癌的药物组合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5026560A (en) | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
| US5464632C1 (en) | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| KR100554924B1 (ko) | 1998-05-18 | 2006-03-03 | 다케다 야쿠힌 고교 가부시키가이샤 | 구강내 붕괴 정제 |
| US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US20020015730A1 (en) * | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
| US20030147936A1 (en) | 2002-02-07 | 2003-08-07 | Velayudhan Sahadevan | Prostatic hormonal implants treatment of prostate cancer |
| PE20060003A1 (es) * | 2004-03-12 | 2006-03-01 | Smithkline Beecham Plc | Formulacion farmaceutica polimerica para moldear por inyeccion |
| IL175338A0 (en) * | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| WO2008045461A2 (en) * | 2006-10-11 | 2008-04-17 | Oregon Health & Science University | Transdermal diethylstilbestrol for treating prostate cancer |
| AU2008237246B2 (en) * | 2007-04-05 | 2014-06-05 | University Of Kansas | Rapidly dissolving pharmaceutical compositions comprising pullulan |
| WO2009029543A1 (en) | 2007-08-24 | 2009-03-05 | Aegis Therapeutics, Llc | Controlled release formulations |
| US8900634B2 (en) * | 2008-11-03 | 2014-12-02 | Nal Pharmaceuticals, Ltd. | Diethylstilbestrol dosage form and methods of treatment using thereof |
| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
-
2011
- 2011-03-03 US US13/040,143 patent/US8900634B2/en not_active Expired - Fee Related
-
2012
- 2012-03-02 WO PCT/GB2012/050475 patent/WO2012117257A1/en not_active Ceased
- 2012-03-02 BR BR112013022438A patent/BR112013022438A2/pt not_active IP Right Cessation
- 2012-03-02 EP EP12709150.2A patent/EP2680813B1/en active Active
- 2012-03-02 CN CN201280011570.XA patent/CN103561720A/zh active Pending
- 2012-03-02 RU RU2013144383/15A patent/RU2602296C2/ru active
- 2012-03-02 ES ES12709150T patent/ES2733282T3/es active Active
- 2012-03-02 TW TW101106943A patent/TWI548426B/zh not_active IP Right Cessation
- 2012-03-02 AU AU2012223023A patent/AU2012223023B2/en not_active Ceased
- 2012-03-02 SG SG2013062864A patent/SG192845A1/en unknown
- 2012-03-02 JP JP2013555938A patent/JP6059153B2/ja not_active Expired - Fee Related
- 2012-03-02 KR KR1020137025787A patent/KR101865776B1/ko not_active Expired - Fee Related
- 2012-03-02 CA CA2827892A patent/CA2827892C/en not_active Expired - Fee Related
-
2016
- 2016-10-07 JP JP2016199070A patent/JP2017061465A/ja not_active Withdrawn
-
2017
- 2017-05-05 AU AU2017203009A patent/AU2017203009B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014506914A5 (enExample) | ||
| RU2013144383A (ru) | Лекарственная форма и применение диэтилстильбестрола для лечения рака предстательной железы или молочной железы | |
| US8715715B2 (en) | Dosage form for insertion into the mouth | |
| JP7653218B2 (ja) | 送達増強エピネフリン組成物 | |
| JP2012513955A5 (enExample) | ||
| AU2014363599B2 (en) | Orally disintegrating solid dosage unit containing an estetrol component | |
| JP7670700B2 (ja) | 発作性障害の治療用のカンナビジオール（ｃｂｄ）を含む経皮医薬組成物 | |
| KR102845228B1 (ko) | 강화된 투과를 가지는 약물학적 조성물 | |
| KR20180021127A (ko) | 케타민 경피 전달 시스템 | |
| CA2816564A1 (en) | Inflammatory disease | |
| JP2009536147A5 (enExample) | ||
| TW201201796A (en) | Transdermal delivery patch | |
| JP2011503044A5 (enExample) | ||
| JP2014518285A5 (enExample) | ||
| JP2011500781A5 (enExample) | ||
| RU2504363C2 (ru) | Усилитель чрескожного всасывания и трансдермальный препарат с его использованием | |
| WO2020030991A1 (en) | Dosage form for insertion into the mouth | |
| JP2013545802A5 (enExample) | ||
| RU2501550C2 (ru) | Сублингвальная спреевая композиция, содержащая дигидроартемизинин | |
| RU2015143993A (ru) | Твердые лекарственные формы, обладающие противорвотным действием, с замедленным высвобождением | |
| JP2016520114A5 (enExample) | ||
| TW200930381A (en) | Compositions and methods for the treatment of bladder cancer | |
| KR20150048301A (ko) | 수면마취용 구강점막 부착형 패치 및 이의 제조방법 | |
| CN108472375A (zh) | 中重度流感的治疗方法 | |
| RU2019102890A (ru) | Фармацевтические композиции, содержащие флурбипрофен |