CA2827892C - Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer - Google Patents

Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer Download PDF

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Publication number
CA2827892C
CA2827892C CA2827892A CA2827892A CA2827892C CA 2827892 C CA2827892 C CA 2827892C CA 2827892 A CA2827892 A CA 2827892A CA 2827892 A CA2827892 A CA 2827892A CA 2827892 C CA2827892 C CA 2827892C
Authority
CA
Canada
Prior art keywords
sucrose
diethylstilbestrol
pharmaceutical composition
weight
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2827892A
Other languages
English (en)
French (fr)
Other versions
CA2827892A1 (en
Inventor
Diana Shu-Lian Chow
Roland A. Ako
Je Phil Ryoo
Chun Kwong Chu
Zheng Wang
Original Assignee
NAL Pharmaceutical Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAL Pharmaceutical Group Ltd filed Critical NAL Pharmaceutical Group Ltd
Publication of CA2827892A1 publication Critical patent/CA2827892A1/en
Application granted granted Critical
Publication of CA2827892C publication Critical patent/CA2827892C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2827892A 2011-03-03 2012-03-02 Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer Expired - Fee Related CA2827892C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/040,143 2011-03-03
US13/040,143 US8900634B2 (en) 2008-11-03 2011-03-03 Diethylstilbestrol dosage form and methods of treatment using thereof
PCT/GB2012/050475 WO2012117257A1 (en) 2011-03-03 2012-03-02 Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer

Publications (2)

Publication Number Publication Date
CA2827892A1 CA2827892A1 (en) 2012-09-07
CA2827892C true CA2827892C (en) 2019-12-03

Family

ID=45841525

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2827892A Expired - Fee Related CA2827892C (en) 2011-03-03 2012-03-02 Diethylstilbestrol dosage form and use for the treatment of prostate or breast cancer

Country Status (13)

Country Link
US (1) US8900634B2 (enExample)
EP (1) EP2680813B1 (enExample)
JP (2) JP6059153B2 (enExample)
KR (1) KR101865776B1 (enExample)
CN (1) CN103561720A (enExample)
AU (2) AU2012223023B2 (enExample)
BR (1) BR112013022438A2 (enExample)
CA (1) CA2827892C (enExample)
ES (1) ES2733282T3 (enExample)
RU (1) RU2602296C2 (enExample)
SG (1) SG192845A1 (enExample)
TW (1) TWI548426B (enExample)
WO (1) WO2012117257A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8900634B2 (en) * 2008-11-03 2014-12-02 Nal Pharmaceuticals, Ltd. Diethylstilbestrol dosage form and methods of treatment using thereof
US8715715B2 (en) * 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth
EP2906224A1 (en) 2012-10-15 2015-08-19 CHAMAELEO Pharma Bvba Fosfestrol for use in curative or palliative treatment of prostate cancer
CN105899214A (zh) * 2012-10-15 2016-08-24 变色蜥制药公司 用于根治性治疗或姑息性治疗雌性哺乳动物的癌症的磷雌酚
JP2016511218A (ja) * 2012-10-15 2016-04-14 チャマエレオ ファーマ ビーブイビーエー がんを処置するためのサルフェストロール
CA2953546A1 (en) 2014-06-24 2015-12-30 Taho Pharmaceuticals Fast acting orally disintegrating film
CN105997857A (zh) * 2016-06-29 2016-10-12 冯志清 一种用于治疗猪乳房炎的注射液
US11007144B2 (en) 2016-11-15 2021-05-18 Klaria Pharma Holding Ab Pharmaceutical formulation
GB201709141D0 (en) 2017-06-08 2017-07-26 Klaria Pharma Holding Ab Pharmaceutical formulation
KR101940401B1 (ko) * 2017-06-12 2019-01-21 경상대학교산학협력단 맛이 차폐된 구강붕해필름 및 이의 제조방법
WO2019028457A2 (en) * 2017-08-04 2019-02-07 University Of Houston System FORMULATION OF NANOSUSPENSION OF DIETHYLSTILBESTROL INJECTABLE
GB201808462D0 (en) 2018-05-23 2018-07-11 Klaria Pharma Holding Ab Pharmaceutical formulation
WO2020030991A1 (en) * 2018-08-09 2020-02-13 Nal Pharmaceutical Group Limited Dosage form for insertion into the mouth
CN113133983B (zh) * 2020-01-20 2023-12-12 鲁南制药集团股份有限公司 一种治疗前列腺癌的药物组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026560A (en) 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
PT1121103E (pt) 1998-05-18 2007-02-28 Takeda Pharmaceutical Comprimidos de desintegração oral compreendendo um benzimidazole
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20020015730A1 (en) * 2000-03-09 2002-02-07 Torsten Hoffmann Pharmaceutical formulations and method for making
US20030147936A1 (en) 2002-02-07 2003-08-07 Velayudhan Sahadevan Prostatic hormonal implants treatment of prostate cancer
TW200539903A (en) * 2004-03-12 2005-12-16 Smithkline Beecham Plc Pharmaceutical formulations
IL175338A0 (en) * 2006-05-01 2006-09-05 Biota Ltd Orally administrable films and preparation thereof
WO2008045461A2 (en) 2006-10-11 2008-04-17 Oregon Health & Science University Transdermal diethylstilbestrol for treating prostate cancer
EP2144601A4 (en) * 2007-04-05 2012-10-10 Univ Kansas RAPID DISSOLVING PHARMACEUTICAL COMPOSITIONS COMPRISING PULLULANE
WO2009029543A1 (en) 2007-08-24 2009-03-05 Aegis Therapeutics, Llc Controlled release formulations
US8900634B2 (en) * 2008-11-03 2014-12-02 Nal Pharmaceuticals, Ltd. Diethylstilbestrol dosage form and methods of treatment using thereof
US8715715B2 (en) * 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth

Also Published As

Publication number Publication date
TWI548426B (zh) 2016-09-11
JP2014506914A (ja) 2014-03-20
AU2017203009B2 (en) 2018-07-19
EP2680813A1 (en) 2014-01-08
AU2012223023A1 (en) 2013-09-19
WO2012117257A8 (en) 2013-09-19
CN103561720A (zh) 2014-02-05
KR101865776B1 (ko) 2018-06-08
US20110189288A1 (en) 2011-08-04
AU2017203009A1 (en) 2017-05-25
BR112013022438A2 (pt) 2016-12-06
EP2680813B1 (en) 2019-05-08
ES2733282T3 (es) 2019-11-28
TW201249484A (en) 2012-12-16
SG192845A1 (en) 2013-09-30
US8900634B2 (en) 2014-12-02
WO2012117257A1 (en) 2012-09-07
JP2017061465A (ja) 2017-03-30
CA2827892A1 (en) 2012-09-07
JP6059153B2 (ja) 2017-01-11
AU2012223023B2 (en) 2017-03-16
RU2013144383A (ru) 2015-04-10
RU2602296C2 (ru) 2016-11-20
KR20140021587A (ko) 2014-02-20

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Legal Events

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EEER Examination request

Effective date: 20170227

MKLA Lapsed

Effective date: 20220302