JP2014506884A5 - - Google Patents
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- JP2014506884A5 JP2014506884A5 JP2013552722A JP2013552722A JP2014506884A5 JP 2014506884 A5 JP2014506884 A5 JP 2014506884A5 JP 2013552722 A JP2013552722 A JP 2013552722A JP 2013552722 A JP2013552722 A JP 2013552722A JP 2014506884 A5 JP2014506884 A5 JP 2014506884A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- lipid
- less
- apoa
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004895 Lipoproteins Human genes 0.000 claims description 29
- 108090001030 Lipoproteins Proteins 0.000 claims description 29
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims description 22
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims description 22
- 150000003904 phospholipids Chemical class 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 12
- 230000007935 neutral effect Effects 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims 37
- 238000000034 method Methods 0.000 claims 33
- 235000004252 protein component Nutrition 0.000 claims 12
- 239000000725 suspension Substances 0.000 claims 11
- 101710129138 ATP synthase subunit 9, mitochondrial Proteins 0.000 claims 6
- 101710168506 ATP synthase subunit C, plastid Proteins 0.000 claims 6
- 101710114069 ATP synthase subunit c Proteins 0.000 claims 6
- 101710197943 ATP synthase subunit c, chloroplastic Proteins 0.000 claims 6
- 101710187091 ATP synthase subunit c, sodium ion specific Proteins 0.000 claims 6
- 238000005227 gel permeation chromatography Methods 0.000 claims 6
- 102000019758 lipid binding proteins Human genes 0.000 claims 6
- 230000004576 lipid-binding Effects 0.000 claims 5
- 238000000265 homogenisation Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 102000023856 peptide binding proteins Human genes 0.000 claims 4
- 108091008399 peptide binding proteins Proteins 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000007592 Apolipoproteins Human genes 0.000 claims 3
- 108010071619 Apolipoproteins Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- BIABMEZBCHDPBV-BEBVUIBBSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-BEBVUIBBSA-N 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 239000003599 detergent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- 101000733802 Homo sapiens Apolipoprotein A-I Proteins 0.000 claims 1
- RWKUXQNLWDTSLO-GWQJGLRPSA-N N-hexadecanoylsphingosine-1-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)[C@H](O)\C=C\CCCCCCCCCCCCC RWKUXQNLWDTSLO-GWQJGLRPSA-N 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000002296 dynamic light scattering Methods 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 238000005194 fractionation Methods 0.000 claims 1
- 238000001641 gel filtration chromatography Methods 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 description 10
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 4
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440371P | 2011-02-07 | 2011-02-07 | |
| US61/440,371 | 2011-02-07 | ||
| US201161452630P | 2011-03-14 | 2011-03-14 | |
| US61/452,630 | 2011-03-14 | ||
| US201161487263P | 2011-05-17 | 2011-05-17 | |
| US61/487,263 | 2011-05-17 | ||
| PCT/US2012/024020 WO2012109162A1 (en) | 2011-02-07 | 2012-02-06 | Lipoprotein complexes and manufacturing and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017186171A Division JP6720126B2 (ja) | 2011-02-07 | 2017-09-27 | リポタンパク質複合体ならびにその製造および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506884A JP2014506884A (ja) | 2014-03-20 |
| JP2014506884A5 true JP2014506884A5 (enExample) | 2016-10-13 |
| JP6219170B2 JP6219170B2 (ja) | 2017-10-25 |
Family
ID=45592833
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552722A Active JP6219170B2 (ja) | 2011-02-07 | 2012-02-06 | リポタンパク質複合体ならびにその製造および使用 |
| JP2017186171A Active JP6720126B2 (ja) | 2011-02-07 | 2017-09-27 | リポタンパク質複合体ならびにその製造および使用 |
| JP2020104518A Active JP7009559B2 (ja) | 2011-02-07 | 2020-06-17 | リポタンパク質複合体ならびにその製造および使用 |
| JP2022003351A Pending JP2022050603A (ja) | 2011-02-07 | 2022-01-12 | リポタンパク質複合体ならびにその製造および使用 |
| JP2024151092A Pending JP2024170492A (ja) | 2011-02-07 | 2024-09-03 | リポタンパク質複合体ならびにその製造および使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017186171A Active JP6720126B2 (ja) | 2011-02-07 | 2017-09-27 | リポタンパク質複合体ならびにその製造および使用 |
| JP2020104518A Active JP7009559B2 (ja) | 2011-02-07 | 2020-06-17 | リポタンパク質複合体ならびにその製造および使用 |
| JP2022003351A Pending JP2022050603A (ja) | 2011-02-07 | 2022-01-12 | リポタンパク質複合体ならびにその製造および使用 |
| JP2024151092A Pending JP2024170492A (ja) | 2011-02-07 | 2024-09-03 | リポタンパク質複合体ならびにその製造および使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (9) | US20120232005A1 (enExample) |
| EP (4) | EP2673296B1 (enExample) |
| JP (5) | JP6219170B2 (enExample) |
| KR (1) | KR20140053848A (enExample) |
| CN (4) | CN107337728B (enExample) |
| AU (1) | AU2012214672B2 (enExample) |
| CA (1) | CA2826158A1 (enExample) |
| CY (2) | CY1121317T1 (enExample) |
| DK (3) | DK3466969T3 (enExample) |
| ES (3) | ES2717455T3 (enExample) |
| HR (2) | HRP20190138T1 (enExample) |
| HU (2) | HUE042314T2 (enExample) |
| IL (1) | IL227634B (enExample) |
| IN (1) | IN2013DN07828A (enExample) |
| LT (2) | LT2767546T (enExample) |
| MX (2) | MX343907B (enExample) |
| PH (2) | PH12013501644A1 (enExample) |
| PL (2) | PL2673296T3 (enExample) |
| PT (2) | PT2673296T (enExample) |
| RS (2) | RS58243B1 (enExample) |
| RU (2) | RU2627173C2 (enExample) |
| SG (2) | SG192693A1 (enExample) |
| SI (2) | SI2673296T1 (enExample) |
| SM (2) | SMT201900194T1 (enExample) |
| TW (2) | TW201240671A (enExample) |
| WO (1) | WO2012109162A1 (enExample) |
| ZA (1) | ZA201305628B (enExample) |
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| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| WO2012000048A1 (en) | 2010-06-30 | 2012-01-05 | Csl Limited | A reconstituted high density lipoprotein formulation and production method thereof |
| HUE042314T2 (hu) | 2011-02-07 | 2019-06-28 | Cerenis Therapeutics Holding Sa | Lipoprotein komplexek és azok gyártása és alkalmazásai |
| US9125943B2 (en) | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
| US9994611B2 (en) * | 2013-02-28 | 2018-06-12 | Agency For Science, Technology And Research | Chromatographic purification of antibodies from chromatin-deficient cell culture harvests |
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| NZ631126A (en) * | 2013-08-08 | 2018-06-29 | Csl Ltd | Contaminant removal method |
| EP2853259A1 (en) * | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Reconstituted high density lipoproteins composition and uses thereof |
| MX2016014306A (es) | 2014-05-02 | 2017-06-12 | Cerenis Therapeutics Holding Sa | Marcadores para terapia con lipoproteinas de alta densidad (hdl). |
| WO2016019333A1 (en) | 2014-07-31 | 2016-02-04 | Kinemed, Inc. | The effect of phospholipid composition of reconstituted hdl on its cholesterol efflux and anti-inflammatory properties |
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| EP3471778A4 (en) | 2016-06-20 | 2020-02-19 | The Regents of The University of Michigan | COMPOSITIONS AND METHODS FOR ADMINISTERING BIOMACROMOLECULAR AGENTS |
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| TW201919686A (zh) * | 2017-08-10 | 2019-06-01 | 法商塞勒尼斯醫療控股公司 | 脫輔基子(apomers) |
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| US11484551B2 (en) | 2019-11-20 | 2022-11-01 | Alkahest, Inc. | Method of treating liver failure with plasma fraction IV-4 |
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| WO2021209808A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Cer-001 therapy for treating kidney disease |
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| EP4259280A4 (en) * | 2020-12-11 | 2025-02-12 | The Regents Of The University Of Michigan | Compositions and methods for preventing, attenuating, and treating medical conditions with shdl nanoparticles |
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