MX343907B - Complejos de lipoproteina y fabricacion y usos de los mismos. - Google Patents
Complejos de lipoproteina y fabricacion y usos de los mismos.Info
- Publication number
- MX343907B MX343907B MX2013009083A MX2013009083A MX343907B MX 343907 B MX343907 B MX 343907B MX 2013009083 A MX2013009083 A MX 2013009083A MX 2013009083 A MX2013009083 A MX 2013009083A MX 343907 B MX343907 B MX 343907B
- Authority
- MX
- Mexico
- Prior art keywords
- lipoprotein complexes
- manufacturing
- lipoprotein
- apolipoproteins
- complexes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a un método para preparar complejos de lipoproteína, caracterizado porque comprende: (a) enfriar una suspensión inicial que comprende un componente de lípido y un componente de proteína desde una temperatura en una primera escala de temperatura hasta una temperatura en segunda escala de temperatura, en donde dicha primera escala de temperatura incluye temperaturas de no menos de 10 grados abajo y no más de 15 grados arriba de la temperatura de transición de dicho componente de proteína, y en donde (i) el componente de lípido consiste esencialmente de partículas de lípidos formadas mediante homogeneización; y (ii) el componente de proteína consiste esencialmente en péptidos de unión a lípido y/o proteínas de unión a lípido que no han sido sometidas a homogeneización y, opcionalmente, un lípido en una cantidad que es 10% o menos en peso del contenido total de lípido en la suspensión inicial ; (b) calentar la suspensión enfriada de (a) desde una temperatura de dicha segunda escala de temperatura hasta una temperatura de dicha primera escala de temperatura; (c) enfriar dicha suspensión calentada de (b) desde una temperatura de dicha primera escala de temperatura hasta una temperatura de dicha segunda escala de temperatura; y (d) repetir los pasos (b) y (c) hasta que por lo menos 80% del componente de proteína esté incorporado en complejos de lipoproteína, formado de esta manera complejos de lipoproteína.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161440371P | 2011-02-07 | 2011-02-07 | |
US201161452630P | 2011-03-14 | 2011-03-14 | |
US201161487263P | 2011-05-17 | 2011-05-17 | |
PCT/US2012/024020 WO2012109162A1 (en) | 2011-02-07 | 2012-02-06 | Lipoprotein complexes and manufacturing and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013009083A MX2013009083A (es) | 2014-02-03 |
MX343907B true MX343907B (es) | 2016-11-28 |
Family
ID=45592833
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013009083A MX343907B (es) | 2011-02-07 | 2012-02-06 | Complejos de lipoproteina y fabricacion y usos de los mismos. |
MX2016011834A MX355159B (es) | 2011-02-07 | 2013-08-06 | Complejos de lipoproteina y fabricacion y usos de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011834A MX355159B (es) | 2011-02-07 | 2013-08-06 | Complejos de lipoproteina y fabricacion y usos de los mismos. |
Country Status (27)
Country | Link |
---|---|
US (8) | US20120232005A1 (es) |
EP (4) | EP4400511A2 (es) |
JP (4) | JP6219170B2 (es) |
KR (1) | KR20140053848A (es) |
CN (4) | CN103443123B (es) |
AU (1) | AU2012214672B2 (es) |
CA (1) | CA2826158A1 (es) |
CY (2) | CY1121317T1 (es) |
DK (2) | DK2767546T3 (es) |
ES (2) | ES2716349T3 (es) |
HK (1) | HK1198834A1 (es) |
HR (2) | HRP20190072T1 (es) |
HU (2) | HUE042314T2 (es) |
IL (1) | IL227634B (es) |
IN (1) | IN2013DN07828A (es) |
LT (2) | LT2673296T (es) |
MX (2) | MX343907B (es) |
PH (1) | PH12016500191A1 (es) |
PL (2) | PL2673296T3 (es) |
PT (2) | PT2673296T (es) |
RS (2) | RS58275B1 (es) |
RU (2) | RU2017126088A (es) |
SG (2) | SG192693A1 (es) |
SI (2) | SI2673296T1 (es) |
TW (2) | TW201737935A (es) |
WO (1) | WO2012109162A1 (es) |
ZA (1) | ZA201305628B (es) |
Families Citing this family (40)
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US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
PL3178481T3 (pl) | 2010-06-30 | 2019-07-31 | Csl Limited | Odtworzona formulacja lipoproteiny o wysokiej gęstości i sposób jej produkcji |
CN103443123B (zh) | 2011-02-07 | 2020-05-29 | 塞勒尼斯医疗控股公司 | 脂蛋白复合物及其制备和用途 |
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EP2970344A2 (en) | 2013-03-15 | 2016-01-20 | Cerenis Therapeutics Holding SA | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
WO2015017888A1 (en) * | 2013-08-08 | 2015-02-12 | Csl Limited | Contaminant removal method |
EP2853259A1 (en) * | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Reconstituted high density lipoproteins composition and uses thereof |
RU2016144908A (ru) | 2014-05-02 | 2018-06-05 | Серени Терапеутикс Холдинг Са | Маркеры hdl-терапии |
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KR101671580B1 (ko) * | 2014-08-26 | 2016-11-02 | 영남대학교 산학협력단 | 미녹시딜 수용액 제조방법 |
US10307491B2 (en) | 2015-01-30 | 2019-06-04 | The Regents Of The University Of Michigan | Liposomal particles comprising biological molecules and uses thereof |
AU2016238290B9 (en) | 2015-03-25 | 2019-06-13 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
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