JP2014506249A5 - - Google Patents
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- JP2014506249A5 JP2014506249A5 JP2013545417A JP2013545417A JP2014506249A5 JP 2014506249 A5 JP2014506249 A5 JP 2014506249A5 JP 2013545417 A JP2013545417 A JP 2013545417A JP 2013545417 A JP2013545417 A JP 2013545417A JP 2014506249 A5 JP2014506249 A5 JP 2014506249A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- solvent
- transsurface
- ethyl
- liquid carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 methoxyethyl Chemical group 0.000 claims 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 239000002904 solvent Substances 0.000 claims 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 5
- 239000006184 cosolvent Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 239000003981 vehicle Substances 0.000 claims 5
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 4
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 claims 4
- LZCLXQDLBQLTDK-BYPYZUCNSA-N ethyl (2S)-lactate Chemical compound CCOC(=O)[C@H](C)O LZCLXQDLBQLTDK-BYPYZUCNSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000004544 spot-on Substances 0.000 claims 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims 2
- QCAHUFWKIQLBNB-UHFFFAOYSA-N 3-(3-methoxypropoxy)propan-1-ol Chemical compound COCCCOCCCO QCAHUFWKIQLBNB-UHFFFAOYSA-N 0.000 claims 2
- 239000005891 Cyromazine Substances 0.000 claims 2
- 239000005893 Diflubenzuron Substances 0.000 claims 2
- 239000005894 Emamectin Substances 0.000 claims 2
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 239000005912 Lufenuron Substances 0.000 claims 2
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 239000005927 Pyriproxyfen Substances 0.000 claims 2
- 239000005942 Triflumuron Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229960005233 cineole Drugs 0.000 claims 2
- LVQDKIWDGQRHTE-UHFFFAOYSA-N cyromazine Chemical compound NC1=NC(N)=NC(NC2CC2)=N1 LVQDKIWDGQRHTE-UHFFFAOYSA-N 0.000 claims 2
- 229950000775 cyromazine Drugs 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 claims 2
- 229940019503 diflubenzuron Drugs 0.000 claims 2
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims 2
- 235000019441 ethanol Nutrition 0.000 claims 2
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 2
- HJUFTIJOISQSKQ-UHFFFAOYSA-N fenoxycarb Chemical compound C1=CC(OCCNC(=O)OCC)=CC=C1OC1=CC=CC=C1 HJUFTIJOISQSKQ-UHFFFAOYSA-N 0.000 claims 2
- 239000003630 growth substance Substances 0.000 claims 2
- 125000004970 halomethyl group Chemical group 0.000 claims 2
- HICUREFSAIZXFQ-JOWPUVSESA-N i9z29i000j Chemical compound C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\[C@H](OC(=O)C(=N/OC)\C=1C=CC=CC=1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 HICUREFSAIZXFQ-JOWPUVSESA-N 0.000 claims 2
- 229950000961 latidectin Drugs 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims 2
- 229960000521 lufenuron Drugs 0.000 claims 2
- 229950003442 methoprene Drugs 0.000 claims 2
- 229930002897 methoprene Natural products 0.000 claims 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 2
- CKVMAPHTVCTEMM-ALPQRHTBSA-N milbemycin oxime Chemical compound O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)C(=N/O)/[C@H]3OC\2)O)C[C@H]4C1.C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)C(=N/O)/[C@H]3OC\1)O)C[C@H]4C2 CKVMAPHTVCTEMM-ALPQRHTBSA-N 0.000 claims 2
- 229940099245 milbemycin oxime Drugs 0.000 claims 2
- YZBLFMPOMVTDJY-CBYMMZEQSA-N moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-CBYMMZEQSA-N 0.000 claims 2
- 229960004816 moxidectin Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims 2
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 claims 2
- 229960002245 selamectin Drugs 0.000 claims 2
- XAIPTRIXGHTTNT-UHFFFAOYSA-N triflumuron Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)NC(=O)C1=CC=CC=C1Cl XAIPTRIXGHTTNT-UHFFFAOYSA-N 0.000 claims 2
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 claims 1
- WMDZKDKPYCNCDZ-UHFFFAOYSA-N 2-(2-butoxypropoxy)propan-1-ol Chemical compound CCCCOC(C)COC(C)CO WMDZKDKPYCNCDZ-UHFFFAOYSA-N 0.000 claims 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims 1
- 208000026803 Animal Parasitic disease Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229920005555 halobutyl Polymers 0.000 claims 1
- 125000004968 halobutyl group Chemical group 0.000 claims 1
- 125000004969 haloethyl group Chemical group 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 229940067107 phenylethyl alcohol Drugs 0.000 claims 1
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 1
- 239000004540 pour-on Substances 0.000 claims 1
- 125000004673 propylcarbonyl group Chemical group 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 0 CC=*OCNC Chemical compound CC=*OCNC 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10197090 | 2010-12-27 | ||
| EP10197090.3 | 2010-12-27 | ||
| US201161430241P | 2011-01-06 | 2011-01-06 | |
| US61/430,241 | 2011-01-06 | ||
| PCT/EP2011/073830 WO2012089623A1 (en) | 2010-12-27 | 2011-12-22 | Topical localized isoxazoline formulation comprising glycofurol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138739A Division JP6357508B2 (ja) | 2010-12-27 | 2016-07-13 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014506249A JP2014506249A (ja) | 2014-03-13 |
| JP2014506249A5 true JP2014506249A5 (https=) | 2015-02-05 |
Family
ID=43920659
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545417A Pending JP2014506249A (ja) | 2010-12-27 | 2011-12-22 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
| JP2016138739A Active JP6357508B2 (ja) | 2010-12-27 | 2016-07-13 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
| JP2018115590A Active JP6539384B2 (ja) | 2010-12-27 | 2018-06-18 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138739A Active JP6357508B2 (ja) | 2010-12-27 | 2016-07-13 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
| JP2018115590A Active JP6539384B2 (ja) | 2010-12-27 | 2018-06-18 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20130274302A1 (https=) |
| EP (1) | EP2658541B2 (https=) |
| JP (3) | JP2014506249A (https=) |
| KR (2) | KR101992589B1 (https=) |
| CN (2) | CN103260620A (https=) |
| AU (1) | AU2011351579B2 (https=) |
| BR (1) | BR112013015498A2 (https=) |
| CA (1) | CA2822853C (https=) |
| DK (1) | DK2658541T4 (https=) |
| ES (1) | ES2908254T5 (https=) |
| FI (1) | FI2658541T4 (https=) |
| HU (1) | HUE058290T2 (https=) |
| MX (2) | MX390508B (https=) |
| NZ (1) | NZ611474A (https=) |
| PL (1) | PL2658541T5 (https=) |
| PT (1) | PT2658541T (https=) |
| RU (1) | RU2602189C2 (https=) |
| WO (1) | WO2012089623A1 (https=) |
| ZA (1) | ZA201304515B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6002148B2 (ja) | 2010-12-27 | 2016-10-05 | インターベット インターナショナル ベー． フェー． | 経表面局所イソオキサゾリン製剤 |
| NZ611474A (en) * | 2010-12-27 | 2015-08-28 | Intervet Int Bv | Topical localized isoxazoline formulation comprising glycofurol |
| RS58417B1 (sr) | 2011-09-12 | 2019-04-30 | Merial Inc | Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima |
| EP3216448B8 (en) | 2012-02-06 | 2019-06-05 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| JP6273252B2 (ja) * | 2012-03-13 | 2018-01-31 | バイエル・ニュージーランド・リミテッド | 長時間作用型の組成物 |
| WO2015066277A1 (en) | 2013-11-01 | 2015-05-07 | Merial Limited | Antiparisitic and pesticidal isoxazoline compounds |
| EP2875726A1 (fr) * | 2013-11-13 | 2015-05-27 | Ceva Animal Health | Nouvelles applications de compositions vétérinaires dans le traitement contre les parasites |
| EP3082806B1 (en) | 2013-12-20 | 2021-05-12 | Intervet International B.V. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
| EP3082867B1 (en) * | 2013-12-20 | 2024-01-17 | Intervet International B.V. | Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals |
| EP3131398B1 (en) | 2014-04-17 | 2019-10-23 | Boehringer Ingelheim Animal Health USA Inc. | Use of malononitrile compounds for protecting animals from parasites |
| EP3236960B1 (en) | 2014-12-22 | 2025-01-29 | Intervet International B.V. | Fluralaner for use in the treatment of demodicosis |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| SG11201708068PA (en) | 2015-04-08 | 2017-10-30 | Merial Inc | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| LT3298027T (lt) | 2015-05-20 | 2021-08-10 | Boehringer Ingelheim Animal Health USA Inc. | Antihelmintiniai depsipeptido junginiai |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| CN111386112A (zh) * | 2017-11-23 | 2020-07-07 | 法国诗华大药厂 | 用于治疗寄生虫感染的含有莫昔克丁的组合物 |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| CN113260419A (zh) | 2018-11-20 | 2021-08-13 | 勃林格殷格翰动物保健美国公司 | 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法 |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| JP7558197B2 (ja) * | 2019-05-03 | 2024-09-30 | インターベット インターナショナル ベー． フェー． | 注射可能な医薬組成物及びその使用 |
| AU2020315758B2 (en) | 2019-07-16 | 2024-08-01 | Donaghys Limited | Transdermal solvent system and methods of use |
| EP4077286A1 (en) | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| AU2021278871A1 (en) | 2020-05-28 | 2023-01-19 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
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2011
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- 2011-12-22 MX MX2019011837A patent/MX390508B/es unknown
- 2011-12-22 WO PCT/EP2011/073830 patent/WO2012089623A1/en not_active Ceased
- 2011-12-22 EP EP11799292.5A patent/EP2658541B2/en active Active
- 2011-12-22 ES ES11799292T patent/ES2908254T5/es active Active
- 2011-12-22 KR KR1020187033062A patent/KR101992589B1/ko active Active
- 2011-12-22 AU AU2011351579A patent/AU2011351579B2/en active Active
- 2011-12-22 US US13/996,080 patent/US20130274302A1/en not_active Abandoned
- 2011-12-22 DK DK11799292.5T patent/DK2658541T4/da active
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- 2011-12-22 BR BR112013015498A patent/BR112013015498A2/pt not_active Application Discontinuation
- 2011-12-22 MX MX2013007501A patent/MX348079B/es active IP Right Grant
- 2011-12-22 KR KR1020137016604A patent/KR101920476B1/ko active Active
- 2011-12-22 PT PT117992925T patent/PT2658541T/pt unknown
- 2011-12-22 CN CN2011800628265A patent/CN103260620A/zh active Pending
- 2011-12-22 CN CN201810083356.4A patent/CN108125951A/zh active Pending
- 2011-12-22 RU RU2013135415/15A patent/RU2602189C2/ru active
- 2011-12-22 PL PL11799292.5T patent/PL2658541T5/pl unknown
- 2011-12-22 FI FIEP11799292.5T patent/FI2658541T4/fi active
- 2011-12-22 HU HUE11799292A patent/HUE058290T2/hu unknown
- 2011-12-22 JP JP2013545417A patent/JP2014506249A/ja active Pending
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