JP2014506249A5 - - Google Patents
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- JP2014506249A5 JP2014506249A5 JP2013545417A JP2013545417A JP2014506249A5 JP 2014506249 A5 JP2014506249 A5 JP 2014506249A5 JP 2013545417 A JP2013545417 A JP 2013545417A JP 2013545417 A JP2013545417 A JP 2013545417A JP 2014506249 A5 JP2014506249 A5 JP 2014506249A5
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- JP
- Japan
- Prior art keywords
- methyl
- solvent
- transsurface
- ethyl
- liquid carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 methoxyethyl Chemical group 0.000 claims 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 239000002904 solvent Substances 0.000 claims 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 5
- 239000006184 cosolvent Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 239000003981 vehicle Substances 0.000 claims 5
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 4
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 claims 4
- LZCLXQDLBQLTDK-BYPYZUCNSA-N ethyl (2S)-lactate Chemical compound CCOC(=O)[C@H](C)O LZCLXQDLBQLTDK-BYPYZUCNSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000004544 spot-on Substances 0.000 claims 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims 2
- QCAHUFWKIQLBNB-UHFFFAOYSA-N 3-(3-methoxypropoxy)propan-1-ol Chemical compound COCCCOCCCO QCAHUFWKIQLBNB-UHFFFAOYSA-N 0.000 claims 2
- 239000005891 Cyromazine Substances 0.000 claims 2
- 239000005893 Diflubenzuron Substances 0.000 claims 2
- 239000005894 Emamectin Substances 0.000 claims 2
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 239000005912 Lufenuron Substances 0.000 claims 2
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 239000005927 Pyriproxyfen Substances 0.000 claims 2
- 239000005942 Triflumuron Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229960005233 cineole Drugs 0.000 claims 2
- LVQDKIWDGQRHTE-UHFFFAOYSA-N cyromazine Chemical compound NC1=NC(N)=NC(NC2CC2)=N1 LVQDKIWDGQRHTE-UHFFFAOYSA-N 0.000 claims 2
- 229950000775 cyromazine Drugs 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- QQQYTWIFVNKMRW-UHFFFAOYSA-N diflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC=C(Cl)C=C1 QQQYTWIFVNKMRW-UHFFFAOYSA-N 0.000 claims 2
- 229940019503 diflubenzuron Drugs 0.000 claims 2
- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 claims 2
- 235000019441 ethanol Nutrition 0.000 claims 2
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 2
- HJUFTIJOISQSKQ-UHFFFAOYSA-N fenoxycarb Chemical compound C1=CC(OCCNC(=O)OCC)=CC=C1OC1=CC=CC=C1 HJUFTIJOISQSKQ-UHFFFAOYSA-N 0.000 claims 2
- 239000003630 growth substance Substances 0.000 claims 2
- 125000004970 halomethyl group Chemical group 0.000 claims 2
- HICUREFSAIZXFQ-JOWPUVSESA-N i9z29i000j Chemical compound C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\[C@H](OC(=O)C(=N/OC)\C=1C=CC=CC=1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 HICUREFSAIZXFQ-JOWPUVSESA-N 0.000 claims 2
- 229950000961 latidectin Drugs 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 claims 2
- 229960000521 lufenuron Drugs 0.000 claims 2
- 229950003442 methoprene Drugs 0.000 claims 2
- 229930002897 methoprene Natural products 0.000 claims 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 2
- CKVMAPHTVCTEMM-ALPQRHTBSA-N milbemycin oxime Chemical compound O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)C(=N/O)/[C@H]3OC\2)O)C[C@H]4C1.C1C[C@H](C)[C@@H](CC)O[C@@]21O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)C(=N/O)/[C@H]3OC\1)O)C[C@H]4C2 CKVMAPHTVCTEMM-ALPQRHTBSA-N 0.000 claims 2
- 229940099245 milbemycin oxime Drugs 0.000 claims 2
- YZBLFMPOMVTDJY-CBYMMZEQSA-N moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-CBYMMZEQSA-N 0.000 claims 2
- 229960004816 moxidectin Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims 2
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- AFJYYKSVHJGXSN-KAJWKRCWSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N\O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-KAJWKRCWSA-N 0.000 claims 2
- 229960002245 selamectin Drugs 0.000 claims 2
- XAIPTRIXGHTTNT-UHFFFAOYSA-N triflumuron Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)NC(=O)C1=CC=CC=C1Cl XAIPTRIXGHTTNT-UHFFFAOYSA-N 0.000 claims 2
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 claims 1
- WMDZKDKPYCNCDZ-UHFFFAOYSA-N 2-(2-butoxypropoxy)propan-1-ol Chemical compound CCCCOC(C)COC(C)CO WMDZKDKPYCNCDZ-UHFFFAOYSA-N 0.000 claims 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims 1
- 208000026803 Animal Parasitic disease Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229920005555 halobutyl Polymers 0.000 claims 1
- 125000004968 halobutyl group Chemical group 0.000 claims 1
- 125000004969 haloethyl group Chemical group 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 229940067107 phenylethyl alcohol Drugs 0.000 claims 1
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 1
- 239000004540 pour-on Substances 0.000 claims 1
- 125000004673 propylcarbonyl group Chemical group 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 0 CC=*OCNC Chemical compound CC=*OCNC 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10197090 | 2010-12-27 | ||
| EP10197090.3 | 2010-12-27 | ||
| US201161430241P | 2011-01-06 | 2011-01-06 | |
| US61/430,241 | 2011-01-06 | ||
| PCT/EP2011/073830 WO2012089623A1 (en) | 2010-12-27 | 2011-12-22 | Topical localized isoxazoline formulation comprising glycofurol |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138739A Division JP6357508B2 (ja) | 2010-12-27 | 2016-07-13 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014506249A JP2014506249A (ja) | 2014-03-13 |
| JP2014506249A5 true JP2014506249A5 (cg-RX-API-DMAC7.html) | 2015-02-05 |
Family
ID=43920659
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545417A Pending JP2014506249A (ja) | 2010-12-27 | 2011-12-22 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
| JP2016138739A Active JP6357508B2 (ja) | 2010-12-27 | 2016-07-13 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
| JP2018115590A Active JP6539384B2 (ja) | 2010-12-27 | 2018-06-18 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016138739A Active JP6357508B2 (ja) | 2010-12-27 | 2016-07-13 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
| JP2018115590A Active JP6539384B2 (ja) | 2010-12-27 | 2018-06-18 | グリコフロールを含む経表面局所イソオキサゾリン製剤 |
Country Status (18)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9173870B2 (en) * | 2010-12-27 | 2015-11-03 | Intervet Inc. | Topical localized isoxazoline formulation |
| HUE058290T2 (hu) * | 2010-12-27 | 2022-07-28 | Intervet Int Bv | Topikális lokalizált izoxazolin formuláció, amely tartalmaz glikofurolt |
| SG11201400558YA (en) | 2011-09-12 | 2014-04-28 | Merial Ltd | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| TR201909461T4 (tr) | 2012-02-06 | 2019-07-22 | Boehringer Ingelheim Animal Health Usa Inc | Si̇stemi̇k olarak etki̇ eden akti̇f maddeleri̇ i̇çeren parazi̇ti̇si̇dal oral veteri̇nerli̇ğe ai̇t bi̇leşi̇mler, bunlarin yöntemleri̇ ve kullanimlari |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| JP6273252B2 (ja) * | 2012-03-13 | 2018-01-31 | バイエル・ニュージーランド・リミテッド | 長時間作用型の組成物 |
| ES2905848T3 (es) | 2013-11-01 | 2022-04-12 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de isoxazolina antiparasitarios y plaguicidas |
| EP2875726A1 (fr) * | 2013-11-13 | 2015-05-27 | Ceva Animal Health | Nouvelles applications de compositions vétérinaires dans le traitement contre les parasites |
| US10272071B2 (en) | 2013-12-20 | 2019-04-30 | Intervet Inc. | Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry |
| CN110327468B (zh) | 2013-12-20 | 2023-04-28 | 英特维特国际股份有限公司 | 异噁唑啉组合物及其在预防或治疗动物的寄生虫侵袭中的用途 |
| NZ726251A (en) | 2014-04-17 | 2017-11-24 | Merial Inc | Use of malononitrile compounds for protecting animals from parasites |
| FI4008329T3 (fi) | 2014-12-22 | 2025-08-22 | Intervet Int Bv | Isoksatsoliiniyhdisteitä käytettäväksi hoidettaessa demodikoosia |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| BR112017021073A2 (pt) | 2015-04-08 | 2018-07-03 | Merial Inc | composições injetáveis de liberação prolongada compreendendo um agente ativo de isoxazolina, seus métodos e usos |
| ES2916216T3 (es) | 2015-05-20 | 2022-06-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de depsipéptidos antihelmínticos |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CN110381738B (zh) | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| AU2017361099A1 (en) | 2016-11-16 | 2019-06-06 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| CN111194316A (zh) | 2017-08-14 | 2020-05-22 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的吡唑-异噁唑啉化合物 |
| BR112020010291A2 (pt) * | 2017-11-23 | 2020-11-17 | Ceva Sante Animale | composição contendo moxidectina para tratamento de infestações de parasitas |
| AR113997A1 (es) | 2017-12-21 | 2020-07-08 | Intervet Int Bv | Composiciones antiparasitarias para unción dorsal continua |
| IL279977B2 (en) | 2018-07-09 | 2024-06-01 | Boehringer Ingelheim Animal Health Usa Inc | Heterocyclic anthelmintic compounds |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| JP7637630B2 (ja) | 2019-03-19 | 2025-02-28 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 駆虫性アザベンゾチオフェンおよびアザベンゾフラン化合物 |
| AU2020268618B2 (en) * | 2019-05-03 | 2025-12-04 | Intervet International B.V. | Injectable pharmaceutical compositions and uses thereof |
| AU2020315758B2 (en) | 2019-07-16 | 2024-08-01 | Donaghys Limited | Transdermal solvent system and methods of use |
| MX2022007455A (es) | 2019-12-18 | 2022-08-15 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como plaguicidas. |
| WO2021242481A1 (en) | 2020-05-28 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| EP4185585A1 (en) | 2020-07-24 | 2023-05-31 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
| US12161089B2 (en) | 2020-12-21 | 2024-12-10 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal collar comprising isoxazoline compounds |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| BR112023015168A2 (pt) | 2021-01-27 | 2023-10-03 | Corteva Agriscience Llc | Compostos de ciclopropilamida contra parasitas em peixes |
| WO2023156938A1 (en) | 2022-02-17 | 2023-08-24 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| NO20240925A1 (en) | 2023-09-15 | 2025-03-17 | Evah Atlantic Inc | Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish |
| WO2025191150A2 (en) * | 2024-03-15 | 2025-09-18 | Krka, D.D., Novo Mesto | Stable isoxazoline formulation for topical application to the skin |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
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2011
- 2011-12-22 HU HUE11799292A patent/HUE058290T2/hu unknown
- 2011-12-22 CN CN2011800628265A patent/CN103260620A/zh active Pending
- 2011-12-22 BR BR112013015498A patent/BR112013015498A2/pt not_active Application Discontinuation
- 2011-12-22 AU AU2011351579A patent/AU2011351579B2/en active Active
- 2011-12-22 KR KR1020187033062A patent/KR101992589B1/ko active Active
- 2011-12-22 NZ NZ611474A patent/NZ611474A/en unknown
- 2011-12-22 MX MX2019011837A patent/MX390508B/es unknown
- 2011-12-22 CA CA2822853A patent/CA2822853C/en active Active
- 2011-12-22 US US13/996,080 patent/US20130274302A1/en not_active Abandoned
- 2011-12-22 DK DK11799292.5T patent/DK2658541T3/da active
- 2011-12-22 MX MX2013007501A patent/MX348079B/es active IP Right Grant
- 2011-12-22 RU RU2013135415/15A patent/RU2602189C2/ru active
- 2011-12-22 PL PL11799292T patent/PL2658541T3/pl unknown
- 2011-12-22 ES ES11799292T patent/ES2908254T3/es active Active
- 2011-12-22 CN CN201810083356.4A patent/CN108125951A/zh active Pending
- 2011-12-22 KR KR1020137016604A patent/KR101920476B1/ko active Active
- 2011-12-22 EP EP11799292.5A patent/EP2658541B2/en active Active
- 2011-12-22 JP JP2013545417A patent/JP2014506249A/ja active Pending
- 2011-12-22 WO PCT/EP2011/073830 patent/WO2012089623A1/en not_active Ceased
- 2011-12-22 PT PT117992925T patent/PT2658541T/pt unknown
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2013
- 2013-06-19 ZA ZA2013/04515A patent/ZA201304515B/en unknown
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2014
- 2014-09-11 US US14/483,542 patent/US20150011596A1/en not_active Abandoned
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2016
- 2016-07-13 JP JP2016138739A patent/JP6357508B2/ja active Active
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2018
- 2018-06-18 JP JP2018115590A patent/JP6539384B2/ja active Active
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