JP2014505685A5 - - Google Patents
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- Publication number
- JP2014505685A5 JP2014505685A5 JP2013547648A JP2013547648A JP2014505685A5 JP 2014505685 A5 JP2014505685 A5 JP 2014505685A5 JP 2013547648 A JP2013547648 A JP 2013547648A JP 2013547648 A JP2013547648 A JP 2013547648A JP 2014505685 A5 JP2014505685 A5 JP 2014505685A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- delivery polymer
- compound
- amidobenzyl
- polymer according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JDFXJJLFADUZIY-UHFFFAOYSA-N CON(C(CC1)=O)C1=O Chemical compound CON(C(CC1)=O)C1=O JDFXJJLFADUZIY-UHFFFAOYSA-N 0.000 description 1
- ZRQUIRABLIQJRI-UHFFFAOYSA-N COc(c(F)c(c(F)c1F)F)c1F Chemical compound COc(c(F)c(c(F)c1F)F)c1F ZRQUIRABLIQJRI-UHFFFAOYSA-N 0.000 description 1
- RDWOLIZQAHPNKO-UHFFFAOYSA-N COc(cc1)ccc1[NH+]([O-])[O-] Chemical compound COc(cc1)ccc1[NH+]([O-])[O-] RDWOLIZQAHPNKO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061427936P | 2010-12-29 | 2010-12-29 | |
| US61/427,936 | 2010-12-29 | ||
| US13/336,028 US8426554B2 (en) | 2010-12-29 | 2011-12-23 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
| US13/336,028 | 2011-12-23 | ||
| PCT/US2011/067588 WO2012092373A2 (en) | 2010-12-29 | 2011-12-28 | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505685A JP2014505685A (ja) | 2014-03-06 |
| JP2014505685A5 true JP2014505685A5 (enExample) | 2014-09-11 |
| JP5941926B2 JP5941926B2 (ja) | 2016-06-29 |
Family
ID=46383848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013547648A Expired - Fee Related JP5941926B2 (ja) | 2010-12-29 | 2011-12-28 | 酵素感受性連結を有するインビボポリヌクレオチド送達結合体 |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP2658579A4 (enExample) |
| JP (1) | JP5941926B2 (enExample) |
| KR (1) | KR20130136494A (enExample) |
| CN (1) | CN103491982B (enExample) |
| AU (1) | AU2011352204B2 (enExample) |
| BR (1) | BR112013014115A2 (enExample) |
| CA (1) | CA2816041C (enExample) |
| CL (2) | CL2013001876A1 (enExample) |
| MX (2) | MX347298B (enExample) |
| NZ (1) | NZ611656A (enExample) |
| PE (1) | PE20140198A1 (enExample) |
| RU (1) | RU2619453C2 (enExample) |
| SG (1) | SG189942A1 (enExample) |
| WO (1) | WO2012092373A2 (enExample) |
| ZA (1) | ZA201302896B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2889044A1 (en) | 2012-11-15 | 2014-05-22 | Roche Innovation Center Copenhagen A/S | Anti apob antisense conjugate compounds |
| WO2015021092A1 (en) * | 2013-08-07 | 2015-02-12 | Arrowhead Research Corporation | Polyconjugates for delivery of rnai triggers to tumor cells in vivo |
| JOP20160211B1 (ar) | 2015-10-01 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| KR102775461B1 (ko) * | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| EP3630742B1 (en) * | 2017-05-24 | 2023-08-16 | Ramot at Tel-Aviv University Ltd. | Chemiluminescent probes for imaging/detection of proteases |
| CN118638787A (zh) | 2017-12-06 | 2024-09-13 | 艾维迪提生物科学公司 | 治疗肌萎缩和强直性肌营养不良的组合物和方法 |
| AU2019416109A1 (en) * | 2018-12-28 | 2021-07-22 | Sirnaomics, Inc. | Targeted delivery of therapeutic molecules |
| CN114450326B (zh) * | 2019-06-24 | 2025-02-11 | 普罗美加公司 | 用于将生物分子递送到细胞中的改性聚胺聚合物 |
| TW202144572A (zh) | 2020-03-19 | 2021-12-01 | 美商亞維代堤生物科學公司 | 治療臉肩胛肱骨肌肉失養症之組合物及方法 |
| CN115209922A (zh) * | 2021-01-28 | 2022-10-18 | 南京桦冠生物技术有限公司 | 缀合物及其用途 |
| KR20240024104A (ko) * | 2021-06-24 | 2024-02-23 | 가부시키가이샤 토호쿠 테크노 아치 | 형광 프로브 |
| KR102712976B1 (ko) * | 2021-07-27 | 2024-10-07 | 국립안동대학교 산학협력단 | 등검은말벌 추출물을 유효성분으로 함유하는 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품 |
| CN113621003B (zh) * | 2021-09-10 | 2023-02-03 | 国科温州研究院(温州生物材料与工程研究所) | 一种制备有机分子共价修饰的功能化核酸材料的方法及其应用 |
| EP4401792A4 (en) | 2021-09-16 | 2025-12-03 | Avidity Biosciences Inc | COMPOSITIONS AND METHODS OF TREATMENT OF FACIO-SCAPULO-HUMERAL MUSCULAR DYSTROPHY |
| CN121079108A (zh) * | 2023-05-12 | 2025-12-05 | 五稜化药株式会社 | 冻结干燥制剂、冻结干燥溶液和这些的制造方法、以及液剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| EP1242609A2 (en) * | 1999-12-30 | 2002-09-25 | Novartis AG | Novel colloid synthetic vectors for gene therapy |
| HUP0300024A2 (en) * | 2000-02-24 | 2003-05-28 | Genentech Inc | Caspase activated prodrugs therapy |
| EP1243276A1 (en) * | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| US7541330B2 (en) * | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
| US20080171067A1 (en) * | 2007-01-17 | 2008-07-17 | Immunomedics, Inc. | Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites |
| WO2007059404A2 (en) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
| RU2430740C2 (ru) * | 2006-08-18 | 2011-10-10 | Ф.Хоффманн-Ля Рош Аг | Поликонъюгаты для введения in vivo полинуклеотидов |
| TW201004647A (en) * | 2008-05-20 | 2010-02-01 | Sigma Tau Ind Farmaceuti | Novel dual targeting antitumoural conjugates |
| US8501930B2 (en) * | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
-
2011
- 2011-12-28 MX MX2016006733A patent/MX347298B/es unknown
- 2011-12-28 NZ NZ611656A patent/NZ611656A/en not_active IP Right Cessation
- 2011-12-28 SG SG2013029830A patent/SG189942A1/en unknown
- 2011-12-28 CN CN201180061179.6A patent/CN103491982B/zh active Active
- 2011-12-28 BR BR112013014115A patent/BR112013014115A2/pt not_active IP Right Cessation
- 2011-12-28 EP EP11853858.6A patent/EP2658579A4/en not_active Withdrawn
- 2011-12-28 WO PCT/US2011/067588 patent/WO2012092373A2/en not_active Ceased
- 2011-12-28 MX MX2013007316A patent/MX341118B/es active IP Right Grant
- 2011-12-28 CA CA2816041A patent/CA2816041C/en active Active
- 2011-12-28 RU RU2013117286A patent/RU2619453C2/ru active
- 2011-12-28 PE PE2013001496A patent/PE20140198A1/es not_active Application Discontinuation
- 2011-12-28 KR KR1020137017195A patent/KR20130136494A/ko not_active Ceased
- 2011-12-28 JP JP2013547648A patent/JP5941926B2/ja not_active Expired - Fee Related
- 2011-12-28 AU AU2011352204A patent/AU2011352204B2/en not_active Ceased
-
2013
- 2013-04-22 ZA ZA2013/02896A patent/ZA201302896B/en unknown
- 2013-06-25 CL CL2013001876A patent/CL2013001876A1/es unknown
-
2015
- 2015-12-10 CL CL2015003580A patent/CL2015003580A1/es unknown
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